EKS-NOL-00263

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00263

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	388.9	1.4E-116	217	515	299

Status

Unreviewed

Ensembl Protein

ENSNLEP00000008547

UniProt Accession

G1R5S5;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000007004	ENSNLEP00000008547	ENSNLET00000008950
ENSNLEG00000007004	ENSNLEP00000008549	ENSNLET00000008953

Organism

Nomascus leucogenys

Functional Description

Protein Length

1052

Protein Sequence
(FASTA)

MFLSLLSCFL AGPGMTSSLQ RPWRVPWLPW TILLVSTAAA SQNQERLCAF KDPYQQDLGI 60

GESRISHENG TILCSKGSTC YGLWEKSKGD INLVKQGCWS HIGDPQECHY EECVVTTTPP 120

SIQNGTYRFC CCSTDLCNVN FTENFPPPDT TPLSPPHSFN RDETIIIALA SVSVLAVLIV 180

ALCFGYRMLT GDRKQGLHSM NMMEAAASEP SLDLDNLKLL ELIGRGRYGA VYKGSLDERP 240

VAVKVFSFAN RQNFINEKNI YRVPLMEHDN IARFIVGDER VTADGRMEYL LVMEYYPNGS 300

LCKYLSLHTS DWVSSCRLAH SVTRGLAYLH TELPRGDHYK PAISHRDLNS RNVLVKNDGT 360

CVISDFGLSM RLTGNRLVRP GEEDNAAISE VGTIRYMAPE VLEGAVNLRD CESALKQVDM 420

YALGLIYWEI FMRCTDLFPG ESVPEYQMAF QTEVGNHPTF EDMQVLVSRE KQRPKFPEAW 480

KENSLAVRSL KETIEDCWDQ DAEARLTAQC AEERMAELMM IWERNKSVSP TVNPMSTAMQ 540

NERNLSHNRR VPKIGPYPDY SSSSYIEDSI HHTDSIVKNI SSEHSMSSTP LTIGEKNRNS 600

INYERQQAQA RIPSPETSVT SLSTNTTTTN TTGLTPSTGM TTISEMPYPD ETNLHTTNVA 660

QSIGPTPVCL QLTEEDLETN KLDPKEVDKN LKESSDENLM EHSLKQFSGP DPLSSTSSSL 720

LYPLIKLAVE ATGQQDFTQA ANGQACLIPD VLPTQIYPLP KQQNLPKRPT SLPLNTKNST 780

KEPRLKFGSK HKSNLKQVET GVAKMNTINA AEPHVVTVTM NGVAGRNHSV NSHAATTQYA 840

NGTVLSGQTT NIVTHRAQEM LQNQFIGEDT RLNINSSPDE HEPLLRREQQ AGHDEGVLDR 900

LVDRRERPLE GGRTNSNNNN SNPCSEQDVL TQGVPSTAAD PGPSKPRRAQ RPNSLDLSAT 960

NVLDGSSIQI GESTQDGKSG SGEKIKKRVK TPYSLKRWRP STWVISTESL DCEVNNNGSN 1020

RAVHSKSSTA VYLAEGGTAT TMVSKDIGMN CL 1052

Nucleotide Sequence
(FASTA)

ATGTTTCTTT CTTTGCTCTC CTGCTTCTTG GCTGGCCCAG GGATGACTTC CTCGCTGCAG 60

CGGCCCTGGC GGGTGCCCTG GCTACCATGG ACCATCCTGC TGGTCAGCAC TGCGGCCGCT 120

TCGCAGAATC AAGAACGGCT ATGTGCATTT AAAGATCCAT ATCAGCAAGA CCTTGGGATA 180

GGTGAGAGTA GAATCTCTCA TGAAAATGGG ACAATATTAT GCTCAAAAGG TAGCACCTGC 240

TATGGCCTTT GGGAGAAATC AAAAGGGGAC ATAAATCTTG TAAAACAAGG ATGTTGGTCT 300

CACATTGGAG ATCCCCAAGA GTGTCACTAT GAAGAATGTG TAGTAACTAC CACTCCTCCC 360

TCAATTCAGA ATGGAACATA CCGTTTCTGC TGTTGTAGCA CAGATTTATG TAATGTCAAC 420

TTTACTGAGA ATTTTCCACC TCCTGACACA ACACCACTCA GTCCACCTCA TTCATTTAAC 480

CGAGATGAGA CAATAATCAT TGCTTTGGCA TCAGTCTCTG TATTAGCTGT TTTGATAGTT 540

GCCTTATGCT TTGGATACAG AATGTTGACA GGAGACCGTA AACAAGGTCT TCATAGTATG 600

AACATGATGG AGGCAGCAGC ATCCGAACCC TCTCTTGACC TAGATAATCT GAAACTGTTG 660

GAGCTGATTG GCCGAGGTCG ATATGGAGCA GTATATAAAG GCTCCTTGGA TGAGCGTCCA 720

GTTGCTGTAA AAGTATTTTC CTTTGCAAAC CGTCAGAATT TTATCAACGA AAAGAACATT 780

TATAGAGTGC CTTTGATGGA ACATGACAAC ATTGCCCGCT TTATAGTTGG AGATGAGAGA 840

GTCACTGCAG ATGGACGCAT GGAATATTTG CTTGTGATGG AGTATTATCC CAATGGATCT 900

TTGTGCAAGT ATTTAAGTCT CCACACAAGT GACTGGGTAA GCTCATGCCG TCTTGCTCAT 960

TCTGTTACTA GAGGACTGGC TTATCTTCAC ACAGAATTAC CACGAGGAGA TCATTATAAA 1020

CCTGCAATTT CCCATCGAGA TTTAAACAGC AGAAATGTCC TAGTGAAAAA TGATGGAACC 1080

TGTGTCATTA GTGACTTTGG ATTGTCCATG AGGCTGACTG GAAATAGACT GGTGCGCCCA 1140

GGGGAGGAAG ATAATGCAGC CATTAGCGAG GTTGGCACTA TCAGATATAT GGCACCAGAA 1200

GTGCTAGAAG GAGCTGTGAA CTTGAGGGAC TGTGAATCAG CTTTGAAACA AGTAGACATG 1260

TATGCTCTTG GACTAATCTA TTGGGAGATA TTTATGAGAT GTACAGACCT CTTCCCAGGG 1320

GAATCCGTAC CAGAGTACCA GATGGCTTTT CAGACAGAAG TTGGAAACCA TCCCACTTTT 1380

GAGGATATGC AGGTTCTTGT GTCTAGGGAA AAACAGAGAC CCAAGTTCCC AGAAGCCTGG 1440

AAAGAAAATA GCCTGGCAGT GAGGTCACTC AAGGAGACAA TTGAAGACTG TTGGGACCAG 1500

GATGCAGAGG CTCGGCTTAC TGCACAGTGT GCTGAGGAAA GGATGGCTGA ACTTATGATG 1560

ATTTGGGAAA GAAACAAATC TGTGAGCCCA ACAGTCAATC CAATGTCTAC TGCTATGCAG 1620

AATGAACGCA ACCTGTCACA TAATAGGCGT GTGCCAAAAA TTGGTCCTTA TCCAGATTAT 1680

TCTTCCTCCT CATACATTGA AGACTCTATC CATCATACTG ACAGCATCGT GAAGAATATT 1740

TCCTCTGAGC ATTCTATGTC CAGCACACCT TTGACTATAG GGGAAAAAAA CCGAAATTCA 1800

ATTAACTATG AACGACAGCA AGCACAAGCT CGAATCCCCA GCCCTGAAAC AAGTGTCACC 1860

AGCCTCTCCA CCAACACAAC AACCACAAAC ACCACAGGCC TCACGCCAAG TACTGGCATG 1920

ACTACTATAT CTGAGATGCC ATACCCAGAT GAAACAAATC TGCATACCAC AAATGTTGCA 1980

CAGTCAATTG GGCCAACCCC TGTCTGCTTA CAGCTGACAG AAGAAGACTT GGAGACCAAC 2040

AAGCTAGACC CAAAAGAAGT TGATAAGAAC CTCAAGGAAA GCTCTGATGA GAATCTCATG 2100

GAGCACTCTC TTAAACAGTT CAGTGGCCCA GACCCACTGA GCAGTACTAG TTCTAGCTTG 2160

CTTTACCCAC TCATAAAACT TGCAGTAGAA GCAACTGGAC AGCAGGACTT CACACAGGCT 2220

GCAAATGGCC AAGCATGTTT GATTCCTGAT GTTCTGCCTA CTCAGATCTA TCCTCTCCCC 2280

AAGCAGCAGA ACCTTCCCAA GAGACCTACT AGTTTGCCTT TGAACACCAA AAATTCAACA 2340

AAAGAGCCCC GGCTAAAATT TGGCAGCAAG CACAAATCAA ACTTGAAACA AGTTGAAACT 2400

GGAGTTGCCA AGATGAATAC AATCAATGCA GCAGAACCTC ATGTGGTGAC AGTCACCATG 2460

AATGGTGTGG CAGGTAGAAA CCACAGTGTT AACTCCCATG CTGCCACAAC CCAATATGCC 2520

AATGGGACAG TACTATCTGG CCAAACAACC AACATAGTGA CACATAGGGC CCAAGAAATG 2580

TTGCAGAATC AGTTTATCGG TGAGGACACC CGGCTGAATA TTAATTCCAG TCCTGATGAG 2640

CATGAGCCTT TACTGAGACG AGAGCAACAA GCTGGCCATG ATGAAGGTGT TCTGGATCGT 2700

CTTGTGGACA GGAGGGAACG GCCACTAGAA GGTGGCCGAA CTAATTCCAA TAACAACAAC 2760

AGCAATCCAT GTTCAGAACA AGATGTTCTT ACACAGGGTG TTCCAAGCAC AGCAGCAGAT 2820

CCTGGGCCAT CAAAGCCCAG AAGAGCACAG AGGCCTAATT CTCTGGATCT TTCAGCCACA 2880

AATGTCCTGG ATGGCAGCAG TATACAGATA GGTGAGTCAA CACAAGATGG CAAATCAGGA 2940

TCAGGTGAAA AGATCAAGAA ACGTGTGAAA ACTCCCTATT CTCTTAAGCG GTGGCGCCCC 3000

TCCACCTGGG TCATCTCCAC TGAATCACTG GACTGTGAAG TCAACAATAA TGGCAGTAAC 3060

AGGGCAGTTC ATTCCAAATC CAGCACTGCT GTTTACCTTG CAGAAGGAGG CACTGCCACA 3120

ACCATGGTGT CTAAAGATAT AGGAATGAAC TGTCTGTGA 3159

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 217   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  276

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 277   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  336

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 337   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  395

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 396   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  455

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 456   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  515

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009267	; P:cellular response to starvation
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0003085	; P:negative regulation of systemic arterial blood pressure
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013