EKS-NOL-00166

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00166

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	443.4	2.8E-133	254	522	269

Status

Unreviewed

Ensembl Protein

ENSNLEP00000006341

UniProt Accession

G1QZH0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000005225	ENSNLEP00000023343	ENSNLET00000031602
ENSNLEG00000005225	ENSNLEP00000006341	ENSNLET00000006665

Organism

Nomascus leucogenys

Functional Description

Protein Length

596

Protein Sequence
(FASTA)

MPTQRDSCTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF 60

DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE 120

DKSIYRRGAR RWRKLYCANG HTFQAKRFNR RAHCAICTDR IWGLGRQGYK CINCKLLVHK 180

KCHKLVTIEC GRHSLPTEPM MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR 240

ESGKASSSLG LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ 300

TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL PEEHARFYSA 360

EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC KEGLRPGDTT STFCGTPNYI 420

APEILRGEDY GFSVDWWALG VLMFEMMAGR SPFDIVGSSD NPDQNTEDYL FQVILEKQIR 480

IPRSLSVKAA SVLKSFLNKD PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK 540

PNISGEFGLD NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV 596

Nucleotide Sequence
(FASTA)

ATGCCGACCC AGAGGGACAG CTGCACCATG TCCCACACGG TCGCAGGCGG CGGCAGCGGG 60

GACCATTCCC ACCAGGTCCG GGTGAAAGCC TACTACCGCG GGGATATCAT GATAACACAT 120

TTTGAACCTT CCATCTCCTT TGAGGGCCTT TGCAATGAGG TTCGAGACAT GTGTTCTTTT 180

GACAACGAAC AGCTCTTCAC CATGAAATGG ATAGATGAGG AAGGAGACCC GTGTACAGTA 240

TCATCTCAGT TGGAGTTAGA AGAAGCCTTT AGGCTTTATG AGCTAAACAA GGATTCTGAA 300

CTCTTGATTC ATGTGTTCCC TTGTGTACCG GAACGTCCTG GGATGCCCTG TCCAGGAGAA 360

GATAAATCCA TCTACCGTAG AGGTGCGCGC CGCTGGAGAA AGCTTTATTG TGCCAATGGC 420

CACACTTTCC AAGCCAAGCG CTTCAACAGG CGTGCTCACT GTGCCATCTG CACAGACCGA 480

ATATGGGGAC TTGGACGCCA AGGATATAAG TGCATCAACT GCAAACTCTT GGTTCATAAG 540

AAATGCCATA AACTCGTCAC AATTGAATGT GGGCGGCATT CTTTGCCAAC GGAACCAATG 600

ATGCCCATGG ATCAGTCATC CATGCATTCT GACCATGCAC AGACAGTAAT TCCATATAAT 660

CCTTCAAGTC ATGAGAGTTT GGATCAAGTT GGTGAAGAAA AAGAGGCAAT GAACACCAGG 720

GAAAGTGGCA AAGCTTCATC CAGTCTAGGT CTTCAGGATT TTGATTTGCT CCGGGTAATA 780

GGAAGAGGAA GTTATGCCAA AGTACTGTTG GTTCGATTAA AAAAAACAGA TCGTATTTAT 840

GCAATGAAAG TTGTGAAAAA AGAGCTTGTT AATGATGATG AGGATATTGA TTGGGTGCAG 900

ACAGAGAAGC ATGTGTTTGA GCAGGCATCC AATCATCCTT TCCTTGTTGG GCTGCATTCT 960

TGCTTTCAGA CAGAAAGCAG ATTGTTCTTT GTTATAGAGT ATGTAAATGG AGGAGACCTA 1020

ATGTTTCATA TGCAGCGACA AAGAAAACTT CCTGAAGAAC ATGCCAGATT TTACTCTGCG 1080

GAAATCAGTC TAGCATTAAA TTATCTTCAT GAGCGAGGGA TAATTTATAG AGATTTGAAA 1140

CTGGACAATG TATTACTGGA CTCTGAAGGC CACATTAAAC TAACTGACTA TGGCATGTGT 1200

AAGGAAGGAT TACGGCCAGG AGATACAACC AGCACTTTCT GTGGTACTCC TAATTACATT 1260

GCTCCTGAAA TTTTAAGAGG AGAAGATTAT GGTTTCAGTG TTGACTGGTG GGCTCTTGGA 1320

GTGCTAATGT TTGAGATGAT GGCAGGAAGG TCTCCATTTG ATATTGTTGG GAGCTCTGAT 1380

AACCCTGACC AGAACACAGA AGATTATCTC TTCCAAGTTA TTTTGGAAAA ACAAATTCGC 1440

ATACCACGTT CTCTGTCTGT AAAAGCTGCA AGTGTTCTGA AGAGTTTTCT TAACAAGGAC 1500

CCTAAGGAAC GATTGGGTTG TCATCCTCAA ACAGGATTTG CTGATATTCA GGGACATCCA 1560

TTCTTCCGAA ATGTTGACTG GGATATGATG GAGCAAAAAC AGGTGGTACC TCCCTTTAAA 1620

CCAAATATTT CTGGGGAGTT TGGTTTGGAC AACTTTGATT CTCAGTTTAC TAATGAACCT 1680

GTCCAGCTCA CTCCAGATGA TGATGACATT GTGAGGAAGA TTGATCAGTC TGAATTTGAA 1740

GGTTTTGAGT ATATCAATCC TCTTTTGATG TCTGCAGAAG AATGTGTCTG A 1791

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkktd++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 254   FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  313

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 314   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  373

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 374   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  433

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 434   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  493

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         k++l+kdp++rlG++ ++g +di+ h+ff

Q: 494   KSFLNKDPKERLGCHpQTGFADIQGHPFF  522

         **************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVRL KKTDRIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240

KSFLNKDPKE RLGCHPQTGF ADIQGHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0045216	; P:cell-cell junction organization
GO:0035556	; P:intracellular signal transduction
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:2000353	; P:positive regulation of endothelial cell apoptotic process
GO:0060252	; P:positive regulation of glial cell proliferation
GO:0010976	; P:positive regulation of neuron projection development
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013