EKS-NOL-00221

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00221

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.1	3.1E-116	20	271	252

Status

Unreviewed

Ensembl Protein

ENSNLEP00000005711

UniProt Accession

G1QXN5;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000004656	ENSNLEP00000005711	ENSNLET00000006009

Organism

Nomascus leucogenys

Functional Description

Protein Length

746

Protein Sequence
(FASTA)

MIRGRNSATS ADEQPHIGNY RLLKTIGKGN FAKVKLARHI LTGKEVAVKI IDKTQLNSSS 60

LQKLFREVRI MKVLNHPNIV KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR 120

AKFRQIVSAV QYCHQKFIVH RDLKAENLLL DADMNIKIAD FGFSNEFTFG NKLDTFCGSP 180

PYAAPELFQG KKYDGPEVDV WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM 240

STDCENLLKK FLILNPSKRG TLEQIMKDRW MNVGHEDDEL KPYVEPLPDY KDPRRTELMV 300

SMGYTREEIQ DSLVGQRYNE VMATYLLLGY KSSELEGDTI TLKPRPSADL TNSSAPSPSH 360

KVQRSVSANP KQRRFSDQAA GPAIPTSNSY SKKTQSNNAE NKRPEEDRES GRKASSTAKV 420

PASPLPGLER KKTTPTPSTN SVLSTSTNRS RNSPLLERAS LGQASIQNGK DSLTMPGSRA 480

STASASAAVS AARPRQHQKS MSASVHPNKA SGLPPTESNC EVPRPSTAPQ RVPVASPSAH 540

NISSSGGAPD RTNFPRGVSS RSTFHAGQLR QVRDQQNLPY GVTPASPSGH SQGRRGASGS 600

IFSKFTSKFV RRNLNEPESK DRVETLRPHV VGSGGNDKEK EEFREAKPRS LRFTWSMKTT 660

SSMEPNEMMR EIRKVLDANS CQSELHEKYM LLCMHGTPGH EDFVQWEMEV CKLPRLSLNG 720

VRFKRISGTS MAFKNIASKI ANELKL 746

Nucleotide Sequence
(FASTA)

ATGATTCGGG GCCGCAACTC AGCCACCTCT GCTGATGAGC AGCCCCACAT TGGAAACTAC 60

CGGCTCCTCA AGACCATTGG CAAGGGTAAC TTTGCCAAGG TGAAGTTGGC CCGACACATC 120

CTGACTGGGA AAGAGGTAGC TGTGAAGATC ATTGACAAGA CTCAACTGAA CTCCTCCAGC 180

CTCCAGAAAC TATTCCGTGA AGTAAGAATA ATGAAGGTTT TGAATCATCC CAACATAGTT 240

AAATTATTTG AAGTGATTGA GACTGAGAAA ACGCTCTACC TTGTCATGGA GTACGCTAGT 300

GGCGGAGAGG TATTTGATTA CCTAGTGGCT CATGGCAGGA TGAAAGAAAA AGAGGCTCGA 360

GCCAAATTCC GCCAGATAGT GTCTGCTGTG CAGTACTGTC ACCAGAAGTT TATTGTCCAT 420

AGAGACTTAA AGGCAGAAAA CCTGCTCTTG GATGCTGATA TGAACATCAA GATTGCAGAC 480

TTTGGCTTCA GCAATGAATT CACCTTTGGG AACAAGCTGG ACACCTTCTG TGGCAGTCCC 540

CCTTATGCTG CCCCAGAACT CTTCCAGGGC AAAAAATATG ATGGACCCGA GGTGGATGTG 600

TGGAGCCTAG GAGTTATCCT CTATACACTG GTCAGCGGAT CCCTGCCTTT TGATGGACAG 660

AACCTCAAGG AGCTGCGGGA ACGGGTACTG AGGGGAAAAT ACCGTATTCC GTTCTACATG 720

TCCACGGACT GTGAAAACCT GCTTAAGAAA TTTCTCATTC TTAATCCCAG CAAGAGAGGC 780

ACTTTAGAGC AAATCATGAA AGATCGATGG ATGAATGTGG GTCACGAAGA TGATGAACTA 840

AAGCCTTACG TGGAGCCACT CCCTGACTAC AAGGACCCCC GGCGGACAGA GCTGATGGTG 900

TCCATGGGTT ATACACGGGA AGAGATCCAG GACTCGCTGG TGGGCCAGAG ATACAACGAG 960

GTGATGGCCA CTTATCTGCT CCTGGGCTAC AAGAGCTCCG AGCTGGAAGG CGACACCATC 1020

ACCCTGAAAC CCCGGCCTTC AGCTGATCTG ACCAATAGCA GCGCCCCATC CCCATCCCAC 1080

AAGGTACAGC GCAGCGTGTC GGCCAATCCC AAGCAGCGGC GCTTCAGCGA CCAGGCAGCT 1140

GGTCCTGCCA TTCCCACCTC TAATTCTTAC TCTAAGAAGA CTCAGAGTAA CAACGCAGAA 1200

AATAAGCGGC CTGAGGAGGA CCGGGAGTCA GGGCGGAAAG CCAGCAGCAC AGCCAAGGTG 1260

CCTGCCAGCC CCCTGCCCGG TCTGGAGAGG AAGAAGACCA CCCCAACCCC CTCCACGAAC 1320

AGCGTCCTCT CCACCAGCAC AAATCGAAGC AGGAATTCCC CACTTTTGGA GCGGGCCAGC 1380

CTCGGCCAGG CCTCCATCCA GAATGGCAAA GACAGCCTAA CCATGCCAGG GTCCCGGGCC 1440

TCCACGGCTT CTGCTTCTGC CGCAGTCTCT GCGGCCCGGC CCCGCCAGCA CCAGAAATCC 1500

ATGTCGGCCT CCGTGCACCC CAACAAGGCC TCTGGGCTGC CCCCCACGGA GAGTAACTGT 1560

GAGGTGCCGC GGCCCAGCAC AGCCCCCCAG CGTGTCCCTG TCGCCTCCCC ATCCGCCCAC 1620

AACATCAGCA GCAGTGGTGG AGCCCCAGAC CGAACTAATT TCCCGCGGGG TGTGTCCAGC 1680

CGAAGCACCT TCCATGCTGG GCAGCTCCGA CAGGTGCGGG ACCAGCAGAA TTTGCCCTAC 1740

GGTGTGACCC CAGCCTCTCC CTCTGGCCAC AGCCAGGGCC GGCGGGGGGC CTCTGGGAGC 1800

ATCTTTAGCA AGTTCACCTC CAAGTTTGTA CGCAGGAACC TGAATGAACC TGAAAGCAAA 1860

GACCGAGTGG AGACGCTCAG ACCTCACGTG GTGGGCAGTG GCGGCAACGA CAAAGAAAAA 1920

GAAGAATTTC GGGAGGCCAA GCCCCGCTCC CTCCGCTTCA CGTGGAGTAT GAAGACCACG 1980

AGCTCCATGG AGCCCAACGA GATGATGCGG GAGATCCGCA AGGTGCTGGA CGCGAACAGC 2040

TGCCAGAGCG AGCTGCATGA GAAGTACATG CTGCTGTGCA TGCACGGCAC GCCGGGCCAC 2100

GAGGACTTCG TGCAGTGGGA GATGGAGGTG TGCAAACTGC CGCGGCTCTC TCTCAATGGG 2160

GTTCGATTTA AGCGGATATC GGGCACCTCC ATGGCCTTCA AAAACATTGC CTCCAAAATA 2220

GCCAACGAGC TGAAGCTTTA A 2241

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 20    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  79

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 80    VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 140   HRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 200   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 260   GTLEQIMKDRWM  271

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKFIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GTLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030010	; P:establishment of cell polarity
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0007243	; P:intracellular protein kinase cascade
GO:0010976	; P:positive regulation of neuron projection development
GO:0050770	; P:regulation of axonogenesis
GO:0006979	; P:response to oxidative stress

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013