EKS-NOL-00103
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00103
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec475.23.8E-143363613251
StatusUnreviewed
Ensembl ProteinENSNLEP00000004798
UniProt AccessionG1QV28;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000003943ENSNLEP00000004798ENSNLET00000005046
OrganismNomascus leucogenys
Functional Description
Protein Length621
Protein Sequence
(FASTA)
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPKY 120
HPNFWMDGKW RCCSQLEKLA AGCAQYDPTK NASKKPLPPT PEDNRRPLWE PEETVVIALY 180
DYQTNDPQEL SLRRNEEYCL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY 240
NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AVVSENNPCI KHYHIKETND 300
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG LRYGKWVIDP 360
SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420
LYGVCLEQAP ICLVFEFMEH GCLSDYLRTQ RGLFAAETLL GMCLDVCEGM AYLEEACVIH 480
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540
VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASTHVYQI MNHCWKERPE 600
DRPAFSRLLR QLAEIAESGL L 621
Nucleotide Sequence
(FASTA)
ATGAACAACT TTATCCTCCT GGAAGAACAG CTCATCAAAA AATCCCAACA AAAGAGAAGA 60
ACTTCTCCCT CGAACTTTAA AGTCCGCTTC TTTGTGTTAA CCAAAGCCAG CCTGGCATAC 120
TTTGAGGATC GTCATGGGAA GAAGCGCACG CTGAAGGGGT CCATCGAGCT CTCCCGAATC 180
AAATGTGTTG AGATTGTGAA AAGTGACATC AGCATCCCAT GCCACTATAA ATACCCGTTT 240
CAGGTGGTGC ATGACAATTA CCTCCTATAT GTGTTTGCTC CAGATCGTGA GAGCCGGCAG 300
CGCTGGGTGC TGGCCCTTAA AGAAGAAACA AGGAACAATA ACAGTTTGGT GCCTAAATAT 360
CATCCTAATT TCTGGATGGA TGGGAAGTGG AGGTGCTGTT CTCAGCTGGA GAAGCTTGCA 420
GCAGGCTGTG CCCAATATGA TCCAACAAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480
CCTGAAGACA ACAGGCGACC ACTTTGGGAA CCTGAAGAAA CTGTGGTCAT TGCCTTGTAT 540
GACTACCAAA CCAATGATCC TCAGGAACTC TCACTGCGGC GCAACGAAGA GTACTGCCTG 600
CTGGACAGTT CTGAGATTCA CTGGTGGAGA GTCCAGGACA GGAATGGGCA TGAAGGATAT 660
GTACCAAGCA GTTATCTGGT GGAAAAATCT CCAAATAATC TGGAAACTTA TGAATGGTAC 720
AATAAGAGTA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG CAAAGAAGGA 780
GCCTTCATGG TAAGAGATTC CAGGACTCCA GGAACATACA CCGTGTCTGT TTTCACCAAG 840
GCTGTTGTGA GTGAGAACAA TCCCTGTATA AAGCATTATC ACATCAAGGA AACAAATGAC 900
AATCCTAAGC GATACTATGT GGCTGAAAAG TATGTGTTCG ATTCCATCCC TCTTCTCATC 960
AACTATCACC AGCATAATGG AGGAGGCCTG GTGACTCGAC TCCGGTATCC AGTTTGTTTT 1020
GGGAGGCAGA AAGCCCCAGT TACAGCAGGG CTGAGATACG GGAAATGGGT GATCGATCCC 1080
TCGGAGCTCA CTTTTGTGCA AGAGATTGGC AGTGGGCAAT TTGGGTTGGT ACATCTGGGC 1140
TACTGGCTCA ACAAGGACAA GGTGGCTATC AAAACCATTC AGGAAGGGGC TATGTCAGAA 1200
GAGGACTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTCT CTCATCCCAA ACTGGTGCAG 1260
CTGTATGGGG TGTGCCTGGA GCAGGCCCCC ATCTGCCTGG TGTTTGAGTT CATGGAGCAC 1320
GGCTGCCTGT CAGATTATCT ACGCACCCAG CGGGGACTTT TTGCTGCAGA GACCCTGCTG 1380
GGCATGTGTC TGGATGTGTG TGAGGGCATG GCCTACTTGG AAGAGGCATG TGTCATCCAC 1440
AGAGACTTGG CTGCCCGAAA TTGTTTGGTG GGAGAAAACC AAGTCATCAA GGTGTCCGAC 1500
TTCGGGATGA CAAGGTTCGT TCTGGATGAT CAGTACACCA GTTCCACAGG CACCAAATTC 1560
CCAGTGAAGT GGGCATCCCC AGAAGTTTTC TCTTTTAGTC GCTATAGCAG CAAGTCGGAT 1620
GTGTGGTCAT TTGGTGTGCT GATGTGGGAA GTTTTCAGCG AAGGCAAAAT CCCGTATGAA 1680
AACCGAAGCA ACTCAGAAGT GGTGGAAGAC ATCAGTACCG GATTTCGGTT GTACAAGCCC 1740
CGGCTGGCCT CCACACATGT CTACCAGATT ATGAATCACT GCTGGAAAGA GAGACCAGAA 1800
GATCGGCCAG CCTTCTCCAG ACTGCTGCGA CAACTGGCTG AAATTGCAGA ATCAGGACTT 1860
TTGTAG 1866
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly
Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  422
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd
Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRD  482
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las++vy++m++cwke+pe+r
Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDR  602
         ************************************************************
S: 241   ptfkellsale  251
         p+f++ll++l+
Q: 603   PAFSRLLRQLA  613
         ********996
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRTQRG LFAAETLLGM CLDVCEGMAY LEEACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASTHVYQIMN HCWKERPEDR 240
PAFSRLLRQL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543; F:phospholipid binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013