EPS-NOL-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-NOL-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	191.3	2.6E-56	234	487	254

Status

Unreviewed

Ensembl Protein

ENSNLEP00000010291

UniProt Accession

G1RAP4;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000008452	ENSNLEP00000010291	ENSNLET00000010797
ENSNLEG00000008452	ENSNLEP00000023467	ENSNLET00000031827

Organism

Nomascus leucogenys

Functional Description

Protein Length

755

Protein Sequence
(FASTA)

MAGCIPEEKT YRRFLELFLG EFRGPCGGGE PEPEPEPEPE PEPESEPEPE PELVEAEAAE 60

ASVEEPGEEA ATVAATEEGD QEQDPEPEEE AGEEEEEEEE AAATVAAAPG HSAVPPPPQP 120

QLPPLPLLPR PLSERITREE VEGESLDLCL QQLYKYNCPS FLAAALARAT SDEVLQSDLS 180

AHYIPKEMDG TEGTVEIETV KLARSVFSKL HEICCSWVKD FPLRRRPKLY YETSIHAIKN 240

MRRKMEDKHV CIPDFNMLFN LEDQEEQAYF AVFDGHGGVD AAIYASIHLH VNLVRQEMFP 300

HDPAEALCRA FRVTDERFVQ KAARESLRCG TTGVVTFIRG NMLHVAWVGD SQVMLVRKGQ 360

AVELMKPHKP DREDEKQRIE ALGGCVVWFG AWRVNGSLSV SRAIGDAEHK PYICGDADSA 420

STVLDGTEDY LILACDGFYD TVNPDEAVKV VSDHLKENNG DSSMVAHKLV ASARDAGSSD 480

NITVIVVFLR DMNKAVNVSE ESDWTENSFQ GGQEDGGDDK ENHGECKRPW PQHQCSAPAD 540

LGYDGRVDSF TDRTSLSPGS QINVLEDPGY LDLTQIEASK PHSAQFLLPV EMFGPGAPKK 600

ANLNELMMEK KSVQSSLPEW SGAREFPTAF NLGSTGEQIY RMESLSPVCS GLENEQFKSL 660

GNRVSRLSHL RHHYSKKWHR FRFNPKFYSF LSAQEPSHKI GTSLSSLTGS GKRNRIRSSL 720

PWRQNSWKGY SENMRKLRKT HDIPCPDLPW SYKIE 755

Nucleotide Sequence
(FASTA)

ATGGCCGGCT GCATCCCTGA GGAGAAAACT TACCGGCGCT TCCTGGAGCT ATTCCTGGGC 60

GAGTTTCGCG GACCGTGCGG CGGCGGCGAG CCAGAGCCGG AACCCGAACC CGAACCCGAA 120

CCCGAACCCG AGTCCGAGCC CGAGCCCGAA CCTGAACTGG TAGAAGCTGA GGCGGCCGAG 180

GCTTCGGTAG AGGAACCTGG GGAGGAGGCG GCCACGGTAG CCGCGACGGA GGAGGGGGAC 240

CAGGAGCAAG ACCCGGAGCC TGAGGAGGAG GCGGGTGAGG AGGAGGAGGA GGAGGAGGAG 300

GCGGCGGCAA CGGTGGCGGC AGCCCCGGGG CACTCGGCCG TGCCGCCGCC GCCGCAGCCC 360

CAGCTGCCGC CTTTGCCCCT GCTCCCGCGA CCGCTGTCAG AGCGCATCAC CCGCGAGGAG 420

GTGGAGGGCG AAAGCCTGGA CCTGTGCCTG CAGCAGCTCT ACAAATATAA TTGCCCTTCC 480

TTTTTGGCTG CTGCTTTAGC CAGAGCCACA TCAGATGAAG TCCTTCAGAG TGATCTTTCT 540

GCACATTATA TCCCAAAGGA AATGGATGGC ACAGAAGGGA CTGTGGAGAT TGAGACAGTG 600

AAATTGGCCC GTTCAGTCTT CAGCAAACTA CACGAGATTT GCTGCAGCTG GGTGAAAGAC 660

TTCCCCCTCC GCAGGAGACC CAAGCTTTAT TATGAGACAT CAATCCATGC CATCAAAAAC 720

ATGCGCAGGA AAATGGAGGA CAAACATGTC TGCATTCCTG ACTTTAATAT GCTCTTCAAC 780

CTAGAGGACC AGGAAGAACA AGCTTACTTT GCAGTGTTTG ATGGCCATGG GGGAGTAGAT 840

GCTGCTATTT ATGCCTCCAT TCACCTCCAC GTTAACTTAG TCCGCCAGGA GATGTTTCCC 900

CATGATCCTG CTGAGGCCCT GTGCAGGGCC TTCCGGGTCA CTGATGAGCG GTTTGTGCAG 960

AAAGCAGCCA GGGAGAGCTT GAGATGTGGG ACCACAGGAG TGGTGACTTT CATCAGAGGC 1020

AACATGCTAC ATGTGGCCTG GGTGGGTGAT TCCCAGGTTA TGCTTGTGAG AAAGGGCCAA 1080

GCTGTTGAAC TAATGAAGCC ACACAAACCA GACAGAGAGG ATGAAAAGCA GAGAATTGAG 1140

GCCCTTGGAG GTTGCGTAGT CTGGTTTGGT GCCTGGAGGG TGAATGGAAG TCTGTCGGTC 1200

TCCAGAGCTA TTGGAGATGC TGAACATAAG CCATATATCT GTGGGGATGC AGATTCTGCC 1260

TCCACTGTTC TGGATGGGAC CGAAGACTAC CTCATTCTGG CCTGTGATGG CTTCTATGAC 1320

ACCGTGAACC CTGATGAGGC AGTGAAAGTT GTGTCCGACC ACCTGAAAGA GAATAACGGA 1380

GACAGCAGCA TGGTTGCCCA CAAATTAGTG GCATCAGCTC GTGATGCTGG GTCAAGTGAT 1440

AACATCACGG TTATTGTGGT ATTCCTGAGG GACATGAACA AAGCTGTAAA TGTTAGTGAG 1500

GAATCAGATT GGACAGAGAA CTCTTTTCAA GGAGGGCAAG AAGATGGTGG GGATGATAAG 1560

GAGAATCACG GAGAGTGCAA ACGCCCTTGG CCTCAGCACC AGTGCTCAGC ACCAGCCGAC 1620

CTAGGCTATG ATGGGCGTGT GGATTCATTC ACTGATAGAA CTAGCCTGAG CCCAGGGTCC 1680

CAAATCAACG TGCTGGAAGA CCCAGGCTAC CTAGATCTCA CACAAATAGA AGCAAGCAAA 1740

CCTCACAGTG CCCAGTTTTT GCTACCAGTT GAGATGTTTG GTCCTGGTGC ACCAAAGAAA 1800

GCAAATCTTA ATGAGTTAAT GATGGAGAAA AAATCAGTTC AGTCATCATT GCCTGAATGG 1860

AGTGGTGCTA GAGAGTTTCC CACTGCTTTC AATTTGGGTT CAACAGGAGA GCAGATATAC 1920

AGAATGGAGA GCTTGTCTCC TGTCTGTTCA GGGTTGGAAA ATGAACAGTT CAAATCCCTG 1980

GGAAACAGAG TTTCTAGATT GTCTCATTTA CGCCACCACT ACTCAAAGAA GTGGCACAGA 2040

TTCAGGTTTA ATCCAAAGTT TTATTCATTT CTCTCTGCTC AAGAGCCTTC CCACAAAATA 2100

GGCACTAGCC TGTCCTCACT TACTGGAAGT GGGAAGAGAA ATAGGATAAG AAGTTCTCTG 2160

CCATGGAGGC AAAATAGTTG GAAAGGGTAC AGTGAAAACA TGAGGAAGCT CAGAAAGACT 2220

CATGATATTC CATGCCCAGA TCTTCCTTGG AGCTATAAAA TAGAATAA 2268

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 234   SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNL  293

         567899**************99766555544459************************99

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 294   VRQEM----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  347

         99955....6788888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         vGdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 348   VGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  406

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+  +++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 407   AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVA  466

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 467   HKLVASARDAGSSDNITVIVV  487

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNL 60

VRQEMFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWVGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGTEDYLIL ACDGFYDTVN PDEAVKVVSD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013