EKS-NOL-00154
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00154
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb495.23.7E-149427684258
StatusUnreviewed
Ensembl ProteinENSNLEP00000011368
UniProt AccessionG1RDR9;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA1
Gene Synonyms/Alias RPS6KA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000009314ENSNLEP00000011368ENSNLET00000011927
OrganismNomascus leucogenys
Functional Description
Protein Length744
Protein Sequence
(FASTA)
MEQDPKPPRL RLWALLPWLP RKQRPRISQT SLPVPGPGSG PQRDSDEGVL KEISITHHVK 60
AGSEKADPSH FELLKVLGQG SFGKVFLVRK VTRPDSGHLY AMKVLKKATL KVRDRVRTKM 120
ERDILADVNH PFVVKLHYAF QTEGKLYLIL DFLRGGDLFT RLSKEVMFTE EDVKFYLAEL 180
ALGLDHLHSL GIIYRDLKPE NILLDEEGHI KLTDFGLSKE AIDHEKKAYS FCGTVEYMAP 240
EVVNRQGHSH SADWWSYGVL MFEMLTGSLP FQGKDRKETM TLILKAKLGM PQFLSTEAQS 300
LLRALFKRNP ANRLGSGPDG AEEIKRHVFY STIDWNKLYR REIKPPFKPA VAQPDDTFYF 360
DTEFTSRTPK DSPGIPPSAG AHQLFRGFSF VATGLMEDDG KPRAPQAPLH SVVQQLHGKN 420
LVFSDGYVVK ETIGVGSYSE CKRCVHKATN MEYAVKVIDK SKRDPSEEIE ILLRYGQHPN 480
IITLKDVYDD GKHVYLVTEL MRGGELLDKI LRQKFFSERE ASFVLHTIGK TVEYLHSQGV 540
VHRDLKPSNI LYVDESGNPE CLRICDFGFA KQLRAENGLL MTPCYTANFV APEVLKRQGY 600
DEGCDIWSLG ILLYTMLAGY TPFANGPSDT PEEILTRIGS GKFTLSGGNW NTVSETAKDL 660
VSKMLHVDPH QRLTAKQVLQ HPWVTQKDKL PQSQLSHQDL QLVKGAMAAT YSALNSSKPT 720
PQLKPIESSI LAQRRVRKLP STTL 744
Nucleotide Sequence
(FASTA)
ATGGAGCAGG ATCCCAAGCC GCCCCGTCTG CGGCTCTGGG CCCTGCTCCC CTGGCTGCCC 60
AGGAAGCAGC GGCCCAGGAT CAGCCAGACC TCTCTGCCTG TCCCTGGCCC TGGCTCTGGC 120
CCCCAGCGGG ACTCGGATGA GGGCGTCCTC AAGGAGATCT CCATCACGCA CCACGTCAAG 180
GCTGGCTCTG AGAAGGCTGA TCCATCCCAT TTCGAGCTCC TCAAGGTTCT GGGCCAGGGA 240
TCCTTTGGCA AAGTCTTCCT GGTGCGAAAA GTCACCCGGC CTGACAGTGG GCACCTGTAT 300
GCTATGAAGG TGCTGAAGAA GGCAACACTG AAAGTACGTG ACCGCGTCCG GACCAAGATG 360
GAGAGAGACA TCCTGGCCGA TGTAAATCAC CCATTCGTGG TGAAGCTGCA CTATGCCTTC 420
CAGACCGAGG GCAAGCTCTA TCTCATTCTG GACTTCCTGC GTGGTGGGGA CCTCTTCACA 480
CGGCTCTCAA AAGAGGTGAT GTTCACGGAG GAGGATGTGA AGTTTTATCT GGCCGAGCTG 540
GCTCTGGGCC TGGATCACTT GCACAGCCTG GGTATCATTT ACAGAGATCT CAAGCCTGAG 600
AACATCCTTC TGGATGAGGA GGGCCACATC AAACTCACTG ACTTTGGCCT GAGCAAGGAG 660
GCCATTGACC ATGAGAAGAA GGCCTACTCT TTCTGCGGGA CAGTGGAGTA CATGGCCCCC 720
GAGGTTGTCA ACCGCCAGGG CCACTCCCAC AGTGCGGATT GGTGGTCCTA TGGGGTGTTG 780
ATGTTTGAGA TGCTGACGGG CTCCCTGCCC TTCCAGGGGA AGGACCGGAA GGAGACCATG 840
ACACTGATTC TGAAGGCGAA GCTAGGCATG CCCCAGTTTC TGAGCACTGA AGCCCAGAGC 900
CTCTTGCGGG CCCTGTTCAA GCGGAATCCT GCCAACCGGC TCGGCTCCGG CCCTGATGGG 960
GCAGAGGAAA TCAAGCGGCA TGTCTTCTAC TCCACCATTG ACTGGAATAA GCTATACCGT 1020
CGGGAGATCA AGCCACCCTT CAAGCCAGCA GTGGCTCAGC CTGATGACAC CTTCTACTTT 1080
GACACTGAGT TCACGTCCCG TACACCCAAG GATTCCCCAG GCATCCCCCC TAGCGCTGGG 1140
GCCCATCAGC TGTTCCGGGG CTTCAGCTTC GTGGCCACCG GCCTGATGGA GGACGACGGC 1200
AAGCCTCGTG CCCCGCAGGC ACCCCTGCAC TCAGTGGTAC AGCAACTCCA TGGGAAGAAC 1260
CTGGTTTTTA GCGACGGCTA CGTGGTAAAG GAGACGATTG GTGTGGGCTC CTACTCTGAG 1320
TGCAAGCGCT GTGTCCACAA GGCCACCAAC ATGGAGTATG CTGTCAAGGT CATTGATAAG 1380
AGCAAGCGGG ATCCTTCAGA AGAGATTGAG ATTCTTCTGC GGTACGGCCA GCACCCCAAC 1440
ATCATCACTC TGAAAGATGT GTATGATGAT GGCAAACACG TGTACCTGGT GACAGAGCTG 1500
ATGCGGGGTG GGGAGCTGCT GGACAAGATC CTGCGGCAGA AGTTCTTCTC AGAGCGGGAG 1560
GCCAGCTTTG TCCTGCACAC CATCGGCAAA ACTGTGGAGT ATCTGCACTC ACAGGGGGTT 1620
GTGCACAGGG ACCTGAAGCC CAGCAACATC CTGTATGTGG ACGAATCCGG GAATCCCGAG 1680
TGCCTGCGCA TCTGTGACTT TGGTTTTGCC AAACAGCTGC GGGCTGAGAA TGGGCTCCTC 1740
ATGACACCTT GCTACACGGC CAACTTCGTG GCGCCCGAGG TGCTGAAGCG CCAGGGCTAC 1800
GATGAAGGCT GCGACATCTG GAGCCTGGGC ATTCTGCTCT ACACCATGCT GGCAGGATAC 1860
ACTCCATTTG CCAACGGTCC CAGTGACACA CCAGAGGAAA TCCTAACCCG GATTGGCAGT 1920
GGGAAGTTTA CCCTCAGTGG GGGAAATTGG AACACAGTTT CAGAGACAGC CAAGGACCTG 1980
GTGTCCAAGA TGCTACACGT GGATCCCCAC CAGCGCCTCA CAGCTAAGCA GGTTCTGCAG 2040
CATCCATGGG TCACCCAGAA AGACAAGCTT CCCCAAAGCC AGCTGTCCCA CCAGGACCTA 2100
CAGCTTGTGA AGGGAGCCAT GGCTGCCACG TACTCCGCAC TCAACAGCTC CAAGCCCACC 2160
CCCCAGCTGA AGCCCATTGA GTCATCCATC CTGGCCCAGC GGCGAGTGAG AAAGTTGCCA 2220
TCCACCACCC TGTGA 2235
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         y+vke++GvGsys ckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd
Q: 427   YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  486
         689*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelld+i+++kffsereas +l+t+ k+veylh+qGvvhrdlk
Q: 487   VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK  546
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+
Q: 547   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  606
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vse+akdlvsk+l+
Q: 607   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH  666
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl+++q+l+h+w+
Q: 667   VDPHQRLTAKQVLQHPWV  684
         *****************7
Domain Sequence
(FASTA)
YVVKETIGVG SYSECKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKHVYL VTELMRGGEL LDKILRQKFF SEREASFVLH TIGKTVEYLH SQGVVHRDLK 120
PSNILYVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180
WSLGILLYTM LAGYTPFANG PSDTPEEILT RIGSGKFTLS GGNWNTVSET AKDLVSKMLH 240
VDPHQRLTAK QVLQHPWV 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00153
EKS-ANC-00156
EKS-BOT-00160
EKS-CAE-00123
EKS-CAJ-00166
EKS-CAF-00167
EKS-CAP-00160
EKS-CII-00107
EKS-CIS-00193
EKS-DAR-00450
EKS-DRM-00076
EKS-EQC-00159
EKS-ERE-00040
EKS-FEC-00151
EKS-GAG-00138
EKS-GAA-00191
EKS-GOG-00161
EKS-HOS-00166
EKS-ICT-00155
EKS-LAC-00172
EKS-LOA-00161
EKS-MAM-00159
EKS-MAE-00059
EKS-MEG-00129
EKS-MIM-00076
EKS-MOD-00160
EKS-MUM-00165
EKS-MUP-00163
EKS-MYL-00171
EKS-ORN-00201
EKS-ORA-00139
EKS-ORC-00148
EKS-ORL-00188
EKS-OTG-00166
EKS-PAT-00151
EKS-PES-00143
EKS-PEM-00086
EKS-POA-00157
EKS-PRC-00043
EKS-RAN-00158
EKS-SAH-00155
EKS-SUS-00142
EKS-TAG-00190
EKS-TAR-00208
EKS-TEN-00200
EKS-TUT-00150
EKS-VIP-00076
EKS-XET-00151
EKS-XIM-00195
Gene Ontology
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0043066; P:negative regulation of apoptotic process
GO:2000491; P:positive regulation of hepatic stellate cell activation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013