EKS-NOL-00368
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00368
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR604.28.1E-182586921336
StatusUnreviewed
Ensembl ProteinENSNLEP00000010174
UniProt AccessionG1RAC7;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000008295ENSNLEP00000010174ENSNLET00000010675
OrganismNomascus leucogenys
Functional Description
Protein Length973
Protein Sequence
(FASTA)
MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PGEPSPPSIH PAKSELIVRV GDEIRLLCTD 60
PGFVKWTFEI LDETNENKQN EWIREKAEAT NTGKYTCTNK HGLSSSIYVF VRDPAKLFLV 120
DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG CQGKPLPKDL RFVPDPKAGI MIKSVKRTYH 180
RLCLHCSVDQ EGKSVLSEKF ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS 240
SVYSTWKREN SQQTKLQEKY NSWHHGDFNY ERQATLTISS ARVNDSGVFM CYANNTFGSA 300
NVTTALEVVD KGFINIFPMI NTTVFVNDGE NVDLIVEYEA FPKPEHQQWI YMNRTFTDKW 360
EDYPKSENES NIRYVSELHL TRLKGTEGGT YTFLVSNSDV SASIAFNVYV NTKPEILTYD 420
RLVNGMLQCV AAGFPEPTID WYFCPGTEQR CSASVLPVDV QTLNSSGPPF GKLVVQSSID 480
SSAFKHNGTV ECKAYNDVGK TSAYFNFAFK EQIHPHTLFT PLLIGFVIVA GMMCIIVMIL 540
TYKYLQKPMY EVQWKVVEEI NGNNYVYIDP TQLPYDHKWE FPRNRLSFGK TLGAGAFGKV 600
VEATAYGLIK SDAAMTVAVK MLKPSAHLTE REALMSELKV LSYLGNHMNI VNLLGACTIG 660
GPTLVITEYC CYGDLLNFLR RKRDSFICSK QEDHAEAALY KNLLHSKESS CSDSTNEYMD 720
MKPGVSYVVP TKADKRRSAR IGSYIERDVT PAIMEDDELA LDLEDLLSFS YQVAKGMAFL 780
ASKNCIHRDL AARNILLTHG RITKICDFGL ARDIKNDSNY VVKGNARLPV KWMAPESIFN 840
CVYTFESDVW SYGIFLWELF SLGSSPYPGM PVDSKFYKMI KEGFRMLSPE HAPAEMYDIM 900
KTCWDADPLK RPTFKQIVQL IEKQISESTN HIYSNLANCS PNRQKPVVDH SVRINSVGST 960
ASSSQPLLVH DDV 973
Nucleotide Sequence
(FASTA)
ATGAGAGGCG CTCGCGGCGC CTGGGATTTT CTCTGCGTTC TGCTCCTACT GCTCCGCGTC 60
CAGACAGGCT CTTCTCAACC ATCTGTGAGT CCAGGGGAAC CGTCTCCACC ATCCATCCAT 120
CCAGCAAAAT CAGAGTTAAT AGTCCGCGTG GGCGACGAGA TTAGGCTGTT ATGCACTGAT 180
CCAGGCTTTG TCAAATGGAC TTTTGAGATC CTGGATGAAA CGAATGAGAA TAAGCAGAAT 240
GAATGGATCA GGGAAAAGGC AGAAGCCACC AACACCGGCA AATACACGTG CACCAACAAA 300
CACGGCTTAA GCAGTTCCAT TTATGTGTTT GTTAGAGATC CCGCCAAGCT TTTCCTTGTT 360
GACCGCTCCT TGTATGGGAA AGAAGACAAC GACACGCTGG TCCGCTGTCC TCTCACAGAC 420
CCAGAAGTGA CAAATTATTC CCTCAAGGGG TGCCAGGGGA AGCCTCTTCC CAAGGACTTG 480
AGGTTTGTTC CTGACCCCAA GGCGGGCATC ATGATCAAAA GTGTGAAACG CACCTACCAT 540
CGGCTCTGTT TGCATTGTTC CGTGGACCAG GAGGGCAAGT CAGTGCTGTC GGAAAAATTC 600
ATCCTGAAAG TGAGGCCAGC CTTCAAAGCT GTGCCTGTTG TGTCTGTGTC CAAAGCAAGC 660
TATCTCCTTA GGGAAGGGGA AGAATTCACA GTGACGTGCA CAATAAAAGA TGTGTCTAGT 720
TCTGTGTACT CAACGTGGAA AAGAGAAAAC AGCCAGCAAA CTAAACTACA GGAGAAATAC 780
AATAGCTGGC ATCACGGTGA CTTCAATTAT GAACGTCAGG CAACATTGAC TATCAGTTCA 840
GCGAGAGTTA ATGATTCTGG AGTGTTCATG TGTTATGCCA ATAATACTTT TGGATCAGCA 900
AATGTCACAA CAGCCTTGGA AGTAGTAGAT AAAGGATTCA TTAATATCTT CCCCATGATA 960
AACACTACAG TATTTGTAAA CGATGGAGAA AATGTAGATT TGATTGTTGA ATATGAGGCA 1020
TTCCCCAAAC CTGAACACCA GCAGTGGATC TATATGAACA GAACCTTCAC TGATAAATGG 1080
GAAGATTATC CCAAGTCGGA GAATGAAAGT AATATCAGAT ACGTAAGTGA ACTTCATCTA 1140
ACCAGATTAA AAGGCACTGA AGGAGGCACT TATACATTCC TGGTGTCCAA TTCTGACGTC 1200
AGTGCTTCCA TAGCATTTAA TGTTTATGTG AATACAAAAC CAGAAATCCT GACTTACGAC 1260
AGGCTCGTGA ATGGCATGCT CCAATGTGTG GCAGCAGGAT TCCCAGAGCC CACAATAGAT 1320
TGGTATTTTT GCCCAGGAAC TGAGCAGAGA TGCTCTGCTT CTGTACTGCC AGTGGATGTG 1380
CAGACACTAA ACTCATCTGG GCCACCTTTT GGAAAGCTAG TGGTTCAGAG TTCCATAGAT 1440
TCTAGTGCAT TCAAGCACAA TGGCACAGTT GAATGTAAGG CTTACAACGA TGTGGGCAAG 1500
ACTTCTGCCT ATTTTAACTT TGCATTTAAA GAGCAAATCC ATCCCCACAC CCTGTTCACT 1560
CCGTTGCTGA TTGGTTTCGT AATCGTAGCT GGCATGATGT GCATTATTGT GATGATTCTG 1620
ACCTACAAAT ATTTACAGAA ACCCATGTAT GAAGTACAGT GGAAGGTTGT TGAGGAGATA 1680
AATGGAAACA ATTACGTTTA CATAGACCCA ACACAACTTC CTTATGATCA CAAATGGGAG 1740
TTTCCCAGAA ACAGGCTGAG TTTTGGGAAA ACCCTGGGTG CTGGCGCTTT TGGGAAGGTT 1800
GTTGAGGCAA CTGCTTATGG CTTAATTAAG TCGGATGCAG CCATGACTGT CGCTGTAAAG 1860
ATGCTCAAGC CAAGTGCCCA TTTAACAGAA CGGGAAGCCC TCATGTCTGA ACTCAAAGTC 1920
CTGAGTTACC TTGGTAATCA TATGAATATT GTGAATCTTC TTGGAGCCTG CACCATTGGA 1980
GGGCCCACCC TGGTCATTAC AGAATATTGT TGCTATGGTG ATCTTTTGAA TTTTTTGAGA 2040
AGAAAACGTG ATTCATTTAT TTGTTCAAAG CAGGAAGATC ATGCAGAAGC TGCACTTTAT 2100
AAGAATCTTC TGCATTCAAA GGAGTCTTCC TGCAGCGATA GTACTAACGA GTACATGGAC 2160
ATGAAACCTG GAGTTTCTTA TGTTGTCCCA ACCAAGGCCG ACAAAAGGAG ATCTGCGAGA 2220
ATAGGCTCAT ACATAGAAAG AGATGTGACT CCCGCCATCA TGGAGGATGA TGAGTTGGCC 2280
CTAGACCTAG AGGACTTGCT GAGCTTTTCT TACCAGGTGG CAAAGGGCAT GGCTTTCCTC 2340
GCCTCCAAGA ATTGTATTCA CAGAGACTTG GCAGCCAGAA ATATCCTCCT TACTCATGGT 2400
CGGATCACAA AGATTTGTGA TTTTGGTCTC GCCAGAGACA TCAAGAATGA TTCTAATTAT 2460
GTGGTTAAAG GAAACGCTCG ACTACCTGTG AAGTGGATGG CACCTGAAAG CATTTTCAAC 2520
TGTGTGTACA CGTTTGAAAG TGACGTCTGG TCCTATGGGA TTTTTCTTTG GGAGCTGTTC 2580
TCTTTAGGAA GCAGCCCCTA TCCTGGAATG CCGGTCGATT CTAAGTTCTA CAAGATGATC 2640
AAGGAAGGCT TCCGGATGCT CAGCCCTGAA CATGCACCTG CAGAAATGTA TGACATAATG 2700
AAGACTTGCT GGGATGCGGA TCCCCTAAAA AGACCAACGT TCAAGCAAAT CGTTCAGCTA 2760
ATTGAGAAGC AGATTTCAGA GAGCACCAAT CACATTTACT CCAACTTAGC AAACTGCAGC 2820
CCCAACCGAC AGAAGCCCGT GGTGGACCAT TCTGTGCGGA TCAATTCTGT CGGCAGCACC 2880
GCTTCCTCCT CCCAGCCTCT GCTTGTGCAC GACGATGTCT GA 2922
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 586   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  645
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 646   NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKN  702
         ******************************************...99999*********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++s+s++ey+d+k++vs+v ++kadk++s+++ s++er+v++a++e+d
Q: 703   L-----LHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDD  757
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 758   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  817
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 818   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  877
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 878   KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI  921
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA EAALYKNLLH 120
SKESSCSDST NEYMDMKPGV SYVVPTKADK RRSARIGSYI ERDVTPAIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD ADPLKRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0038093; P:Fc receptor signaling pathway
GO:0038109; P:Kit signaling pathway
GO:0008584; P:male gonad development
GO:0002551; P:mast cell chemotaxis
GO:0032762; P:mast cell cytokine production
GO:0043303; P:mast cell degranulation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013