EKS-NOL-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	303.8	9.9E-91	1148	1316	169

Status

Unreviewed

Ensembl Protein

ENSNLEP00000008444

UniProt Accession

G1R5H2;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000006926	ENSNLEP00000008444	ENSNLET00000008843

Organism

Nomascus leucogenys

Functional Description

Protein Length

1375

Protein Sequence
(FASTA)

MELLPPLPQS FLLLLLLPAK PAAGEDWQCP HTPYAASRDF DVKYVVPSFS AGGLVQAMVT 60

YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT 120

KVLVLEPALP ALISCGSSLQ GRCFLHDLEP QGTAVHLAGP ACLFSAHRNR PDDCPDCVAS 180

PLGTRVTVVE QGQASYFYVA SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPK 240

HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DAPSALHTRL ARLSATEPEL GDYRELVLDC 300

RFAPKRRRRG APEGGQPYPV LRVAHSAPVG AQLATELSIA EGQEVLFGVF VAGKDGGPGM 360

GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP PGLEALSPNT 420

SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELARSL 480

NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIRGPGCHHF LTCGRCLRAQ 540

RFMGCGWCGN MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG 600

LVPEGTHQVT VGQSPCRPLP KDSSKLRSVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT 660

NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN 720

GTECLLARVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFHYREDP VVLSISPKCG 780

YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG 840

NLSARGDGAA GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGVNVTV 900

GGESCQHEFR GDTVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVQPGP DGVPQSTLLG 960

ILLPLLLLVA ALATALVFSY WWQRKQLVLP PNLNDLASLD QTAGATPLPI LYSGSDYRSG 1020

LALPATDGLD STTCVHGASF SDSEDESCVP LLRNESIQLR DLDSALLAEV KDVLIPHEWV 1080

VTHSDRVIGK GWGPGGAGAE MESQHRLGWA WWLTPVIPAL WEAEAGRSRG QEIETVLAHS 1140

ETPSLLKIQK KPANPTVKDL ISFGLQVARG MEYLAEQKFV HRDLAARNCM LDESFTVKVA 1200

DFGLARDILD KEYYSVRQHR HARLPVKWMA LESLQTYRFT TKSDVWSFGV LLWELLTRGA 1260

PPYPHIDPFD LTHFLAQGRR LPQPEYCPDS LYQVMQQCWE VDPAVRPTFG VLVGEVEQIV 1320

SALLGDHYVQ LPATYMNLGP STSHEMNVRP EQPQSSPMPG SARRPRPLSE PPRPT 1375

Nucleotide Sequence
(FASTA)

ATGGAGCTCC TCCCGCCGCT GCCTCAGTCC TTCCTGTTGC TGCTGCTGTT GCCTGCCAAG 60

CCCGCGGCGG GCGAGGACTG GCAGTGCCCG CACACCCCCT ACGCGGCCTC TCGCGACTTT 120

GACGTGAAGT ACGTGGTGCC CAGCTTCTCC GCCGGAGGCC TGGTACAGGC CATGGTGACC 180

TACGAGGGCG ACAGAAATGA GAGTGCTGTG TTTGTAGCCA TACGCAATCG CCTGCACGTG 240

CTTGGGCCTG ACCTGAAGTC TGTCCAGAGC CTGGCCACGG GCCCTGCTGG GGACCCTGGC 300

TGCCAGACGT GTGCAGCCTG TGGCCCAGGC CCCCATGGCC CTCCCGGTGA CACAGACACA 360

AAGGTGCTGG TGCTGGAGCC CGCGCTGCCT GCGCTGATCA GTTGTGGCTC CAGCCTGCAG 420

GGCCGCTGCT TCCTGCATGA CCTAGAGCCC CAAGGGACAG CCGTGCATCT GGCGGGGCCA 480

GCCTGCCTCT TCTCAGCCCA CCGTAACCGG CCCGATGACT GCCCCGACTG TGTGGCCAGC 540

CCACTGGGCA CCCGTGTGAC TGTGGTTGAG CAAGGCCAGG CCTCCTATTT CTACGTGGCA 600

TCCTCACTGG ACGCAGCCGT GGCTGCCAGC TTCAGCCCAC GCTCAGTGTC TATCAGGCGT 660

CTCAAGGCCG ACGCCTCGGG ATTCGCACCG GGTTTTGTGG CATTGTCAGT GCTGCCCAAG 720

CATCTTGTCT CCTACAGTAT TGAATACGTG CACAGCTTCC ACACGGGAGC CTTTGTCTAT 780

TTCCTGACTG TACAGCCGGC CAGCGTGACA GATGCTCCTA GTGCCCTGCA CACACGCCTG 840

GCACGGCTTA GCGCCACTGA GCCAGAGTTG GGTGACTATC GGGAGCTGGT CCTCGACTGC 900

AGATTTGCTC CAAAACGCAG GCGCCGGGGG GCCCCAGAGG GCGGACAGCC CTACCCTGTG 960

CTGCGGGTGG CCCACTCCGC TCCAGTGGGT GCCCAACTTG CCACTGAGCT GAGCATCGCT 1020

GAGGGCCAGG AAGTGCTATT TGGGGTCTTT GTGGCTGGCA AGGATGGTGG TCCTGGCATG 1080

GGCCCCAACT CTGTCGTCTG TGCCTTCCCC ATTGACCTGC TGGACACACT AATTGATGAG 1140

GGTGTGGAGC GCTGTTGTGA ATCCCCAGTC CATCCAGGCC TCCGGCGAGG CCTGGACTTC 1200

TTCCAGTCGC CCAGTTTTTG CCCCAACCCG CCTGGCCTGG AGGCCCTCAG CCCCAACACC 1260

AGCTGCCGCC ACTTCCCTCT GCTGGTCAGT AGCAGCTTCT CACGTGTGGA CCTATTCAAT 1320

GGGCTGTTGG GACCAGTACA GGTCACTGCA CTGTATGTGA CACGCCTTGA CAACGTCACA 1380

GTGGCGCACA TGGGCACTAT GGATGGGCGT ATCCTGCAGG TGGAGCTGGC CAGGTCACTC 1440

AACTACTTGC TGTATGTGTC CAACTTCTCA CTGGGTGACA GCGGGCAGCC CGTGCAGCGG 1500

GATGTCAGTC GTCTTGGGGA CCACCTACTC TTCGCCTCTG GGGACCAGGT TTTCCAGGTA 1560

CCTATCCGAG GCCCTGGCTG CCACCACTTC CTCACCTGTG GGCGTTGCCT AAGGGCACAG 1620

CGTTTCATGG GCTGTGGCTG GTGTGGGAAC ATGTGTGGAC AGCAGAAGGA GTGTCCTGGC 1680

TCCTGGCAAC AGGACCACTG CCCACCTAAG CTTACTGAGT TCCACCCCCA CAGTGGACCT 1740

CTAAGGGGCA GTACAAGGCT GACCCTGTGT GGCTCCAACT TCTACCTGCA CCCTTCTGGT 1800

CTGGTGCCTG AGGGAACCCA TCAGGTCACT GTGGGCCAAA GTCCCTGCCG GCCACTGCCC 1860

AAGGACAGCT CAAAACTCAG ATCAGTGCCC CGAAAAGACT TTGTAGAGGA GTTTGAGTGT 1920

GAACTGGAGC CCTTGGGCAC CCAGGCAGTG GGGCCTACCA ACGTCAGCCT CACCGTGACT 1980

AACATGCCAC CGGGCAAGCA CTTCCGGGTA GACGGCACCT CCGTGCTGAG AGGCTTCTCT 2040

TTCATGGAGC CAGTGCTGAT AGCAGTGCAA CCCCTCTTTG GCCCACGGGC AGGAGGCACC 2100

TGTCTCACTC TTGAAGGCCA GAGTCTGTCT GTAGGCACCA GCCGGGCTGT GCTGGTCAAT 2160

GGGACTGAGT GTCTGCTAGC ACGGGTCAGT GAGGGGCAGC TTTTATGTGC CACACCCCCT 2220

GGGGCCACGG TGGCCAGTGT CCCCCTTAGC CTGCAGGTGG GGGGTGCCCA GGTACCTGGT 2280

TCCTGGACCT TCCACTACAG AGAAGACCCT GTCGTGCTAA GCATCAGCCC CAAATGTGGC 2340

TACATCAACT CCCACATCAC CATCTGTGGC CAGCATCTAA CTTCAGCATG GCACTTAGTG 2400

CTGTCATTCC ATGATGGGCT TAGGGCAGTG GAGAGCAGGT GTGAGAGGCA GCTTCCAGAG 2460

CAGCAGCTGT GCCGCCTTCC TGAATATGTG GTCCGAGACC CCCAGGGATG GGTGGCAGGG 2520

AATCTGAGTG CCCGGGGGGA TGGAGCTGCT GGCTTTACAC TGCCTGGCTT TCGCTTCCTA 2580

CCCCCACCCC ATCCACCCAG TGCCAACCTA GTTCCACTGA AGCCTGAGGA GCATGCCATT 2640

AAGTTTGAGT ATATTGGGCT GGGCGCTGTG GCTGACTGCG TGGGTGTCAA CGTGACCGTG 2700

GGTGGTGAGA GCTGCCAGCA CGAGTTCCGG GGGGACACGG TTGTCTGCCC CCTGCCCCCA 2760

TCCCTGCAGC TTGGCCAAGA TGGTGCCCCA TTGCAGGTCT GCGTGGATGG TGAATGTCAT 2820

ATCCTGGGTA GAGTAGTGCA GCCAGGGCCA GATGGGGTCC CACAGAGCAC GCTCCTTGGT 2880

ATCCTGCTGC CTTTGCTGCT ACTAGTGGCC GCACTGGCCA CTGCACTGGT CTTCAGCTAC 2940

TGGTGGCAGA GGAAGCAGCT AGTTCTTCCT CCCAACCTGA ATGACCTGGC ATCCCTGGAC 3000

CAGACTGCTG GAGCCACACC CCTGCCTATT CTGTACTCAG GCTCTGACTA CAGAAGTGGC 3060

CTTGCACTCC CTGCCACTGA TGGTCTGGAT TCCACCACTT GTGTCCATGG AGCATCCTTC 3120

TCCGATAGTG AAGATGAATC CTGTGTCCCA CTGCTGCGGA ACGAGTCCAT CCAGCTAAGG 3180

GACCTGGACT CTGCGCTCTT GGCCGAGGTC AAGGATGTGC TGATTCCCCA TGAGTGGGTG 3240

GTCACCCACA GTGACCGAGT CATTGGCAAA GGTTGGGGGC CAGGTGGGGC TGGGGCAGAG 3300

ATGGAGTCTC AACATAGGCT AGGCTGGGCG TGGTGGCTCA CGCCTGTAAT CCCAGCACTT 3360

TGGGAGGCCG AGGCGGGCAG ATCACGAGGT CAGGAGATCG AGACCGTCCT GGCTCACAGT 3420

GAAACCCCGT CTTTACTAAA AATACAAAAA AAACCAGCCA ACCCCACCGT GAAGGACCTC 3480

ATCAGCTTTG GCCTGCAGGT AGCCCGCGGC ATGGAGTACC TGGCAGAGCA GAAGTTTGTG 3540

CACAGGGACC TGGCTGCACG GAACTGCATG CTGGATGAGT CATTCACAGT CAAGGTGGCT 3600

GACTTTGGTT TGGCCCGCGA CATCCTGGAC AAGGAGTACT ATAGTGTTCG ACAGCATCGC 3660

CACGCTCGCC TGCCTGTCAA GTGGATGGCG CTGGAGAGCC TGCAGACCTA TAGATTTACC 3720

ACCAAGTCTG ATGTGTGGTC ATTTGGTGTG CTGCTGTGGG AACTGCTGAC ACGGGGTGCC 3780

CCACCATACC CCCACATCGA CCCTTTTGAC CTCACCCACT TCCTGGCCCA GGGTCGGCGC 3840

CTGCCCCAGC CTGAGTATTG CCCTGATTCT CTGTACCAAG TGATGCAGCA ATGCTGGGAG 3900

GTGGACCCAG CAGTGAGACC CACCTTCGGA GTACTAGTGG GGGAAGTGGA GCAGATAGTG 3960

TCTGCACTGC TTGGGGACCA TTATGTGCAG CTGCCAGCAA CCTACATGAA CTTGGGCCCC 4020

AGCACCTCGC ATGAGATGAA TGTGCGTCCA GAACAGCCTC AGTCCTCACC CATGCCCGGT 4080

AGTGCACGTC GGCCCCGGCC ACTCTCAGAG CCTCCTCGGC CCACTTGA 4128

Domain Profile

S: 92    irneernltvkdllefalqvakgmeylaskkfvhrdlaarnclldekltvkvadfGlard  151

         i+++  n+tvkdl++f+lqva+gmeyla++kfvhrdlaarnc+lde++tvkvadfGlard

Q: 1148  IQKKPANPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARD  1207

         6777889*****************************************************

S: 152   vldkelyvveeerdarlpvkwlaleslqtfkqfttksdvwsfGvllwelltrgatpysev  211

         +ldke+y+v+++r+arlpvkw+aleslqt++ fttksdvwsfGvllwelltrga+py+++

Q: 1208  ILDKEYYSVRQHRHARLPVKWMALESLQTYR-FTTKSDVWSFGVLLWELLTRGAPPYPHI  1266

         *******************************.****************************

S: 212   asfdltlylkegrrlrkpeycpdklydvmlkcwkakpaerpqfsdlvsii  261

         ++fdlt++l++grrl++peycpd+ly+vm++cw+ +pa rp+f  lv  +

Q: 1267  DPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEVDPAVRPTFGVLVGEV  1316

         *******************************************9998765

Domain Sequence
(FASTA)

IQKKPANPTV KDLISFGLQV ARGMEYLAEQ KFVHRDLAAR NCMLDESFTV KVADFGLARD 60

ILDKEYYSVR QHRHARLPVK WMALESLQTY RFTTKSDVWS FGVLLWELLT RGAPPYPHID 120

PFDLTHFLAQ GRRLPQPEYC PDSLYQVMQQ CWEVDPAVRP TFGVLVGEV 169

Keyword

Complete proteome; Disulfide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0009615	; P:response to virus

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013