EKS-NOL-00365
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00365
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl470.41.5E-141508763256
StatusUnreviewed
Ensembl ProteinENSNLEP00000009985
UniProt AccessionG1R9T9;
Protein Name
Protein Synonyms/Alias
Gene NameENSG00000092445
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000008203ENSNLEP00000009985ENSNLET00000010473
OrganismNomascus leucogenys
Functional Description
Protein Length869
Protein Sequence
(FASTA)
GQLGLLLLPP PPPQRLRLLL AALASLLLPE SAAAGLKLMG APEKLTVSGQ LVKLNCSVEG 60
MEEPDIQWVK DGAVVQNLEQ LCIPVSEQHI SFLSLKSVVC SDRGQYWCQV DGGKTEISQP 120
VWLTVEGVPL FTVEPKDLAV PPNAPFQLSC KAVGPPEPVT IVWWRGTTKI RGPAPSPSVL 180
NVTGPRAPMF SCEAHSLKCL ASSRIATVLL QAFPAVPFNI TVTKLSSGNT SVAWMPGADG 240
RALLQSCTVQ VTQAPGGWEV LAVVVLVPPF TCLLRDLVPA TSYSLRVCCA NSLGPSPYAD 300
WVPFQTKGLA PASVPQNLHA IHTDSGLILE WEEVIPEGPL EGPLGPYKLS WVQDNGTQDE 360
LTMEGTRANL TGWDPQKGLI VHVCVSNAVG CGPWSQPLVV SSHDHAGQKG PPHSRTSWVP 420
VVLGVLTALV MVAALALILL LKRRKEMWFG QGFDSVMAWG EPAIHFRAAR SFNRERPKCI 480
ETLDSLGINS ELKEKLEDVL IPEQQFTGQM LGKGEFGSVW AQLKQEDGSF VKVAVKMLKA 540
DIIASSDIEE FLREAACMKE FDHPHVAKLV GVSLASRAKG CHPIPMVILL FMKHGDLHAF 600
LLTSQLGENP FLIRFMVDIA CGMEYLSSRN FIHRDLAAQN CMLAEDMTVC VADFGLSWKI 660
YSGDYYCQGC ASKLPVKWLA LESLADNLYT VHSDVWAFGV TMWEIMTRGQ MPYAGIKNAE 720
IYNYLIGGNR LKQLPERMED VYDRMYQCWS ADPKQRPSFA CLQMELENIL GQLSVLSASQ 780
DPLYINIKRA EEPTVGGSLE LPSRYQPYSG AGDGSGMGAV GGTPSDYYIL TPGGLAEQPG 840
QAEHQPESPL NETQRLLLLQ QGLLPHNSC 869
Nucleotide Sequence
(FASTA)
GGGCAGCTGG GGCTCCTGCT GCTGCCACCG CCACCACCAC AGCGGCTGAG GCTGCTGCTG 60
GCGGCTCTGG CTTCTCTGCT GCTCCCGGAG TCTGCAGCTG CAGGTCTGAA GCTCATGGGA 120
GCCCCAGAAA AGCTGACAGT GTCTGGGCAG CTGGTGAAGC TCAACTGCAG CGTGGAGGGG 180
ATGGAGGAGC CTGACATCCA GTGGGTGAAG GATGGGGCTG TGGTCCAGAA CTTGGAACAG 240
TTGTGCATCC CAGTCAGCGA GCAGCACATC AGCTTCCTCA GCCTGAAGTC AGTGGTGTGC 300
TCTGACAGGG GCCAGTACTG GTGCCAGGTG GATGGGGGCA AAACCGAGAT CTCCCAGCCA 360
GTGTGGCTCA CGGTAGAAGG TGTGCCACTT TTCACAGTGG AGCCAAAAGA TCTGGCAGTA 420
CCACCCAATG CCCCTTTCCA ACTGTCTTGC AAGGCTGTGG GTCCCCCTGA ACCTGTTACC 480
ATTGTCTGGT GGAGAGGAAC TACGAAGATC CGGGGACCTG CTCCCTCTCC TTCTGTTTTA 540
AATGTAACGG GTCCCAGAGC ACCCATGTTT TCCTGTGAAG CTCACAGCCT AAAATGCCTG 600
GCCTCTTCTC GCATAGCCAC TGTTCTCCTT CAAGCATTTC CTGCAGTCCC CTTCAACATC 660
ACTGTGACAA AGCTTTCCAG CGGCAACACT AGTGTGGCCT GGATGCCAGG TGCTGATGGC 720
CGAGCCCTGC TACAGTCCTG TACAGTTCAG GTGACACAGG CCCCAGGAGG CTGGGAAGTC 780
CTGGCTGTTG TGGTCCTTGT GCCCCCCTTT ACCTGCCTGC TCCGGGACCT GGTGCCTGCC 840
ACCAGCTACA GCCTCAGGGT GTGCTGTGCC AATTCCTTGG GGCCCTCTCC CTATGCTGAC 900
TGGGTCCCCT TTCAGACCAA GGGTCTAGCC CCAGCCAGTG TTCCCCAAAA CCTCCATGCC 960
ATCCACACAG ATTCAGGCCT CATTTTGGAG TGGGAAGAAG TGATCCCCGA GGGCCCTTTG 1020
GAAGGCCCCC TGGGACCCTA TAAACTCTCC TGGGTTCAAG ACAATGGAAC CCAAGATGAG 1080
CTGACAATGG AGGGGACCAG GGCCAATTTG ACAGGCTGGG ATCCCCAAAA GGGCCTGATT 1140
GTACATGTGT GTGTCTCCAA TGCAGTTGGC TGTGGACCCT GGAGTCAGCC ACTGGTGGTC 1200
TCTTCTCATG ACCATGCAGG CCAGAAGGGC CCTCCTCACA GCCGCACATC CTGGGTACCT 1260
GTGGTCCTTG GTGTGCTAAC GGCCCTGGTG ATGGTTGCTG CCCTGGCCCT CATCTTGCTT 1320
CTAAAGAGAC GGAAAGAGAT GTGGTTTGGG CAAGGCTTTG ACAGTGTCAT GGCCTGGGGA 1380
GAGCCAGCCA TTCACTTCCG GGCAGCCCGG TCCTTCAATC GAGAAAGGCC CAAGTGCATC 1440
GAGACATTGG ACAGCTTGGG CATCAACAGT GAACTAAAGG AAAAGCTGGA GGATGTGCTC 1500
ATCCCAGAGC AGCAGTTCAC CGGCCAGATG TTGGGCAAGG GAGAGTTTGG TTCAGTGTGG 1560
GCCCAGCTGA AGCAGGAGGA TGGCTCCTTT GTGAAAGTGG CTGTGAAGAT GCTGAAAGCT 1620
GATATCATTG CCTCAAGTGA CATTGAAGAG TTCCTCAGGG AAGCAGCTTG CATGAAGGAG 1680
TTTGACCATC CACACGTGGC CAAACTTGTT GGGGTGAGCC TCGCCTCTAG GGCTAAAGGC 1740
TGTCACCCCA TCCCCATGGT CATCTTGCTC TTCATGAAGC ATGGGGACCT GCACGCCTTC 1800
CTGCTCACCT CCCAGCTTGG GGAGAACCCC TTTCTGATCC GGTTCATGGT GGACATTGCC 1860
TGTGGCATGG AGTACCTGAG CTCTCGGAAC TTCATCCACC GAGACCTGGC CGCTCAGAAC 1920
TGCATGCTGG CAGAGGACAT GACGGTGTGT GTGGCTGACT TCGGACTCTC CTGGAAGATC 1980
TACAGCGGGG ACTACTATTG TCAGGGCTGT GCCTCCAAAT TGCCCGTCAA GTGGCTGGCC 2040
CTGGAGAGCC TGGCTGACAA CCTGTATACT GTGCACAGTG ACGTGTGGGC CTTCGGGGTG 2100
ACCATGTGGG AGATCATGAC ACGTGGGCAG ATGCCATACG CCGGCATCAA AAACGCTGAG 2160
ATTTACAACT ACCTCATTGG CGGGAATCGC CTGAAACAGC TTCCAGAGCG TATGGAGGAC 2220
GTTTATGATC GCATGTACCA GTGCTGGAGT GCTGACCCCA AGCAGCGCCC AAGCTTTGCT 2280
TGTCTGCAAA TGGAACTGGA GAACATCCTG GGCCAGCTGT CTGTGCTATC CGCCAGCCAG 2340
GACCCCTTAT ACATCAACAT CAAGAGAGCC GAGGAGCCCA CTGTGGGAGG CAGCCTGGAG 2400
CTGCCTAGCA GGTATCAGCC CTACAGTGGA GCTGGGGATG GCAGTGGCAT GGGGGCAGTG 2460
GGTGGCACTC CCAGTGACTA TTACATCCTC ACCCCTGGAG GGCTGGCTGA GCAGCCAGGG 2520
CAGGCAGAGC ACCAGCCAGA GAGTCCCCTC AATGAGACGC AGAGGCTTTT GCTGCTGCAG 2580
CAAGGGCTAC TGCCACACAA TAGCTGT 2607
Domain Profile
S: 4     gkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdhpnv  63
         g++lg+gefgsv  +qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdhp+v
Q: 508   GQMLGKGEFGSVW-AQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHV  566
         99*********97.8*********************************************
S: 64    irlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmvdia  123
         ++lvgvsl s++kg  p+p+vil fmk+gdlhafll s+lgenp+      l++fmvdia
Q: 567   AKLVGVSLASRAKGCHPIPMVILLFMKHGDLHAFLLTSQLGENPF------LIRFMVDIA  620
         ********************************************7......89*******
S: 124   sgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvkwia  183
         +gmeylssrnfihrdlaa+ncmlaedmtvcvadfgls kiysgdyy qg+++klpvkw+a
Q: 621   CGMEYLSSRNFIHRDLAAQNCMLAEDMTVCVADFGLSWKIYSGDYYCQGCASKLPVKWLA  680
         ************************************************************
S: 184   iesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedclde  243
         +eslad++yt++sdvwafgvtmwei+trgq pyag++naeiy+yl++gnrlkq ++ +++
Q: 681   LESLADNLYTVHSDVWAFGVTMWEIMTRGQMPYAGIKNAEIYNYLIGGNRLKQLPERMED  740
         ************************************************************
S: 244   lydlmyrcweadpkdrpsfsvlr  266
         +yd my+cw+adpk+rpsf+ l+
Q: 741   VYDRMYQCWSADPKQRPSFACLQ  763
         *******************9875
Domain Sequence
(FASTA)
GQMLGKGEFG SVWAQLKQED GSFVKVAVKM LKADIIASSD IEEFLREAAC MKEFDHPHVA 60
KLVGVSLASR AKGCHPIPMV ILLFMKHGDL HAFLLTSQLG ENPFLIRFMV DIACGMEYLS 120
SRNFIHRDLA AQNCMLAEDM TVCVADFGLS WKIYSGDYYC QGCASKLPVK WLALESLADN 180
LYTVHSDVWA FGVTMWEIMT RGQMPYAGIK NAEIYNYLIG GNRLKQLPER MEDVYDRMYQ 240
CWSADPKQRP SFACLQ 256
KeywordComplete proteome; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Gorilla gorilla"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Xiphophorus maculatus"; ?>
EKS-GOG-00388
EKS-ORN-00511
EKS-ORA-00344
EKS-PAT-00375
EKS-POA-00391
EKS-XIM-00503
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005635; C:nuclear envelope
GO:0005524; F:ATP binding
GO:0043548; F:phosphatidylinositol 3-kinase binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0021885; P:forebrain cell migration
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0042698; P:ovulation cycle
GO:0070527; P:platelet aggregation
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013