EKS-NOL-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.7	9.2E-186	477	755	279

Status

Unreviewed

Ensembl Protein

ENSNLEP00000006496

UniProt Accession

G1QZX5;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000005305	ENSNLEP00000006496	ENSNLET00000006824

Organism

Nomascus leucogenys

Functional Description

Protein Length

787

Protein Sequence
(FASTA)

MSVQSSSGSL EGPPSWSQLS TSPTPGSAAA ARSLLNHTPP SGRPREGAMD ELHSLDPRRQ 60

ELLEARFTGV ASGSTGSTGS CSVGAKASTN NESSNHSFGS LGSLSDKESE TPEKKQSESS 120

RGRKRKAENQ NESSQGKHIT SSFSAYLLTS CASYILGKSI GGRGHKISDY FEYQGGNGSS 180

PVRGIPPAIR SPQNSHSHST PSSSVRPNSP SPTALAFGDH PIVQPKQLSF KIIQTDLTML 240

KLAALESNKI QDLEKKEGRI DDLLRANCDL RRQIDEQQKL LEKYKERLNK CISMSKKLLI 300

EKSTQEKLSS REKSMQDRLR LGHFTTVRHG ASFTEQWTDG FAFQNLVKQQ EWVNQQREDI 360

ERQRKLLAKR KPPTANNSQA PSTNSEPKQR KNKAVNGAEN DPFVRPNLPQ LLTLAEYHEQ 420

EEIFKLRLGH LKKEEAEIQA ELERLERVRN LHIRELKRIN NEDNSQFKDH PTLNERYLLL 480

HLLGRGGFSE VYKAFDLYEQ RYAAVKIHQL NKSWRDEKKE NYHKHACREY RIHKELDHPR 540

IVKLYDYFSL DTDTFCTVLE YCEGNDLDFY LKQHKLMSEK EARSIVMQIV NALRYLNEIK 600

PPIIHYDLKP GNILLVDGTA CGEIKITDFG LSKIMDDDSY GVDGMDLTSQ GAGTYWYLPP 660

ECFVVGKEPP KISNKVDVWS VGVIFFQCLY GRKPFGHNQS QQDILQENTI LKATEVQFPV 720

KPVVSSEAKA FIRRCLAYRK EDRFDVHQLA NDPYLLPHMR RSNSSGNLHM AGLTASPTPP 780

SSSIITY 787

Nucleotide Sequence
(FASTA)

ATGAGTGTCC AAAGTAGCAG TGGAAGTTTG GAGGGGCCGC CATCTTGGTC CCAGCTCTCC 60

ACGTCTCCAA CCCCGGGCTC GGCGGCGGCG GCCAGGTCCC TGCTGAATCA CACGCCGCCA 120

TCCGGGAGGC CCAGGGAAGG TGCAATGGAT GAGCTTCATA GTCTGGATCC AAGAAGGCAA 180

GAGTTATTGG AAGCTAGATT TACTGGAGTT GCAAGTGGGA GCACTGGAAG TACGGGCAGT 240

TGCAGTGTTG GAGCTAAAGC CTCAACAAAT AACGAAAGCT CTAATCACAG TTTTGGAAGC 300

TTGGGATCCT TAAGTGACAA AGAATCAGAG ACACCAGAGA AGAAACAATC GGAATCATCC 360

AGGGGAAGAA AGAGAAAAGC AGAAAACCAG AATGAAAGTA GTCAGGGTAA GCACATAACA 420

TCTTCCTTCA GCGCCTACCT ACTAACATCA TGCGCTTCTT ATATTTTAGG AAAAAGTATT 480

GGGGGACGTG GCCACAAAAT TAGCGACTAT TTTGAATACC AGGGTGGAAA TGGCTCAAGT 540

CCAGTAAGAG GCATACCTCC TGCAATCCGT TCTCCTCAAA ATTCACATTC ACATTCCACT 600

CCTTCCTCAT CTGTTCGACC GAATAGCCCT TCTCCTACTG CATTAGCATT TGGGGACCAC 660

CCTATTGTAC AACCAAAGCA GTTATCCTTT AAAATTATTC AGACTGATCT CACAATGCTG 720

AAATTAGCAG CATTAGAAAG TAATAAAATC CAGGACCTGG AAAAGAAGGA GGGACGTATA 780

GATGATTTGC TCAGGGCTAA CTGTGATCTC AGACGGCAAA TAGATGAACA ACAAAAATTA 840

CTTGAAAAAT ACAAAGAACG ATTAAATAAG TGCATATCAA TGAGCAAGAA ACTTCTTATT 900

GAAAAGAGTA CACAAGAAAA ACTGTCAAGC AGAGAGAAGA GTATGCAAGA TCGATTACGC 960

CTCGGGCACT TTACAACAGT TAGACATGGG GCTTCATTTA CTGAACAATG GACAGATGGT 1020

TTTGCATTTC AGAATCTTGT GAAGCAACAA GAATGGGTGA ATCAGCAAAG GGAAGATATT 1080

GAAAGGCAAA GGAAACTTCT AGCCAAACGC AAACCTCCCA CAGCTAATAA TTCTCAGGCA 1140

CCCTCTACCA ATTCTGAACC AAAACAAAGG AAAAACAAAG CAGTCAATGG AGCAGAGAAT 1200

GATCCCTTTG TTAGACCAAA TTTACCACAA CTGTTGACTT TGGCAGAATA TCATGAACAG 1260

GAAGAAATTT TCAAACTTAG ACTAGGACAT CTCAAAAAGG AAGAGGCAGA AATCCAGGCA 1320

GAACTTGAAC GTTTGGAAAG AGTCAGAAAT CTTCACATAC GTGAGCTGAA AAGAATAAAC 1380

AATGAAGATA ATTCACAGTT CAAAGATCAC CCAACATTAA ATGAAAGATA TTTATTACTT 1440

CATCTGCTTG GTAGAGGTGG CTTTAGTGAA GTATATAAGG CTTTTGACCT TTATGAACAA 1500

AGATATGCTG CTGTGAAGAT ACATCAGCTT AATAAAAGCT GGAGAGATGA GAAGAAAGAA 1560

AACTACCACA AACATGCCTG CAGAGAGTAT AGAATACACA AAGAACTGGA TCACCCCAGA 1620

ATAGTTAAAC TCTATGATTA TTTCTCCTTG GATACAGATA CGTTTTGTAC AGTGTTAGAA 1680

TACTGTGAAG GCAATGACTT GGATTTCTAT CTGAAGCAAC ACAAGTTAAT GTCAGAGAAA 1740

GAAGCTAGGT CTATTGTAAT GCAGATTGTA AACGCACTAA GATATCTCAA TGAGATCAAA 1800

CCCCCTATTA TACATTATGA TCTTAAGCCA GGAAACATCC TACTGGTAGA TGGAACAGCA 1860

TGTGGTGAAA TCAAAATCAC TGATTTTGGT CTGTCCAAGA TTATGGATGA TGATAGCTAT 1920

GGTGTAGATG GAATGGATCT AACTTCCCAG GGGGCAGGCA CTTACTGGTA TTTACCTCCT 1980

GAGTGTTTTG TAGTTGGAAA AGAGCCACCA AAGATTTCCA ACAAGGTTGA TGTATGGTCG 2040

GTTGGAGTCA TCTTCTTTCA GTGTCTTTAT GGTAGAAAGC CATTTGGTCA CAATCAATCT 2100

CAACAAGACA TTCTTCAAGA AAATACAATA TTAAAAGCCA CAGAAGTCCA GTTCCCTGTA 2160

AAACCAGTTG TAAGCAGTGA AGCCAAGGCC TTTATAAGAC GCTGTTTGGC ATATCGAAAA 2220

GAAGATCGAT TTGATGTGCA CCAGCTGGCA AATGACCCAT ACCTTCTCCC ACACATGAGA 2280

AGATCAAATT CTTCAGGAAA CCTACACATG GCTGGGCTGA CAGCATCCCC TACGCCCCCT 2340

TCTTCAAGCA TAATTACTTA CTGA 2364

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 477   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  536

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 537   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  596

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 597   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  655

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 656   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  715

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvsseakafirrclayrkedr+dv+qla+d+yl

Q: 716   VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL  755

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSS EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013