EKS-NOL-00157
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00157
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb431.41.1E-129414673260
StatusUnreviewed
Ensembl ProteinENSNLEP00000006123
UniProt AccessionG1QYV2;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000005042ENSNLEP00000006123ENSNLET00000006438
OrganismNomascus leucogenys
Functional Description
Protein Length771
Protein Sequence
(FASTA)
MGDEDEDESC AVELRITEAN LTGHEEKVSV ENFELLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QYFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKAGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SREVARWQVP FLPLLLPPAP YLGDSLDGKS SSNHLPTPNA RWALASWRNC 300
PGLDWAALAA RKIPAPFRPQ IRSELDVGNF AEEFTRLEPV YSPPGSPPPG DPRIFQGYSF 360
VAPSILFDHN NAVMTDVLEA PGAGDRPGRA AVARSAMMQD SPFFQQYELD LREPALGQGS 420
FSVCRRCRQR QSGQEFAVKI LSRRLEANTQ REVAALRLCQ SHPNVVNLHE VHHDQLHTYL 480
VLELLRGGEL LEHIRKKRHF SESEASQILR SLVSAVSFMH EEAGVVHRDL KPENILYADD 540
TPGAPVKIID FGFARLRPQS PGVPMQTPCF TLQYAAPELL AQQGYDESCD LWSLGVILYM 600
MLSGQVPFQG ASGQGGQSQA AEIMCKIREG RFSLDGEAWQ GVSEEAKELV RGLLTVDPAK 660
RLKIEGLRGS SWLQDGSARS SPPLRTPDVL ESSGPAVRSG LNATFMAFNR GKREGFFLKS 720
VENAPLAKRR KQKLRSATAS RRGSPAPAAP GRAPVAAKGA PRRANGPLPP S 771
Nucleotide Sequence
(FASTA)
ATGGGGGACG AGGACGAGGA TGAGAGCTGC GCGGTGGAGC TGCGGATCAC AGAAGCCAAC 60
CTGACCGGGC ACGAGGAGAA GGTGAGCGTG GAGAACTTCG AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGCAAGGT GTTCCTGGTG CGGAAGGCGG GCGGGCACGA CGCGGGGAAG 180
CTGTACGCCA TGAAGGTGCT GCGCAAGGCG GCGCTGGTGC AGCGTGCCAA GACGCAGGAG 240
CACACGCGCA CCGAGCGCTC GGTGCTGGAG CTGGTGCGCC AGGCGCCCTT CCTGGTCACG 300
CTGCACTACG CTTTCCAGAC GGATGCCAAG CTGCACCTCA TCCTGGACTA TGTGAGCGGC 360
GGGGAGATGT TCACCCACCT CTACCAGCGC CAGTACTTCA AGGAGGCTGA GGTGCGCGTG 420
TATGGGGGTG AGATCGTGCT GGCCCTGGAA CACCTGCATA AGCTCGGCAT CATTTACCGA 480
GACCTGAAAC TGGAGAATGT GCTGCTGGAC TCCGAGGGCC ACATTGTCCT CACGGACTTC 540
GGGCTGAGCA AGGAGTTCCT GACGGAGGAG AAAGAGCGGA CCTTCTCCTT CTGTGGCACC 600
ATCGAGTACA TGGCCCCCGA AATTATCCGT AGCAAGGCAG GGCATGGCAA GGCTGTGGAC 660
TGGTGGAGTC TGGGCATCTT GCTCTTCGAG CTGCTGACGG GGGCCTCGCC CTTCACCCTG 720
GAGGGCGAGA GGAACACGCA GGCTGAGGTG TCTCGGGAGG TTGCTAGGTG GCAAGTGCCC 780
TTTTTGCCCC TTCTCCTTCC TCCTGCTCCC TACCTGGGAG ACAGCTTAGA TGGCAAGAGC 840
TCCAGCAACC ATCTGCCCAC CCCAAATGCC AGATGGGCCC TTGCCTCATG GAGGAACTGC 900
CCAGGCCTCG ATTGGGCTGC TCTGGCTGCC AGGAAGATTC CAGCCCCATT CCGGCCCCAA 960
ATCCGCTCAG AGCTGGATGT GGGCAACTTT GCAGAGGAAT TCACTCGGCT GGAGCCTGTC 1020
TACTCACCCC CTGGCAGCCC CCCACCTGGG GACCCCCGAA TCTTTCAGGG ATACTCCTTT 1080
GTGGCACCCT CCATCCTCTT CGACCACAAC AACGCGGTGA TGACCGATGT GCTGGAAGCG 1140
CCTGGTGCTG GAGACCGGCC AGGTCGGGCA GCGGTGGCCA GGAGCGCTAT GATGCAGGAC 1200
TCGCCCTTCT TCCAGCAGTA CGAGCTGGAC CTGCGGGAGC CTGCGCTGGG CCAGGGCAGC 1260
TTCTCTGTGT GTCGCCGCTG CCGCCAGCGC CAGAGCGGCC AGGAGTTCGC GGTCAAGATC 1320
CTCAGTCGCA GGCTGGAGGC GAACACGCAG CGCGAAGTGG CTGCCCTGCG CCTGTGCCAG 1380
TCACACCCCA ATGTGGTGAA TCTGCACGAG GTGCATCACG ACCAGCTGCA CACGTACCTG 1440
GTCCTGGAGC TGCTGCGGGG CGGGGAGCTG CTGGAGCACA TCCGCAAGAA GCGGCACTTC 1500
AGCGAGTCGG AAGCGAGCCA GATCCTGCGC AGCCTCGTGT CGGCCGTGAG CTTCATGCAC 1560
GAGGAGGCGG GCGTGGTGCA CCGCGACCTC AAGCCGGAGA ACATCCTGTA CGCCGACGAC 1620
ACGCCCGGGG CGCCGGTGAA GATCATCGAC TTCGGGTTCG CGCGGCTGCG GCCGCAGAGT 1680
CCCGGGGTGC CCATGCAGAC GCCCTGCTTC ACGCTGCAGT ACGCTGCCCC CGAGCTGCTG 1740
GCGCAGCAGG GCTACGACGA GTCCTGCGAC CTCTGGAGCC TGGGCGTCAT TCTGTACATG 1800
ATGCTGTCGG GGCAGGTCCC CTTCCAGGGG GCCTCTGGCC AGGGCGGGCA GAGCCAGGCG 1860
GCCGAGATCA TGTGCAAAAT CCGCGAGGGG CGCTTCTCCC TTGACGGTGA GGCCTGGCAG 1920
GGCGTATCGG AGGAAGCCAA GGAGCTGGTC CGAGGGCTTC TGACCGTGGA CCCCGCCAAG 1980
CGGCTGAAGA TAGAGGGACT GCGGGGCAGC TCGTGGCTGC AGGACGGCAG CGCGCGCTCC 2040
TCGCCCCCGC TCCGGACGCC CGACGTGCTC GAGTCCTCTG GGCCCGCAGT GCGCTCGGGT 2100
CTCAACGCCA CCTTCATGGC GTTCAACCGG GGCAAGCGGG AGGGCTTCTT CCTGAAGAGT 2160
GTGGAGAACG CACCCCTGGC CAAGAGGCGG AAGCAGAAGC TTCGGAGCGC CACCGCCTCC 2220
CGCCGGGGCT CCCCCGCACC AGCCGCCCCG GGCCGAGCCC CCGTCGCCGC CAAAGGGGCC 2280
CCCCGCCGAG CCAACGGCCC CCTGCCCCCC TCCTAA 2316
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l++v++
Q: 414   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVAALRLCQSHPNVVNLHEVHH  473
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 474   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  533
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++g +++tpc+tl+++ape+l++qGyde+cdlw
Q: 534   NILYADDTPGAP-VKIIDFGFARLRPQSPGvPMQTPCFTLQYAAPELLAQQGYDESCDLW  592
         ************.*****************99****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 593   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  652
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlk+e+l+ +swl
Q: 653   LLTVDPAKRLKIEGLRGSSWL  673
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV AALRLCQSHP NVVNLHEVHH 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPGV PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK IEGLRGSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013