EKS-NOL-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/BRD	N/A	N/A	N/A	N/A	N/A

Status

Unreviewed

Ensembl Protein

ENSNLEP00000006353

UniProt Accession

G1QZI2;

Protein Name

Protein Synonyms/Alias

Gene Name

BRD4

Gene Synonyms/Alias

BRD4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000005233	ENSNLEP00000006353	ENSNLET00000006678

Organism

Nomascus leucogenys

Functional Description

Protein Length

1364

Protein Sequence
(FASTA)

MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT 60

NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW 120

NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG 180

RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT 240

VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI 300

DSIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI 360

LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA 420

DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPATKVV 480

APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE 540

KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN NNVSKKEPAP MKSKPPPTYE 600

SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK 660

PSTLRELERY VTSCLRKKRK PQAEKVDVIP GSSKMKGFSS SESESSSESS SSDSEDSETE 720

MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPA QQQQQPPPPP 780

PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP 840

QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL 900

PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP 960

PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP 1020

HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT 1080

HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI 1140

KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG 1200

SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM 1260

RSREDEDALE QARRAHEEAR RRQEQQQQQQ QRQEQQQQQQ QQAAAVAAAA TTQAQSSQPQ 1320

SMLDQQRELA RKREQERRRR EAMAATIDMN FQSDLLSIFE ENLF 1364

Nucleotide Sequence
(FASTA)

ATGTCTGCGG AGAGCGGCCC TGGGACGAGA TTGAGAAATC TGCCAGTAAT GGGGGATGGA 60

CTAGAAACTT CCCAAATGTC TACAACGCAG GCCCAGGCCC AACCCCAGCC AGCCAACGCA 120

GCCAGCACCA ACCCCCCGCC CCCGGAGACC TCCAACCCTA ACAAGCCCAA GAGGCAGACC 180

AACCAACTGC AATACCTGCT CAGAGTGGTG CTCAAGACAC TATGGAAACA CCAGTTTGCG 240

TGGCCTTTCC AGCAGCCTGT GGATGCTGTC AAGCTGAACC TCCCTGATTA CTATAAGATC 300

ATTAAAACGC CTATGGATAT GGGAACAATA AAGAAGCGCT TGGAAAACAA CTATTACTGG 360

AATGCTCAGG AATGTATCCA GGACTTCAAC ACTATGTTTA CAAATTGTTA CATCTACAAC 420

AAGCCTGGAG ATGACATAGT CTTAATGGCA GAAGCTCTGG AAAAGCTCTT CTTGCAAAAA 480

ATAAATGAAC TACCCACAGA AGAAACCGAG ATCATGATAG TCCAGGCAAA AGGAAGAGGA 540

CGTGGGAGGA AAGAAACAGG GACAGCAAAA CCTGGCGTTT CCACGGTACC AAACACAACT 600

CAAGCATCGA CTCCTCCGCA GACCCAGACC CCTCAGCCGA ATCCTCCTCC TGTGCAGGCC 660

ACGCCTCACC CCTTCCCTGC TGTCACCCCA GACCTCATCG TCCAGACCCC TGTCATGACA 720

GTGGTGCCTC CCCAGCCACT GCAGACGCCC CCGCCGGTGC CCCCCCAGCC ACAACCCCCA 780

CCCGCTCCAG CTCCCCAGCC CGTACAGAGC CACCCACCCA TCATCGCGGC CACCCCACAG 840

CCTGTGAAGA CAAAGAAGGG AGTGAAGAGG AAAGCAGACA CCACCACCCC CACCACCATT 900

GACTCCATTC ACGAGCCACC CTCGCTGCCC CCGGAGCCCA AGACCACCAA GCTGGGCCAG 960

CGACGGGAGA GCAGCCGGCC TGTGAAACCT CCAAAGAAGG ACGTGCCCGA CTCTCAGCAG 1020

CACCCAGCAC CAGAGAAGAG CAGCAAGGTC TCGGAGCAGC TCAAGTGCTG CAGCGGCATC 1080

CTCAAGGAGA TGTTTGCCAA GAAGCACGCT GCCTACGCCT GGCCCTTCTA CAAGCCTGTG 1140

GACGTGGAGG CACTGGGCCT ACACGACTAC TGTGACATCA TCAAGCACCC CATGGACATG 1200

AGTACAATCA AGTCTAAACT GGAGGCCCGT GAGTACCGTG ATGCTCAGGA GTTTGGTGCT 1260

GACGTCCGAT TGATGTTCTC CAACTGCTAT AAGTACAACC CTCCTGACCA TGAGGTGGTT 1320

GCCATGGCCC GCAAGCTCCA GGATGTGTTC GAAATGCGCT TTGCCAAGAT GCCGGACGAG 1380

CCTGAGGAGC CAGTGGTGGC CGTGTCCTCC CCGGCAGTGC CCCCTGCCAC CAAGGTTGTG 1440

GCCCCGCCCT CATCCAGCGA TAGCAGCAGC GATAGCTCCT CGGACAGTGA CAGTTCGACT 1500

GATGACTCTG AGGAGGAGCG AGCCCAGCGG CTGGCTGAGC TCCAGGAGCA GCTCAAAGCC 1560

GTGCACGAGC AGCTTGCAGC CCTCTCTCAG CCCCAGCAGA ACAAACCAAA GAAAAAGGAG 1620

AAAGACAAGA AGGAAAAGAA AAAAGAAAAG CACAAAAGGA AAGAGGAAGT GGAAGAGAAT 1680

AAAAAAAGCA AAGCCAAGGA ACCTCCTCCT AAAAAGACAA AGAAAAATAA TAGCAGCAAC 1740

AACAATGTGA GCAAGAAGGA GCCAGCGCCC ATGAAGAGCA AGCCCCCTCC CACGTATGAG 1800

TCAGAGGAAG AGGACAAGTG CAAGCCTATG TCCTATGAGG AGAAGCGGCA GCTCAGCTTG 1860

GACATCAACA AGCTCCCCGG CGAGAAGCTG GGCCGCGTGG TGCACATCAT CCAGTCACGG 1920

GAGCCCTCCC TGAAGAATTC CAACCCCGAC GAGATTGAAA TCGACTTTGA GACCCTGAAG 1980

CCGTCCACAC TGCGTGAGCT GGAGCGCTAT GTCACCTCCT GTTTGCGGAA GAAAAGGAAA 2040

CCTCAAGCTG AGAAAGTTGA TGTGATTCCT GGCTCCTCCA AGATGAAGGG CTTCTCGTCC 2100

TCAGAGTCGG AGAGCTCCAG TGAGTCCAGC TCCTCTGACA GCGAAGACTC CGAAACAGAG 2160

ATGGCTCCGA AGTCAAAAAA GAAGGGGCAC CCCGGGAGGG AGCAGAAGAA GCACCATCAT 2220

CACCACCATC AGCAGATGCA GCAGGCCCCG GCTCCTGTGC CCCAGCAGCC GCCCCCGCCT 2280

CCCCAGCAGC CCCCACCGCC TCCACCTGCG CAGCAGCAAC AGCAGCCGCC ACCCCCGCCT 2340

CCCCCACCCT CCATGCCGCA GCAGGCAGCC CCGGCGATGA AGTCCTCGCC CCCACCCTTC 2400

ATTGCCACCC AGGTGCCCGT CCTGGAGCCC CAGCTCCCAG GCAGTGTCTT TGACCCCATC 2460

GGCCACTTCA CCCAGCCCAT CCTGCACCTG CCGCAGCCTG AGCTGCCCCC TCACCTGCCC 2520

CAGCCGCCTG AGCACAGCAC TCCACCCCAT CTCAACCAGC ACGCAGTGGT CTCTCCTCCA 2580

GCTTTGCACA ACGCACTGCC CCAGCAGCCA TCACGGCCCA GCAACCGAGC CGCTGCCCTG 2640

CCTCCCAAGC CCGCCCGGCC CCCAGCCGTG TCACCAGCCT TGACCCAAAC ACCCCTGCTC 2700

CCACAGCCCC CCATGGCCCA ACCCCCCCAA GTGCTGCTGG AGGATGAAGA GCCACCTGCC 2760

CCACCCCTCA CCTCCATGCA GATGCAGCTG TACCTGCAGC AGCTGCAGAA GGTGCAGCCC 2820

CCTACGCCGC TACTCCCTTC CGTGAAGGTG CAGTCCCAGC CCCCACCCCC CCTGCCGCCC 2880

CCACCCCACC CCTCTGTGCA GCAGCAGCTG CAGCAGCAGC CGCCACCACC CCCACCACCC 2940

CAGCCCCAGC CCCCGCCCCA GCAGCAGCAT CAGCCCCCTC CACGGCCCGT GCACTTGCAG 3000

CCCATGCAGT TCTCCACCCA CATCCAACAG CCCCCACCAC CCCAGGGCCA GCAGCCCCCG 3060

CATCCACCCC CGGGCCAGCA GCCACCCCCG CCGCAGCCTG CCAAGCCTCA GCAAGTCATC 3120

CAGCACCACC ATTCACCCCG GCACCACAAG TCGGACCCCT ACTCAACCGG TCACCTCCGC 3180

GAAGCCCCCT CCCCGCTTAT GATACATTCC CCCCAGATGT CACAGTTCCA GAGCCTGACC 3240

CACCAGTCTC CACCCCAGCA AAACGTCCAG CCTAAGAAAC AGGAGCTGCG TGCTGCCTCC 3300

GTGGTCCAGC CCCAGCCCCT CGTGGTGGTG AAGGAGGAGA AGATCCACTC ACCCATCATC 3360

CGCAGCGAAC CCTTCAGCCC CTCGCTGCGG CCGGAGCCCC CCAAGCACCC GGAGAGCATC 3420

AAGGCCCCCG TCCACCTGCC CCAGCGGCCG GAGATGAAGC CTGTGGATGT CGGGAGGCCT 3480

GTGATCCGGC CCCCCGAGCA GAACGCACCG CCACCGGGGG CCCCTGACAA GGACAAACAG 3540

AAACAGGAGC CGAAGACTCC AGTTGCGCCC AAAAAGGACC TGAAAATCAA GAACATGGGC 3600

TCCTGGGCCA GCCTAGTGCA GAAGCATCCG ACCACCCCCT CCTCCACAGC CAAGTCATCC 3660

AGCGACAGCT TCGAGCAGTT CCGCCGCGCC GCTCGGGAGA AAGAGGAGCG TGAGAAGGCT 3720

CTGAAGGCTC AGGCCGAGCA CGCCGAGAAG GAGAAGGAGC GGCTGCGGCA GGAGCGCATG 3780

AGGAGCCGAG AGGATGAGGA TGCGCTGGAG CAGGCCCGGC GGGCGCATGA AGAGGCACGT 3840

CGGCGCCAGG AGCAGCAGCA GCAGCAGCAG CAGCGCCAGG AGCAACAGCA GCAGCAGCAA 3900

CAGCAAGCAG CTGCGGTGGC TGCCGCCGCC ACCACCCAGG CCCAGAGCTC CCAGCCCCAG 3960

TCCATGCTGG ACCAGCAGAG GGAGTTGGCC CGGAAGCGGG AGCAGGAGCG AAGACGCCGG 4020

GAAGCCATGG CAGCTACCAT TGACATGAAT TTCCAGAGTG ATCTATTGTC AATATTTGAA 4080

GAAAATCTTT TCTGA 4095

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Bromodomain; Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000794	; C:condensed nuclear chromosome
GO:0005737	; C:cytoplasm
GO:0010971	; P:positive regulation of G2/M transition of mitotic cell cycle
GO:0032968	; P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0000114	; P:regulation of transcription involved in G1 phase of mitotic cell cycle

KEGG

InterPros

IPR001487	; Bromodomain.
IPR018359	; Bromodomain_CS.

Pfam

PF00439

; Bromodomain; 2.

SMARTs

SM00297

; BROMO; 2.

Prosites

PS00633	; BROMODOMAIN_1; 1.
PS50014	; BROMODOMAIN_2; 2.

Prints

PR00503

; BROMODOMAIN.

Created Date

20-Feb-2013