EKS-NOL-00031
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00031
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak313.11.7E-93518774257
StatusUnreviewed
Ensembl ProteinENSNLEP00000007120
UniProt AccessionG1R1P8;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000005873ENSNLEP00000007102ENSNLET00000007454
ENSNLEG00000005873ENSNLEP00000007120ENSNLET00000007473
OrganismNomascus leucogenys
Functional Description
Protein Length1128
Protein Sequence
(FASTA)
MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA EDLCVQAAKA 60
SGILPVYHSL FALATEDLSC WFPPSHIFSV DDASTQVLLY RIRFYFPNWF GLEKCHRFGL 120
RKDLASAILD LPVLEHLFAQ HRSDLVSGRL PVGLSLKEQG ECLSLAVLDL ARMAREQAQR 180
PGELLKTVSY KACLPPSLRD LIQGLSFVTR KRIRRTTKRQ SEALRAGRLR SGAGIKGRGP 240
AERGRRGLAE GVGDVWGWVG EVGRGLEGLS GKGGPYFGTP PLSQVLQPFC DFPEIVDISI 300
KQAPRVGPAG EHRLVTVTRT DNQILEAEFP GLPEALSFVA LVDGYFRLTT DSQHFFCKEV 360
APPRLLEEVA EQCHGPITLD FAINKLKTGG SRPGSYVLRR SPQDFDSFLL TVCVQTPLGP 420
DYKGCLIRRS PTGTFLLVGL SRPHSSLREL LATCWDGGLH VDGVAATLTS CCIPRPKEKS 480
NLIVVQRGHS PPTSSLVQPQ SQCQLSQMTF HKIPADSLEW HENLGHGSFT KIYRGCRHEV 540
VDGEARKTEV LLKVMDAKHK NCMESFLEAA SLMSQVSYRH LVLLHGVCMA GDSTMVQEFV 600
HLGAIDMYLR KRGHLVPASW KLQVVKQLAY ALNYLEDKGL PHGNVSARKV LLAREGADGS 660
PPFIKLSDPG VSPAVLSLEM LTDRIPWVAP ECLREAQTLS LEADKWGFGA TVWEVFSGVT 720
MPISALDPAE KLQFYEDRQQ LPAPKWTELA LLIQQCMAYE PVQRPSFRAV IRDLNSLISS 780
DYELLSDPTP GALAPRDGLW NGAQLYACQD PTIFEERHLK YISQLGKGNF GSVELCRYDP 840
LGDNTGALVA VKQLQHSGPD QQRDFQREIQ ILKALHSDFI VKYRGVSYGP GRQSLRLVME 900
YLPSGCLRDF LQRHRARLDA NRLLLYSSQI CKGMEYLGSR RCVHRDLAAR NILVESEAHV 960
KIADFGLAKL LPLDKDYYVV REPGQSPIFW YAPESLSDNI FSRQSDVWSF GVVLYELFTY 1020
CDKSCSPSAE FLLMMGCERD VPALCRLLEL LEEGQRLPAP PACPAEVSCY SGWRDDICSM 1080
GWWPTVIPRW DLACSPCPRP LTITATTVQL PPTLHATAAS VAVPNKTC 1128
Nucleotide Sequence
(FASTA)
ATGGCACCTC CAAGTGAAGA GACGCCCCTG ATCCCTCAGC GTTCATGCAG CCTCTTGTCC 60
ACGGAGGCTG GTGCCCTGCA TGTGCTGCTG CCCGCTCGGG GCCCCGGGCC CCCCCAGCGC 120
CTATCTTTCT CCTTTGGGGA CCACTTGGCT GAGGACCTGT GCGTGCAGGC TGCCAAGGCC 180
AGCGGCATCC TGCCTGTGTA CCACTCCCTC TTTGCTCTGG CCACGGAGGA CCTGTCCTGC 240
TGGTTCCCCC CAAGCCACAT CTTCTCCGTG GACGATGCCA GCACCCAAGT CCTGCTCTAC 300
AGGATTCGCT TTTACTTCCC CAATTGGTTT GGGCTGGAGA AGTGCCACCG CTTCGGGCTA 360
CGCAAGGATT TGGCCAGCGC TATCCTTGAC CTGCCAGTCC TGGAGCACCT CTTTGCCCAG 420
CACCGCAGTG ACCTGGTGAG TGGGCGCCTT CCCGTGGGCC TGAGTCTCAA GGAGCAGGGT 480
GAATGTCTCA GCCTGGCCGT GCTGGACCTG GCCCGGATGG CGCGAGAGCA GGCCCAGCGG 540
CCGGGAGAGC TGCTGAAGAC TGTCAGCTAC AAGGCCTGCC TACCCCCAAG CCTGCGCGAC 600
CTGATCCAGG GCCTGAGCTT CGTGACGCGG AAGCGTATTC GGAGGACGAC TAAAAGACAG 660
AGTGAGGCTC TGAGAGCTGG GAGGCTGCGA AGCGGGGCAG GGATCAAGGG GCGGGGTCCG 720
GCCGAGAGAG GGAGACGGGG ATTGGCAGAG GGGGTGGGAG ATGTTTGGGG ATGGGTAGGG 780
GAGGTGGGGC GCGGCTTGGA AGGGTTGAGT GGGAAAGGGG GCCCCTACTT CGGTACTCCC 840
CCTCTTTCCC AGGTCCTCCA GCCCTTCTGC GACTTTCCAG AAATCGTAGA CATTAGCATC 900
AAGCAGGCCC CGCGCGTTGG CCCGGCCGGG GAGCATCGCC TGGTCACTGT TACCAGGACA 960
GACAACCAGA TTTTGGAGGC CGAGTTCCCA GGGCTGCCCG AGGCTCTGTC TTTCGTGGCG 1020
CTCGTGGACG GCTACTTCCG GCTGACCACG GACTCCCAGC ACTTCTTCTG CAAGGAGGTG 1080
GCACCGCCGA GGCTGCTGGA GGAAGTGGCC GAGCAGTGCC ATGGCCCCAT CACTCTGGAC 1140
TTTGCCATCA ACAAGCTTAA GACTGGGGGC TCACGTCCTG GCTCCTATGT TCTCCGCCGC 1200
AGCCCCCAGG ATTTTGACAG CTTCCTCCTC ACTGTGTGTG TCCAGACCCC CCTTGGTCCT 1260
GATTATAAGG GCTGCCTCAT CCGGCGCAGC CCCACAGGAA CCTTCCTTCT GGTTGGCCTC 1320
AGCCGACCCC ACAGCAGTCT TCGAGAGCTC CTGGCAACCT GCTGGGATGG GGGGCTGCAC 1380
GTAGATGGGG TGGCAGCGAC CCTCACCTCC TGCTGTATCC CCAGACCCAA AGAAAAGTCC 1440
AACCTGATCG TGGTGCAGAG AGGTCACAGC CCACCCACAT CATCCTTGGT TCAGCCCCAA 1500
TCCCAATGCC AGCTGAGTCA GATGACATTT CACAAGATCC CTGCTGACAG CCTGGAGTGG 1560
CATGAGAACC TGGGCCATGG GTCCTTCACC AAGATTTACC GGGGCTGTCG CCATGAGGTG 1620
GTGGATGGGG AGGCCCGAAA GACAGAGGTG CTGCTGAAGG TGATGGATGC TAAGCACAAG 1680
AACTGCATGG AGTCATTCCT GGAAGCAGCG AGCTTGATGA GCCAAGTGTC GTACCGGCAT 1740
CTCGTGCTGC TCCACGGCGT GTGCATGGCT GGAGACAGCA CCATGGTGCA GGAATTTGTA 1800
CACCTGGGGG CGATAGACAT GTATCTACGA AAACGTGGCC ACCTGGTGCC AGCCAGCTGG 1860
AAGCTACAGG TGGTCAAACA GCTGGCCTAT GCCCTCAACT ATCTGGAGGA CAAAGGCCTC 1920
CCCCACGGCA ATGTCTCTGC CCGGAAGGTG CTCCTGGCTC GGGAGGGGGC TGATGGGAGC 1980
CCACCCTTCA TCAAGCTGAG TGACCCTGGG GTCAGCCCCG CTGTGTTAAG CCTGGAGATG 2040
CTCACCGACA GGATCCCCTG GGTGGCCCCC GAGTGTCTCC GGGAGGCCCA GACACTTAGC 2100
TTGGAAGCTG ACAAGTGGGG CTTCGGCGCC ACGGTCTGGG AAGTGTTTAG TGGCGTCACC 2160
ATGCCCATCA GCGCCCTGGA TCCTGCTGAG AAACTCCAAT TTTATGAGGA CCGGCAGCAG 2220
CTGCCAGCCC CCAAGTGGAC AGAGCTGGCC CTGCTGATTC AACAGTGCAT GGCCTATGAG 2280
CCGGTCCAGA GGCCCTCCTT CCGAGCCGTC ATTCGTGACC TCAATAGCCT CATCTCTTCA 2340
GACTATGAGC TCCTCTCAGA CCCCACACCT GGTGCCCTGG CACCTCGTGA TGGGCTGTGG 2400
AATGGTGCCC AGCTCTATGC CTGCCAAGAT CCCACGATCT TCGAGGAGAG ACACCTCAAG 2460
TACATCTCAC AGCTGGGCAA GGGCAACTTT GGCAGCGTGG AGCTGTGCCG CTATGACCCG 2520
CTAGGCGACA ATACAGGTGC CCTGGTGGCT GTGAAACAGC TGCAGCACAG TGGCCCAGAC 2580
CAGCAGAGGG ACTTTCAGCG GGAGATTCAG ATCCTCAAAG CACTGCACAG TGATTTCATT 2640
GTCAAGTATC GTGGTGTCAG CTACGGCCCG GGCCGCCAGA GCCTGCGGCT AGTCATGGAG 2700
TACCTGCCCA GCGGCTGCTT GCGCGACTTC CTGCAGCGGC ACCGTGCGCG CCTCGATGCC 2760
AACCGCCTCC TTCTCTACTC CTCGCAGATC TGCAAGGGCA TGGAGTACCT GGGCTCCCGC 2820
CGCTGCGTGC ACCGCGACCT GGCCGCTAGG AACATCCTTG TGGAGAGCGA GGCACACGTC 2880
AAGATCGCTG ACTTCGGCCT AGCTAAGCTG CTCCCGCTTG ACAAAGACTA CTACGTGGTC 2940
CGCGAGCCGG GCCAGAGCCC CATTTTCTGG TATGCCCCCG AATCACTCTC GGACAACATC 3000
TTCTCTCGCC AGTCAGACGT CTGGAGCTTC GGGGTCGTCC TGTACGAGCT CTTCACCTAC 3060
TGCGACAAAA GCTGCAGCCC CTCGGCCGAG TTCCTGCTAA TGATGGGATG TGAGCGGGAT 3120
GTCCCCGCCC TCTGCCGCCT CCTGGAACTG CTGGAGGAGG GCCAGAGGCT GCCGGCGCCT 3180
CCTGCCTGCC CTGCTGAGGT GAGTTGCTAC AGTGGCTGGA GAGACGACAT CTGCTCCATG 3240
GGCTGGTGGC CGACAGTAAT CCCACGCTGG GACCTGGCCT GCAGCCCCTG CCCCAGACCT 3300
CTCACCATCA CCGCCACCAC CGTGCAGCTG CCACCAACCC TGCACGCTAC TGCTGCCTCA 3360
GTGGCTGTAC CCAACAAGAC CTGCTGA 3387
Domain Profile
S: 1     lkqiesLgkgtftkvfevred..aegdsteeevalkvLkesgedisrdfkreaeilsqls  58
         l+++e+Lg+g+ftk+++++++   +g+++++ev+lkv++ ++++++++f ++a+++sq+s
Q: 518   LEWHENLGHGSFTKIYRGCRHevVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVS  577
         689*****************8899************************************
S: 59    hehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         ++h+v l+gvc+a++++ +V+e+v+ G++d+yLrk+ + +++s++l+v+kqla+a++YLe
Q: 578   YRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLE  636
         ****************8.******************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqdeYylvreerdsripwlap  178
         dk l h++v+ar+vL++re+ +g+ppf+klsdpg++ av      l+ e+ ++ripw+ap
Q: 637   DKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAV------LSLEMLTDRIPWVAP  690
         ***************************************......***************
S: 179   eclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpkcpa  238
         ecl+ea++ls+++d+W+Fg+t++e+  +s  ++p+++ ++++kl+++e++++lp+pk++ 
Q: 691   ECLREAQTLSLEADKWGFGATVWEV--FSGVTMPISALDPAEKLQFYEDRQQLPAPKWT-  747
         *************************..9*******************************.
S: 239   elaelmtnclsyepsqrpsFrailedl  265
         ela l+++c++yep+qrpsFra+++dl
Q: 748   ELALLIQQCMAYEPVQRPSFRAVIRDL  774
         *************************98
Domain Sequence
(FASTA)
LEWHENLGHG SFTKIYRGCR HEVVDGEARK TEVLLKVMDA KHKNCMESFL EAASLMSQVS 60
YRHLVLLHGV CMAGDSTMVQ EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED 120
KGLPHGNVSA RKVLLAREGA DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ 180
TLSLEADKWG FGATVWEVFS GVTMPISALD PAEKLQFYED RQQLPAPKWT ELALLIQQCM 240
AYEPVQRPSF RAVIRDL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-EQC-00030
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LOA-00032
EKS-MAM-00030
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-ORA-00026
EKS-OTG-00032
EKS-PAT-00027
EKS-POA-00030
EKS-PTV-00031
EKS-RAN-00034
EKS-SAH-00030
EKS-SUS-00027
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775; Tyr_kinase_non-rcpt_Jak3.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01826; JANUSKINASE3.
PR00109; TYRKINASE.
Created Date20-Feb-2013