EKS-NOL-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	436.6	5.4E-131	131	427	297

Status

Unreviewed

Ensembl Protein

ENSNLEP00000003907

UniProt Accession

G1QSI9;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK4

Gene Synonyms/Alias

DYRK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000003196	ENSNLEP00000003907	ENSNLET00000004100

Organism

Nomascus leucogenys

Functional Description

Protein Length

547

Protein Sequence
(FASTA)

MVSFPHISKK VLLQSSLLYQ ENQAHNQMPA SELKASEIPF HPSIKTHDPK AEEKSPKKHK 60

VPLTAAEALK LFKNQLSPYE QSEILGYAEL WFLGLEAKKL DMAPEKFSKT SFDDEHGSYL 120

KVLHDHIAYR YEVLEMIGKG SFGQVAKCLD HKNNELVALK IIRNKKRFHQ QALTEVKILE 180

ALRKKDKDNT YNVVHMKDFF CFRNHFCITF ELLGINLYEL MKNNNFQGFS LSIVRRFTLS 240

VLKCLQMLSV EKIIHCDLKP ENIVLYQKGQ VSVKVIDFGS SCYEHQKVYT YIQSRFYRSP 300

EVILGHPYDT AIDMWSLGCI MAELYTGYPL FPGENEVEQL ACIMEVLGLP PAGFIQTASR 360

RQTFFDSKGF PKNITNNKGK KRYPDSKDLM MVLKTYDTSF LDFLRRCLIW EPSLRMTPDQ 420

ALKHAWIHQS RNLKPQPRPQ TLRKFNSFFP SETRKDKVQG CHHSSKKADE ITKETTEKTK 480

DGPMKHVQHS GDQHDSLQHG ADTVQLPQLV EAPKKSGAAV GAEVSMTSPG QSKNFSLKNT 540

NILPPIV 547

Nucleotide Sequence
(FASTA)

ATGGTAAGCT TCCCACACAT TAGCAAGAAA GTCCTGCTGC AGTCATCCCT GCTGTATCAG 60

GAGAATCAAG CTCACAATCA GATGCCGGCC TCAGAGCTCA AGGCTTCAGA AATACCTTTC 120

CACCCTAGCA TTAAAACCCA CGATCCCAAG GCAGAGGAGA AGTCACCAAA GAAGCACAAG 180

GTGCCTCTGA CAGCGGCAGA GGCCCTAAAG CTTTTTAAGA ACCAGCTGTC TCCATATGAG 240

CAAAGTGAAA TCCTGGGCTA CGCGGAGCTG TGGTTCCTGG GGCTTGAAGC CAAGAAGCTC 300

GACATGGCTC CTGAGAAATT CAGCAAGACG AGTTTTGATG ATGAGCATGG CTCCTATCTG 360

AAGGTCCTGC ATGATCACAT TGCCTACCGC TATGAAGTTC TGGAGATGAT CGGGAAGGGG 420

TCCTTTGGAC AGGTGGCCAA GTGCTTGGAT CACAAAAACA ATGAGCTGGT GGCCCTGAAA 480

ATCATCAGGA ACAAGAAGAG ATTTCACCAG CAGGCCCTGA CGGAGGTGAA GATCCTGGAA 540

GCTCTCAGAA AGAAGGACAA AGACAACACC TACAATGTGG TGCATATGAA GGACTTTTTC 600

TGCTTTCGCA ATCACTTCTG CATCACCTTT GAGCTCCTGG GAATCAACTT GTACGAGTTG 660

ATGAAGAATA ACAACTTTCA AGGCTTCAGT CTGTCGATAG TTCGGCGCTT CACTCTCTCT 720

GTTTTGAAGT GCTTGCAGAT GCTTTCTGTA GAGAAAATCA TTCACTGCGA TCTCAAGCCC 780

GAAAATATAG TGCTATACCA AAAGGGCCAA GTCTCTGTTA AAGTCATTGA CTTTGGATCA 840

AGCTGTTATG AACACCAGAA AGTATACACG TACATCCAAA GCCGGTTCTA CCGATCCCCA 900

GAAGTGATCC TGGGCCACCC CTACGACACG GCCATTGACA TGTGGAGCCT GGGCTGCATC 960

ATGGCAGAGT TGTACACGGG CTACCCCCTG TTCCCTGGGG AGAATGAGGT GGAGCAGCTG 1020

GCCTGCATCA TGGAGGTGCT GGGTCTGCCG CCAGCTGGCT TCATTCAGAC GGCCTCCAGG 1080

AGACAGACAT TCTTTGATTC CAAAGGTTTT CCTAAAAATA TAACCAACAA CAAGGGGAAA 1140

AAAAGATACC CAGATTCCAA GGACCTCATG ATGGTGCTGA AAACCTATGA CACCAGCTTC 1200

CTGGACTTTC TCAGAAGGTG TTTGATATGG GAACCTTCTC TTCGCATGAC CCCGGACCAG 1260

GCCCTCAAGC ATGCTTGGAT TCATCAGTCT CGGAACCTCA AGCCACAGCC CAGGCCCCAG 1320

ACCCTGAGGA AATTCAATTC CTTTTTCCCC TCTGAGACAA GGAAGGACAA GGTTCAAGGC 1380

TGTCATCACT CGAGCAAAAA AGCAGATGAG ATCACCAAAG AGACTACAGA GAAAACAAAA 1440

GATGGCCCCA TGAAGCATGT TCAGCATTCA GGTGATCAGC ACGACTCTCT CCAGCACGGA 1500

GCTGACACCG TTCAGCTGCC TCAACTGGTA GAAGCTCCCA AGAAGTCAGG GGCAGCTGTT 1560

GGGGCGGAGG TGTCCATGAC CTCCCCAGGA CAGAGCAAAA ACTTCTCCCT CAAGAACACA 1620

AATATTTTAC CCCCTATTGT ATGA 1644

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle+igkGsfgqV+k+ld+k++e va+kii+nkkrf++qa +Ev+iLe+l+kkdk+++

Q: 131   YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALTEVKILEALRKKDKDNT  190

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         ynvv+++++f frnh+c++fell +nLyel+k+n+f+g+sl++vr+++ ++lk+L++L+

Q: 191   YNVVHMKDFFCFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSV  250

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNi+l++k++ +vkviDFGss++++qk +ytyiqsrfYr+PE+ilg++yd

Q: 251   EKIIHCDLKPENIVLYQKGQVSVKVIDFGSSCYEHQK-VYTYIQSRFYRSPEVILGHPYD  309

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         +aiDmWSlGc++aEl+tG+pLfpGenev+qla+i+evlglpp+ ++++a+++++ff++k+

Q: 310   TAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKG  369

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +pk i+                +++ k+++p sk+l ++lk+++++ f d+l+r+l ++p

Q: 370   FPKNIT----------------NNKGKKRYPDSKDLMMVLKTYDTS-FLDFLRRCLIWEP  412

         *99776................334567899999999999988877.*************

S: 301   akRitpkealkhpfv  315

         + R+tp++alkh ++

Q: 413   SLRMTPDQALKHAWI  427

         *************97

Domain Sequence
(FASTA)

YEVLEMIGKG SFGQVAKCLD HKNNELVALK IIRNKKRFHQ QALTEVKILE ALRKKDKDNT 60

YNVVHMKDFF CFRNHFCITF ELLGINLYEL MKNNNFQGFS LSIVRRFTLS VLKCLQMLSV 120

EKIIHCDLKP ENIVLYQKGQ VSVKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHPYDT 180

AIDMWSLGCI MAELYTGYPL FPGENEVEQL ACIMEVLGLP PAGFIQTASR RQTFFDSKGF 240

PKNITNNKGK KRYPDSKDLM MVLKTYDTSF LDFLRRCLIW EPSLRMTPDQ ALKHAWI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013