EKS-NOL-00231

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00231

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	317.8	4.3E-95	11	263	253

Status

Unreviewed

Ensembl Protein

ENSNLEP00000004582

UniProt Accession

G1QUG2;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000003720	ENSNLEP00000004582	ENSNLET00000004820

Organism

Nomascus leucogenys

Functional Description

Protein Length

651

Protein Sequence
(FASTA)

MKDYDELLKY YELHETIGTG GFAKVKLACH ILTGEMVAIK IMDKNTLGSD LPRIKTEIEA 60

LKNLRHQHIC QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV 120

AYVHSQGYAH RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 180

QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL 240

QQMLQVDPKK RISMKNLLNH PWIMQDYNYP VEWQSKNPFI HLDDDCITEL SVHHRNNRQT 300

MEDLISLWQY DHLTATYLLL LAKKARGKPV RLRLSSFSCG QASATPFTDI KSNNRSLEDV 360

TTSDKNYVAG LIDYDWCEDN LSTGAATPQT SQFTKYWTES NGVESKSLTP ALCRTPANKL 420

KNKENIYTPK SAVKNEEYFM FPEPKTPVNK NQHKREILTT PNRYTTPSKA RNQCLKETPI 480

KIPVNSTGTD KLMTGVISPE RRCRSVELDL NQAHMEETPK RKGAKVFGSL ERGLDKVITV 540

LTRSKRKGSA RDGPRRLKLH YNVTTTRLVN PDQLLNEIMS ILPKKHVDFV QKGYTLKCQT 600

QSDFGKVTMQ FELEVCQLQK PDVVGIRRQR LKGDAWVYKR LVEDILSSCK V 651

Nucleotide Sequence
(FASTA)

ATGAAAGATT ATGATGAACT TCTCAAATAT TATGAATTAC ATGAAACTAT TGGGACAGGT 60

GGCTTTGCAA AGGTCAAACT TGCATGCCAT ATCCTTACTG GAGAGATGGT AGCTATAAAA 120

ATCATGGATA AAAACACACT AGGGAGTGAT TTGCCCCGGA TCAAAACGGA GATTGAGGCC 180

TTGAAGAACC TGAGACATCA GCATATATGT CAACTCTACC ATGTGCTCGA GACAGCCAAC 240

AAAATATTCA TGGTTCTTGA GTACTGCCCT GGAGGAGAGC TGTTTGACTA TATAATTTCC 300

CAGGATCGCC TGTCAGAAGA GGAGACCCGG GTTGTCTTCC GTCAGATAGT ATCTGCTGTT 360

GCTTATGTGC ATAGCCAGGG CTATGCTCAC AGGGACCTCA AGCCAGAAAA TTTGCTGTTT 420

GATGAATATC ATAAATTAAA GCTGATTGAC TTTGGTCTCT GTGCAAAACC CAAGGGTAAC 480

AAGGATTACC ATCTACAGAC ATGCTGTGGG AGTCTGGCTT ATGCAGCACC TGAATTAATA 540

CAAGGCAAAT CGTATCTTGG ATCAGAGGCA GATGTTTGGA GCATGGGCAT ACTGTTATAT 600

GTTCTTATGT GTGGATTTCT ACCATTTGAT GATGATAATG TAATGGCTTT ATACAAGAAG 660

ATTATGAGAG GAAAATATGA TGTTCCCAAG TGGCTCTCTC CCAGTAGCAT TCTGCTGCTT 720

CAACAAATGC TGCAGGTGGA CCCAAAGAAA CGGATTTCTA TGAAAAATCT ATTGAACCAT 780

CCCTGGATCA TGCAAGATTA CAACTATCCT GTTGAGTGGC AAAGCAAGAA TCCTTTTATT 840

CACCTCGATG ATGATTGCAT AACAGAACTT TCTGTACATC ACAGAAACAA CAGGCAAACA 900

ATGGAGGATT TAATTTCACT GTGGCAGTAT GATCACCTCA CAGCTACCTA TCTTCTGCTT 960

CTAGCCAAGA AGGCTCGGGG AAAACCAGTT CGATTAAGGC TTTCTTCTTT CTCTTGTGGA 1020

CAAGCCAGTG CTACCCCATT CACAGACATC AAGTCAAATA ATCGGAGTCT GGAAGATGTG 1080

ACCACAAGTG ATAAAAATTA TGTGGCGGGA TTAATAGACT ATGATTGGTG TGAAGATAAT 1140

TTATCAACAG GTGCTGCTAC TCCCCAAACA TCACAGTTTA CCAAGTACTG GACAGAATCA 1200

AATGGGGTGG AATCTAAATC ATTAACTCCA GCCTTATGCA GAACACCTGC AAATAAATTA 1260

AAGAACAAAG AAAATATATA TACTCCTAAG TCTGCTGTAA AGAATGAAGA GTACTTTATG 1320

TTTCCTGAGC CAAAGACTCC AGTTAATAAG AACCAGCATA AGAGAGAAAT ACTCACTACG 1380

CCAAATCGTT ACACTACACC CTCAAAAGCT AGAAACCAGT GCCTGAAAGA AACTCCAATT 1440

AAAATACCAG TAAATTCAAC AGGAACAGAC AAGTTAATGA CAGGTGTTAT TAGCCCTGAG 1500

AGGCGGTGCC GCTCAGTGGA ACTGGATCTC AACCAAGCAC ATATGGAGGA GACTCCAAAA 1560

AGAAAGGGAG CCAAAGTGTT TGGGAGCCTT GAAAGGGGAT TGGATAAGGT TATCACTGTA 1620

CTCACCAGGA GCAAAAGGAA GGGCTCTGCC AGAGACGGGC CCAGAAGACT AAAGCTTCAC 1680

TATAATGTGA CTACAACTAG ATTAGTGAAT CCAGATCAAC TGTTGAATGA AATAATGTCT 1740

ATTCTTCCAA AGAAGCATGT TGACTTTGTA CAAAAGGGTT ATACACTGAA GTGTCAAACA 1800

CAGTCAGATT TTGGGAAAGT GACAATGCAA TTTGAACTAG AAGTGTGCCA GCTTCAAAAA 1860

CCGGATGTGG TGGGTATCAG GAGGCAGCGG CTTAAGGGCG ATGCCTGGGT TTACAAAAGA 1920

TTAGTGGAAG ACATCCTATC TAGCTGCAAG GTATAA 1956

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l++t+G+g f+kVkla+h +t+e+va+Ki++k++l +  l +ik+Eie+lk+l+h++i

Q: 11    YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIEALKNLRHQHI  69

         99********************************99875.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++v+et +k+++vley+ ggeLfdyi ++ rl+e+e+r +f+q+vsav Y+hs+g +

Q: 70    CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA  129

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+ +++k++DFGl+++ k +   +l+t+cGs++YaaPel++gk+Y g++

Q: 130   HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNkdYHLQTCCGSLAYAAPELIQGKSYLGSE  189

         *************************9665443389*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+G++Ly+l++g lPfd++n+ +l++ki++gk+++pk+ls++ + Ll+++L+vdp+

Q: 190   ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPK  249

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR++++++l+h+w+

Q: 250   KRISMKNLLNHPWI  263

         *************7

Domain Sequence
(FASTA)

YELHETIGTG GFAKVKLACH ILTGEMVAIK IMDKNTLGSD LPRIKTEIEA LKNLRHQHIC 60

QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV AYVHSQGYAH 120

RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA 180

DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL QQMLQVDPKK 240

RISMKNLLNH PWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0008283	; P:cell proliferation
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013