EKS-NOL-00007
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00007
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph503.86.5E-152633891259
StatusUnreviewed
Ensembl ProteinENSNLEP00000007624
UniProt AccessionG1R352;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB3
Gene Synonyms/Alias EPHB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000006254ENSNLEP00000007619ENSNLET00000007988
ENSNLEG00000006254ENSNLEP00000007624ENSNLET00000007993
OrganismNomascus leucogenys
Functional Description
Protein Length997
Protein Sequence
(FASTA)
MARARPPPPP SPPPGLLPLL PPLLLLLPLL LPAGCRALEE TLMDTKWVTS ELAWTSHPES 60
GWEEVSGYDE AMNPIRTYQV CNVRESSQNN WLRTGFIWRR DVQRVYVELK FTVRDCNSIP 120
NIPGSCKETF NLFYYEADSD VASASSPFWM ENPYVKVDTI APDESFSRLD AGRVNTKVRS 180
FGPLSKAGFY LAFQDQGACM SLISVRAFYK KCASTTAGFA LFPETLTGAE PTSLVIAPGT 240
CIPNAVEVSV PLKLYCNGDG EWMVPVGACT CATGHEPAAK ESQCRPCPPG SYKAKQGEGP 300
CLPCPPNSRT TSPAASICTC HNNFYRADSD SADSACTTVP SPPRGVISNV NETSLILEWS 360
EPRDLGGRDD LLYNVICKKC HGAGGASACS RCDDNVEFVP RQLGLTERRV HISHLLAHTR 420
YTFEVQAVNG VSGKSPLPPR YAAVNITTNQ AAPSEVPTLR LHSSSGSSLT LSWAPPERPN 480
GVILDYEMKY FEKSEGIAST VTSQMNSVQL DGLRPDARYV VQVRARTVAG YGQYSRPAEF 540
ETTSERGSGA QQLQEQLPLI VGSATAGLVF VVAVVVIAIV CLRKQRHGSD SEYTEKLQQY 600
IAPGMKVYID PFTYEDPNEA VREFAKEIDV SCVKIEEVIG AGEFGEVCRG RLKQPGRREV 660
FVAIKTLKVG YTERQRRDFL SEASIMGQFD HPNIIRLEGV VTKSRPVMIL TEFMENCALD 720
SFLRLNDGQF TVIQLVGMLR GIAAGMKYLS EMNYVHRDLA ARNILVNSNL VCKVSDFGLS 780
RFLEDDPSDP TYTSSLGGKI PIRWTAPEAI AYRKFTSASD VWSYGIVMWE VMSYGERPYW 840
DMSNQDVINA VEQDYRLPPP MDCPTALHQL MLDCWVRDRN RPKFSQIVNT LDKLIRNAAS 900
LKVIASAQSG MSQPLLDRTV PDYTTFTTVG DWLDAIKMGR YKESFVSAGF ASFDLVAQMT 960
AEDLLRIGVT LAGHQKKILS SIQDMRLQMN QTLPVQV 997
Nucleotide Sequence
(FASTA)
ATGGCCAGAG CCCGCCCGCC GCCGCCGCCG TCGCCGCCGC CGGGGCTTCT GCCGCTGCTC 60
CCTCCGCTGC TGCTGCTGCT GCCGCTGCTG CTGCCCGCCG GCTGCCGGGC GCTGGAAGAG 120
ACCCTCATGG ACACTAAATG GGTGACATCT GAGTTGGCGT GGACATCTCA TCCAGAAAGT 180
GGGTGGGAAG AGGTGAGTGG CTACGATGAG GCCATGAATC CCATCCGCAC ATACCAGGTG 240
TGTAATGTGC GTGAGTCAAG CCAGAACAAC TGGCTTCGCA CGGGGTTCAT CTGGCGGCGG 300
GATGTGCAAC GGGTCTACGT GGAGCTCAAG TTCACTGTGC GTGACTGCAA CAGCATCCCC 360
AACATCCCTG GCTCCTGCAA GGAGACCTTC AACCTCTTCT ACTACGAGGC TGACAGCGAT 420
GTGGCCTCGG CCTCCTCCCC CTTCTGGATG GAGAACCCCT ACGTGAAAGT GGACACCATC 480
GCGCCCGATG AGAGCTTCTC GCGGCTCGAT GCCGGCCGTG TCAACACCAA GGTGCGCAGC 540
TTTGGGCCAC TTTCCAAGGC TGGCTTCTAC CTGGCCTTCC AGGACCAGGG CGCCTGCATG 600
TCGCTCATCT CCGTGCGCGC CTTCTACAAG AAGTGTGCAT CCACCACCGC AGGCTTCGCA 660
CTCTTCCCCG AGACCCTCAC TGGGGCGGAG CCCACCTCGC TGGTCATTGC TCCTGGCACC 720
TGCATCCCTA ACGCCGTGGA GGTGTCGGTG CCACTCAAGC TCTACTGCAA CGGCGATGGG 780
GAGTGGATGG TGCCTGTGGG TGCCTGCACC TGTGCCACCG GCCATGAGCC AGCCGCCAAG 840
GAGTCCCAGT GCCGCCCCTG TCCCCCTGGG AGCTACAAGG CGAAGCAGGG AGAGGGGCCC 900
TGCCTCCCAT GTCCCCCCAA CAGCCGTACC ACCTCCCCAG CCGCCAGCAT CTGCACCTGC 960
CACAATAACT TCTACCGTGC AGACTCAGAC TCTGCGGACA GTGCCTGCAC CACCGTGCCA 1020
TCTCCACCCC GAGGTGTGAT CTCCAACGTG AATGAAACCT CACTGATCCT TGAGTGGAGT 1080
GAGCCCCGGG ACCTGGGTGG CCGGGATGAC CTCCTGTACA ATGTCATCTG CAAGAAGTGC 1140
CATGGGGCTG GAGGGGCCTC AGCCTGCTCA CGCTGTGACG ACAACGTGGA GTTTGTGCCT 1200
CGGCAGCTGG GCCTGACGGA GCGCCGGGTC CACATCAGCC ATCTGCTGGC CCACACGCGC 1260
TACACGTTCG AGGTGCAGGC GGTCAACGGT GTTTCGGGCA AGAGCCCTCT GCCGCCTCGT 1320
TACGCGGCTG TGAATATCAC CACAAACCAG GCTGCCCCGT CTGAAGTGCC CACACTACGC 1380
CTGCACAGCA GCTCAGGCAG CAGCCTCACC CTATCCTGGG CACCCCCAGA GCGGCCCAAC 1440
GGAGTCATCC TGGACTACGA GATGAAGTAC TTTGAGAAGA GTGAGGGCAT CGCCTCCACA 1500
GTGACCAGCC AGATGAACTC CGTGCAGCTG GATGGGCTTC GGCCTGACGC CCGCTATGTG 1560
GTCCAGGTCC GTGCCCGCAC AGTAGCTGGC TATGGGCAGT ACAGCCGCCC TGCTGAGTTT 1620
GAGACCACAA GTGAGAGAGG CTCCGGGGCC CAGCAGCTCC AGGAGCAGCT TCCCCTCATT 1680
GTGGGCTCCG CTACAGCTGG GCTTGTCTTC GTGGTGGCTG TTGTGGTCAT CGCTATCGTC 1740
TGCCTCAGGA AGCAGCGACA CGGCTCTGAT TCGGAGTACA CAGAGAAGCT GCAGCAGTAC 1800
ATTGCTCCTG GAATGAAGGT TTATATTGAC CCTTTTACCT ACGAGGACCC TAATGAGGCT 1860
GTTCGGGAGT TTGCCAAGGA GATCGACGTG TCCTGCGTCA AGATCGAGGA GGTGATCGGA 1920
GCTGGGGAGT TTGGGGAAGT GTGCCGTGGT CGACTGAAAC AGCCTGGCCG CCGAGAGGTG 1980
TTTGTGGCCA TCAAGACGCT GAAGGTGGGC TACACCGAGA GGCAGCGGCG GGACTTCCTA 2040
AGCGAGGCCT CCATCATGGG TCAGTTTGAT CACCCCAATA TAATCCGGCT CGAGGGCGTG 2100
GTCACCAAAA GTCGGCCAGT TATGATCCTC ACTGAATTCA TGGAAAACTG CGCCCTGGAC 2160
TCCTTCCTCC GGCTCAACGA TGGGCAGTTC ACGGTCATCC AGCTGGTGGG CATGTTGCGG 2220
GGCATTGCTG CCGGCATGAA GTACCTGTCC GAGATGAACT ATGTGCACCG TGACCTGGCT 2280
GCTCGCAACA TCCTTGTCAA CAGCAACCTG GTCTGCAAAG TCTCAGACTT TGGCCTCTCC 2340
CGCTTCCTGG AGGATGACCC CTCCGATCCT ACCTACACCA GTTCCCTGGG CGGGAAGATC 2400
CCCATCCGCT GGACTGCCCC GGAGGCCATA GCCTATCGGA AGTTCACTTC TGCTAGTGAT 2460
GTCTGGAGCT ACGGAATTGT CATGTGGGAG GTCATGAGCT ATGGAGAGCG ACCCTACTGG 2520
GACATGAGCA ACCAGGATGT CATCAATGCT GTGGAGCAGG ATTACCGGCT GCCACCACCC 2580
ATGGACTGTC CCACAGCACT GCACCAGCTC ATGCTGGACT GCTGGGTGCG AGACCGGAAC 2640
AGGCCCAAAT TCTCCCAGAT TGTCAATACC CTGGACAAGC TCATCCGCAA TGCTGCCAGC 2700
CTCAAGGTCA TCGCCAGCGC TCAGTCTGGC ATGTCACAGC CCCTCCTGGA CCGCACGGTC 2760
CCAGATTACA CAACCTTCAC GACAGTTGGC GATTGGCTGG ATGCCATCAA GATGGGGCGG 2820
TACAAGGAGA GCTTCGTCAG TGCGGGGTTT GCATCCTTTG ACCTGGTGGC CCAGATGACG 2880
GCAGAAGACC TGCTCCGTAT TGGGGTCACC CTGGCCGGCC ACCAGAAGAA GATCCTGAGC 2940
AGTATCCAGG ACATGCGGCT GCAGATGAAC CAGACGCTGC CTGTGCAGGT CTGA 2994
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pg+re+ vaiktlk g+te+qrrdflseasi+Gqfdhp
Q: 633   VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHP  692
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+men+aldsflr +dgqftviqlvgmlrGia+gmkyls+m
Q: 693   NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM  752
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt+s ggkipirwtapeaiay
Q: 753   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPsDPTYTSSlGGKIPIRWTAPEAIAY  812
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+a+e++yrlpppmdcp+al+qlml
Q: 813   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML  872
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcw +dr+ rpkf+qiv++l
Q: 873   DCWVRDRN-RPKFSQIVNTL  891
         ******96.9*******975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KQPGRREVFV AIKTLKVGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMILTE FMENCALDSF LRLNDGQFTV IQLVGMLRGI AAGMKYLSEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDPSDPTY TSSLGGKIPI RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVINAVE QDYRLPPPMD CPTALHQLML 240
DCWVRDRNRP KFSQIVNTL 259
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00007
EKS-ANC-00006
EKS-BOT-00005
EKS-CAJ-00014
EKS-CAF-00007
EKS-CAP-00005
EKS-DAR-00007
EKS-DIO-00001
EKS-EQC-00007
EKS-FEC-00005
EKS-GAM-00001
EKS-GAG-00007
EKS-GAA-00005
EKS-GOG-00006
EKS-HOS-00008
EKS-ICT-00006
EKS-LAC-00005
EKS-MAM-00006
EKS-MEG-00006
EKS-MUM-00007
EKS-MUP-00007
EKS-MYL-00008
EKS-ORN-00006
EKS-ORA-00005
EKS-ORC-00007
EKS-ORL-00004
EKS-OTG-00006
EKS-PAT-00007
EKS-PES-00005
EKS-RAN-00007
EKS-SAH-00006
EKS-SUS-00005
EKS-TAG-00006
EKS-TAR-00004
EKS-TUT-00006
EKS-XET-00006
EKS-XIM-00005
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0016477; P:cell migration
GO:0046777; P:protein autophosphorylation
GO:0043088; P:regulation of Cdc42 GTPase activity
GO:0022407; P:regulation of cell-cell adhesion
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013