EKS-NOL-00349

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00349

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	293.3	1.6E-87	564	820	257

Status

Unreviewed

Ensembl Protein

ENSNLEP00000011583

UniProt Accession

G1RED3;

Protein Name

Protein Synonyms/Alias

Gene Name

TNNI3K

Gene Synonyms/Alias

TNNI3K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000009478	ENSNLEP00000011583	ENSNLET00000012156

Organism

Nomascus leucogenys

Functional Description

Protein Length

936

Protein Sequence
(FASTA)

MAAARDPPEV SLREATQRKL RRFSELRGKL VAPGEFWDIV AITAADEKQE LAYNQQLSEK 60

LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSDEWKKK 120

VSESYVITIE RLEEDLQIKE KELTEWNVFF SSDEAFSKVN LNYRTENGLS LLHLCCICGG 180

NKSHIRTLML KGLRPSRLTR NGFTALHLAV YKDNAELITS LLHSGADIQQ VGYGGLTALH 240

IATIAGHLEA ADVLLQHGAN VNIQDAVFFT PLHIAAYYGH EQVTRLLLKF GADVNVSGEV 300

GDRPLHLASA KGFLNIAKLL TEEGSKADVN AQDNEDHVPL HFCSRFGHHD IVKYLLQSDL 360

EVQPHVVNIY GDTPLHLACY NGKFEVAKEI IQISGTESLT KENIFSETAF HSACTYGKSI 420

DLVKFLLDQN VININHQGRD GHTGLHSACY HGHIRLVQFL LDNGADMNLV ACDPSRSSGE 480

KDEQTCLMWA YEKGHDAIVT LLKHYKRPQD ELPCNEYSQP GGDGSYVSVP SPLGKIKSMT 540

KEKADILLLR AGLPSHFHLQ LSEIEFHEII GSGSFGKVYK GRCRNKIVAI KRYRANTYCS 600

KSDVDMFCRE VSILCQLNHP CVIQFVGACL NDPSQFAIVT QYISGGSLFS LLHEQKRILD 660

LQSKLIIAVD VAKGMEYLHN LTQPIIHRDL NSHNILLYED GHAVVADFGE SRFLQSLDED 720

NMTKQPGNLR WMAPEVFTQC TRYTIKADVF SYALCLWEIL TGEIPFAHLK PAAAAADMAY 780

HHIRPPIGYS IPKPISSLLI RGWNAYPEGR PEFSEVVMKL EECLCNIEPM SPASSNSSGS 840

LSPSPSSDCL VSRGGPGRSH VAALRSRFEL EYALNARSYA ALSQSAGQYS SQGLSLEEMK 900

RSLQYTPIDK YGYVSDPMSP MHFHSCRNSS SFEDSS 936

Nucleotide Sequence
(FASTA)

ATGGCAGCTG CTAGGGACCC TCCGGAAGTA TCGCTGCGAG AAGCCACCCA GCGAAAATTG 60

CGGAGGTTTT CCGAGCTAAG AGGCAAACTT GTAGCACCTG GAGAATTCTG GGACATAGTT 120

GCAATAACAG CGGCTGATGA AAAACAGGAA CTTGCTTACA ACCAACAGCT GTCAGAAAAG 180

CTGAAAAGAA AGGAGTTACC CCTTGGAGTT CAATATCACG TTTTTGTAGA TCCTGCTGGA 240

GCCAAAATTG GAAATGGAGG ATCAACACTT TGTGCCCTTC AATGTTTGGA AAAGCTATAT 300

GGAGATAAAT GGAATTCTTT TACCATCTTA TTAATTCACT CTGATGAATG GAAGAAAAAA 360

GTCAGTGAAT CATATGTTAT CACAATAGAA AGATTAGAAG AAGACCTGCA GATCAAGGAA 420

AAAGAACTGA CAGAATGGAA TGTTTTTTTC AGCTCTGATG AAGCCTTCAG TAAAGTCAAT 480

TTAAATTACC GCACTGAAAA TGGGTTGTCT CTACTTCATT TATGTTGCAT TTGTGGAGGC 540

AACAAATCAC ATATTCGAAC TCTTATGTTA AAAGGGCTCC GCCCATCTCG ACTGACAAGA 600

AATGGATTTA CAGCCTTGCA TTTAGCAGTT TACAAGGATA ATGCAGAATT GATCACTTCT 660

CTGCTTCACA GTGGAGCTGA TATACAGCAG GTTGGATACG GTGGCCTCAC TGCCCTCCAT 720

ATTGCTACAA TAGCTGGCCA CCTAGAGGCT GCTGATGTGC TGTTGCAACA TGGAGCTAAT 780

GTCAATATTC AAGATGCAGT TTTTTTCACC CCATTGCACA TTGCAGCGTA CTATGGGCAT 840

GAACAGGTAA CTCGCCTTCT TTTGAAATTT GGTGCTGATG TAAATGTAAG TGGTGAAGTT 900

GGAGATAGAC CCCTCCACCT AGCATCTGCA AAAGGATTCT TGAATATTGC AAAACTCTTA 960

ACGGAAGAAG GCAGCAAAGC AGATGTGAAT GCCCAAGATA ATGAAGACCA TGTCCCACTC 1020

CATTTCTGTT CTCGATTTGG ACACCATGAT ATAGTTAAGT ATCTGCTGCA AAGTGATTTG 1080

GAAGTTCAAC CTCATGTTGT TAATATCTAT GGAGATACCC CCTTGCACCT GGCATGCTAC 1140

AATGGCAAAT TTGAAGTTGC CAAGGAAATC ATCCAAATAT CAGGAACAGA AAGTCTGACT 1200

AAGGAAAACA TCTTCAGTGA AACAGCTTTT CATAGTGCTT GTACCTATGG CAAGAGCATT 1260

GACCTAGTCA AATTTCTTCT TGATCAGAAT GTCATAAACA TCAACCACCA AGGAAGGGAT 1320

GGGCACACTG GATTACACTC TGCTTGCTAC CACGGTCACA TTCGCCTGGT TCAGTTCTTA 1380

CTGGATAATG GAGCTGATAT GAATCTAGTG GCTTGTGATC CCAGCAGGTC TAGTGGTGAA 1440

AAAGATGAGC AGACATGTTT GATGTGGGCT TATGAAAAAG GGCATGATGC CATTGTCACA 1500

CTCCTGAAGC ATTATAAGAG ACCGCAAGAT GAATTGCCCT GTAATGAATA TTCTCAGCCT 1560

GGAGGAGATG GCTCCTATGT GTCTGTTCCA TCACCCTTGG GGAAGATTAA AAGTATGACA 1620

AAAGAGAAGG CAGATATTCT CCTCCTAAGA GCTGGATTGC CTTCACATTT CCATCTTCAG 1680

CTCTCAGAAA TTGAGTTCCA TGAGATTATT GGCTCAGGTT CTTTTGGGAA AGTATATAAA 1740

GGACGATGCA GAAATAAAAT AGTGGCTATA AAACGTTATC GAGCCAATAC CTACTGCTCC 1800

AAGTCAGATG TGGATATGTT TTGCCGAGAG GTGTCCATTC TCTGCCAGCT CAATCATCCC 1860

TGTGTAATTC AGTTTGTGGG CGCTTGCTTG AATGATCCCA GCCAGTTTGC CATTGTCACT 1920

CAATACATAT CAGGGGGTTC TCTGTTCTCC CTCCTTCATG AGCAGAAGAG GATTCTTGAT 1980

TTGCAGTCTA AATTAATTAT TGCAGTAGAT GTTGCCAAAG GCATGGAGTA CCTTCACAAC 2040

CTGACACAGC CAATTATACA TCGTGACTTG AACAGTCACA ATATTCTTCT CTATGAGGAC 2100

GGGCATGCTG TGGTGGCAGA TTTTGGAGAA TCAAGATTTC TACAGTCTCT GGATGAAGAC 2160

AACATGACAA AACAACCTGG GAACCTCCGT TGGATGGCTC CTGAGGTGTT CACGCAGTGC 2220

ACTCGGTACA CCATCAAAGC AGACGTCTTC AGCTACGCTC TGTGTCTGTG GGAAATTCTC 2280

ACTGGCGAAA TTCCATTTGC TCATCTCAAG CCAGCGGCTG CGGCAGCAGA CATGGCTTAC 2340

CACCACATCA GACCTCCCAT TGGCTATTCC ATTCCCAAGC CCATATCATC TCTGCTGATA 2400

CGAGGGTGGA ACGCATATCC TGAAGGAAGA CCCGAGTTTT CTGAAGTTGT CATGAAGTTA 2460

GAAGAGTGTC TCTGCAACAT TGAGCCGATG TCTCCTGCAT CAAGTAACAG CAGTGGGTCT 2520

CTCTCACCTT CCCCTTCTTC TGATTGCCTG GTGAGCCGGG GAGGACCTGG CCGGAGTCAT 2580

GTGGCAGCTT TAAGAAGTCG TTTCGAATTG GAATATGCTC TAAATGCAAG GTCCTATGCT 2640

GCTTTGTCCC AAAGTGCTGG ACAATATTCC TCTCAAGGTC TGTCTTTGGA GGAGATGAAA 2700

AGAAGTCTTC AGTATACACC CATTGACAAA TATGGCTATG TATCCGATCC CATGAGCCCC 2760

ATGCATTTTC ATTCCTGCCG AAATAGTAGC AGCTTTGAGG ACAGCAGCTG A 2811

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 564   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCQLNHPCVI  623

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr +dl+  + +a+++A+Gm+YLh+ +

Q: 624   QFVGACLNDPSqFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLT  682

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 683   Q-PIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  740

         6.9*************.9*****************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWe+lt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 741   TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLI  800

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn+ pe Rp+fse+v++l

Q: 801   RGWNAYPEGRPEFSEVVMKL  820

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCQLNHPCVI 60

QFVGACLNDP SQFAIVTQYI SGGSLFSLLH EQKRILDLQS KLIIAVDVAK GMEYLHNLTQ 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWEILTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PISSLLIRGW 240

NAYPEGRPEF SEVVMKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 3.
PF12796	; Ank_2; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013