EKS-NOL-00049
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00049
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF412.86.6E-124349606258
StatusUnreviewed
Ensembl ProteinENSNLEP00000024343
UniProt AccessionG1QXT4;
Protein Name
Protein Synonyms/Alias
Gene NameRAF1
Gene Synonyms/Alias RAF1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000004732ENSNLEP00000024343ENSNLET00000032706
ENSNLEG00000004732ENSNLEP00000005755ENSNLET00000006054
OrganismNomascus leucogenys
Functional Description
Protein Length648
Protein Sequence
(FASTA)
MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD PSKTSNTIRV 60
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS 120
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 180
PTMCVDWSNI RQLLLFPNST IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF 240
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 300
SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 360
GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 420
TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 480
TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 540
LMTGELPYSH INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP 600
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF 648
Nucleotide Sequence
(FASTA)
ATGGAGCACA TACAGGGAGC TTGGAAGACG ATCAGCAATG GTTTTGGATT CAAAGATGCC 60
GTGTTTGATG GCTCCAGCTG CATCTCTCCT ACAATAGTTC AGCAGTTTGG CTATCAGCGC 120
CGGGCATCAG ATGATGGCAA ACTTACAGAT CCTTCTAAGA CAAGCAACAC TATCCGTGTT 180
TTCTTGCCGA ACAAGCAAAG AACAGTGGTC AATGTGCGAA ATGGAATGAG CTTGCATGAC 240
TGCCTTATGA AAGCACTCAA GGTGAGGGGC CTGCAACCAG AGTGCTGTGC AGTGTTCAGA 300
CTTCTCCACG AACACAAAGG TAAAAAAGCA CGCTTAGATT GGAATACTGA TGCTGCGTCT 360
TTGATTGGAG AAGAACTTCA AGTAGATTTC CTGGATCATG TTCCGCTCAC AACACACAAC 420
TTTGCTCGGA AGACGTTCCT GAAGCTTGCC TTCTGTGACA TCTGTCAGAA ATTCCTGCTG 480
AACGGATTTC GATGTCAGAC TTGTGGCTAC AAATTTCATG AGCACTGTAG CACCAAAGTA 540
CCTACTATGT GTGTGGACTG GAGTAACATC AGACAGCTCT TATTGTTTCC AAATTCCACT 600
ATTGGTGATA GTGGAGTCCC AGCACTACCT TCTTTGACTA TGCGTCGTAT GCGAGAGTCT 660
GTTTCCAGGA TGCCTGTTAG TTCTCAGCAC AGATATTCTA CACCTCACGC CTTCACCTTT 720
AACACCTCCA GTCCCTCATC TGAAGGTTCC CTCTCCCAGA GGCAGAGGTC GACGTCCACA 780
CCTAATGTCC ACATGGTCAG CACCACCCTG CCTGTGGACA GCAGGATGAT TGAGGATGCA 840
ATTCGAAGTC ACAGCGAATC AGCCTCACCT TCAGCCCTGT CCAGTAGCCC CAACAATCTG 900
AGCCCAACAG GCTGGTCACA GCCGAAAACC CCCGTGCCGG CACAAAGAGA GCGGGCACCA 960
GTATCCGGGA CCCAGGAGAA AAACAAAATT AGGCCTCGGG GACAGAGAGA TTCAAGCTAT 1020
TACTGGGAAA TAGAAGCCAG TGAAGTGATG CTGTCCACTC GGATTGGGTC AGGCTCTTTT 1080
GGAACCGTTT ATAAGGGTAA ATGGCACGGA GATGTTGCAG TAAAGATCCT AAAGGTTGTT 1140
GACCCAACCC CAGAGCAATT CCAGGCCTTC AGGAATGAGG TGGCTGTTCT GCGCAAAACA 1200
CGGCATGTGA ACATTCTGCT TTTCATGGGG TACATGACAA AGGACAACCT GGCAATTGTG 1260
ACCCAGTGGT GTGAGGGCAG CAGCCTCTAC AAACACCTGC ATGTCCAGGA GACCAAGTTT 1320
CAGATGTTCC AGCTAATTGA CATTGCCCGG CAGACGGCTC AGGGAATGGA CTATTTGCAT 1380
GCAAAGAACA TCATCCACAG AGACATGAAA TCCAACAATA TATTTCTCCA TGAAGGCTTA 1440
ACAGTGAAAA TTGGAGATTT TGGTTTGGCA ACAGTAAAGT CACGCTGGAG TGGTTCTCAG 1500
CAGGTTGAAC AACCTACTGG CTCTGTCCTG TGGATGGCCC CAGAGGTGAT CCGAATGCAG 1560
GATAACAACC CATTCAGTTT CCAGTCGGAT GTCTACTCCT ATGGCATCGT ATTGTATGAG 1620
CTGATGACAG GGGAGCTTCC TTATTCTCAC ATCAACAACC GAGATCAGAT CATCTTCATG 1680
GTGGGCCGAG GATATGCCTC CCCAGATCTT AGTAAGCTAT ATAAGAACTG CCCCAAAGCA 1740
ATGAAGAGGC TGGTAGCTGA CTGTGTGAAG AAAGTAAAGG AAGAGAGGCC TCTTTTTCCC 1800
CAGATCCTGT CTTCCATTGA GCTGCTCCAA CACTCTCTAC CGAAGATCAA CCGGAGTGCT 1860
TCCGAGCCAT CCTTGCATCG GGCAGCCCAC ACTGAGGATA TCAACGCTTG CACGCTGACC 1920
ACGTCCCCGA GGCTGCCTGT CTTCTAG 1947
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+l+++iGsG+fGtvy+gkwhGdvavk+l+v ++++eq++aF++eva+++ktRh+ni+LF
Q: 349   VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLF  408
         57899*******************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mGy++k++laivt++c+gssLyk+lh+qetk+++ +lidiarq+aqgmdYLhak+i+h+D
Q: 409   MGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRD  468
         ************************************************************
S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180
         +ks+ni+l+egl+v+i+DFgl++vk+++sg  ++q+e+p+g++l++apevir+      q
Q: 469   MKSNNIFLHEGLTVKIGDFGLATVKSRWSG--SQQVEQPTGSVLWMAPEVIRM------Q  520
         ******************************..*********************......*
S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238
         d++pfs++sDvy++Givlyel+++elpy++ +++dqi+f+vgrG ++pdlsk+++++pk+
Q: 521   DNNPFSFQSDVYSYGIVLYELMTGELPYSHiNNRDQIIFMVGRGyASPDLSKLYKNCPKA  580
         ************************************************************
S: 239   lkellleClkfekeeRPlftqilkkl  264
         +k+l+++C+k+ keeRPlf+qil+++
Q: 581   MKRLVADCVKKVKEERPLFPQILSSI  606
         **********************9875
Domain Sequence
(FASTA)
VMLSTRIGSG SFGTVYKGKW HGDVAVKILK VVDPTPEQFQ AFRNEVAVLR KTRHVNILLF 60
MGYMTKDNLA IVTQWCEGSS LYKHLHVQET KFQMFQLIDI ARQTAQGMDY LHAKNIIHRD 120
MKSNNIFLHE GLTVKIGDFG LATVKSRWSG SQQVEQPTGS VLWMAPEVIR MQDNNPFSFQ 180
SDVYSYGIVL YELMTGELPY SHINNRDQII FMVGRGYASP DLSKLYKNCP KAMKRLVADC 240
VKKVKEERPL FPQILSSI 258
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00047
EKS-ANC-00042
EKS-CAJ-00050
EKS-CAF-00051
EKS-CAP-00051
EKS-DAR-00066
EKS-DRM-00019
EKS-EQC-00049
EKS-FEC-00049
EKS-GAM-00023
EKS-GAG-00042
EKS-GAA-00068
EKS-GOG-00050
EKS-HOS-00051
EKS-ICT-00048
EKS-LAC-00054
EKS-LOA-00050
EKS-MAM-00049
EKS-MEG-00040
EKS-MOD-00049
EKS-MUM-00051
EKS-MUP-00053
EKS-MYL-00053
EKS-OCP-00036
EKS-ORN-00070
EKS-ORC-00047
EKS-ORL-00067
EKS-OTG-00054
EKS-PAT-00047
EKS-PES-00046
EKS-POA-00048
EKS-PRC-00035
EKS-RAN-00050
EKS-SAH-00048
EKS-TAG-00047
EKS-TAR-00071
EKS-TEN-00074
EKS-XET-00052
EKS-XIM-00068
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0031333; P:negative regulation of protein complex assembly
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013