EKS-NOL-00149

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00149

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	364.4	3.8E-109	5	266	262

Status

Unreviewed

Ensembl Protein

ENSNLEP00000007776

UniProt Accession

G1R3K4;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000006392	ENSNLEP00000007776	ENSNLET00000008150

Organism

Nomascus leucogenys

Functional Description

Protein Length

421

Protein Sequence
(FASTA)

GPHCFELLRV LGKGGYGKVF QVRKVQGTNL GKIYAMKVLR KAKIVRNAKD TAHTQAERNI 60

LESVKHPFIV ELAYAFQTGG KLYLILECLS GGELFTHLER EGIFLEDTAC FYLAEITLAL 120

GHLHSQGIIY RDLKPENIML SSQGHIKLTD FGLCKESIHE GAVTHTFCGT IEYMAPEILV 180

RSGHNRAVDW WSLGALMYDM LTGSPPFTAE NRKKTMDKII KGKLALPPYL TPDARDLVKK 240

FLKRNPSQRI GGGPGDAADV QRHPFFRHMN WDDLLAWRVD PPFRPCLQSE EDVSQFDTRF 300

TRQTPVDSPD DTALSESANQ AFLGFTYVAP SVLDSIKEGF SFQPKLRSPR RLNSSPRAPI 360

SPLKFSPFEG FRPSPSLPEP TEPPLPPLLP PPPPPSITAP LPIRPPSGTK KSKRGCGHPG 420

R 421

Nucleotide Sequence
(FASTA)

GGGCCCCACT GCTTTGAGCT GCTTCGTGTG CTGGGCAAGG GGGGCTATGG CAAGGTGTTC 60

CAGGTGCGAA AGGTGCAAGG CACCAACTTG GGCAAAATAT ATGCCATGAA AGTCCTAAGG 120

AAGGCCAAAA TTGTGCGCAA CGCCAAGGAC ACAGCACACA CACAGGCTGA GCGGAACATT 180

CTAGAGTCAG TGAAGCACCC CTTTATTGTG GAACTGGCCT ATGCCTTCCA GACTGGTGGC 240

AAACTCTACC TCATCCTTGA GTGTCTCAGT GGTGGCGAGC TCTTCACGCA TCTGGAGCGA 300

GAGGGCATCT TCCTGGAAGA TACGGCTTGC TTCTACCTGG CGGAGATCAC GCTGGCCCTG 360

GGCCATCTCC ACTCGCAGGG CATCATCTAC CGGGACCTCA AGCCCGAGAA CATCATGCTC 420

AGCAGCCAGG GCCACATCAA ACTGACCGAC TTTGGACTCT GCAAGGAGTC GATCCATGAG 480

GGTGCCGTCA CTCACACCTT CTGCGGCACC ATTGAGTACA TGGCCCCTGA GATTCTGGTG 540

CGCAGTGGCC ACAACCGGGC TGTGGACTGG TGGAGCCTGG GGGCCCTGAT GTACGACATG 600

CTCACTGGAT CGCCGCCCTT CACTGCAGAG AACCGGAAGA AAACCATGGA TAAGATCATC 660

AAGGGCAAGC TGGCGCTGCC CCCCTACCTC ACCCCAGATG CCCGGGACCT TGTCAAAAAG 720

TTTCTGAAAC GGAATCCCAG CCAGCGGATT GGGGGTGGCC CAGGGGATGC TGCTGATGTG 780

CAGAGACATC CCTTTTTCCG GCACATGAAT TGGGACGACC TTCTGGCCTG GCGTGTGGAC 840

CCCCCTTTCA GGCCCTGTCT GCAGTCAGAG GAGGACGTGA GCCAGTTTGA TACCCGCTTC 900

ACACGGCAGA CGCCGGTGGA CAGTCCCGAT GACACGGCCC TCAGCGAGAG TGCCAACCAG 960

GCCTTCCTAG GCTTCACGTA CGTGGCGCCG TCTGTCCTGG ACAGCATCAA GGAGGGCTTC 1020

TCCTTCCAGC CCAAGCTGCG CTCACCCAGG CGCCTCAACA GTAGCCCCCG GGCCCCCATC 1080

AGCCCCCTCA AGTTCTCCCC TTTTGAGGGG TTTCGGCCCA GTCCCAGCCT GCCAGAGCCC 1140

ACGGAGCCAC CTCTACCTCC ACTCCTGCCA CCGCCGCCAC CACCTTCGAT CACTGCCCCT 1200

CTCCCCATCC GTCCCCCCTC AGGGACCAAG AAGTCCAAGA GGGGCTGTGG GCATCCAGGG 1260

CGCTAG 1266

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 5     FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTQAERNILESV  64

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 65    KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  124

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 125   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  183

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dlvk

Q: 184   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LALPPY--LTPDARDLVK  239

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 240   KFLKRNPSQRIGGgpgDAADVQRHPFF  266

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT QAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL ALPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045948	; P:positive regulation of translational initiation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013