EKS-NOL-00393

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00393

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	381.9	1.7E-114	16	277	262

Status

Unreviewed

Ensembl Protein

ENSNLEP00000010351

UniProt Accession

G1RAV4;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK1

Gene Synonyms/Alias

ULK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000008460	ENSNLEP00000010351	ENSNLET00000010858

Organism

Nomascus leucogenys

Functional Description

Protein Length

1049

Protein Sequence
(FASTA)

MEPGRGGTET VGKFEFSRKD LIGHGAFAVV FKGRHREKHD LEVAVKCINK KNLAKSQTLL 60

GKEIKILKEL KHENIVALYD FQEMANSVYL VMEYCNGGDL ADYLHTMRTL SEDTIRLFLQ 120

QIAGAMRLLH SKGIIHRDLK PQNILLSNPA GRRANPNSIR VKIADFGFAR YLQSNMMAAT 180

LCGSPMYMAP EVIMSQHYDG KADLWSIGTI VYQCLTGKAP FQASSPQDLR LLYEKNKTLV 240

PTIPRETAPL RQLLLALLQC NHKDRMDFDE FFHHPFLDAS PSVRKSPPVP VPSYPSSGSG 300

SSSSSSSTSH LASPPSLGEM QQLQKTLTSP ADTAGFLHSS RDSGGSKDSS CDTDDFVMVP 360

AQFPGDLVAE APSAKPPPDS LMCSGSSLVA SAGLESHGRT PSPSPPCSSS PSPSGRAGPF 420

SSSRCGASVP IPVPTQVQNY QRIERNLQSP TQFQTPRSSA IRRSGSTSPL GFARASPSPP 480

AHAEHGGVLA RKMSPGGGRP YMPSPQVGTI PERPGWSGTP SLQGAEMRGG RSPRPGSSAP 540

EHSTRTPGLG CRLHSAPNLS DLHVVRPKLP KPPTDPLGAM FSPPQASPPQ PSHGLQSCRN 600

LRGSPKLPDF LQRNPLPPIL GSPTKAVPSF DFPKTPSSQN LLALLARQGV VMTPPRNRTL 660

PDLSEVGPFH GQPLGPGLRP GEDPKGPFGR SFSTSRLTDL LLKAAFGTQA PDPGSTESLQ 720

EKPMEIAPSA GFGGSLHPGA RAGGASSPSP VVFTVGSPPS GSTPPQGPRT RMFSVGSTGS 780

AGSSARHLVP GACSEAPAPE LPAPGHGCSF ADPIAANLEG AVTFEAPDLP EETLMEQEHT 840

EILRGLRFTL LFVQHVLEIA ALKGSASEAA GGPEYQLQES VVADQISLLS REWGFAEQLV 900

LYLKVAELLS SGLQTAIDQI RAGKLCLSST VKQVVRRLNE LYKASVVSCQ GLSLRLQRFF 960

LDKQRLLDRI HSITAERLIF SHAVQMVQSA ALDEMFQHRE GCVPRYHKAL LLLEGLQHML 1020

SDQADIENVA KCKLCIERRL SALLTGICA 1049

Nucleotide Sequence
(FASTA)

ATGGAGCCCG GCCGCGGCGG CACAGAGACC GTGGGCAAGT TCGAGTTCTC CCGCAAGGAC 60

CTGATCGGCC ACGGCGCCTT CGCGGTGGTC TTCAAGGGCC GCCACCGCGA GAAGCACGAT 120

TTGGAGGTCG CCGTCAAGTG CATTAACAAG AAAAACCTCG CCAAGTCTCA GACGCTGCTG 180

GGGAAGGAAA TCAAAATCTT GAAGGAACTG AAACATGAAA ACATCGTGGC CCTGTACGAC 240

TTCCAGGAAA TGGCTAATTC TGTCTACCTG GTTATGGAGT ACTGCAACGG TGGGGACCTG 300

GCCGACTACC TGCACACCAT GCGCACGCTG AGCGAGGACA CCATCAGGCT CTTCCTGCAG 360

CAGATCGCGG GCGCCATGCG GCTTCTGCAC AGCAAGGGCA TCATCCACCG CGACCTGAAG 420

CCGCAGAACA TCCTGCTGTC CAACCCTGCC GGCCGCCGCG CCAACCCCAA CAGCATCCGC 480

GTCAAGATCG CTGACTTCGG CTTCGCGCGG TACCTCCAGA GCAACATGAT GGCGGCCACA 540

CTCTGCGGCT CCCCCATGTA CATGGCCCCC GAGGTCATCA TGTCCCAGCA CTACGACGGG 600

AAGGCGGACC TGTGGAGCAT CGGCACCATC GTCTACCAGT GCCTGACGGG GAAGGCGCCC 660

TTCCAGGCCA GCAGCCCCCA GGACCTGCGC CTGTTGTACG AGAAGAACAA GACGTTGGTC 720

CCCACCATCC CCCGGGAGAC CGCCCCACTG CGGCAGCTGC TCCTGGCCCT GCTGCAGTGC 780

AACCACAAGG ACCGCATGGA CTTCGATGAG TTTTTCCATC ACCCTTTCCT CGACGCCAGC 840

CCCTCGGTCA GGAAATCCCC ACCTGTGCCT GTGCCCTCGT ACCCAAGCTC GGGGTCCGGC 900

AGCAGCTCCA GCAGCAGCTC CACCTCCCAC CTGGCCTCCC CGCCGTCCCT GGGCGAGATG 960

CAGCAGCTGC AGAAGACACT GACCTCCCCG GCTGACACCG CTGGCTTCCT GCACAGCTCC 1020

CGGGACTCTG GTGGCAGCAA GGACTCCTCC TGTGACACAG ACGACTTCGT CATGGTCCCT 1080

GCGCAGTTTC CAGGTGACCT GGTGGCTGAG GCGCCCAGTG CCAAACCCCC GCCGGACAGC 1140

CTAATGTGCA GTGGGAGTTC ACTGGTGGCC TCTGCGGGCT TGGAGAGCCA CGGCCGGACC 1200

CCATCTCCAT CCCCACCCTG CAGCAGCTCC CCCAGTCCCT CAGGCCGGGC TGGCCCGTTC 1260

TCCAGCAGCA GGTGCGGCGC CTCTGTCCCC ATTCCAGTCC CCACGCAGGT GCAGAACTAC 1320

CAGCGCATTG AGCGAAACCT GCAGTCACCC ACCCAGTTCC AAACACCTCG GTCCTCTGCC 1380

ATCCGCAGGT CAGGCAGCAC CAGCCCCCTG GGCTTTGCAA GGGCCAGCCC CTCACCCCCT 1440

GCCCACGCTG AGCATGGAGG CGTCCTGGCC AGGAAGATGT CTCCGGGTGG AGGCCGGCCC 1500

TACATGCCAT CCCCTCAAGT TGGAACCATC CCTGAGCGGC CAGGCTGGAG CGGGACGCCC 1560

TCCCTACAGG GAGCTGAGAT GCGGGGTGGC AGGTCCCCTC GTCCAGGCTC CTCTGCACCC 1620

GAGCACTCTA CCCGCACTCC TGGGCTGGGC TGCCGCCTGC ACAGCGCCCC CAACCTGTCT 1680

GACTTGCACG TCGTCCGTCC CAAGCTGCCC AAACCTCCCA CGGACCCCCT GGGAGCCATG 1740

TTCAGCCCAC CACAGGCCAG CCCTCCCCAG CCGTCCCACG GGCTGCAGTC CTGCCGGAAC 1800

CTGCGGGGCT CACCCAAACT GCCCGACTTC CTGCAACGAA ACCCCCTGCC CCCCATCCTG 1860

GGCTCCCCTA CCAAGGCTGT GCCCTCCTTC GACTTCCCAA AGACCCCCAG CTCCCAGAAC 1920

CTGCTGGCCC TCCTAGCCCG GCAGGGCGTG GTGATGACGC CCCCTCGAAA CCGGACGCTG 1980

CCCGACCTCT CTGAGGTGGG ACCCTTCCAC GGTCAGCCGC TGGGCCCTGG CCTGCGGCCA 2040

GGCGAGGACC CCAAGGGTCC CTTTGGCCGG TCTTTCAGCA CCAGCCGCCT CACTGACCTG 2100

CTCCTTAAGG CGGCGTTTGG GACACAAGCC CCAGACCCGG GCAGCACAGA GAGCCTGCAG 2160

GAGAAGCCCA TGGAGATCGC ACCCTCAGCT GGCTTTGGAG GGAGCCTGCA CCCAGGAGCC 2220

CGTGCTGGGG GCGCCAGCAG CCCCTCCCCG GTAGTCTTCA CCGTGGGCTC TCCCCCGAGC 2280

GGGAGCACGC CGCCCCAGGG CCCCCGCACC AGGATGTTCT CAGTGGGCTC CACTGGCTCT 2340

GCTGGCTCTT CTGCCCGCCA CCTGGTGCCT GGGGCCTGCA GCGAGGCCCC AGCCCCTGAG 2400

CTCCCTGCTC CAGGACACGG CTGCAGCTTT GCCGACCCCA TTGCTGCGAA CCTGGAGGGC 2460

GCTGTGACCT TCGAGGCCCC CGACCTCCCT GAGGAGACCC TCATGGAGCA AGAGCACACC 2520

GAGATCCTGC GTGGTCTGCG CTTCACGCTG CTGTTCGTGC AGCACGTCTT GGAGATTGCA 2580

GCCCTGAAGG GCAGTGCCAG CGAGGCGGCC GGGGGCCCTG AGTACCAGCT GCAGGAGAGT 2640

GTGGTGGCCG ACCAGATCAG CCTGCTGAGC CGAGAATGGG GCTTCGCGGA ACAGCTGGTG 2700

CTGTACCTGA AGGTGGCCGA GCTACTGTCC TCCGGCCTTC AAACTGCCAT CGACCAGATC 2760

CGGGCTGGCA AGCTCTGCCT GTCGTCCACC GTGAAGCAGG TGGTGCGCAG GCTGAATGAG 2820

CTGTACAAGG CCAGCGTGGT GTCCTGCCAG GGCCTGAGCC TGCGGCTGCA GCGCTTCTTC 2880

CTGGACAAGC AGCGGCTCCT GGACCGCATC CACAGCATCA CTGCCGAGAG GCTCATCTTC 2940

AGCCATGCTG TGCAGATGGT GCAGTCGGCT GCCCTGGACG AGATGTTCCA GCACCGTGAG 3000

GGCTGTGTCC CGCGCTACCA CAAGGCCCTG CTGCTCCTGG AGGGGCTGCA GCACATGCTC 3060

TCGGACCAGG CTGACATCGA GAACGTCGCC AAGTGCAAAC TGTGCATTGA ACGGAGACTC 3120

TCGGCGCTGC TGACTGGCAT CTGTGCCTGA 3150

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         +s ++ iG+G+favv+kgr+r+k++ +vA+k+++kk+l+ks++ l keikilkelkheni

Q: 16    FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI  75

         7889********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+d++e++++vylvmeyc+ggdLa++l+++++Lsedt+r flqq+a a+++Lhsk+i+

Q: 76    VALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGII  135

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLls+  +++ + +++++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 136   HRDLKPQNILLSNPAGRRaNPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMS  195

         ************99999999****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+yd kaDlWSiGti+y++l+Gk+Pf+a+s+++L+  +ekn++l p+ip+e+   l++ll

Q: 196   QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLLYEKNKTLVPTIPRETA-PLRQLL  254

         **************************************************986.69****

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLq ++k+R++f+e+f+hpfl

Q: 255   LALLQCNHKDRMDFDEFFHHPFL  277

         *********************96

Domain Sequence
(FASTA)

FSRKDLIGHG AFAVVFKGRH REKHDLEVAV KCINKKNLAK SQTLLGKEIK ILKELKHENI 60

VALYDFQEMA NSVYLVMEYC NGGDLADYLH TMRTLSEDTI RLFLQQIAGA MRLLHSKGII 120

HRDLKPQNIL LSNPAGRRAN PNSIRVKIAD FGFARYLQSN MMAATLCGSP MYMAPEVIMS 180

QHYDGKADLW SIGTIVYQCL TGKAPFQASS PQDLRLLYEK NKTLVPTIPR ETAPLRQLLL 240

ALLQCNHKDR MDFDEFFHHP FL 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005776	; C:autophagic vacuole
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0031175	; P:neuron projection development
GO:0016239	; P:positive regulation of macroautophagy
GO:0008104	; P:protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013