EKS-NOL-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	317.7	5.6E-95	17	260	244

Status

Unreviewed

Ensembl Protein

ENSNLEP00000007004

UniProt Accession

G1R1D2;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100603568

Gene Synonyms/Alias

LOC100603568;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000005760	ENSNLEP00000007004	ENSNLET00000007351

Organism

Nomascus leucogenys

Functional Description

Protein Length

800

Protein Sequence
(FASTA)

MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 60

SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE EMDMDHIMTW ATDVAKGMHY 120

LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHNH TTHMSLVGTF PWMAPEVIQS 180

LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH 240

QCWEADAKKR PSFKQIISIL ESMSNDTSLP DKCNSFLHNK AEWRCEIEAT LERLKKLERD 300

LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LPSFEIGAWT EDDVYCWVQQ LVRKGDSSAE 360

MSVYASLFKE NNITGKRLLL LEEEDLKDMG IVSKGHIIHF KSAIEKLTHD YINLFHFPPL 420

IKDSGGEPEE NEEKIVNLEL VFGFHLKPGT GPQDCKWKMY MEMDGDEIAI TYIKDVTFNT 480

NLPDAEILKM TKPPFVMEKW IVGIAKNQTV ECTVTYESDV RTPKSTKHVH SIQWSRTKPQ 540

DEVKAVQLAI QTLFTNSDGN PGSRSDSSAD CQWLDTLRMR QIASNTSLQR SQSNPILGSP 600

FFSYFDGQDS YAAAVRRTQV PIKYQQITPV NQSRSSSPTQ YGLTKNFSSL HLNSRDSGFS 660

SGNTDTSSER GRYSDRSRNK YGRGSTSLNS SPRGRYSGKS QHSTPSRGRY PGKFYRVSQS 720

ALNPHQSPDF KRSPRDLHQP NTIPGMPLHP ETDSRASEEE SKVSEGGWTK VEYRKKPHRP 780

SPAKTNKERA RGDHRGWRNF 800

Nucleotide Sequence
(FASTA)

ATGTCGTCTC TCGGTGCCTC CTTTGTGCAA ATTAAATTTG ATGACTTGCA GTTTTTTGAA 60

AACTGCGGTG GAGGAAGTTT TGGGAGTGTT TATCGAGCCA AATGGATATC ACAGGACAAG 120

GAGGTGGCTG TAAAGAAGCT CCTCAAAATA GAGAAAGAGG CAGAAATACT CAGTGTCCTC 180

AGTCACAGAA ACATCATCCA GTTTTATGGA GTAATTCTTG AACCTCCCAA CTATGGCATT 240

GTCACAGAAT ATGCTTCTCT GGGATCACTC TATGATTACA TTAACAGTAA TAGAAGTGAG 300

GAGATGGATA TGGATCACAT TATGACCTGG GCCACTGATG TAGCCAAAGG AATGCACTAT 360

TTACATATGG AGGCTCCTGT CAAGGTGATT CACAGAGACC TCAAGTCAAG AAATGTTGTT 420

ATAGCTGCTG ATGGAGTATT GAAGATCTGT GACTTTGGTG CCTCTCGGTT CCATAACCAT 480

ACAACACACA TGTCCTTGGT TGGAACTTTC CCATGGATGG CTCCAGAAGT TATCCAAAGT 540

CTCCCTGTGT CAGAAACTTG TGACACATAT TCCTATGGTG TGGTTCTCTG GGAGATGCTA 600

ACAAGGGAGG TCCCCTTTAA AGGTTTGGAA GGATTACAAG TAGCTTGGCT TGTAGTGGAA 660

AAAAACGAGA GATTAACCAT TCCAAGCAGT TGCCCCAGAA GTTTTGCTGA ACTGTTACAT 720

CAGTGTTGGG AAGCTGATGC CAAGAAACGG CCATCATTCA AGCAAATCAT TTCAATCCTG 780

GAGTCCATGT CAAATGACAC GAGCCTTCCT GACAAGTGTA ACTCATTCCT ACACAACAAG 840

GCAGAGTGGA GGTGCGAAAT TGAGGCAACT CTTGAGAGGC TAAAGAAACT GGAGCGTGAT 900

CTCAGCTTTA AGGAGCAGGA GCTTAAAGAA CGAGAAAGAC GTTTAAAGAT GTGGGAGCAA 960

AAGCTGACAG AGCAGTCCAA CACCCCGCTG CTGCCTTCCT TTGAGATTGG TGCATGGACA 1020

GAAGACGATG TGTATTGTTG GGTTCAGCAG CTCGTCAGAA AAGGTGACTC TTCAGCAGAG 1080

ATGAGTGTAT ATGCAAGCTT GTTTAAAGAA AACAACATTA CAGGGAAGCG ACTGCTGCTG 1140

CTGGAGGAAG AAGACCTGAA AGACATGGGC ATTGTCTCCA AGGGGCATAT CATTCACTTC 1200

AAGTCAGCCA TTGAGAAATT AACCCATGAT TACATAAATT TGTTTCACTT CCCACCACTA 1260

ATTAAGGACT CAGGAGGTGA ACCTGAAGAA AATGAGGAAA AGATAGTGAA CCTGGAACTG 1320

GTTTTTGGTT TTCACTTGAA ACCAGGAACT GGCCCACAGG ATTGTAAGTG GAAAATGTAT 1380

ATGGAGATGG ATGGGGATGA AATTGCAATA ACCTACATAA AAGATGTGAC ATTCAACACT 1440

AACCTACCTG ATGCGGAGAT TTTAAAGATG ACAAAGCCAC CATTTGTAAT GGAGAAGTGG 1500

ATTGTAGGAA TAGCAAAAAA TCAGACTGTG GAGTGCACTG TCACATATGA GAGTGATGTT 1560

AGAACTCCAA AAAGCACTAA ACATGTCCAT TCGATTCAGT GGAGTAGAAC AAAACCTCAG 1620

GATGAAGTGA AAGCAGTCCA ACTTGCCATT CAGACATTAT TCACCAATTC AGATGGCAAC 1680

CCTGGAAGCA GGTCTGACTC AAGTGCTGAT TGCCAGTGGT TAGATACTCT GAGGATGCGG 1740

CAGATTGCAT CCAACACTTC TTTACAGCGT TCCCAGAGCA ATCCTATTCT GGGGTCACCA 1800

TTCTTCTCAT ACTTTGATGG CCAGGATTCC TATGCTGCTG CTGTGAGACG GACCCAAGTG 1860

CCCATTAAGT ATCAACAGAT TACACCTGTG AACCAGTCCA GAAGCTCTTC TCCTACTCAG 1920

TACGGACTGA CCAAAAACTT CTCTTCCCTA CATCTCAACT CTAGGGACAG TGGCTTTTCC 1980

AGTGGCAATA CTGACACCTC TTCAGAGAGG GGTCGATACT CAGACAGAAG CAGGAACAAA 2040

TATGGACGTG GTAGTACATC ACTCAATTCT TCTCCTAGAG GAAGATACAG TGGAAAAAGT 2100

CAGCATTCCA CTCCTTCAAG AGGAAGATAC CCTGGAAAGT TCTACAGGGT TTCTCAGTCA 2160

GCACTCAATC CTCACCAGTC GCCTGACTTC AAGAGAAGCC CCAGGGACCT CCACCAACCC 2220

AACACCATAC CAGGGATGCC TTTGCACCCT GAGACTGACT CAAGGGCCAG TGAAGAGGAA 2280

AGCAAAGTCA GCGAAGGGGG CTGGACAAAA GTGGAATACC GGAAAAAGCC CCACAGGCCG 2340

TCTCCCGCCA AAACCAATAA AGAGAGAGCC AGAGGGGACC ACCGTGGATG GAGAAACTTT 2400

TGA 2403

Domain Profile

S: 2     eleeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpnii  59

         ++ e +g g+fg+vy+akw +++  vavKkl +          +e+ea++ls lsh+nii

Q: 17    QFFENCGGGSFGSVYRAKWISQDkeVAVKKLLK----------IEKEAEILSVLSHRNII  66

         67799**************665444****9987..........899**************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119

         +++Gv+le+pn+++v+ey++ gsL++++++++++e+d++++++wa+++A+Gm+YLh eap

Q: 67    QFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP  126

         ************************************************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         +k+ihrdLks+nv++ +++ +lkicdFG +r+++++t+ms  gt+ wmaPEv+++ +vse

Q: 127   VKVIHRDLKSRNVVI-AADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSE  185

         ***************.********************************************

S: 180   ksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwne  239

         ++D +SygvvLWe+ltrevP+k+l+ l++a+ v++k++rl+ipsscp+++++L+++cw++

Q: 186   TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEA  245

         ************************************************************

S: 240   dpekRpsfseivksl  254

         d++kRpsf++i+++l

Q: 246   DAKKRPSFKQIISIL  260

         ***********9875

Domain Sequence
(FASTA)

QFFENCGGGS FGSVYRAKWI SQDKEVAVKK LLKIEKEAEI LSVLSHRNII QFYGVILEPP 60

NYGIVTEYAS LGSLYDYINS NRSEEMDMDH IMTWATDVAK GMHYLHMEAP VKVIHRDLKS 120

RNVVIAADGV LKICDFGASR FHNHTTHMSL VGTFPWMAPE VIQSLPVSET CDTYSYGVVL 180

WEMLTREVPF KGLEGLQVAW LVVEKNERLT IPSSCPRSFA ELLHQCWEAD AKKRPSFKQI 240

ISIL 244

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007257	; P:activation of JUN kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0007050	; P:cell cycle arrest
GO:0000077	; P:DNA damage checkpoint
GO:0043065	; P:positive regulation of apoptotic process
GO:0009314	; P:response to radiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013