EKS-NOL-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	394.8	1.6E-118	116	376	261

Status

Unreviewed

Ensembl Protein

ENSNLEP00000011450

UniProt Accession

G1RE00;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000009405	ENSNLEP00000011450	ENSNLET00000012012

Organism

Nomascus leucogenys

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

MLPEAGSLWL LKLLRDIQLA QFYWPILEEL NVTRPEHFDF VKPEDLDGIG MGRPAQRRLS 60

EALKRLRSGP KSKNWVYKIL GGFAPEHKEP TLPSDSPRHL PEPEGGLKCL IPEGAVCRGE 120

LLGSGCFGVV HRGLWTLPSG KSVPVAVKSL RVGPEGPMGT ELGDFLREVS VMMNLEHPHV 180

LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPPLLVA LLCLFLRQLA GAMAYLGARG 240

LVHRDLATRN LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRHGAF 300

SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEDRA RLPRPPLCSR ALYSLALHCW 360

APHPADRPSF SHLEGLLQEA WPSEGCCVKD VTEPGALRME TGDPITVIEG SSSFHSPDST 420

IWKGQNGRTF KVGSFPASAV TLADAGGLPA TRPVHRGTPA RGDQHPGGID GDRKKANLWD 480

APPARGQRRN VPLERMKGIS RSLESVLSLG PRPTGGGSSP PEIRQARAVP QGPPGLPPRP 540

PLSSSSPQPS QPPRERLPWP KRKPPHNHPM GAPGTSKAAA LSGGLLPDPE LQRKIMEVEL 600

SVHGVTHQEC QTALGATGGD VVSAIRNLKV DQLFHLSSRS RADCRRILEH YQWDLSAASR 660

YVLARP 666

Nucleotide Sequence
(FASTA)

ATGCTTCCTG AGGCCGGCTC CCTGTGGCTA CTGAAGCTGC TCCGGGACAT CCAGTTGGCC 60

CAGTTTTACT GGCCCATCCT TGAGGAGCTT AATGTCACTC GGCCAGAGCA CTTCGACTTT 120

GTAAAGCCCG AGGACCTGGA CGGCATTGGC ATGGGTCGGC CTGCCCAGCG CAGACTGTCT 180

GAAGCTCTGA AACGGCTACG TTCCGGGCCT AAGTCTAAGA ACTGGGTCTA CAAGATCCTT 240

GGAGGTTTTG CCCCTGAACA CAAGGAGCCC ACCCTGCCCT CGGACAGCCC ACGGCACCTC 300

CCTGAGCCAG AGGGGGGCCT CAAGTGTCTG ATCCCAGAGG GTGCTGTTTG CAGAGGGGAG 360

CTGCTGGGTT CTGGCTGCTT CGGTGTGGTG CACCGAGGGC TGTGGACGCT GCCCAGTGGC 420

AAGAGTGTCC CAGTGGCGGT CAAGTCCCTC CGGGTAGGTC CCGAAGGCCC GATGGGCACA 480

GAACTGGGGG ACTTCCTGAG AGAGGTATCG GTCATGATGA ACTTGGAGCA CCCACACGTG 540

CTGCGTCTGC ACGGCCTTGT ACTGGGCCAG CCTCTGCAGA TGGTGATGGA GCTGGCGCCA 600

CTGGGCTCCC TGCACGCGCG CCTAACGGCC CCGGCCCCGA CACCCCCGCT GCTCGTGGCC 660

CTGCTCTGCC TCTTCCTGCG GCAGCTGGCG GGAGCCATGG CGTACCTGGG GGCCCGCGGG 720

CTGGTGCACC GAGACCTCGC TACGCGCAAC CTGCTGCTGG CGTCGCCGCG CACCATCAAG 780

GTGGCTGACT TCGGGCTGGT GCGGCCTCTG GGCGGTGCCC GGGGCCGCTA CGTCATGGGC 840

GGGCCCCGCC CCATCCCCTA CGCCTGGTGT GCCCCAGAGA GCCTGCGCCA CGGAGCCTTC 900

TCGTCTGCCT CGGACGTGTG GATGTTTGGG GTGACGCTGT GGGAGATGTT CTCCGGGGGC 960

GAGGAACCCT GGGCCGGGGT CCCACCGTAC CTCATCCTGC AGCGGCTGGA GGACAGAGCC 1020

CGGCTGCCTA GGCCTCCCCT CTGCTCCAGG GCCCTCTACT CCCTCGCCTT GCACTGCTGG 1080

GCCCCCCACC CTGCCGACCG GCCTAGCTTT TCCCACCTGG AGGGGCTGCT GCAAGAGGCC 1140

TGGCCTTCGG AAGGATGCTG TGTGAAGGAT GTCACAGAGC CAGGCGCCCT GAGGATGGAG 1200

ACTGGTGACC CCATCACAGT CATCGAGGGC AGCTCCTCTT TCCACAGCCC CGACTCCACA 1260

ATCTGGAAGG GCCAGAATGG TCGCACCTTC AAAGTGGGCA GCTTCCCAGC CTCGGCGGTG 1320

ACGCTGGCAG ATGCGGGGGG CTTGCCAGCC ACCCGTCCAG TCCACAGAGG CACCCCTGCC 1380

CGGGGAGATC AACACCCAGG AGGCATAGAT GGAGACAGAA AGAAGGCAAA TCTTTGGGAT 1440

GCGCCCCCAG CACGGGGCCA GAGGAGGAAT GTGCCCCTGG AGAGGATGAA AGGCATTTCC 1500

AGGAGTCTGG AGTCAGTTCT GTCCCTGGGT CCTCGTCCCA CAGGGGGTGG TTCAAGCCCC 1560

CCCGAAATTC GACAAGCCAG AGCTGTGCCC CAGGGACCCC CAGGCCTGCC TCCACGCCCA 1620

CCTTTATCCT CTAGCTCTCC TCAGCCCAGC CAGCCCCCTA GGGAGAGGCT TCCCTGGCCC 1680

AAAAGAAAAC CCCCACACAA TCACCCCATG GGAGCACCTG GAACCAGTAA AGCCGCTGCC 1740

CTCTCTGGAG GCCTCCTGCC CGATCCTGAG TTGCAGAGGA AGATTATGGA GGTGGAGCTG 1800

AGTGTGCATG GCGTCACCCA CCAGGAGTGC CAGACAGCAC TAGGAGCCAC TGGGGGAGAT 1860

GTGGTTTCTG CCATCCGGAA CCTCAAGGTA GACCAGCTCT TCCACCTGAG TAGCCGGTCC 1920

AGAGCTGACT GCCGGCGCAT CCTGGAGCAT TACCAGTGGG ACCTCTCAGC TGCCAGCCGC 1980

TATGTCCTAG CCAGGCCCTG A 2001

Domain Profile

S: 1     iklleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkl  58

         ++++e+lG+G+fgvv+rg W+ psgksv+vavk+l+  ++  ++tel+dflrevsv+++l

Q: 116   VCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRvgPEGPMGTELGDFLREVSVMMNL  175

         56889******************************9999*********************

S: 59    ehenlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglay  118

         eh++++rl+G+vl+qpl++v+ela+lgsl++rl+++a +++llvall+ +++q+a ++ay

Q: 176   EHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAY  235

         ************************************************************

S: 119   leskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPesl  178

         l+++ lvhrdla+rnlllas++++k++dfGlvr+lg ++++yv+  ++++P+aWcaPesl

Q: 236   LGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESL  295

         ************************************************************

S: 179   rtrkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediys  238

         r+ +fssasdvW+fGvtlWemfs GeePW+g++++ il++++ +++rl++P++c++++ys

Q: 296   RHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE-DRARLPRPPLCSRALYS  354

         ******************************************.9****************

S: 239   lllkcWakkpadrpkfsalkek  260

         l+l+cWa +padrp+fs+l++

Q: 355   LALHCWAPHPADRPSFSHLEGL  376

         *******************976

Domain Sequence
(FASTA)

VCRGELLGSG CFGVVHRGLW TLPSGKSVPV AVKSLRVGPE GPMGTELGDF LREVSVMMNL 60

EHPHVLRLHG LVLGQPLQMV MELAPLGSLH ARLTAPAPTP PLLVALLCLF LRQLAGAMAY 120

LGARGLVHRD LATRNLLLAS PRTIKVADFG LVRPLGGARG RYVMGGPRPI PYAWCAPESL 180

RHGAFSSASD VWMFGVTLWE MFSGGEEPWA GVPPYLILQR LEDRARLPRP PLCSRALYSL 240

ALHCWAPHPA DRPSFSHLEG L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013