EKS-NOL-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.5	1.4E-122	189	476	288

Status

Unreviewed

Ensembl Protein

ENSNLEP00000006554

UniProt Accession

G1R033;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000005401	ENSNLEP00000006554	ENSNLET00000006886

Organism

Nomascus leucogenys

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 60

ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 120

GPEVTYEPPT APTLLTVLAY SLLPIGGLSL IVLLAFWMYR HRKPPYGHVD IHEDPGPPPP 180

SPLVGLKPLQ LLEIKARGRF GCVWKAQLMN DFVAVKIFPL QDKQSWQSER EIFSTPGMKH 240

ENLLQFIAAE KRGSNLEVEL WLITAFHDKG SLTDYLKGNI ITWNELCHVA ETMSRGLSYL 300

HEDVPWCRGE GHKPSIAHRD FKSKNVLLKS DLTAVLADFG LAVRFEPGKP PGDTHGQVGT 360

RRYMAPEVLE GAINFQRDAF LRIDMYAMGL VLWELVSRCK AADGPVDEYM LPFEEEIGQH 420

PSLEELQEVV VHKKMRPTIK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERVSLI 480

RRSVNGTTSD CLVSLVTSVT NVDLPPKESS I 511

Nucleotide Sequence
(FASTA)

ATGACGGCGC CCTGGGCGGC CCTCGCCCTC CTCTGGGGAT CGCTGTGCGC CGGCTCTGGG 60

CGTGGGGAGG CTGAGACACG GGAGTGCATC TACTACAACG CCAACTGGGA GCTGGAGCGC 120

ACCAACCAGA GCGGCCTGGA GCGCTGCGAA GGCGAGCAGG ACAAGCGGCT GCACTGCTAC 180

GCCTCCTGGC GCAACAGCTC TGGCACCATC GAGCTCGTGA AGAAGGGCTG CTGGCTAGAT 240

GACTTCAACT GCTACGATAG GCAGGAGTGC GTGGCCACTG AGGAGAACCC CCAGGTGTAC 300

TTCTGCTGCT GTGAAGGCAA CTTCTGCAAC GAGCGCTTCA CTCATTTGCC AGAGGCTGGG 360

GGCCCAGAAG TCACGTACGA GCCACCGACA GCCCCCACCC TGCTCACGGT GCTGGCCTAC 420

TCACTGTTGC CCATCGGGGG TCTTTCCCTC ATCGTCCTGC TGGCCTTTTG GATGTACCGG 480

CATCGCAAGC CCCCCTACGG TCATGTGGAC ATCCATGAGG ACCCTGGGCC TCCACCCCCA 540

TCCCCTTTGG TGGGCCTGAA GCCACTGCAG CTGCTGGAGA TCAAGGCTCG GGGGCGCTTT 600

GGCTGTGTCT GGAAGGCCCA GCTCATGAAT GACTTTGTAG CTGTCAAGAT CTTCCCACTC 660

CAGGACAAGC AGTCGTGGCA GAGTGAACGG GAGATCTTCA GCACACCTGG CATGAAGCAC 720

GAGAACCTGC TACAGTTCAT TGCTGCCGAG AAGCGAGGCT CCAACCTCGA AGTAGAGCTG 780

TGGCTCATCA CGGCCTTCCA CGACAAGGGC TCCCTCACGG ATTACCTCAA GGGGAACATC 840

ATCACGTGGA ACGAACTGTG TCATGTAGCA GAGACGATGT CACGAGGCCT CTCATACCTG 900

CATGAGGATG TGCCCTGGTG CCGTGGCGAG GGCCACAAGC CGTCTATTGC CCACAGGGAC 960

TTTAAAAGTA AGAATGTATT GCTGAAGAGC GACCTCACAG CCGTGCTGGC TGACTTTGGC 1020

TTGGCTGTTC GATTTGAGCC AGGGAAACCT CCAGGGGACA CCCACGGACA GGTAGGCACG 1080

AGACGGTACA TGGCTCCTGA GGTGCTTGAG GGAGCCATCA ACTTCCAGAG AGATGCCTTC 1140

CTGCGCATTG ACATGTATGC CATGGGGTTG GTGCTGTGGG AGCTTGTGTC TCGCTGCAAG 1200

GCTGCAGACG GACCCGTGGA TGAGTACATG CTGCCCTTTG AGGAAGAGAT TGGCCAGCAC 1260

CCTTCGTTGG AGGAGCTGCA GGAGGTGGTG GTGCACAAGA AGATGAGGCC CACCATTAAA 1320

GATCACTGGT TGAAACACCC GGGTCTGGCC CAGCTTTGTG TGACCATCGA GGAGTGCTGG 1380

GACCATGATG CAGAGGCTCG CTTGTCTGCG GGCTGTGTGG AGGAGCGGGT GTCCCTGATT 1440

CGGAGGTCGG TCAACGGCAC TACCTCGGAC TGTCTGGTTT CCCTGGTAAC CTCTGTCACC 1500

AATGTGGACC TGCCCCCTAA AGAGTCAAGC ATCTAA 1536

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 189   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  248

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 249   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  308

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 309   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  366

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 367   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  425

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP+i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 426   LQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  476

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPT IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0030509	; P:BMP signaling pathway
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013