EKS-NOL-00192

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00192

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	516.0	1.9E-155	4	287	284

Status

Unreviewed

Ensembl Protein

ENSNLEP00000009747

UniProt Accession

G1R958;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000007984	ENSNLEP00000009747	ENSNLET00000010218

Organism

Nomascus leucogenys

Functional Description

Protein Length

570

Protein Sequence
(FASTA)

MEKYENLGLV GKGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QIVQKYLFQI INGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN IIPRHQELFY KNPVFAGVRL 240

PEIKEREPLE RRYPKLSKVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL 300

QLKVQKDARN VSLSKKSQNR KKEKEKDDYL GEETKTLLVQ GTNADPKIKD CKLFKIKGSK 360

IDGEKAEKGS RASNASCLHD SRTSHNKIVP STSFKDCSNV SVDHTRNPSV AIPPLTHNLS 420

AVAPGINSGM GTATIPIQGY RVNEKTKKCS IPFVKPSRHS PSGICNVNVT TLVSSEKSLF 480

WASKKRREYS RTDVHLPELN YNHLPELRAL EGIARNSRLT KKESKILSES RIPSLAAIDL 540

HTPSITLHQV SGPPLSDDSG ADLPEMEHQH 570

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAAAACCT GGGTTTGGTT GGAAAAGGGA GTTATGGAAT GGTGATGAAG 60

TGTAGGAATA AAGATACTGG AAGAATTGTG GCCATAAAGA AGTTCTTAGA AAGTGACGAT 120

GACAAAATGG TTAAAAAGAT TGCAATGCGA GAAATCAAGT TACTAAAGCA ACTGAGGCAT 180

GAAAACTTGG TGAATCTCTT GGAAGTGTGT AAGAAAAAAA AACGATGGTA CCTAGTCTTT 240

GAATTTGTTG ACCACACAAT TCTTGATGAC TTGGAGCTCT TTCCAAATGG ACTAGACTAC 300

CAAATAGTTC AAAAGTATTT GTTTCAGATT ATTAATGGAA TTGGATTTTG TCACAGTCAC 360

AATATCATAC ACAGAGATAT AAAGCCAGAG AATATATTAG TCTCCCAGTC TGGCGTTGTC 420

AAGCTGTGCG ATTTTGGATT TGCACGAACA TTGGCAGCTC CTGGGGAGGT TTATACTGAT 480

TATGTGGCAA CCCGATGGTA CAGAGCTCCA GAACTATTGG TTGGTGACGT CAAGTATGGC 540

AAGGCTGTTG ATGTGTGGGC CATTGGTTGT CTGGTAACTG AAATGTTCAT GGGGGAACCC 600

CTATTTCCTG GAGATTCTGA TATTGATCAG CTATATCATA TTATGATGTG TTTAGGTAAT 660

ATAATTCCAA GACATCAGGA GCTTTTTTAT AAAAATCCTG TGTTTGCTGG AGTAAGGTTG 720

CCTGAAATCA AGGAAAGAGA ACCTCTTGAA AGACGCTATC CTAAGCTCTC TAAAGTGGTG 780

ATAGATTTAG CAAAGAAATG CTTACATATT GACCCTGACA AAAGACCCTT CTGTGCTGAG 840

CTCCTACACC ATGATTTCTT TCAAATGGAT GGATTTGCTG AGAGGTTTTC CCAAGAACTA 900

CAGTTAAAAG TACAGAAAGA TGCCAGAAAT GTTTCTTTAT CTAAAAAATC CCAAAACAGA 960

AAGAAGGAAA AAGAAAAAGA TGATTACTTA GGTGAAGAAA CAAAAACACT TCTGGTACAG 1020

GGTACCAATG CTGATCCCAA AATTAAGGAT TGTAAACTAT TTAAAATAAA AGGCTCAAAA 1080

ATTGATGGAG AAAAAGCTGA AAAAGGCAGT AGAGCTTCAA ATGCCAGCTG TCTCCATGAC 1140

AGTAGGACAA GCCACAACAA AATAGTGCCT TCAACAAGCT TCAAAGACTG CAGCAATGTC 1200

AGCGTGGACC ACACAAGGAA TCCAAGTGTG GCAATTCCCC CACTTACGCA CAATCTTTCT 1260

GCAGTTGCTC CCGGCATTAA TTCTGGAATG GGGACTGCGA CTATACCAAT TCAGGGTTAC 1320

AGAGTGAATG AGAAAACTAA GAAGTGTTCT ATTCCATTTG TTAAACCGAG CAGACATTCC 1380

CCATCAGGCA TTTGTAACGT TAATGTGACC ACATTAGTCT CTAGTGAAAA AAGCCTCTTT 1440

TGGGCAAGTA AGAAAAGAAG AGAATACTCC AGGACAGATG TCCATTTGCC TGAACTAAAC 1500

TATAATCATC TCCCTGAACT AAGAGCATTG GAAGGCATAG CTCGAAATTC CAGGCTAACA 1560

AAGAAAGAGA GCAAAATTCT TTCAGAATCT CGAATTCCTT CTCTGGCTGC TATTGACCTG 1620

CACACCCCCA GTATTACATT ACATCAGGTA TCAGGACCTC CCCTGTCAGA TGATTCAGGG 1680

GCTGATTTGC CTGAAATGGA ACACCAGCAC TGA 1713

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vG+GsyG+v+kcrnkdtg+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGKGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+t+ld+le +pnG++++ v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQIVQKYLFQIINGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGcl++e+++Geplfpg+sd+dqly+i+++lG++iprhq++f+kn+vfaGv+lpe+

Q: 184   DVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNIIPRHQELFYKNPVFAGVRLPEI  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++e+le++ypkl++v++dl+kkcl++dp++r +c+ell+h++f

Q: 244   KEREPLERRYPKLSKVVIDLAKKCLHIDPDKRPFCAELLHHDFF  287

         ******************************************98

Domain Sequence
(FASTA)

YENLGLVGKG SYGMVMKCRN KDTGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTILDDLEL FPNGLDYQIV QKYLFQIING IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DVWAIGCLVT EMFMGEPLFP GDSDIDQLYH IMMCLGNIIP RHQELFYKNP VFAGVRLPEI 240

KEREPLERRY PKLSKVVIDL AKKCLHIDPD KRPFCAELLH HDFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013