EKS-NOL-00089

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00089

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	406.2	1.1E-121	2696	3013	318

Status

Unreviewed

Ensembl Protein

ENSNLEP00000008823

UniProt Accession

G1R6K1;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000007230	ENSNLEP00000023230	ENSNLET00000031595
ENSNLEG00000007230	ENSNLEP00000008823	ENSNLET00000009242

Organism

Nomascus leucogenys

Functional Description

Protein Length

3055

Protein Sequence
(FASTA)

MSLVLNDLLI CCRQLEHDRA TERKKEVEKF KRLIRDPETI KHLDRHSDSK QGKYLNWDAV 60

FRFLQKYIQK ETECLRIAKP NVSASTQASR QKKMQEISSL VKYFIKCANR RAPRLKCQEL 120

LNYIMDTVKD SSNGAIYGAD YSNILLKDIL SVRKYWCEIS QQQWLELFSV YFRLYLKPSQ 180

DVHRVLVARI IHAVTKGCCS QTDGLNSKFL EFFSKAIQCA RQEKSSSGLN HILAALTIFL 240

KTLAVNFRIR VCELGDEILP TLLYIWTQHR LNDSLKEVII ELFQLQIYIH HPKGAKTQEK 300

GAYESTKWKS ILYNLYDLLV NEISHIGSRG KYSSGFRNIA VKENLIELMA DICHQVFNED 360

TRSLEISQSY TTTQRESSDY SVPCKRKKIE LGWEVIKDHL QKSQNDFDLV PWLQIATQLI 420

SKYPASLPNC ELSPLLMILS QLLPQQRHGE RTPYVLRCLT EVALCQDKRS NLESSQKSDL 480

LKLWNKIWCI TFRGISSEQI QAENFGLLGA IIQGSLVEVD REFWKLFTGS ACRPSCPAVC 540

CLTLALTTSI VPGTVKMGIE QNMCEVNRSF SLKESIMKWL LFYQLEGDLE NSTEVPPILH 600

SNFPHLVLEK ILVSLTMKNC KAAMNFFQSV PECEHHQKDK EELSFSEVEE LFLQTTFDKM 660

DFLTIVRECG IEKHQSSTGF SVHQNLKESL DRCLLELSEQ LLNNHSSEIT DSETLVRCSR 720

LLVGVLGCYC YMGVIAEEEA YKSELFQKAK SLMQCAGESI TVFKNKTNEE FRIGSLRNMM 780

HLCTHCLSNC TKKSPNKIAS GFFLRLLTSK LMNDIADICK SLASLIKKPS DRGEVESMED 840

DTNGNLMEVE DQSSMNLFND YPDSSVSDAN EPGESQSTIG AINPLAEEYL SKQDLLFLDM 900

LKFLCLCVTT AQTNTVSFRA ADIRRKLLML IDSSTLDPTK SLHLHMYLML LKELPGEEYP 960

LPVEDVVELL KPLSNVCSLY RRDQDVCKTI LNHVLHIVKN LGQSNMDSEN TRDAQGQFLT 1020

VIGAFWHLTK ERKYTFSVRM ALVNCLKTLL EADPYSKWAI LNVMGKDFPV NEVFTQFLAD 1080

NHHQVRMLAA ESINRLFQDT KGDSSRLLKA LPLKLQQTAF ENAYLKAQEG MREMSHSAEN 1140

PEPVDEIYNR KSVLLTLIAV VLSCSPICEK QALFALCKSV KENGLEPHLV KKVLEKVSET 1200

FGYRCLEDFM ASHLDYLVLE WLNLQDTEYN LSSFPFILLN YTNIEDFYRS CYKVLIPHLV 1260

IRSHFDEVKS IANQIQEDWK TLLTDCFPKI LVNILPYFAY EGTGDSGMAQ QRETATKVYD 1320

MLKSENLLGK QIDHLFISNL PEIVVELLMT LHEPANSSAS QSTDLCDFSG DLDPAPNPPH 1380

FPSHVIKATF AYISNCYKNK LKSILEILSK SPDSYQKILL AICEQAAETN NVYKKHRILK 1440

IYHLFVSLLL KDIKSGLGGA WAFVLRDVIY TLIHYINQRP SCIMDVSLRS FSLCCDLLSQ 1500

VCQTAVTYCK DALENHLHVI VGTLIPLVDE QVEVQKQVLD LLKYLVIDNK DNENLYLTIK 1560

LLDPFPDHVV FKDLRITQQK IKYSRGPFSL LEEINHFLSV SVYDALPLTR LEGLKDLRRQ 1620

LELHKDQMMD IMRASQDNPQ DGIMVKLVVN LLQLSKMAIN HTGEKEVLEA VGSCLGEVGP 1680

IDFSTIAIQH SKDASYTKAL KLFEDKELQW TFIMLTYLNN TLVEDCVKVR SAAVTCLKNI 1740

LATKTGHSFW EIYKMTTDPM LAYLQPFRTS RKKFLEVPRF DKENPFEGLD DINLWIPLSE 1800

NHDIWIKTLT CAFLDSGGTK CEILQLLKPM CEVKTDFCQT VLPYLIHDIL LQDTNESWRN 1860

LLSTHVQGFF TSCLRHFSQM SRSTTPANLD SESEHFFRCC LDKKSQRTML AVVDYMRRQK 1920

RPSSGTIFND AFWLDLNYLE VAKVAQSCAA HFTALLYAEI YADKKSMDDQ EKRSLAFEEG 1980

SQSTTISSLS EKSKEETGIS LQDLLLEIYR SIGEPDSLYG CGGGKMLQPI TRLRTYEHEA 2040

MWGKALVTYD LETAIPSSTR QAGIIQALQN LGLCHILSIY LKGLDYENKD WCPELEELHY 2100

QAAWRNMQWD HCTSVSKEIE GTSYHESLYN ALQSLRDREF STFYESLKYA RVKEVEELCK 2160

RSLESVYSLY PTLSRLQAIG ELESIGELFS RSVTHRQLSE VYIKWQKHSQ LLKDSDFSFQ 2220

EPIMALRTVI LEILMEKEMD NSQRECIKDI LTKHLVELSI LARTFKNTQL PERAVFQIKQ 2280

YNSVSCGVSE WQLEEAQVFW AKKEQSLALS ILKQMIKKLD ASCAANNPSL KLIYTECLRV 2340

CGNWLAETCL ENPAVIMQTY LEKAVEVAGN YDGESNDELR NGKMKAFLSL ARFSDTQYQR 2400

IENYMKSSEF ENKQALLKRA KEEVGLLREH KIQTNRYTVK VQRELELDEL ALCALKEDRK 2460

RFLCKAVENY INCLLSGEEH DMWVFRLCSL WLENSGVSEV NGMMKRDGMK IPTYKFLPLM 2520

YQLAARMGTK MMGGLGFHEV LNNLISRISM DHPHHTLFII LALANANRDE FLTKPEVARR 2580

SRITKNAPKQ SSQLDEDRTE AANRIICTIR SRRPQMVRSV EALCDAYIIL ANLDATQWKT 2640

QRKGINIPAD QPITKLKNLD DVVVPTMEIK VDHTGEYGNL VTIQSFKAEF RLAGGVNLPK 2700

IIDCVGSDGK ERRQLVKGRD DLRQDAVMQQ VFQMCNTLLQ RNTETRKRKL TICTYKVVPL 2760

SQRSGVLEWC TGTVPIGEFL VNNEDGAHKR YRPNDFSAFQ CQKKMMEVQK KSFEEKYEVF 2820

MDVCQNFQPV FRYFCMEKFL DPAIWFEKRL AYTRSVATSS IVGYILGLGD RHVQNILINE 2880

QSAELVHIDL GVAFEQGKIL PTPETVPRLT RDIVDGMGIT GVEGVFRRCC EKTMEVMRNS 2940

QETLLTIVEV LLYDPLFDWT MNPLKALYLQ QRPEDETELH PTLNADDQEC KRNLSDIDQS 3000

FNKVAERVLM RLQEKLKGVE EGTVLSVGGQ VNLLIQQAID PKNLSRLFPG WKAWV 3055

Nucleotide Sequence
(FASTA)

ATGAGTCTAG TACTTAATGA TCTGCTTATT TGCTGCCGTC AACTAGAACA TGATAGAGCT 60

ACAGAACGAA AGAAAGAAGT TGAGAAATTT AAGCGCCTGA TTCGAGATCC TGAAACAATT 120

AAACATCTAG ATCGGCATTC AGATTCCAAA CAAGGAAAAT ATTTGAATTG GGATGCTGTT 180

TTTAGATTTT TACAGAAATA TATTCAGAAA GAAACAGAAT GTCTGAGAAT AGCAAAACCA 240

AACGTATCAG CCTCAACACA AGCCTCCAGG CAGAAAAAGA TGCAGGAAAT CAGTAGTTTG 300

GTCAAATACT TCATCAAATG TGCAAATAGA AGAGCACCTA GGCTGAAATG TCAAGAACTC 360

TTAAATTATA TCATGGATAC AGTGAAAGAT TCATCTAATG GTGCTATTTA TGGAGCTGAT 420

TATAGCAACA TACTACTCAA AGACATTCTT TCTGTGAGAA AATACTGGTG TGAAATATCT 480

CAGCAACAGT GGTTAGAATT GTTCTCTGTG TACTTCAGGC TCTATCTGAA ACCTTCACAA 540

GATGTTCATA GAGTTTTAGT GGCTAGAATA ATTCATGCTG TTACCAAAGG ATGCTGTTCT 600

CAGACTGACG GATTAAATTC CAAATTTTTG GAATTTTTTT CCAAGGCTAT TCAGTGTGCG 660

AGACAAGAAA AGAGCTCGTC AGGTCTAAAT CATATCTTAG CAGCTCTTAC TATCTTCCTC 720

AAGACTTTGG CTGTCAACTT TCGAATTCGA GTGTGTGAAT TAGGAGATGA AATTCTTCCC 780

ACTTTGCTTT ATATTTGGAC TCAACATAGA CTTAATGATT CTTTAAAAGA AGTCATTATT 840

GAATTATTTC AACTGCAAAT TTATATCCAT CATCCAAAAG GAGCCAAAAC CCAAGAAAAA 900

GGTGCTTATG AATCAACAAA ATGGAAAAGT ATTTTATACA ACTTATATGA TCTGCTAGTG 960

AATGAGATAA GTCATATAGG AAGTAGAGGA AAGTATTCTT CAGGATTTCG TAATATTGCC 1020

GTCAAAGAAA ATTTGATTGA ATTGATGGCA GATATTTGTC ACCAGGTTTT CAATGAAGAT 1080

ACCAGATCCT TGGAGATTTC TCAATCTTAT ACTACTACAC AAAGAGAATC TAGTGATTAC 1140

AGTGTACCTT GCAAAAGGAA GAAAATAGAA CTAGGCTGGG AAGTAATAAA AGATCACCTT 1200

CAGAAGTCAC AGAATGATTT TGATCTTGTG CCTTGGCTAC AGATTGCAAC CCAATTAATA 1260

TCAAAGTATC CTGCAAGTTT ACCTAACTGT GAGCTGTCTC CATTACTGAT GATACTATCT 1320

CAGCTTCTAC CCCAACAGCG ACATGGGGAA CGTACACCAT ATGTGTTACG ATGCCTTACA 1380

GAAGTTGCAT TGTGTCAAGA CAAGAGGTCA AACCTAGAAA GCTCACAAAA GTCAGATTTA 1440

TTAAAACTCT GGAATAAAAT TTGGTGTATT ACTTTTCGTG GTATAAGTTC TGAGCAAATA 1500

CAAGCTGAAA ACTTTGGCTT ACTTGGAGCC ATAATTCAGG GTAGTTTAGT TGAGGTTGAC 1560

AGAGAATTCT GGAAGTTATT TACTGGGTCA GCCTGCAGAC CTTCATGTCC TGCAGTATGC 1620

TGTTTGACTT TGGCACTGAC TACCAGTATA GTTCCAGGAA CAGTAAAAAT GGGAATAGAG 1680

CAAAATATGT GTGAAGTAAA TAGAAGCTTT TCTTTAAAGG AATCAATAAT GAAATGGCTC 1740

TTATTCTATC AGCTAGAGGG TGACTTAGAA AATAGTACAG AAGTGCCTCC GATTCTTCAC 1800

AGTAATTTTC CTCATCTTGT ACTGGAGAAA ATTCTTGTGA GTCTCACTAT GAAAAACTGT 1860

AAAGCTGCAA TGAATTTTTT CCAAAGTGTG CCAGAATGTG AACACCACCA AAAAGATAAA 1920

GAAGAACTTT CATTCTCAGA GGTAGAAGAA CTATTTCTTC AGACAACTTT TGACAAGATG 1980

GACTTTTTAA CCATTGTGAG AGAATGTGGT ATAGAAAAGC ACCAGTCCAG TACGGGCTTC 2040

TCTGTCCACC AGAATCTCAA GGAATCACTG GATCGCTGTC TTCTGGAATT ATCAGAACAG 2100

CTTCTAAATA ATCACTCATC TGAGATCACA GATTCAGAAA CTCTCGTCCG GTGTTCACGT 2160

CTTTTGGTGG GTGTCCTTGG CTGCTACTGT TATATGGGTG TAATAGCTGA AGAGGAAGCA 2220

TATAAGTCAG AATTATTCCA GAAAGCCAAG TCTCTAATGC AATGTGCAGG AGAAAGTATC 2280

ACTGTGTTTA AAAATAAGAC AAATGAGGAA TTCAGAATTG GTTCCTTGAG AAATATGATG 2340

CATCTATGTA CACATTGCTT GAGCAACTGT ACCAAGAAGA GTCCAAATAA GATTGCATCT 2400

GGCTTTTTCC TGCGATTGTT AACATCAAAG CTAATGAATG ACATTGCAGA TATTTGTAAA 2460

AGTTTAGCAT CCTTAATCAA AAAGCCATCT GACCGTGGAG AAGTAGAATC AATGGAAGAT 2520

GATACTAATG GAAATCTAAT GGAGGTGGAG GATCAGTCAT CCATGAATCT GTTTAACGAT 2580

TACCCTGATA GTAGTGTTAG TGATGCAAAT GAACCTGGAG AGAGCCAAAG TACCATAGGT 2640

GCCATTAATC CTTTAGCTGA AGAATATCTG TCAAAGCAAG ATCTACTTTT CTTAGACATG 2700

CTCAAGTTCT TGTGTTTGTG TGTAACTACT GCTCAAACCA ATACTGTGTC CTTTAGGGCA 2760

GCTGATATTC GGAGGAAATT GTTAATGTTA ATTGATTCTA GCACGCTAGA CCCTACCAAA 2820

TCCCTCCATC TGCATATGTA TCTAATGCTT TTAAAGGAGC TTCCTGGAGA AGAGTACCCC 2880

TTGCCAGTGG AAGATGTTGT TGAACTTCTG AAACCACTAT CCAATGTGTG TTCTTTGTAT 2940

CGTCGTGACC AAGATGTTTG TAAAACTATT TTAAACCATG TCCTTCATAT AGTGAAAAAC 3000

CTAGGTCAAA GCAATATGGA CTCTGAGAAC ACAAGGGATG CTCAAGGACA GTTTCTTACA 3060

GTGATTGGAG CATTTTGGCA TCTAACAAAG GAGAGGAAAT ATACATTCTC TGTAAGAATG 3120

GCCCTAGTAA ATTGCCTTAA AACTTTGCTT GAGGCCGATC CTTATTCAAA ATGGGCCATT 3180

CTTAATGTAA TGGGAAAAGA CTTTCCTGTA AACGAAGTAT TTACACAATT TCTTGCTGAT 3240

AATCATCACC AAGTTCGCAT GTTGGCTGCA GAGTCAATCA ATAGATTGTT CCAGGACACG 3300

AAGGGAGATT CTTCCAGGTT ACTGAAAGCA CTTCCTTTGA AGCTTCAGCA AACTGCTTTT 3360

GAAAATGCAT ACTTGAAAGC TCAGGAAGGA ATGAGAGAAA TGTCCCATAG TGCTGAGAAC 3420

CCTGAACCTG TGGATGAAAT TTATAATAGA AAATCTGTTT TACTGACGTT GATAGCTGTA 3480

GTTTTATCCT GCAGCCCTAT CTGCGAAAAA CAGGCTTTGT TTGCCCTATG TAAATCTGTG 3540

AAAGAGAATG GATTAGAACC TCACCTTGTG AAAAAGGTTT TAGAGAAAGT TTCTGAAACT 3600

TTTGGATATA GATGTTTAGA AGACTTTATG GCATCTCATT TAGATTATCT GGTTTTGGAA 3660

TGGCTAAATC TTCAAGATAC CGAATACAAC TTATCTTCTT TTCCTTTTAT TTTATTAAAC 3720

TACACAAATA TTGAGGATTT CTATAGATCT TGTTATAAGG TTTTGATTCC ACATCTGGTG 3780

ATTAGAAGTC ATTTTGATGA GGTGAAGTCC ATTGCTAATC AGATTCAAGA GGACTGGAAA 3840

ACTCTTCTAA CAGACTGCTT TCCAAAGATT CTTGTAAATA TTCTTCCTTA TTTTGCCTAT 3900

GAGGGTACAG GAGACAGTGG GATGGCACAG CAAAGAGAGA CCGCTACCAA GGTCTATGAT 3960

ATGCTTAAAA GTGAAAACTT ACTGGGAAAA CAGATTGATC ATTTATTCAT TAGTAATTTA 4020

CCAGAGATTG TGGTGGAGTT ATTGATGACA TTACATGAGC CAGCAAATTC TAGTGCCAGT 4080

CAGAGCACTG ACCTCTGTGA CTTTTCAGGG GATTTGGATC CTGCTCCTAA TCCACCTCAT 4140

TTTCCATCGC ATGTGATTAA AGCAACATTT GCCTATATCA GCAATTGTTA TAAAAACAAG 4200

TTAAAAAGCA TTTTAGAAAT TCTTTCCAAA AGCCCTGATT CCTATCAGAA AATTCTTCTT 4260

GCCATATGTG AGCAAGCAGC TGAAACAAAT AATGTTTATA AGAAGCACAG AATTCTTAAA 4320

ATATACCACC TGTTTGTTAG TTTATTACTG AAAGATATAA AAAGTGGCTT AGGAGGAGCT 4380

TGGGCCTTTG TTCTTCGAGA CGTTATTTAT ACTTTGATTC ACTATATCAA CCAAAGGCCT 4440

TCTTGTATCA TGGATGTGTC ATTACGTAGC TTCTCCCTTT GTTGTGACTT ATTAAGTCAG 4500

GTTTGCCAGA CAGCCGTGAC TTACTGTAAG GATGCTCTAG AAAACCATCT TCATGTTATT 4560

GTTGGTACAC TTATACCCCT TGTGGATGAG CAGGTGGAGG TTCAGAAACA GGTATTGGAC 4620

TTGTTGAAAT ACTTAGTGAT AGATAACAAG GATAATGAAA ACCTCTATCT CACGATTAAG 4680

CTTTTAGATC CTTTTCCTGA CCATGTTGTT TTTAAGGATT TGCGTATTAC TCAGCAAAAA 4740

ATCAAATACA GTAGAGGACC CTTTTCACTC TTGGAGGAAA TTAACCATTT TCTCTCAGTA 4800

AGTGTTTATG ACGCACTTCC ATTGACAAGA CTTGAAGGAC TAAAGGATCT TCGAAGACAA 4860

CTGGAGCTAC ATAAAGATCA GATGATGGAC ATTATGAGAG CATCTCAGGA TAATCCACAA 4920

GATGGGATTA TGGTGAAGCT AGTTGTCAAT TTGTTGCAGT TATCCAAGAT GGCAATAAAC 4980

CACACTGGTG AAAAAGAAGT TCTAGAGGCT GTTGGAAGCT GCTTGGGAGA AGTGGGTCCT 5040

ATAGATTTCT CTACCATAGC TATACAACAT AGTAAAGATG CATCTTATAC CAAGGCCCTT 5100

AAGTTATTTG AAGATAAAGA ACTTCAGTGG ACCTTCATAA TGCTGACCTA CCTGAATAAC 5160

ACACTGGTAG AAGATTGTGT CAAAGTTCGA TCAGCAGCTG TTACCTGTTT GAAAAACATT 5220

TTAGCCACAA AGACTGGACA TAGTTTCTGG GAGATTTATA AGATGACAAC AGATCCAATG 5280

CTGGCCTATC TACAGCCTTT TAGAACATCG AGAAAAAAGT TTTTAGAAGT ACCCAGATTT 5340

GACAAAGAAA ACCCTTTTGA AGGCCTGGAT GATATAAATC TATGGATTCC TCTAAGTGAA 5400

AATCATGACA TTTGGATAAA GACACTGACT TGTGCTTTTT TGGACAGTGG GGGCACCAAA 5460

TGTGAAATTC TTCAATTATT AAAGCCAATG TGTGAAGTGA AAACTGACTT TTGTCAGACT 5520

GTACTTCCAT ACTTGATTCA TGATATTTTA CTCCAAGATA CAAATGAATC ATGGAGAAAT 5580

CTGCTTTCTA CACATGTTCA GGGATTTTTC ACCAGCTGTC TTCGACACTT CTCGCAAATG 5640

AGCCGATCCA CAACCCCTGC AAACTTGGAT TCAGAGTCAG AGCACTTTTT TCGATGCTGT 5700

TTGGATAAAA AATCACAAAG AACAATGCTT GCTGTTGTGG ACTACATGAG AAGACAAAAG 5760

AGACCTTCTT CAGGAACAAT TTTTAATGAT GCTTTCTGGC TGGATTTAAA TTATCTAGAA 5820

GTTGCCAAGG TAGCTCAGTC TTGTGCTGCT CACTTTACAG CTTTACTCTA TGCAGAAATC 5880

TATGCAGATA AGAAAAGCAT GGATGATCAA GAGAAAAGAA GTCTTGCATT TGAAGAAGGA 5940

AGCCAAAGTA CAACTATTTC TAGCTTGAGT GAAAAAAGTA AAGAAGAAAC TGGAATAAGT 6000

TTACAGGATC TTCTCTTAGA AATCTACAGA AGTATAGGAG AGCCAGATAG TTTGTATGGC 6060

TGTGGTGGAG GGAAGATGTT ACAACCCATT ACTAGACTAC GAACATATGA ACACGAAGCA 6120

ATGTGGGGCA AAGCCCTAGT AACATATGAC CTCGAAACAG CAATCCCCTC ATCAACCCGC 6180

CAGGCAGGAA TCATTCAGGC CTTGCAGAAT TTGGGACTCT GCCATATTCT TTCCATCTAT 6240

TTAAAAGGAT TAGATTATGA AAATAAAGAC TGGTGTCCTG AACTAGAGGA ACTTCATTAC 6300

CAAGCAGCAT GGAGGAATAT GCAGTGGGAC CATTGCACTT CTGTCAGCAA AGAAATAGAA 6360

GGAACCAGTT ACCATGAATC ATTGTACAAT GCTCTACAAT CTCTAAGAGA CAGAGAATTC 6420

TCTACATTTT ATGAAAGTCT CAAATATGCC AGAGTAAAAG AAGTGGAAGA GTTGTGTAAG 6480

CGCAGCCTTG AGTCTGTGTA TTCGCTCTAC CCCACACTTA GCAGGTTGCA GGCCATTGGA 6540

GAGCTGGAAA GCATTGGGGA GCTTTTCTCA AGATCAGTCA CACATAGACA ACTCTCTGAA 6600

GTATATATTA AGTGGCAGAA ACACTCCCAG CTTCTCAAGG ACAGTGATTT TAGTTTTCAG 6660

GAGCCTATCA TGGCTCTACG CACAGTGATT TTGGAGATCC TGATGGAAAA GGAAATGGAC 6720

AACTCACAAA GAGAATGTAT TAAGGACATT CTCACCAAAC ACCTTGTAGA ACTCTCTATA 6780

CTGGCCAGAA CTTTCAAGAA CACTCAGCTC CCTGAAAGGG CAGTATTTCA AATTAAACAG 6840

TATAATTCAG TTAGCTGTGG AGTCTCTGAG TGGCAGCTGG AAGAAGCACA AGTATTCTGG 6900

GCAAAAAAGG AGCAGAGTCT TGCCCTGAGT ATTCTCAAGC AAATGATCAA GAAGTTGGAT 6960

GCCAGCTGTG CAGCGAACAA TCCCAGCCTA AAACTTATAT ACACAGAATG TCTGAGGGTT 7020

TGTGGCAACT GGTTAGCAGA AACTTGCTTA GAAAATCCTG CGGTCATCAT GCAGACCTAT 7080

CTAGAAAAGG CAGTAGAAGT TGCTGGAAAT TATGATGGAG AAAGTAATGA TGAGCTAAGA 7140

AATGGAAAAA TGAAGGCATT TCTCTCATTA GCCCGGTTTT CAGATACTCA ATACCAAAGA 7200

ATTGAAAACT ACATGAAATC ATCGGAATTT GAAAACAAGC AAGCTCTCCT GAAAAGAGCC 7260

AAAGAGGAAG TAGGTCTCCT TAGGGAACAT AAAATTCAGA CAAACAGATA CACAGTAAAG 7320

GTTCAGCGAG AGCTGGAGTT GGATGAATTA GCCCTGTGTG CACTGAAAGA GGATCGTAAA 7380

CGCTTCTTAT GTAAAGCAGT TGAAAATTAC ATCAACTGCT TATTAAGTGG AGAAGAACAT 7440

GATATGTGGG TATTCCGACT TTGTTCCCTC TGGCTTGAAA ATTCTGGAGT TTCTGAAGTC 7500

AATGGCATGA TGAAGAGAGA CGGAATGAAG ATTCCAACAT ATAAATTTTT GCCTCTTATG 7560

TATCAATTGG CTGCTAGAAT GGGGACCAAG ATGATGGGAG GCCTAGGATT TCATGAAGTG 7620

CTCAATAATC TAATCTCTAG AATTTCAATG GATCACCCCC ATCATACTTT GTTTATTATA 7680

CTTGCCTTAG CAAATGCAAA CAGAGATGAA TTTCTGACTA AACCAGAGGT AGCAAGAAGA 7740

AGCAGAATAA CTAAAAATGC GCCTAAACAA AGCTCTCAGC TTGATGAGGA TCGAACAGAG 7800

GCTGCAAACA GAATAATATG TACTATCAGA AGTAGGAGAC CTCAGATGGT CAGAAGTGTT 7860

GAGGCACTTT GTGATGCTTA TATTATATTA GCAAACTTGG ATGCCACTCA GTGGAAGACT 7920

CAGAGAAAAG GCATAAATAT TCCAGCAGAC CAGCCAATTA CTAAACTTAA GAATTTAGAC 7980

GATGTTGTTG TCCCTACTAT GGAAATTAAG GTGGACCACA CAGGAGAATA TGGAAATCTG 8040

GTGACTATAC AGTCATTTAA AGCAGAATTT CGCTTAGCAG GAGGTGTAAA TTTACCAAAA 8100

ATAATCGATT GTGTAGGTTC CGATGGCAAG GAGAGGAGAC AGCTTGTTAA GGGCCGTGAT 8160

GACCTGAGAC AAGATGCTGT CATGCAACAG GTCTTCCAGA TGTGTAATAC ATTACTGCAG 8220

AGAAACACCG AAACTAGGAA GAGGAAATTA ACTATCTGTA CTTATAAGGT GGTTCCCCTC 8280

TCTCAGCGAA GTGGTGTTCT TGAATGGTGC ACAGGAACTG TCCCCATTGG TGAATTTCTT 8340

GTTAACAATG AAGATGGTGC TCATAAAAGA TACAGGCCAA ATGATTTCAG TGCCTTTCAG 8400

TGCCAAAAGA AAATGATGGA GGTGCAAAAA AAGTCTTTTG AAGAGAAATA TGAAGTCTTC 8460

ATGGATGTTT GCCAAAATTT TCAGCCAGTT TTCCGTTACT TCTGCATGGA AAAATTCTTG 8520

GATCCAGCTA TTTGGTTTGA GAAGCGATTG GCTTATACGC GCAGTGTAGC CACTTCTTCT 8580

ATTGTTGGTT ACATACTCGG ACTTGGTGAT AGACATGTAC AGAATATCTT GATAAATGAG 8640

CAGTCAGCAG AACTTGTACA TATAGACTTA GGTGTTGCTT TTGAACAGGG CAAAATCCTT 8700

CCTACTCCGG AGACAGTTCC TAGACTCACC AGAGATATTG TGGATGGCAT GGGCATTACT 8760

GGTGTTGAAG GTGTCTTCAG AAGATGCTGT GAGAAAACCA TGGAAGTGAT GAGAAACTCT 8820

CAGGAAACTC TGTTAACCAT TGTAGAGGTC CTTCTGTATG ATCCACTCTT TGACTGGACC 8880

ATGAATCCTT TGAAAGCTTT GTATTTACAG CAGAGGCCGG AAGATGAAAC TGAGCTTCAC 8940

CCTACTCTGA ATGCAGATGA CCAAGAATGC AAACGAAATC TCAGTGATAT TGACCAGAGT 9000

TTCAACAAAG TAGCTGAACG TGTCTTAATG AGACTACAAG AGAAACTGAA AGGAGTGGAA 9060

GAAGGCACTG TGCTCAGTGT TGGTGGGCAA GTGAATTTGC TCATACAGCA GGCCATAGAC 9120

CCCAAAAATC TCAGCCGACT TTTCCCAGGA TGGAAAGCTT GGGTGTGA 9168

Domain Profile

S: 14    kqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrrkLkirty  73

          + pk +   Gsdgke+++Lvkg++Dlrqd++++q+f+++NtlL++++et++rkL+i+ty

Q: 2696  VNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTY  2755

         567999999***************************************************

S: 74    kVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdlstvqarkpklkhl  133

         kVvpls+rsg++ew+++tv+++e+l   v++++++++   +yr++d+s++q++k++++++

Q: 2756  KVVPLSQRSGVLEWCTGTVPIGEFL---VNNEDGAHK---RYRPNDFSAFQCQKKMMEVQ  2809

         *************************...799*****9...********************

S: 134   kls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislvgyiLg  189

         k+s    +evf++v++n++p  +++++++ekf++p+ wfe+r aytrs+A++s+vgyiLg

Q: 2810  KKSfeekYEVFMDVCQNFQP--VFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILG  2867

         ********************..9*************************************

S: 190   LgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveGv  249

         Lgdrh++n+li+++++e+vhid+gvafe++k+ l++pe+vP RLTr+iv+++g+tgveGv

Q: 2868  LGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVP-RLTRDIVDGMGITGVEGV  2925

         ********************************.********.******************

S: 250   frasceavlrvlreskeklltiLevflydplvdwkk......kkktsketeeelaekaka  303

         fr++ce++++v+r+s+e+llti+ev+lydpl+dw++      + ++++e+e+el+++ +a

Q: 2926  FRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMnplkalYLQQRPEDETELHPTLNA  2985

         ******************************************9*****************

S: 304   ealkikkllskvekaenavatrdlllle  331

         +++++k++ls++++++n+va+r+l++l+

Q: 2986  DDQECKRNLSDIDQSFNKVAERVLMRLQ  3013

         ***********************99987

Domain Sequence
(FASTA)

VNLPKIIDCV GSDGKERRQL VKGRDDLRQD AVMQQVFQMC NTLLQRNTET RKRKLTICTY 60

KVVPLSQRSG VLEWCTGTVP IGEFLVNNED GAHKRYRPND FSAFQCQKKM MEVQKKSFEE 120

KYEVFMDVCQ NFQPVFRYFC MEKFLDPAIW FEKRLAYTRS VATSSIVGYI LGLGDRHVQN 180

ILINEQSAEL VHIDLGVAFE QGKILPTPET VPRLTRDIVD GMGITGVEGV FRRCCEKTME 240

VMRNSQETLL TIVEVLLYDP LFDWTMNPLK ALYLQQRPED ETELHPTLNA DDQECKRNLS 300

DIDQSFNKVA ERVLMRLQ 318

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0016303	; F:1-phosphatidylinositol-3-kinase activity
GO:0005524	; F:ATP binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0007050	; P:cell cycle arrest
GO:0071480	; P:cellular response to gamma radiation
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006281	; P:DNA repair
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0071044	; P:histone mRNA catabolic process
GO:0016572	; P:histone phosphorylation
GO:0007094	; P:mitotic cell cycle spindle assembly checkpoint
GO:0030889	; P:negative regulation of B cell proliferation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090399	; P:replicative senescence
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR016024	; ARM-type_fold.
IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013