EKS-NOL-00364
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00364
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl471.95.2E-142477742266
StatusUnreviewed
Ensembl ProteinENSNLEP00000004510
UniProt AccessionG1QU90;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000003740ENSNLEP00000004510ENSNLET00000004747
OrganismNomascus leucogenys
Functional Description
Protein Length849
Protein Sequence
(FASTA)
SGLKLMGAPV KLTVSQGQPV KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG 60
FLSLKSVERS DAGRYWCQVE DGGETEISQP VWLTVEAGLP HCSVGPGSLL PQSPLLLQEE 120
LSKSAMPKGA AWKTGTTKIG GPAPSPSVLN VTGVTQSTMF SCEAHNIKGL ASSRTATSPS 180
TALPAAPFNI TVTKLSSSNA SVAWMPGADG RALLQSCTVQ VTQAPGGWEV LAVVVPVPPF 240
TCLLRDLVPA TNYSLRVRCA NALGPSPYAD WVPFQTKGLA PASAPQNLHA IHTDSGLILE 300
WEEVIPETSL EGPLGPYKLS WVQDNGTQDE LTVEGTRANL TGWDPQKDLI VRVCVSNAVG 360
CGPWSQPLVV SSHDHAGQQG LPHSRTSWVP VVLGVLTALV TAAALALILL RKRRKETRFG 420
QAFDSVMAQG EPAVHFRAAR SNRERPERIE AHILDSLGIS DELKEKLEDV LIPEQQFTLG 480
RMLGKGEFGS VREAQLKQED GSFVKVAVKM LKADIIASSD IEEFLREAAC MKEFDHPHVA 540
KLVDGKIARR HFGRLSIATA HLYLKKKKKI HTHTRIQKLA RCGGNLPLQT LIRFMVDIAC 600
GMEYLSSRNF IHRDLAARNC MLAEDMTVCV ADFGLSRKIY SGDYYRQGCA SKLPVKWLAL 660
ESLADNLYTV QSDVWAFGVT MWEIMTRGQT PYAGIENAEI YNYLIGGNRL KQPPECMEDV 720
YDLMYQCWSA DPKQRPSFTC LRMELENILG QLSVLSASQD PLYINIERAE EPTAGGSLEL 780
PGGDQPYSGA GDGSGMGAVG GTPSDYRYIL TPGGLAEQPG QAEHQPESPL NETQRLLLLQ 840
QGLLPHSSC 849
Nucleotide Sequence
(FASTA)
TCAGGTCTGA AGCTCATGGG AGCCCCGGTG AAGCTGACAG TGTCTCAGGG GCAGCCGGTG 60
AAGCTCAACT GCAGTGTGGA GGGGATGGAG GAGCCTGACA TCCAGTGGGT GAAGGATGGG 120
GCTGTGGTCC AGAACTTGGA CCAGTTGTAC ATCCCAGTCA GCGAGCAGCA CTGGATCGGC 180
TTCCTCAGCC TGAAGTCAGT GGAGCGCTCT GATGCCGGCC GGTACTGGTG CCAGGTGGAG 240
GATGGGGGCG AAACCGAGAT CTCCCAGCCA GTGTGGCTCA CGGTAGAAGC TGGGCTGCCC 300
CACTGCTCTG TGGGGCCTGG TTCTCTCCTC CCCCAGTCTC CTCTCTTACT GCAAGAAGAG 360
CTGTCCAAAT CTGCCATGCC TAAGGGGGCA GCATGGAAGA CAGGAACTAC GAAGATCGGG 420
GGACCCGCTC CCTCTCCATC TGTTTTAAAT GTAACAGGGG TGACCCAGAG CACCATGTTT 480
TCCTGTGAAG CTCACAACAT AAAAGGCCTG GCCTCTTCTC GCACAGCCAC TTCCCCGTCC 540
ACAGCACTGC CTGCAGCCCC CTTCAACATC ACCGTGACAA AGCTTTCCAG CAGCAACGCT 600
AGTGTGGCCT GGATGCCAGG TGCTGATGGC CGAGCCCTGC TACAGTCCTG TACAGTTCAG 660
GTGACACAGG CCCCAGGAGG CTGGGAAGTC CTGGCTGTTG TGGTCCCTGT GCCCCCTTTT 720
ACCTGCCTGC TCCGGGACCT GGTGCCCGCC ACCAACTACA GCCTCAGGGT GCGCTGTGCC 780
AATGCCTTGG GGCCCTCTCC CTATGCTGAC TGGGTGCCCT TTCAGACCAA GGGTCTAGCC 840
CCAGCCAGCG CTCCCCAAAA CCTCCATGCC ATCCACACAG ATTCAGGCCT CATCTTGGAG 900
TGGGAAGAAG TGATCCCCGA GACCTCTTTG GAAGGCCCCC TGGGACCCTA CAAACTGTCC 960
TGGGTTCAAG ACAATGGAAC CCAGGATGAG CTGACAGTGG AGGGGACCAG GGCCAATTTG 1020
ACAGGCTGGG ATCCCCAAAA GGACCTGATC GTACGTGTGT GCGTCTCCAA TGCAGTTGGC 1080
TGTGGACCCT GGAGTCAGCC ACTGGTGGTC TCTTCTCATG ACCATGCAGG CCAGCAGGGC 1140
CTTCCTCACA GCCGCACATC CTGGGTACCT GTGGTCCTTG GTGTGCTAAC GGCCCTGGTG 1200
ACGGCTGCTG CCCTGGCCCT CATCCTGCTT CGAAAGAGAC GGAAAGAGAC GCGGTTTGGG 1260
CAAGCCTTTG ACAGTGTCAT GGCCCAGGGA GAGCCAGCCG TTCACTTCCG GGCAGCCCGG 1320
TCCAATCGAG AAAGGCCCGA GCGCATCGAG GCCCACATCC TGGACAGCTT GGGCATCAGC 1380
GATGAACTAA AGGAAAAACT GGAGGATGTG CTCATCCCAG AGCAGCAGTT CACCCTGGGC 1440
CGGATGTTGG GCAAAGGAGA GTTTGGTTCA GTGCGGGAGG CCCAGCTGAA GCAAGAGGAT 1500
GGCTCCTTTG TGAAAGTGGC TGTGAAGATG CTGAAAGCTG ACATCATTGC CTCAAGTGAC 1560
ATTGAAGAGT TCCTCAGGGA AGCAGCTTGC ATGAAGGAGT TTGACCATCC ACACGTGGCC 1620
AAACTTGTTG ATGGCAAAAT AGCAAGGAGG CACTTTGGGA GGCTGAGTAT AGCAACAGCC 1680
CACCTCTATT TAAAAAAAAA AAAAAAAATA CACACACACA CACGTATACA AAAATTAGCT 1740
AGGTGTGGTG GTAACCTACC CCTCCAGACC CTGATCCGGT TCATGGTGGA CATTGCCTGC 1800
GGCATGGAGT ACCTGAGCTC TCGGAACTTC ATCCACCGAG ACCTGGCCGC TCGGAATTGC 1860
ATGCTGGCAG AGGACATGAC AGTGTGTGTG GCTGACTTCG GACTCTCCCG GAAGATCTAT 1920
AGTGGGGATT ACTATCGTCA AGGCTGTGCC TCCAAACTGC CCGTCAAGTG GCTGGCCCTG 1980
GAGAGCCTGG CTGACAACCT GTATACTGTG CAGAGTGACG TGTGGGCGTT CGGGGTGACC 2040
ATGTGGGAGA TCATGACACG TGGGCAGACG CCATATGCTG GCATTGAAAA CGCTGAGATT 2100
TACAACTACC TCATTGGCGG GAACCGCCTG AAACAGCCTC CGGAGTGTAT GGAGGACGTG 2160
TATGATCTCA TGTACCAGTG CTGGAGTGCT GACCCCAAGC AGCGCCCGAG CTTTACTTGT 2220
CTGCGAATGG AACTGGAGAA CATCTTGGGC CAGCTGTCTG TGCTATCCGC CAGCCAGGAC 2280
CCCTTATACA TCAACATCGA GAGAGCTGAG GAGCCCACTG CGGGAGGCAG CCTGGAGCTA 2340
CCTGGAGGGG ATCAGCCCTA CAGTGGGGCT GGGGATGGCA GTGGCATGGG GGCAGTGGGT 2400
GGCACTCCCA GTGACTATCG GTACATCCTC ACCCCTGGAG GGCTGGCTGA GCAGCCAGGG 2460
CAGGCAGAGC ACCAGCCAGA GAGTCCCCTC AATGAGACAC AGAGGCTTTT GCTGCTGCAG 2520
CAAGGGCTAC TGCCACACAG TAGCTGTTAG 2550
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh
Q: 477   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  536
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v++lv   +  ++ grl +    l + k+  +h++    +l     +lplqtl++fmv
Q: 537   PHVAKLVDGKIARRHFGRLSIATAHLYLKKKKKIHTHTRIQKLARCGGNLPLQTLIRFMV  596
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk
Q: 597   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  656
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c
Q: 657   WLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  716
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ++++ydlmy+cw+adpk+rpsf+ lr
Q: 717   MEDVYDLMYQCWSADPKQRPSFTCLR  742
         ***********************998
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60
PHVAKLVDGK IARRHFGRLS IATAHLYLKK KKKIHTHTRI QKLARCGGNL PLQTLIRFMV 120
DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTVQSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240
MEDVYDLMYQ CWSADPKQRP SFTCLR 266
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LAC-00416
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00374
EKS-PES-00355
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
Created Date20-Feb-2013