EKS-NOL-00274
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00274
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR498.24.3E-150682939258
StatusUnreviewed
Ensembl ProteinENSNLEP00000010419
UniProt AccessionG1RB22;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000008441ENSNLEP00000010419ENSNLET00000010929
OrganismNomascus leucogenys
Functional Description
Protein Length1180
Protein Sequence
(FASTA)
VCQGTSNKLT QLGTFEDHFL SLQRMFNNCE VVLGNLEITY VQRNYDLSFL KTIQEVAGYV 60
LIALNTVERI PLENLQIIRG NMYYENSYAL AVLSNYDANK TGLKELPMRN LQEILHGAVR 120
FSNNPALCNV ESIQWRDIVS SDFLSNMSMD FQNHLGSCQK CDPSCPNGSC WGAGEENCQK 180
LTKIICAQQC SGRCRGKSPS DCCHNQCAAG CTGPRESDCL VCRKFRDEAT CKDTCPPLML 240
YNPTTYQMDV NPEGKYSFGA TCVKKCPRNY VVTDHGSCVR ACGADSYEME EDGVRKCKKC 300
EGPCRKVCNG IGIGEFKDTL SINATNIKHF KNCTSISGDL HILPVAFRGD SFTHTPPLDP 360
QELDILKTVK EITGFLLIQA WPENRTDLHA FENLEIIRGR TKQHGQFSLA VVSLNITSLG 420
LRSLKEISDG DVIISGNKNL CYANTINWKK LFGTSGQKTK IISNRGENSC KATGQVCHAL 480
CSPEGCWGPE PRDCVSCRNV SRGRECVDKC NILEGEPREF VENSECIQCH PECLPQVMNI 540
TCTGQGPDNC IQCAHYIDGP HCVKTCPAGV MGENNTLVWK YADASHVCHL CHPNCTYGCA 600
GPGLEGCANG PKIPSIATGM VGALLLLLVV ALGIGLFMRR RHIVRKRTLR RLLQERELVE 660
PLTPSGEAPN QALLRILKET EFKKIKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA 720
TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD YVREHKDNIG 780
SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH VKITDFGLAK LLGAEEKEYH 840
AEGGKVPIKW MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISSILEKG 900
ERLPQPPICT IDVYMIMVKC WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP 960
SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ QGFFSSPSTS RTPLLSSLSA TSNNSTVACI 1020
DRNGLQSCPI KEDSFLQRYS SDPTGALTED SIDDTFLPVP EYINQSVPKR PAGSVQNPVY 1080
HNQPLNPTPS RDPHYQDPHS TAVGNPEYLN TVQPTCVNST FDSPAHWAQK GSHQISLDNP 1140
DYQQDFFPKE AKPNGIFKGS TAENAEYLRV APQSSEFIGA 1180
Nucleotide Sequence
(FASTA)
GTTTGCCAAG GCACGAGTAA TAAGCTCACA CAGTTGGGCA CTTTTGAAGA TCATTTTCTC 60
AGCCTCCAGA GGATGTTCAA TAACTGTGAG GTTGTCCTTG GGAATTTGGA AATTACCTAC 120
GTGCAGAGGA ATTACGATCT TTCCTTCTTG AAGACCATCC AGGAGGTGGC TGGTTATGTC 180
CTCATCGCCC TCAACACAGT GGAGCGGATT CCTTTGGAAA ACCTGCAGAT CATCAGAGGA 240
AATATGTACT ATGAAAATTC CTACGCCTTA GCAGTCTTAT CTAACTATGA TGCAAATAAA 300
ACCGGACTGA AGGAGCTGCC CATGAGAAAT TTACAGGAAA TCCTGCATGG CGCCGTGCGG 360
TTCAGCAACA ACCCTGCCCT GTGCAACGTG GAGAGCATCC AGTGGCGGGA CATAGTCAGC 420
AGTGACTTTC TCAGCAACAT GTCGATGGAC TTCCAGAACC ACCTGGGCAG CTGCCAAAAG 480
TGTGATCCAA GCTGTCCCAA TGGGAGCTGC TGGGGTGCAG GAGAGGAGAA CTGCCAGAAA 540
CTGACCAAAA TCATCTGTGC CCAGCAGTGC TCTGGGCGCT GCCGTGGCAA GTCCCCCAGT 600
GACTGCTGCC ATAACCAGTG TGCCGCGGGC TGCACGGGCC CCCGAGAGAG CGACTGCCTG 660
GTCTGCCGCA AATTCCGAGA CGAAGCCACG TGCAAGGACA CCTGCCCCCC ACTCATGCTT 720
TACAACCCCA CCACGTACCA GATGGATGTG AACCCCGAGG GCAAATACAG CTTTGGTGCC 780
ACCTGCGTGA AGAAGTGTCC CCGTAATTAT GTGGTGACAG ATCACGGCTC GTGCGTCCGA 840
GCCTGCGGGG CCGACAGCTA TGAGATGGAG GAAGACGGCG TCCGCAAGTG TAAGAAGTGC 900
GAAGGGCCTT GCCGCAAAGT GTGTAACGGA ATAGGTATTG GTGAATTTAA AGACACACTC 960
TCCATAAATG CTACAAATAT TAAACACTTC AAAAACTGCA CCTCCATCAG TGGCGATCTC 1020
CACATCCTGC CGGTGGCATT TAGGGGTGAC TCCTTCACAC ACACTCCGCC TCTGGACCCA 1080
CAGGAACTGG ATATTCTGAA AACCGTAAAG GAAATCACAG GGTTTTTGCT GATTCAGGCT 1140
TGGCCTGAAA ACAGGACGGA CCTCCATGCT TTTGAGAACC TAGAAATCAT ACGCGGCAGG 1200
ACCAAGCAAC ATGGTCAGTT TTCTCTTGCG GTCGTCAGCC TGAACATAAC ATCCTTGGGA 1260
TTACGCTCCC TCAAGGAGAT AAGTGATGGA GATGTGATAA TTTCAGGAAA CAAAAATTTG 1320
TGCTATGCAA ATACAATAAA CTGGAAAAAA CTGTTTGGGA CCTCCGGTCA GAAAACCAAA 1380
ATTATAAGCA ACAGAGGTGA AAACAGCTGC AAGGCCACAG GCCAGGTCTG CCATGCCTTG 1440
TGCTCCCCTG AGGGCTGCTG GGGCCCAGAG CCCAGGGACT GCGTCTCCTG CCGGAATGTC 1500
AGCCGAGGCA GGGAATGCGT GGACAAGTGC AACATTCTGG AGGGCGAGCC AAGGGAGTTT 1560
GTGGAGAACT CTGAGTGCAT ACAGTGCCAC CCAGAATGCC TGCCCCAGGT CATGAACATC 1620
ACCTGCACGG GACAGGGACC AGACAACTGT ATCCAGTGTG CCCACTACAT TGACGGCCCC 1680
CACTGCGTCA AGACCTGCCC GGCAGGAGTC ATGGGAGAAA ACAACACCCT GGTCTGGAAG 1740
TATGCAGACG CCAGCCACGT GTGCCACCTG TGCCATCCAA ACTGCACCTA CGGATGCGCT 1800
GGGCCAGGTC TTGAAGGCTG TGCGAATGGG CCTAAGATTC CGTCCATTGC CACTGGGATG 1860
GTGGGGGCCC TCCTCTTGCT GCTGGTGGTG GCCCTGGGGA TCGGCCTCTT CATGCGAAGG 1920
CGCCACATCG TTCGGAAGCG CACACTGCGG AGGCTGCTGC AGGAGAGGGA GCTTGTGGAG 1980
CCTCTTACGC CCAGTGGAGA AGCTCCCAAC CAAGCTCTCT TGAGGATCTT GAAGGAAACT 2040
GAATTCAAAA AGATCAAAGT GCTGGGCTCC GGCGCGTTCG GCACTGTGTA TAAGGGACTC 2100
TGGATCCCAG AAGGTGAGAA AGTTAAAATT CCCGTTGCTA TCAAGGAATT AAGAGAAGCA 2160
ACGTCTCCGA AAGCCAACAA GGAAATCCTC GATGAAGCCT ACGTGATGGC CAGCGTGGAC 2220
AACCCCCACG TGTGCCGCCT TCTGGGCATC TGCCTCACCT CCACCGTGCA GCTCATCACG 2280
CAGCTCATGC CCTTCGGCTG CCTCCTCGAC TATGTCCGGG AACACAAAGA CAATATCGGC 2340
TCCCAGTACC TGCTCAACTG GTGTGTGCAG ATCGCAAAGG GCATGAACTA CTTAGAGGAC 2400
CGGCGCTTGG TGCACCGGGA CCTGGCAGCC AGGAACGTAC TGGTGAAAAC ACCGCAGCAT 2460
GTCAAGATCA CAGATTTTGG GCTGGCCAAA CTGCTGGGTG CAGAAGAGAA AGAATACCAT 2520
GCAGAAGGAG GCAAAGTGCC TATCAAGTGG ATGGCATTGG AATCAATTTT ACACCGAATT 2580
TATACCCACC AGAGTGATGT CTGGAGCTAT GGGGTGACCG TTTGGGAGTT GATGACCTTT 2640
GGATCCAAGC CATATGACGG AATCCCTGCC AGCGAGATCT CCTCCATCCT GGAAAAAGGA 2700
GAACGCCTCC CCCAGCCACC CATATGCACC ATCGATGTCT ACATGATCAT GGTCAAGTGC 2760
TGGATGATAG ACGCAGATAG TCGCCCAAAG TTCCGTGAGT TGATCATCGA ATTCTCCAAA 2820
ATGGCCCGAG ACCCCCAGCG CTACCTTGTC ATTCAGGGGG ATGAAAGAAT GCATTTGCCA 2880
AGCCCTACAG ACTCCAACTT CTACCGTGCC CTGATGGATG AAGAAGACAT GGACGATGTG 2940
GTGGATGCCG ACGAGTACCT CATCCCACAG CAGGGCTTCT TCAGCAGCCC CTCCACGTCA 3000
CGGACTCCCC TCCTGAGCTC TCTGAGTGCA ACCAGCAACA ATTCCACTGT GGCTTGCATT 3060
GATAGAAATG GGCTGCAAAG CTGTCCCATC AAGGAAGACA GCTTCTTGCA GCGATACAGC 3120
TCAGACCCCA CAGGTGCCTT GACTGAGGAC AGCATAGACG ACACCTTCCT CCCAGTGCCT 3180
GAATACATAA ACCAGTCGGT TCCCAAAAGG CCCGCTGGCT CTGTGCAGAA TCCTGTCTAT 3240
CATAATCAGC CTCTGAACCC CACACCCAGC AGAGATCCAC ACTACCAGGA CCCCCACAGC 3300
ACTGCAGTGG GCAACCCCGA GTATCTCAAC ACTGTCCAGC CTACCTGTGT CAACAGCACA 3360
TTCGACAGCC CTGCCCACTG GGCCCAGAAA GGCAGCCACC AAATTAGCCT GGACAACCCT 3420
GACTACCAGC AGGACTTCTT TCCCAAGGAA GCCAAGCCAA ATGGCATCTT TAAGGGCTCC 3480
ACAGCTGAAA ATGCAGAATA CCTAAGGGTC GCGCCACAAA GCAGTGAATT TATTGGAGCA 3540
TGA 3543
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 682   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  741
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++
Q: 742   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR  801
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y
Q: 802   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  861
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw
Q: 862   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  921
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkf+el+ efs
Q: 922   MIDADSRPKFRELIIEFS  939
         ****************96
Domain Sequence
(FASTA)
FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNIGS QYLLNWCVQI AKGMNYLEDR 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPKF RELIIEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00290
EKS-BOT-00297
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-EQC-00289
EKS-FEC-00283
EKS-GAG-00251
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-ORN-00386
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00359
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-POA-00289
EKS-RAN-00314
EKS-SAH-00279
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0005768; C:endosome
GO:0016021; C:integral to membrane
GO:0045121; C:membrane raft
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0016337; P:cell-cell adhesion
GO:0007173; P:epidermal growth factor receptor signaling pathway
GO:0043066; P:negative regulation of apoptotic process
GO:0042177; P:negative regulation of protein catabolic process
GO:0035413; P:positive regulation of catenin import into nucleus
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0045739; P:positive regulation of DNA repair
GO:0045740; P:positive regulation of DNA replication
GO:0043406; P:positive regulation of MAP kinase activity
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0070141; P:response to UV-A
GO:0023014; P:signal transduction by phosphorylation
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013