EKS-NOL-00387

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00387

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	528.4	3.5E-159	95	352	258

Status

Unreviewed

Ensembl Protein

ENSNLEP00000007976

UniProt Accession

G1R454;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK2

Gene Synonyms/Alias

SGK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000006547	ENSNLEP00000007976	ENSNLET00000008360

Organism

Nomascus leucogenys

Functional Description

Protein Length

427

Protein Sequence
(FASTA)

MQGLLTSGRK PSDRGRCTGR GGWRGQWCLK PWMGGADPPA PALSCLLLPV PPELPDHCYR 60

MNSSPAGTPS PQPSRANGNI NLGPSANPNA RPTDFDFLKV IGKGNYGKVL LAKRKSDGTF 120

YAVKVLQKKS ILKKKEQSHI MAERSVLLKN VRHPFLVGLR YSFQTPEKLY FVLDYVNGGE 180

LFFHLQRERR FLEPRARFYT AEVASAIGYL HSLNIIYRDL KPENILLDCQ GHVVLTDFGL 240

CKEGVEPEET TSTFCGTPEY LAPEVLRKEP YDRAVDWWCL GAVLYEMLHG LPPFYSQDVS 300

QMYENILHQP LQIPGGRTVA ACDLLQSLLH KDQRQRLGSK ADFLEIKNHV FFSPINWDDL 360

YHKRLTPPFN PNVAGPADLK HFDPEFTQEA VSKSIGCTPD TAASSSGASS AFLGFSYAPE 420

DDDILDC 427

Nucleotide Sequence
(FASTA)

ATGCAGGGAT TGCTTACCTC TGGTAGGAAG CCCTCAGACC GTGGCAGGTG CACAGGTAGG 60

GGAGGATGGA GAGGGCAGTG GTGCCTGAAG CCCTGGATGG GCGGAGCTGA CCCCCCAGCA 120

CCAGCTCTCT CATGCCTGCT CCTCCCTGTT CCCCCAGAGC TGCCTGATCA TTGCTACAGA 180

ATGAACTCTA GCCCAGCTGG GACCCCCAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 240

AACCTGGGGC CTTCAGCCAA CCCAAACGCC CGGCCCACAG ACTTCGACTT CCTCAAAGTC 300

ATCGGCAAAG GGAACTACGG GAAGGTCCTG CTGGCCAAGC GCAAGTCTGA TGGGACGTTC 360

TATGCAGTGA AGGTGCTGCA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 420

ATGGCAGAGC GCAGTGTGCT TCTGAAGAAT GTGCGGCATC CCTTCCTCGT GGGCCTGCGC 480

TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 540

CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACACT 600

GCTGAGGTGG CCAGTGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGACCTG 660

AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACAGA TTTTGGCCTC 720

TGCAAGGAAG GCGTAGAGCC TGAAGAGACC ACATCTACCT TCTGTGGTAC CCCTGAGTAC 780

TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGGG CAGTGGACTG GTGGTGCTTG 840

GGGGCAGTCC TCTACGAGAT GCTCCACGGC CTGCCGCCCT TCTACAGCCA AGACGTGTCC 900

CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGGGGCCG GACGGTGGCT 960

GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 1020

GCAGACTTCC TTGAGATTAA GAATCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 1080

TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGG CAGGACCTGC TGACTTGAAG 1140

CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 1200

ACTGCAGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 1260

GATGATGACA TCTTGGATTG CTAG 1284

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         fdflkvigkg++gkvllakrk+d++fyavkvlqkk+ilkkke++himaer+vllknv+hp

Q: 95    FDFLKVIGKGNYGKVLLAKRKSDGTFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP  154

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvgl+ysfqt+eklyfvldyvnggelffhlqrer+fleprarfy+ae+asa+gylhsln

Q: 155   FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHSLN  214

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         i+yrdlkpenilld++ghvvltdfglcke++e e+ttstfcgtpeylapevlrk+pydr+

Q: 215   IIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEETTSTFCGTPEYLAPEVLRKEPYDRA  274

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyeml+glppfys+dv++my+nil++plq+++g++vaa++ll++ll+kd++

Q: 275   VDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQR  334

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         +rlg+k+dfleiknhvff

Q: 335   QRLGSKADFLEIKNHVFF  352

         *****************9

Domain Sequence
(FASTA)

FDFLKVIGKG NYGKVLLAKR KSDGTFYAVK VLQKKSILKK KEQSHIMAER SVLLKNVRHP 60

FLVGLRYSFQ TPEKLYFVLD YVNGGELFFH LQRERRFLEP RARFYTAEVA SAIGYLHSLN 120

IIYRDLKPEN ILLDCQGHVV LTDFGLCKEG VEPEETTSTF CGTPEYLAPE VLRKEPYDRA 180

VDWWCLGAVL YEMLHGLPPF YSQDVSQMYE NILHQPLQIP GGRTVAACDL LQSLLHKDQR 240

QRLGSKADFL EIKNHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0015459	; F:potassium channel regulator activity
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013