EKS-NOL-00057

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00057

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	374.1	3.8E-112	460	752	293

Status

Unreviewed

Ensembl Protein

ENSNLEP00000003763

UniProt Accession

G1QS45;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK13

Gene Synonyms/Alias

CDK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000003097	ENSNLEP00000003763	ENSNLET00000003949

Organism

Nomascus leucogenys

Functional Description

Protein Length

1266

Protein Sequence
(FASTA)

SKSGSSSSSG GRRKSASATS SSSSSRKDRD SKAHRSRTKS SKEPPSAYKE PPKAYREDKT 60

EPKAYRRRRS LSPLGGRDDS PVSHRASQSL RSRKSPSPAG GGSSPYSRRL PRSPSPYSRR 120

RSPSYSRHSS YERGGDVSPS PYSSSSWRRS RSPYSPVLRR SGKSRSRSPY SSRHSRSRSR 180

HRLSRSRSRH SSISPSTLTL KSSLAAELNK NKKARAAEAA RAAEAAKAAE ATKAAEAAAK 240

AAKASNTSTP TKGNTETSAS ASQTNHVKDV KKIKIEHAPS PSSGGTLKND KAKTKPPLQV 300

TKVENNLIVD KATKKAVIVG KESKSAATKE EPVSLKEKTK PLTPSIGAKE REQHVALVTS 360

TLPPLPLPPM LPEDKEADSL RGNISVKAVK KEVEKKLRCL LADLPLPPEL PGGDDLSKSP 420

EEKKTATQLH SKRRPKICGP RYGEIKEKDI DWGKRCVDKF DIIGIIGEGT YGQVYKARDK 480

DTGEMVALKK VRLDNEKEGF PITAIREIKI LRQLTHQSII NMKEIVTDKE DALDFKKDKG 540

AFYLVFEYMD HDLMGLLESG LVHFNENHIK SFMRQLMEGL DYCHKKNFLH RDIKCSNILL 600

NNRGQIKLAD FGLARLYSSE ESRPYTNKVI TLWYRPPELL LGEERYTPAI DVWSCGCILG 660

ELFTKKPIFQ ANQELAQLEL ISRICGSPCP AVWPDVIKLP YFNTMKPKKQ YRRKLREEFV 720

FIPAAALDLF DYMLALDPSK RCTAEQALQC EFLRDVEPSK MPPPDLPLWQ DCHELWSKKR 780

RRQKQMGMTD DVSTIKAPRK DLSLGLDDSR TNTPQGVLPS SQLKSQGNSN VAPVKTGPGQ 840

HLNHSELAIL LNLLQSKTSV NMADFVQVLN IKVNSETQQQ LNKINLPAGI LATGEKQTDP 900

STPQQESSKP LGGIQPSQTI QPKVETDAAQ AAVQSAFAVL LTQLIKAQQS KQKDVLLEER 960

ENGSGHEASL QLRPPPEPST PVSGQDDLIQ HQDMRILELT PEPDRPRILP PDQRPPEPPE 1020

PPPVTEEDLD YRTENQHVPT TSSSLTDPHA GVKAALLQLL AQHQPQDDPK REGGIDYQAG 1080

DTYVSTSDYK DNFGSSSFSS APYVSNDGLG SSSAPPLERR SFIGNSDIQS LDNYSTASSH 1140

SGGPPQPSAF SESFPSSVAG YGDIYLNAGP MLFSGDKDHR FEYSHGPIAV LANSSDPSTG 1200

PESTHPLPAK MHNYNYGGNL QENPSGPSLM HGQTWTSPAQ GPGYSQGYRG HISTSTGRGR 1260

GRGLPY 1266

Nucleotide Sequence
(FASTA)

TCCAAGAGCG GCAGCAGCAG CAGCAGCGGC GGCCGCCGGA AAAGCGCCTC GGCCACGTCC 60

AGCAGCAGTA GCAGCCGCAA GGACCGGGAC TCGAAGGCCC ATCGCAGCCG GACTAAGTCG 120

TCCAAGGAGC CGCCTTCGGC CTACAAGGAA CCGCCCAAGG CCTACCGGGA GGACAAGACT 180

GAACCCAAGG CCTACAGGCG GCGGCGGTCC CTCAGCCCGC TGGGAGGCCG GGACGACAGC 240

CCGGTGTCCC ACAGGGCCTC TCAGAGCCTG AGGAGCCGCA AGTCCCCCAG CCCGGCAGGA 300

GGTGGCAGCA GCCCCTATTC TCGGCGGCTG CCGCGCTCCC CGAGCCCCTA CAGCCGCCGC 360

CGCTCCCCCA GCTACAGCCG CCACAGCTCC TACGAGCGGG GCGGCGACGT GTCCCCTAGT 420

CCCTACAGCA GCAGCAGCTG GCGCCGCTCT CGCAGTCCCT ACAGCCCTGT GCTCAGACGG 480

TCTGGAAAAT CCCGAAGCAG AAGCCCGTAT TCATCTAGGC ATTCAAGATC TCGTAGCAGG 540

CACAGATTGT CTAGATCCAG AAGTCGTCAT TCTAGTATTT CTCCTAGCAC ACTAACTCTG 600

AAGAGTAGCC TGGCAGCTGA ATTGAACAAG AATAAAAAAG CACGAGCAGC AGAGGCAGCA 660

AGAGCCGCAG AAGCAGCGAA AGCTGCAGAA GCAACTAAGG CTGCTGAGGC TGCTGCCAAG 720

GCTGCAAAAG CTTCAAACAC TTCTACACCT ACCAAGGGGA ACACGGAAAC TAGTGCCAGT 780

GCATCACAAA CAAACCATGT GAAGGATGTG AAGAAAATTA AAATTGAACA TGCACCTTCT 840

CCCTCAAGTG GTGGAACTTT AAAAAATGAC AAAGCAAAAA CAAAGCCACC TCTTCAGGTA 900

ACGAAGGTGG AAAATAATTT GATTGTAGAT AAAGCCACCA AGAAAGCAGT CATAGTTGGA 960

AAGGAGAGTA AATCTGCTGC TACAAAGGAG GAACCAGTAT CTCTTAAAGA GAAAACCAAA 1020

CCACTTACAC CAAGCATAGG AGCCAAGGAG AGGGAGCAAC ATGTAGCTTT AGTGACTTCT 1080

ACATTACCAC CGTTACCTTT GCCTCCCATG CTGCCTGAAG ATAAAGAAGC TGATAGCTTA 1140

CGAGGAAATA TTTCAGTAAA AGCAGTTAAA AAAGAAGTAG AAAAGAAACT CCGATGTCTT 1200

CTTGCTGATT TACCGCTGCC CCCTGAGCTA CCAGGAGGAG ATGATCTTTC AAAGAGTCCA 1260

GAGGAAAAGA AAACAGCAAC ACAGTTACAT AGTAAAAGGA GGCCTAAAAT ATGTGGGCCT 1320

CGCTATGGTG AAATCAAAGA AAAAGATATT GACTGGGGAA AACGCTGCGT GGATAAATTT 1380

GATATCATCG GAATTATTGG AGAAGGTACT TACGGACAAG TTTACAAAGC CAGGGATAAA 1440

GACACTGGAG AAATGGTAGC CTTAAAAAAA GTACGTCTGG ATAATGAAAA GGAAGGCTTT 1500

CCAATTACAG CAATTCGAGA AATTAAAATT CTCCGGCAGC TTACCCATCA GAGTATTATC 1560

AATATGAAGG AAATAGTGAC TGATAAAGAA GATGCTTTGG ACTTCAAGAA GGACAAAGGT 1620

GCATTTTATC TGGTGTTTGA ATATATGGAC CATGATCTGA TGGGACTACT GGAATCAGGC 1680

TTGGTTCATT TTAATGAAAA TCACATAAAG TCATTTATGA GACAGCTCAT GGAGGGTCTG 1740

GATTATTGTC ATAAGAAGAA CTTTTTGCAT AGAGATATTA AATGTTCCAA TATCCTTCTA 1800

AATAATAGAG GGCAGATAAA ACTTGCAGAT TTTGGACTTG CTCGATTATA TAGCTCAGAA 1860

GAAAGTCGGC CGTATACTAA CAAGGTAATT ACTTTATGGT ACCGTCCACC TGAACTGCTA 1920

CTGGGAGAAG AACGATACAC ACCAGCCATT GATGTATGGA GCTGTGGCTG TATCCTTGGC 1980

GAACTCTTCA CTAAAAAACC TATATTTCAA GCAAATCAGG AACTTGCACA ACTAGAATTA 2040

ATAAGCCGAA TATGTGGGAG TCCATGTCCT GCAGTGTGGC CTGATGTAAT CAAACTACCA 2100

TATTTCAACA CCATGAAACC AAAGAAGCAA TATCGTCGAA AGTTAAGAGA AGAATTTGTT 2160

TTTATTCCTG CAGCTGCACT AGACTTATTT GATTACATGC TCGCCTTGGA TCCTAGTAAG 2220

CGCTGCACTG CTGAACAGGC TCTTCAATGC GAGTTCCTCC GAGATGTGGA ACCCTCAAAA 2280

ATGCCTCCAC CAGATCTTCC TTTATGGCAA GATTGTCATG AGTTATGGAG TAAAAAGCGA 2340

AGAAGACAGA AGCAGATGGG CATGACTGAT GATGTTTCCA CAATTAAAGC CCCCAGGAAG 2400

GACTTGTCTC TGGGCTTGGA TGACAGCAGA ACCAACACAC CCCAGGGTGT GCTGCCATCT 2460

TCACAGCTGA AATCTCAGGG CAACTCAAAT GTGGCACCTG TAAAAACAGG CCCTGGACAG 2520

CACTTAAACC ACAGTGAATT GGCAATTCTA CTAAACCTAC TACAATCTAA AACAAGTGTT 2580

AATATGGCTG ATTTTGTCCA AGTGTTGAAC ATTAAGGTAA ACTCTGAGAC TCAACAGCAG 2640

CTAAATAAAA TAAACCTTCC TGCTGGAATT TTGGCAACAG GTGAAAAACA GACAGATCCA 2700

TCAACACCAC AACAGGAGTC TTCGAAACCT TTGGGAGGAA TTCAGCCTTC TCAGACCATC 2760

CAGCCTAAAG TGGAGACTGA TGCTGCCCAG GCGGCTGTGC AGAGTGCATT TGCAGTTCTG 2820

TTGACTCAGT TAATAAAGGC TCAACAGTCA AAGCAGAAAG ATGTGCTACT AGAAGAGAGG 2880

GAAAATGGAT CGGGACATGA AGCGTCATTA CAACTCAGGC CACCTCCAGA ACCTAGCACT 2940

CCGGTGTCGG GACAAGATGA CCTCATCCAG CATCAAGATA TGAGGATCTT GGAGCTAACG 3000

CCAGAACCAG ACCGGCCTCG AATTCTGCCT CCTGACCAAC GACCTCCCGA GCCTCCTGAA 3060

CCACCACCAG TCACTGAGGA AGATCTAGAT TATCGGACAG AAAACCAGCA TGTACCCACC 3120

ACCAGTTCTT CATTAACTGA CCCTCATGCC GGAGTGAAGG CAGCCCTGTT ACAGCTGCTT 3180

GCTCAGCATC AGCCCCAGGA TGACCCCAAA AGAGAAGGTG GGATTGATTA TCAAGCAGGA 3240

GACACTTACG TGTCCACTTC AGACTACAAG GACAACTTTG GATCCTCCTC TTTCTCTTCT 3300

GCTCCTTACG TTAGCAATGA TGGTCTAGGA AGCAGTTCTG CTCCACCACT AGAACGACGT 3360

AGTTTCATTG GAAATTCAGA TATTCAGTCT TTGGATAACT ACAGTACTGC TTCATCTCAT 3420

TCTGGTGGTC CACCTCAGCC TTCTGCCTTT TCTGAGTCAT TTCCCAGTTC AGTAGCTGGA 3480

TATGGAGACA TTTACCTCAA TGCTGGTCCC ATGTTGTTTA GTGGAGACAA GGACCATAGA 3540

TTTGAATATA GCCATGGTCC TATTGCAGTC CTGGCAAACA GCAGTGACCC TTCCACGGGG 3600

CCAGAGAGTA CTCATCCTTT GCCAGCAAAG ATGCACAACT ATAACTATGG TGGTAACTTA 3660

CAGGAAAATC CGAGTGGCCC CAGCCTCATG CATGGACAGA CCTGGACTTC TCCTGCCCAA 3720

GGACCTGGAT ATTCACAAGG ATACAGGGGA CATATTAGCA CATCAACTGG CAGAGGCAGA 3780

GGCAGAGGGT TACCATACTG A 3801

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vyka+dk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ i

Q: 460   FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI  519

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         ++++e+v+         kdk  +yLvfe++++dL+ ll++    +++++++ks+++ql+e

Q: 520   INMKEIVTdkedaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENHIKSFMRQLME  578

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 579   GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  638

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++++g+p  +vwp+v k

Q: 639   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK  698

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         lp +++  pkk+++ kl+e++  +  +aldl++ +laldp+kR++a++alq ++

Q: 699   LPYFNTMKPKKQYRrKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF  752

         *****7777777777******999999************************988

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKARD KDTGEMVALK KVRLDNEKEG FPITAIREIK ILRQLTHQSI 60

INMKEIVTDK EDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFNENHI KSFMRQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANQELAQLE LISRICGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRKLREEF VFIPAAALDL FDYMLALDPS KRCTAEQALQ CEF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0030097	; P:hemopoiesis
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013