EKS-NOL-00418

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00418

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	430.4	2.9E-129	26	308	283

Status

Unreviewed

Ensembl Protein

ENSNLEP00000010961

UniProt Accession

G1RCL2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000008913	ENSNLEP00000010961	ENSNLET00000011495

Organism

Nomascus leucogenys

Functional Description

Protein Length

365

Protein Sequence
(FASTA)

MSLIRKKGLY KQDVNKTAWE LPKTYVSPTH VGSGAYGAVC SAIDKRSGEK VAIKKLSRPF 60

QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF HDFYLVMPFM QTDLQKIMGM 120

EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT 180

GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG 240

VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA 300

QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR 360

SGMKL 365

Nucleotide Sequence
(FASTA)

ATGAGCCTCA TCCGGAAAAA GGGCTTATAC AAGCAGGACG TCAACAAGAC CGCTTGGGAG 60

CTGCCCAAGA CCTACGTGTC CCCGACGCAC GTCGGCAGCG GGGCCTATGG CGCCGTGTGC 120

TCGGCCATCG ACAAGCGGTC AGGAGAGAAG GTGGCCATCA AGAAGCTGAG CCGGCCCTTT 180

CAGTCCGAGA TCTTCGCCAA GCGCGCCTAC CGGGAGCTGC TGCTGCTGAA GCATATGCAG 240

CATGAGAACG TCATTGGGCT CCTGGATGTC TTCACCCCAG CCTCCTCCCT GCGCAACTTC 300

CATGACTTCT ACCTGGTGAT GCCCTTCATG CAGACAGATC TGCAGAAGAT CATGGGGATG 360

GAGTTCAGTG AGGAGAAGAT CCAGTACCTG GTGTATCAGA TGCTCAAAGG CCTTAAGTAC 420

ATCCACTCGG CTGGGGTCGT GCACAGGGAC CTGAAGCCAG GCAACCTGGC TGTGAACGAG 480

GACTGTGAAC TGAAGATTCT GGATTTTGGG CTGGCGCGAC ATGCAGACGC CGAGATGACT 540

GGCTATGTGG TGACCCGCTG GTACCGGGCC CCCGAGGTGA TCCTCAGCTG GATGCACTAC 600

AACCAGACGG TGGACATCTG GTCTGTGGGC TGTATCATGG CAGAGATGCT GACAGGGAAA 660

ACTCTGTTCA AGGGGAAAGA TTACCTGGAC CAGCTGACCC AGATCCTGAA AGTGACCGGG 720

GTGCCTGGCA CGGAGTTTGT GCAGAAGCTG AACGACAAAG CGGCCAAATC CTACATCCAG 780

TCCCTGCCGC AGACCCCCAG GAAGGATTTC ACTCAGCTCT TCCCACGGGC CAGCCCCCAG 840

GCCGCGGACC TGCTGGAGAA GATGCTGGAG CTAGACGTGG ACAAGCGCCT GACAGCCGCG 900

CAGGCCCTCA CCCATCCCTT CTTTGAGCCC TTCCGGGACC CTGAGGAAGA GACGGAGGCC 960

CAGCAGCCGT TTGATGATTC CTTAGAACAC GAGAAACTCA CAGTGGATGA ATGGAAGCAG 1020

CACATCTACA AGGAGATTGT GAACTTCAGC CCCATTGCCC GGAAGGACTC GCGGCGCCGG 1080

AGTGGCATGA AGCTGTAG 1098

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNii  61

          s +++g+Gayg v+sa+dkr++e+vaikklsrpfq+e+ akr++REl llk+++heN+i

Q: 26    VSPTHVGSGAYGAVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI  85

         566899******************************************************

S: 62    klldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsa  121

          lldvftp+++l++++d+Ylv+ +m+tdL+k++ ++ +s+e+i++l+yq+l+glky+Hsa

Q: 86    GLLDVFTPASSLRNFHDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSA  144

         **********************************99.9**********************

S: 122   nviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkey  181

         +v+HrDlKP+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++ls+++y

Q: 145   GVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMHY  200

         **********************************....**********************

S: 182   tkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyik  241

         +++vDiWsvGCI+aE+ltgk+lf+gkd++dql++il+v+g p +ef++k++++ a++yi+

Q: 201   NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ  260

         ************************************************************

S: 242   slpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         slp++++kdf++lfp+as++a dLlek+L+ld dkR+++++aL+hp++

Q: 261   SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF  308

         **********************************************95

Domain Sequence
(FASTA)

VSPTHVGSGA YGAVCSAIDK RSGEKVAIKK LSRPFQSEIF AKRAYRELLL LKHMQHENVI 60

GLLDVFTPAS SLRNFHDFYL VMPFMQTDLQ KIMGMEFSEE KIQYLVYQML KGLKYIHSAG 120

VVHRDLKPGN LAVNEDCELK ILDFGLARHA DAEMTGYVVT RWYRAPEVIL SWMHYNQTVD 180

IWSVGCIMAE MLTGKTLFKG KDYLDQLTQI LKVTGVPGTE FVQKLNDKAA KSYIQSLPQT 240

PRKDFTQLFP RASPQAADLL EKMLELDVDK RLTAAQALTH PFF 283

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0006970	; P:response to osmotic stress

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013