EKS-NOL-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	411.8	1.4E-123	165	443	279

Status

Unreviewed

Ensembl Protein

ENSNLEP00000003904

UniProt Accession

G1QSI6;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK3

Gene Synonyms/Alias

IRAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000003204	ENSNLEP00000003904	ENSNLET00000004097

Organism

Nomascus leucogenys

Functional Description

Protein Length

596

Protein Sequence
(FASTA)

MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLTERLSS SWLDVRHIEK 60

YVDQGKSGTR ELLWSWAQKN KTVGDLLQVL QEMGHRRAIH LITNYGAVLS PSEKSYQEGG 120

FPNILFKETA NITVDNVLIP EHNEKGVLLK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY 180

RVEIQNLTYA VKLFKQEKNM QCKKHWKRFL SELEVLLLFR HPNILELAAY FTETEKFCLV 240

YPYMRNGTLF DRLQCVGDTA PLPWHIRISI LIGISKAIHY LHNVQPCSVI CGSISSANIL 300

LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK LSIKTDVYSF 360

GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL SFLDKKVPPC PRNFSAKLFC 420

LAGRCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE 480

DDESQNNNLL PSDEGLRIDR MTQKTPFECS QSEVMFLSLD KKAESKRNEE ACNMPSSSCE 540

ESWFPKYIVP SQDLRPYKVN MDPSSEAPGH SCRSRPVDSS CSSKFSWDEY KQYKKE 596

Nucleotide Sequence
(FASTA)

ATGGCGGGGA ACTGTGGGGC CCGCGGCGCG CTGTCGGCGC ACACGCTGCT GTTCGACCTG 60

CCGCCCGCGC TGCTCGGGGA GCTCTGCGCG GTTCTGGACA GCTGCGACGG CGCGCTGGGC 120

TGGCGCGGCC TGACAGAGAG ACTTTCAAGC AGCTGGCTGG ATGTTCGTCA TATTGAAAAG 180

TATGTAGACC AAGGTAAAAG TGGAACAAGA GAATTACTTT GGTCCTGGGC ACAGAAAAAC 240

AAGACCGTCG GTGACCTTTT ACAGGTCCTC CAGGAGATGG GGCATCGTCG AGCTATTCAT 300

TTAATTACAA ACTATGGAGC AGTGTTGAGT CCTTCAGAGA AGAGTTATCA GGAAGGTGGA 360

TTTCCAAACA TATTATTCAA GGAAACAGCC AATATCACAG TGGATAATGT TCTTATTCCT 420

GAACATAATG AAAAAGGAGT ACTGCTTAAA TCTTCCATCA GCTTTCAAAA CATCATAGAA 480

GGAACTAGAA ATTTCCACAA AGACTTCCTA ATTGGAGAAG GAGAGATTTT TGAGGTATAC 540

AGAGTGGAGA TTCAAAACCT AACATATGCT GTCAAATTAT TTAAACAGGA GAAAAATATG 600

CAGTGTAAGA AGCATTGGAA GAGGTTTTTA TCTGAGCTTG AAGTTTTACT ACTGTTTCGT 660

CACCCAAACA TACTAGAGTT GGCTGCATAT TTTACAGAGA CTGAGAAGTT CTGTCTGGTT 720

TATCCATACA TGAGAAATGG AACACTTTTT GACAGATTGC AGTGTGTAGG TGACACGGCC 780

CCACTCCCTT GGCACATTCG AATCAGTATA TTAATAGGAA TATCCAAAGC CATTCACTAC 840

CTGCACAACG TTCAACCATG CTCGGTCATC TGTGGCAGTA TATCAAGTGC AAACATCCTT 900

TTGGATGATC AGTTTCAACC CAAACTAACT GATTTTGCCA TGGCACACTT CCGGTCCCAC 960

CTAGAACATC AGAGTTGTAC CATAAATATG ACCAGCAGCA GCAGTAAACA TCTGTGGTAC 1020

ATGCCAGAAG AGTACATCAG ACAGGGGAAA CTTTCCATTA AAACAGACGT CTACAGCTTT 1080

GGAATTGTAA TAATGGAAGT TCTAACAGGA TGTAGAGTAG TGTTAGATGA TCCAAAACAT 1140

ATCCAGCTGC GGGATCTCCT TAGAGAATTG ATGGAGAAAA GAGGCCTGGA TTCATGTCTC 1200

TCATTTCTAG ATAAGAAAGT GCCTCCCTGC CCTCGGAATT TCTCCGCCAA GCTCTTCTGT 1260

TTGGCAGGCC GGTGTGCTGC AACGCGGGCA AAGTTAAGAC CATCAATGGA TGAAGTTCTA 1320

AATACTCTTG AAAGTACTCA AGCCAGCTTG TATTTTGCTG AAGATCCTCC CACATCACTA 1380

AAGTCCTTCA GGTGTCCTTC TCCTCTATTC CTGGAGAATG TACCAAGTAT TCCAGTGGAA 1440

GATGATGAAA GCCAGAATAA CAATTTACTG CCTTCTGATG AAGGCCTGAG GATAGACAGA 1500

ATGACTCAGA AAACTCCTTT TGAATGCAGC CAGTCTGAGG TTATGTTTCT GAGCTTGGAC 1560

AAAAAGGCAG AGAGCAAGAG AAATGAGGAA GCTTGCAACA TGCCCAGTTC TTCTTGTGAA 1620

GAAAGTTGGT TCCCAAAGTA TATAGTTCCA TCCCAGGACT TAAGGCCCTA TAAGGTAAAT 1680

ATGGATCCTT CTTCAGAAGC TCCAGGCCAT TCTTGCAGGA GCAGGCCAGT GGATAGCAGC 1740

TGTTCCTCCA AATTTTCCTG GGATGAATAT AAACAGTACA AAAAAGAATG A 1791

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60

         f++d+ igeG+++evyr+e++n+++avk +k+e+++++k+++++fl+El+vl+ frH+ni

Q: 165   FHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKNMQCKKHWKRFLSELEVLLLFRHPNI  224

         89**********************************************************

S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120

         lel++y++e+ek+cLvY+ym+nG+L+drLqc ++++pL+W++R+sil+G+++ai++LH++

Q: 225   LELAAYFTETEKFCLVYPYMRNGTLFDRLQCVGDTAPLPWHIRISILIGISKAIHYLHNV  284

         ************************************************************

S: 121   sp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpee  179

         +p s+i+g+i+saNiLLD++++pKl+Df++a+f+++ e+qs+t+++ts+ +++l+Y+pee

Q: 285   QPcSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEE  344

         ************************************************************

S: 180   firvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfld  239

         +ir+g+l++k+DvySfGiV++EvltG+r+v +d+k+ +L+dll+e +e+++++++ +fld

Q: 345   YIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLD  404

         ************************************************************

S: 240   kkagkleeellealielalaclaekakkrPtmsqvlell  278

         kk+++++++++++l++la++c+a++ak rP+m++vl++l

Q: 405   KKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTL  443

         ***********************************9987

Domain Sequence
(FASTA)

FHKDFLIGEG EIFEVYRVEI QNLTYAVKLF KQEKNMQCKK HWKRFLSELE VLLLFRHPNI 60

LELAAYFTET EKFCLVYPYM RNGTLFDRLQ CVGDTAPLPW HIRISILIGI SKAIHYLHNV 120

QPCSVICGSI SSANILLDDQ FQPKLTDFAM AHFRSHLEHQ SCTINMTSSS SKHLWYMPEE 180

YIRQGKLSIK TDVYSFGIVI MEVLTGCRVV LDDPKHIQLR DLLRELMEKR GLDSCLSFLD 240

KKVPPCPRNF SAKLFCLAGR CAATRAKLRP SMDEVLNTL 279

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0070498	; P:interleukin-1-mediated signaling pathway
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0032088	; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177	; P:negative regulation of protein catabolic process
GO:0043242	; P:negative regulation of protein complex disassembly
GO:0032720	; P:negative regulation of tumor necrosis factor production
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity

KEGG

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50017	; DEATH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013