EKS-NOL-00262
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00262
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR396.09.3E-119269562294
StatusUnreviewed
Ensembl ProteinENSNLEP00000005036
UniProt AccessionG1QVR5;
Protein Name
Protein Synonyms/Alias
Gene NameTGFBR2
Gene Synonyms/Alias TGFBR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000004162ENSNLEP00000005036ENSNLET00000005296
OrganismNomascus leucogenys
Functional Description
Protein Length592
Protein Sequence
(FASTA)
MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SDVEMEAQKD EIICPSCNRT AHPLRHINND 60
MMVTDNNGAV KFPQLCKFCD VRFSTCDNQK SCMSNCSITS ICEKPQEVCV AVWRKNDENI 120
TLETVCHDPK LPYHDFILED AASPKCIMKE KKKPGETFFM CSCSSDECND NIIFSEEYNT 180
SNPDLLLVIF QVTGISLLPP LGVAISVIII FYCYRVNRQQ KLSSSWETGK TRKLMEFSDH 240
CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 300
VKIFPYEEYA SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE 360
YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL 420
CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW 480
EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDNVLRDR GRPEIPSFWL NHQGIQMVCE 540
TLTECWDHDP EARLTAQCVA ERFSELEHLD RLSGRSCSEE KIPEDGSLNT TK 592
Nucleotide Sequence
(FASTA)
ATGGGTCGGG GGCTGCTCAG GGGCCTGTGG CCGCTGCACA TCGTCCTGTG GACGCGTATC 60
GCCAGCACGA TCCCACCGCA CGTTCAGAAG TCGGATGTGG AAATGGAGGC CCAGAAAGAT 120
GAAATCATCT GCCCCAGCTG TAATAGGACT GCCCATCCAC TGAGACATAT TAATAATGAC 180
ATGATGGTCA CTGACAACAA TGGTGCAGTC AAGTTTCCAC AACTGTGTAA ATTTTGTGAT 240
GTGAGATTTT CCACCTGTGA CAACCAGAAA TCCTGCATGA GCAACTGCAG CATCACCTCC 300
ATCTGTGAGA AGCCACAGGA AGTCTGTGTG GCTGTATGGA GAAAGAATGA CGAGAACATA 360
ACACTAGAGA CAGTTTGCCA TGACCCCAAG CTCCCCTACC ACGACTTTAT TCTGGAAGAT 420
GCTGCTTCTC CAAAGTGCAT TATGAAGGAA AAAAAAAAGC CTGGTGAGAC TTTCTTCATG 480
TGTTCCTGTA GCTCTGATGA GTGCAATGAC AACATCATCT TCTCAGAAGA ATATAACACC 540
AGCAATCCTG ACTTGTTGCT AGTCATATTT CAAGTGACAG GCATCAGCCT TCTGCCACCA 600
CTGGGAGTTG CCATATCTGT CATCATCATC TTCTACTGCT ACCGTGTTAA CCGGCAGCAG 660
AAGCTGAGTT CATCCTGGGA AACCGGCAAG ACACGGAAGC TCATGGAGTT CAGCGATCAC 720
TGTGCCATCA TCCTGGAAGA CGACCGCTCT GACATCAGCT CCACGTGCGC CAACAATATC 780
AACCACAACA CAGAGCTGCT GCCCATTGAG CTGGACACCC TGGTAGGGAA AGGTCGCTTT 840
GCTGAGGTCT ATAAGGCCAA GCTGAAGCAG AACACTTCAG AGCAGTTTGA GACAGTGGCA 900
GTCAAAATCT TTCCCTATGA GGAGTATGCA TCTTGGAAGA CGGAGAAGGA CATCTTCTCA 960
GACATCAACC TGAAGCATGA GAACATACTC CAGTTCCTGA CGGCTGAGGA GCGGAAGACG 1020
GAGTTGGGGA AACAGTACTG GCTGATCACT GCCTTCCACG CCAAGGGCAA CCTACAGGAG 1080
TACCTGACGC GGCATGTCAT CAGCTGGGAG GACCTGCGCA AGCTGGGCAG CTCCCTCGCC 1140
CGGGGCATTG CTCACCTCCA TAGTGATCAC ACTCCATGCG GGAGGCCCAA GATGCCCATC 1200
GTGCACAGGG ACCTCAAGAG CTCCAATATC CTCGTGAAGA ATGACCTAAC CTGCTGCCTT 1260
TGTGACTTTG GGCTTTCCCT GCGTCTGGAC CCTACTCTGT CTGTGGATGA CCTGGCTAAC 1320
AGCGGGCAGG TGGGAACTGC AAGATACATG GCTCCAGAAG TCCTAGAATC CAGGATGAAT 1380
TTGGAGAATG TTGAGTCCTT CAAGCAGACC GATGTCTACT CCATGGCTCT AGTGCTCTGG 1440
GAAATGACAT CTCGCTGTAA TGCAGTGGGA GAAGTAAAAG ATTATGAGCC TCCATTTGGT 1500
TCCAAGGTGC GGGAGCACCC CTGTGTCGAA AGCATGAAGG ACAACGTGTT GAGAGATCGA 1560
GGGCGACCAG AAATTCCCAG CTTCTGGCTC AACCACCAGG GCATCCAGAT GGTGTGTGAG 1620
ACATTGACTG AGTGCTGGGA CCACGACCCA GAGGCCCGTC TCACAGCCCA GTGTGTGGCA 1680
GAACGCTTCA GTGAGCTGGA GCACCTGGAC AGGCTCTCGG GGAGGAGCTG CTCGGAGGAG 1740
AAGATTCCTG AAGACGGCTC CCTAAACACT ACCAAATAG 1779
Domain Profile
S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54
         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen
Q: 269   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  328
         678899***************99999999*******************************
S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114
         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+
Q: 329   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  388
         ************************************************************
S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174
         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt 
Q: 389   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  447
         *.8999******************************************************
S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234
         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++
Q: 448   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  506
         *****************************************.999***************
S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290
         P++e+mk+ v++++ rP+ip+ w +++ +++++++l+ecWd+dpeaRlta++v++r
Q: 507   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  562
         *****************************************************987
Domain Sequence
(FASTA)
IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60
ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120
DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180
YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240
VESMKDNVLR DRGRPEIPSF WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00266
EKS-ANC-00272
EKS-BOT-00284
EKS-CAJ-00290
EKS-CAF-00290
EKS-CAP-00319
EKS-CII-00167
EKS-CIS-00048
EKS-DAR-00626
EKS-EQC-00276
EKS-ERE-00022
EKS-FEC-00270
EKS-GAM-00178
EKS-GAG-00237
EKS-GAA-00350
EKS-GOG-00283
EKS-HOS-00290
EKS-ICT-00268
EKS-LAC-00295
EKS-LOA-00294
EKS-MAM-00286
EKS-MEG-00224
EKS-MOD-00279
EKS-MUM-00315
EKS-MUP-00279
EKS-MYL-00286
EKS-OCP-00027
EKS-ORN-00367
EKS-ORA-00245
EKS-ORC-00266
EKS-ORL-00343
EKS-OTG-00289
EKS-PAT-00268
EKS-PES-00253
EKS-PEM-00154
EKS-POA-00275
EKS-RAN-00300
EKS-SAH-00266
EKS-SUS-00252
EKS-TAG-00296
EKS-TAR-00368
EKS-TAS-00020
EKS-TEN-00365
EKS-TUT-00042
EKS-XET-00356
EKS-XIM-00361
Gene Ontology
GO:0005901; C:caveola
GO:0009897; C:external side of plasma membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0005539; F:glycosaminoglycan binding
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0060389; P:pathway-restricted SMAD protein phosphorylation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:2000379; P:positive regulation of reactive oxygen species metabolic process
GO:0070723; P:response to cholesterol
GO:0042493; P:response to drug
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR017194; Transform_growth_fac-b_typ-2.
IPR015013; Transforming_GF_b_rcpt_2_ecto.
Pfam
PF08917; ecTbetaR2; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013