EKS-NOL-00052
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00052
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF391.81.8E-117306564259
StatusUnreviewed
Ensembl ProteinENSNLEP00000004071
UniProt AccessionG1QT03;
Protein Name
Protein Synonyms/Alias
Gene NameARAF
Gene Synonyms/Alias ARAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000003341ENSNLEP00000004071ENSNLET00000004271
OrganismNomascus leucogenys
Functional Description
Protein Length603
Protein Sequence
(FASTA)
MEPPRGPPAN GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV 60
VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 120
HGFRCQTCGY KFHQHCSSKV PTVCVDMSTS RQQFYHSVQD LSGGSRQHEP SNRPLNELLT 180
PQVPAMNNST ASGHSLSFPL QPRTQHWQEG RAMPVGLHAL FLTPVPLLLL TGQSFSTDAA 240
CSRGGSDGTP RGSPSPASVS SGRKSPHSKS PAEQRERKSL ADDKKKVKNL GYRDSGYYWE 300
VPPSEVQLLK RIGTGSFGTV FRGRWHGDVA VKVLKVSQPT AEQAQAFKNE MQVLRKTRHV 360
NILLFMGFMT RPGFAIITQW CEGSSLYHHL HVADTRFDMV QLIDVARQTA QGMDYLHAKN 420
IIHRDLKSNS IYLLLEGLTV KIGDFGLATV KTRWSGAQPL EQPSGSVLWM AAEVIRMQDP 480
NPYSFQSDVY AYGVVLYELM TGSLPYSHIG CRDQIIFMVG RGYLSPDLSK ISSNCPKAMR 540
RLLSDCLKFQ REERPLFPQI LATIELLQRS LPKIERSASE PSLHRTQADE LPACLLSAAR 600
LVP 603
Nucleotide Sequence
(FASTA)
ATGGAGCCAC CACGGGGCCC CCCTGCCAAT GGGGCCGAGC CATCCCGGGC AGTGGGCACC 60
GTCAAAGTGT ACCTGCCTAA CAAGCAACGC ACGGTGGTGA CTGTCCGGGA TGGCATGAGT 120
GTCTACGACT CTCTAGACAA GGCCCTGAAG GTGCGGGGTC TAAATCAGGA CTGCTGTGTG 180
GTCTACCGAC TCATCAAGGG ACGAAAGACC GTCACTGCCT GGGACACAGC CATTGCTCCC 240
CTGGATGGCG AGGAGCTCAT TGTCGAGGTC CTTGAAGATG TCCCGCTGAC CATGCACAAT 300
TTTGTACGGA AGACCTTCTT CAGCCTGGCG TTCTGTGACT TCTGCCTTAA GTTTCTGTTC 360
CATGGCTTCC GTTGCCAAAC CTGTGGCTAC AAGTTCCACC AGCATTGTTC CTCCAAGGTC 420
CCCACAGTCT GTGTTGACAT GAGCACCAGC CGCCAACAGT TCTACCACAG TGTCCAGGAT 480
TTGTCCGGAG GCTCCAGACA ACATGAGCCC TCGAACCGCC CCCTGAATGA GTTGCTAACC 540
CCCCAGGTCC CAGCAATGAA TAATAGTACT GCCAGTGGAC ATTCGCTCTC CTTTCCCCTG 600
CAGCCCCGCA CCCAGCACTG GCAAGAGGGG AGAGCCATGC CTGTTGGCCT CCATGCCCTC 660
TTTTTGACTC CTGTCCCTCT TCTTCTACTC ACTGGCCAGA GTTTCAGCAC TGATGCTGCC 720
TGTAGTAGAG GAGGTAGTGA TGGAACCCCC CGGGGGAGCC CCAGCCCAGC CAGCGTGTCC 780
TCAGGGAGGA AGTCCCCACA TTCCAAGTCA CCAGCAGAGC AGCGCGAGCG GAAGTCCTTG 840
GCCGATGACA AGAAGAAAGT GAAGAACCTG GGGTACCGGG ACTCAGGCTA TTACTGGGAG 900
GTACCACCCA GTGAGGTGCA GCTGCTGAAG AGGATCGGGA CGGGCTCGTT TGGCACCGTG 960
TTTCGAGGGC GGTGGCATGG CGATGTGGCT GTGAAGGTGC TCAAGGTGTC CCAGCCCACA 1020
GCTGAGCAGG CCCAGGCTTT CAAGAATGAG ATGCAGGTGC TCAGGAAGAC GCGACATGTC 1080
AACATCTTGC TGTTTATGGG CTTCATGACC CGGCCAGGAT TTGCCATCAT CACACAGTGG 1140
TGTGAGGGCT CGAGCCTCTA CCATCACCTG CATGTGGCCG ACACACGCTT CGACATGGTC 1200
CAGCTCATCG ACGTGGCCCG GCAGACTGCC CAGGGCATGG ACTACCTCCA TGCCAAGAAC 1260
ATCATCCATC GAGATCTCAA GTCTAACAGT ATCTATCTTC TCTTAGAAGG GCTCACGGTG 1320
AAGATTGGTG ACTTTGGCTT GGCCACAGTG AAGACTCGAT GGAGTGGGGC CCAGCCCTTG 1380
GAGCAGCCCT CAGGCTCTGT GCTGTGGATG GCAGCTGAGG TGATCCGTAT GCAGGACCCA 1440
AACCCCTACA GCTTCCAGTC AGACGTCTAT GCCTACGGGG TTGTGCTCTA CGAGCTTATG 1500
ACTGGCTCAC TGCCTTACAG CCACATTGGC TGCCGTGACC AGATTATCTT TATGGTGGGC 1560
CGTGGCTATC TGTCCCCGGA CCTCAGCAAA ATCTCCAGCA ACTGCCCCAA GGCCATGCGG 1620
CGCCTGCTGT CTGACTGCCT CAAGTTCCAG CGAGAGGAGC GGCCCCTCTT CCCCCAGATC 1680
CTGGCCACAA TTGAGCTGCT GCAACGGTCA CTCCCCAAGA TTGAGAGGAG TGCCTCGGAA 1740
CCCTCCTTGC ACCGCACCCA GGCCGATGAG TTGCCTGCCT GCCTACTCAG CGCAGCCCGC 1800
CTTGTGCCTT AG 1812
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+l ++iG+G+fGtv+rg+whGdvavk+l+v+++++eq++aFk+e+++++ktRh+ni+LF
Q: 306   VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLF  365
         67899*******************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mG++++p +ai+t++c+gssLy++lh+++t++d+++lid+arq+aqgmdYLhak+i+h+D
Q: 366   MGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRD  425
         ************************************************************
S: 121   lksknil.leeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidle  179
         lks+ i+ l egl+v+i+DFgl++vk+++sg  ++ le+p+g++l++a+evir+      
Q: 426   LKSNSIYlLLEGLTVKIGDFGLATVKTRWSG--AQPLEQPSGSVLWMAAEVIRM------  477
         ******725799*******************..9********************......
S: 180   qdelpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpk  237
         qd +p+s++sDvya+G+vlyel++++lpy++  ++dqi+f+vgrG l+pdlsk++s++pk
Q: 478   QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHiGCRDQIIFMVGRGyLSPDLSKISSNCPK  537
         ************************************************************
S: 238   elkellleClkfekeeRPlftqilkkl  264
         ++++ll++Clkf++eeRPlf+qil+++
Q: 538   AMRRLLSDCLKFQREERPLFPQILATI  564
         ***********************9875
Domain Sequence
(FASTA)
VQLLKRIGTG SFGTVFRGRW HGDVAVKVLK VSQPTAEQAQ AFKNEMQVLR KTRHVNILLF 60
MGFMTRPGFA IITQWCEGSS LYHHLHVADT RFDMVQLIDV ARQTAQGMDY LHAKNIIHRD 120
LKSNSIYLLL EGLTVKIGDF GLATVKTRWS GAQPLEQPSG SVLWMAAEVI RMQDPNPYSF 180
QSDVYAYGVV LYELMTGSLP YSHIGCRDQI IFMVGRGYLS PDLSKISSNC PKAMRRLLSD 240
CLKFQREERP LFPQILATI 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>
EKS-ANC-00045
EKS-BOT-00052
EKS-CAJ-00052
EKS-CAF-00053
EKS-CAP-00052
EKS-EQC-00051
EKS-FEC-00050
EKS-GOG-00051
EKS-HOS-00053
EKS-ICT-00049
EKS-LAC-00056
EKS-LOA-00052
EKS-MAM-00052
EKS-MAE-00026
EKS-MUM-00053
EKS-MUP-00054
EKS-MYL-00054
EKS-OTG-00055
EKS-POA-00049
EKS-SAH-00049
EKS-SUS-00043
EKS-TEN-00076
EKS-TUT-00052
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013