EKS-NOL-00243

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00243

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	472.2	8.2E-142	217	530	314

Status

Unreviewed

Ensembl Protein

ENSNLEP00000004190

UniProt Accession

G1QTC2;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000003466	ENSNLEP00000004190	ENSNLET00000004408

Organism

Nomascus leucogenys

Functional Description

Protein Length

596

Protein Sequence
(FASTA)

PSFVSSRTWL PGRGGDSAVR QLQASPGLGA GATRSGVGTG PPSPIALPPL RASNAAAAAH 60

TIGGSKHTMN DHLHVGSHAH GQIQVQQLFE DNSNKRTVLT TQPNGLTTVG KTGLPVVPER 120

QLDSIHRRQG SSTSLKSMEG MGKVKATPMT PEQAMKQYMQ KLTAFEHHEI FSYPEIYFLG 180

LNAKKRQGMT GGPNNGGYDD DQGSYVQVPH DHVAYRYEVL KVIGKGSFGQ VVKAYDHKVH 240

QHVALKMVRN EKRFHRQAAE EIRILEHLRK QDKDNTMNVI HMLENFTFRN HICMTFELLS 300

MNLYELIKKN KFQGFSLPLV RKFAHSILQC LDALHKNRII HCDLKPENIL LKQQGRSGIK 360

VIDFGSSCYE HQRVYTYIQS RFYRAPEVIL GARYGMPIDM WSLGCILAEL LTGYPLLPGE 420

DEGDQLACMI ELLGMPSQKL LDASKRAKNF VSSKGYPRYC TVTTLSDGSV VLNGGRSRRG 480

KLRGPPESRE WGNALKGCDD PLFLDFLKQC LEWDPAVRMT PGQALRHPWL RRRLPKPPTG 540

EKTSVKRITE STGAITSISK LPPPSSSASK LRTNLAQMTD ANGNIQQRTV LPKLVS 596

Nucleotide Sequence
(FASTA)

CCCTCTTTTG TCTCCTCCCG CACGTGGCTT CCAGGCCGAG GTGGGGACAG CGCCGTTCGT 60

CAGCTTCAGG CTTCCCCGGG GCTCGGTGCG GGGGCCACCC GGAGCGGAGT GGGGACCGGC 120

CCGCCCTCCC CCATCGCCCT GCCGCCTCTC CGGGCCAGCA ACGCTGCCGC CGCAGCCCAC 180

ACGATTGGCG GCAGTAAGCA CACAATGAAT GATCACCTCC ATGTCGGCAG CCACGCTCAC 240

GGACAGATCC AGGTTCAACA GCTGTTTGAG GATAACAGTA ACAAGCGGAC AGTGCTTACG 300

ACACAACCAA ATGGGCTTAC AACAGTGGGC AAAACGGGCT TGCCAGTGGT GCCAGAGCGG 360

CAGCTGGACA GTATTCATAG ACGGCAGGGG AGCTCCACCT CTCTAAAGTC CATGGAAGGC 420

ATGGGGAAGG TGAAAGCCAC CCCCATGACA CCTGAACAAG CAATGAAGCA ATACATGCAA 480

AAACTCACAG CCTTCGAACA CCATGAGATT TTCAGCTACC CTGAAATATA TTTCTTGGGT 540

CTAAATGCTA AGAAGCGCCA GGGCATGACA GGTGGGCCCA ACAATGGTGG CTATGATGAT 600

GACCAGGGAT CATATGTGCA GGTGCCCCAC GATCACGTGG CTTACAGGTA TGAGGTCCTC 660

AAGGTCATTG GGAAGGGGAG CTTTGGGCAG GTGGTCAAGG CCTATGATCA CAAAGTCCAC 720

CAGCACGTGG CCCTAAAGAT GGTGCGGAAT GAGAAGCGCT TCCACCGGCA AGCAGCGGAG 780

GAGATCCGAA TCCTGGAACA CCTGCGGAAG CAGGACAAGG ATAACACAAT GAATGTCATC 840

CATATGCTGG AGAATTTCAC CTTCCGCAAC CACATCTGCA TGACGTTTGA GCTGCTGAGC 900

ATGAACCTCT ATGAGCTCAT CAAGAAGAAT AAATTCCAGG GCTTCAGCCT GCCTTTGGTT 960

CGCAAGTTTG CCCACTCGAT TCTGCAGTGC TTGGATGCTT TGCACAAAAA CAGAATAATT 1020

CACTGTGACC TTAAGCCCGA GAACATTTTG TTAAAGCAGC AGGGTAGAAG CGGTATTAAA 1080

GTAATTGATT TTGGCTCCAG TTGTTACGAG CATCAGCGTG TCTACACGTA CATCCAGTCG 1140

CGTTTTTACC GGGCTCCAGA AGTGATCCTT GGGGCTAGGT ATGGCATGCC CATTGATATG 1200

TGGAGCCTGG GCTGCATTTT AGCAGAGCTC CTGACGGGTT ACCCGCTCTT GCCTGGGGAA 1260

GATGAAGGGG ACCAGCTGGC CTGTATGATT GAACTGTTGG GCATGCCCTC ACAGAAACTG 1320

CTGGATGCAT CCAAACGAGC CAAAAATTTT GTGAGCTCCA AGGGTTATCC CCGTTACTGC 1380

ACTGTCACGA CTCTCTCAGA TGGCTCTGTG GTCCTCAACG GAGGCCGTTC CCGGAGGGGG 1440

AAACTGAGGG GCCCACCGGA GAGCAGAGAG TGGGGGAACG CGCTGAAGGG GTGTGACGAT 1500

CCCCTTTTCC TTGACTTCTT AAAACAGTGT TTAGAGTGGG ATCCTGCAGT GCGCATGACC 1560

CCAGGCCAGG CTTTGCGGCA CCCCTGGCTG AGGAGGCGGT TGCCAAAGCC TCCCACTGGG 1620

GAGAAAACGT CAGTGAAAAG GATAACTGAG AGCACTGGTG CTATCACATC CATATCCAAG 1680

TTACCTCCAC CTTCCAGCTC AGCTTCCAAA CTGAGGACTA ATTTGGCGCA GATGACAGAT 1740

GCCAATGGGA ATATTCAGCA GAGGACAGTG TTGCCAAAAC TCGTTAGCTG A 1791

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 217   YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT  276

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 277   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  336

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 337   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  395

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+

Q: 396   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKG  455

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp

Q: 456   YPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  515

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp +al+hp++

Q: 516   AVRMTPGQALRHPWL  530

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNT 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDASKR AKNFVSSKGY 240

PRYCTVTTLS DGSVVLNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPA 300

VRMTPGQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0000151	; C:ubiquitin ligase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0042771	; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725	; P:positive regulation of glycogen biosynthetic process
GO:0007224	; P:smoothened signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013