EKS-NOL-00334
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00334
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.46.3E-135275524250
StatusUnreviewed
Ensembl ProteinENSNLEP00000007631
UniProt AccessionG1R359;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000006271ENSNLEP00000007631ENSNLET00000008000
OrganismNomascus leucogenys
Functional Description
Protein Length541
Protein Sequence
(FASTA)
MGSNKSKPKD ASQRRRSLEP TENVHGAGGG AFPASQTPSK PASAEGHRGP GAAFAPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTLLS 120
LLREGDWWLA HSLSTGQTGY IPSNYVAPSD SIQAEEWYFG KITRRESERL LLNAENPRGT 180
FLVRESETTK GAYCLSVSDF DNAKGLNVKH YRSRKLDSGG FYITSAPVQQ LQQLVASSSE 240
HADGLCHRLT TVCPTSKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTRV 300
AIKTLKPGTM SPEAFLQEAQ VMKKLRHEKL VQLYAVVSEE PIYIVTEYMS KGSLLDFLKG 360
ETGKYLRLPQ LVDMAAQIAS GMAYVERMNY VHRDLRAANI LVGENLVCKV ADFGLARLIE 420
DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILL TELTTKGRVP YPGMVNREVL 480
DQVERGYRMP CPPECPESLH DLMCQCWRKE PEERPTFEYL QAFLEDYFTS TEPQYQPGEN 540
L 541
Nucleotide Sequence
(FASTA)
ATGGGCAGCA ACAAGAGCAA GCCCAAGGAC GCCAGCCAGC GGCGCCGCAG TCTGGAGCCC 60
ACCGAGAACG TGCACGGCGC TGGCGGGGGC GCTTTCCCTG CCTCGCAGAC CCCCAGCAAG 120
CCAGCCTCGG CCGAAGGCCA CCGCGGCCCC GGCGCGGCCT TCGCCCCCGC GGCCGCCGAG 180
CCCAAGCTGT TCGGAGGCTT CAACTCCTCG GACACCGTCA CCTCCCCGCA GAGGGCGGGC 240
CCGCTGGCCG GTGGAGTGAC CACCTTTGTG GCCCTCTATG ACTATGAGTC CAGGACGGAG 300
ACAGACCTGT CCTTCAAGAA AGGCGAGCGG CTCCAGATTG TCAACAACAC CCTTCTGTCC 360
CTGCTCAGAG AGGGAGACTG GTGGCTGGCC CACTCGCTCA GCACGGGACA GACAGGCTAC 420
ATCCCCAGCA ACTACGTGGC GCCCTCCGAC TCCATCCAGG CCGAGGAGTG GTATTTTGGC 480
AAGATCACCA GACGGGAGTC CGAGCGGTTA CTGCTCAACG CGGAGAACCC GAGAGGGACC 540
TTCCTCGTGC GAGAAAGTGA GACCACGAAA GGTGCCTACT GCCTCTCAGT GTCGGACTTC 600
GACAACGCCA AGGGCCTCAA CGTGAAGCAC TACAGATCCC GCAAGCTGGA CAGCGGCGGC 660
TTCTACATCA CCTCCGCACC AGTTCAACAG CTGCAGCAGC TGGTGGCCTC CTCCTCAGAA 720
CACGCCGATG GCCTGTGCCA CCGCCTTACC ACCGTATGCC CCACGTCCAA GCCGCAGACG 780
CAGGGCCTGG CCAAGGATGC CTGGGAGATC CCTCGGGAGT CGCTGCGGCT GGAGGTCAAG 840
CTGGGCCAGG GCTGCTTTGG CGAGGTGTGG ATGGGGACCT GGAATGGCAC CACCAGGGTG 900
GCCATCAAAA CCCTGAAGCC TGGCACGATG TCTCCAGAGG CCTTCCTGCA GGAGGCCCAA 960
GTCATGAAGA AGCTGAGGCA TGAGAAGCTG GTGCAGTTGT ATGCTGTGGT TTCGGAGGAG 1020
CCCATTTACA TCGTCACGGA GTACATGAGC AAGGGGAGTT TGCTGGACTT TCTCAAGGGG 1080
GAGACGGGCA AGTACCTGCG GCTGCCTCAG CTGGTGGACA TGGCTGCTCA GATCGCCTCG 1140
GGCATGGCGT ACGTGGAGCG GATGAACTAT GTCCACCGGG ACCTTCGTGC AGCCAACATC 1200
CTGGTGGGAG AGAACCTGGT GTGCAAAGTG GCCGACTTCG GGCTGGCTCG GCTCATTGAA 1260
GACAATGAGT ACACGGCGCG GCAAGGTGCC AAATTCCCCA TCAAGTGGAC GGCTCCGGAA 1320
GCTGCCCTCT ATGGCCGCTT CACCATCAAG TCGGACGTGT GGTCCTTCGG GATACTGCTG 1380
ACTGAGCTCA CCACAAAGGG ACGGGTGCCC TACCCTGGGA TGGTGAACCG CGAGGTGCTG 1440
GACCAGGTGG AGCGGGGCTA CCGGATGCCC TGCCCGCCGG AGTGTCCTGA GTCCCTGCAC 1500
GACCTCATGT GCCAGTGCTG GCGGAAGGAG CCTGAGGAGC GGCCCACCTT TGAGTACCTG 1560
CAGGCCTTCC TGGAGGACTA CTTCACGTCC ACCGAGCCCC AGTACCAGCC CGGGGAGAAC 1620
CTCTAG 1626
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 275   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  334
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 335   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  393
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 394   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  453
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 454   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  513
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 514   RPTFEYLQAFL  524
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0070555; P:response to interleukin-1
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013