EKS-NOL-00194

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00194

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	464.0	1.3E-139	13	297	285

Status

Unreviewed

Ensembl Protein

ENSNLEP00000023831

UniProt Accession

G1REY2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000009674	ENSNLEP00000023831	ENSNLET00000032208
ENSNLEG00000009674	ENSNLEP00000011782	ENSNLET00000012362

Organism

Nomascus leucogenys

Functional Description

Protein Length

960

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS AKRKPYHVES STLSNRNQAG KSTALQSHHR SNSKDIQNLS VGLPRADEGI 360

PANESFLNGN LAGASLSPLH TKTYQASSQP GSTSKDLTNN NIPHLLSPKE AKSKTEFDFN 420

IDPKPSEGPG TKYLKSNSRS QQNRHSFMES SQSKAGTLQP NEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSEARAQIAE PSTSRYFPSS CLDLNSPTSP TPTRHGDTRT 540

LLSPSGRNNR NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

RSSVKETSRE GTSSFHTRQK SEGGVYHDPH SDDGTAPKEN RHLYNDPVPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SESSSGTNHS KRQPAFDPWK SPENISHSEQ LKEKEKQGFF 780

RSMKKKKKKS QTVPNSDSPD LLTLQKSIHS TSTPSSRPKE WRPEKISDLQ TQSQPLKSLR 840

KLLHLSSASN HPASSDPRFQ PLTAQQTKNS FSEIRIHPLS QASGGSSNIR QEPAPKGRPA 900

LQLPGQMDPG WHVSSVTRSA TEGPSYSEQL GAKSGPNGHP YNRTNRSRMP NLNDLKETAL 960

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCG 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AAGAAACGAC TTTACGAGAG 180

CTTAAAATGC TTCGGACTCT CAAGCAGGAA AACATTGTGG AGTTGAAGGA AGCATTTCGT 240

CGGAGGGGAA AGTTGTACTT GGTGTTTGAG TATGTTGAAA AAAATATGCT CGAATTGCTG 300

GAAGAAATGC CAAATGGAGT TCCACCTGAG AAAGTAAAAA GCTACATCTA TCAGCTAATC 360

AAGGCTATTC ACTGGTGCCA TAAGAATGAT ATTGTCCATC GAGATATAAA ACCAGAAAAT 420

CTCTTAATCA GCCACAATGA TGTCCTAAAA CTGTGTGACT TTGGTTTTGC TCGTAATCTG 480

TCAGAAGGCA ATAATGCTAA TTACACAGAG TACGTTGCCA CCAGATGGTA TCGGTCCCCA 540

GAACTCTTAC TTGGCGCTCC CTATGGGAAG TCCGTAGACA TGTGGTCGGT GGGCTGTATT 600

CTTGGGGAGC TTAGCGATGG ACAGCCTTTA TTTCCTGGAG AAAGTGAAAT TGACCAACTT 660

TTTACTATTC AGAAGGTGCT AGGACCACTT CCATCTGAGC AAATGAAGCT TTTCTACAGT 720

AATCCTCGCT TCCATGGGCT CCGGTTTCCA GCTGTTAACC ATCCTCAGTC CTTGGAAAGA 780

AGATACCTTG GAATTTTGAA TAGTGTTCTA CTTGACCTAA TGAAGAATTT ACTGAAGTTG 840

GACCCAGCTG ACAGATACTT GACAGAACAG TGTTTGAATC ACCCTACATT TCAAACCCAG 900

AGACTTCTGG ATCGTTCTCC TTCAAGGTCA GCAAAAAGAA AACCTTACCA TGTGGAAAGC 960

AGCACATTGT CTAATAGAAA CCAAGCCGGC AAAAGTACTG CTTTGCAGTC TCACCACAGA 1020

TCTAACAGCA AGGACATCCA GAACCTGAGT GTAGGCCTGC CCCGGGCTGA CGAAGGTATC 1080

CCTGCCAATG AAAGCTTCCT AAATGGAAAC CTTGCTGGAG CTAGTCTTAG TCCATTGCAC 1140

ACCAAAACCT ACCAAGCAAG CAGCCAGCCT GGGTCTACCA GCAAAGATCT CACCAACAAC 1200

AACATACCAC ACCTTCTTAG CCCAAAAGAA GCCAAGTCAA AAACAGAGTT TGATTTTAAT 1260

ATTGACCCAA AGCCTTCAGA AGGCCCAGGG ACAAAGTACC TCAAGTCGAA CAGCAGATCT 1320

CAGCAGAACC GCCACTCATT CATGGAAAGC TCTCAAAGCA AAGCTGGGAC ACTGCAGCCC 1380

AATGAAAAGC AGAGTCGGCA TAGCTATATT GACACCATTC CCCAGTCCTC TAGGAGTCCC 1440

TCCTACAGGA CCAAGGCCAA AAGCCATGGG GCACTGAGTG ACTCCAAGTC TGTGAGTAAC 1500

CTTTCTGAAG CCAGGGCCCA AATTGCGGAG CCGAGTACCA GTAGGTACTT CCCATCTAGC 1560

TGCTTAGACT TGAATTCTCC CACCAGCCCA ACCCCCACCA GACACGGTGA CACAAGAACT 1620

TTGCTCAGCC CTTCTGGGAG AAATAACCGA AATGAAGGAA CGCTGGACTC ACGTCGAACC 1680

ACAACCAGAC ATTCTAAGAC AATGGAGGAA TTGAAGCTGC CTGAGCACAT GGACAGTAGC 1740

CATTCCCATT CGCTGTCTGC ACCTCACGAA TCTTTTTCTT ACGGACTGGG CTACACCAGC 1800

CCCTTTTCTT CCCAGCAGCG TCCTCATAGG CATTCTATGT ATGTGACCCG TGACAAAGTG 1860

AGAGCCAAGG GCTTGGATGG AAGCTTGAGC ATAGGGCAAG GGATGGCAGC TAGAGCCAAC 1920

AGCCTGCAAC TCTTGTCACC CCAGCCTGGA GAACAGCTCC CTCCAGAGAT GACTGTGGCA 1980

AGATCGTCGG TCAAAGAGAC GTCCAGAGAA GGCACCTCTT CCTTCCATAC ACGCCAGAAG 2040

TCTGAGGGTG GAGTGTATCA TGACCCACAC TCTGATGATG GCACAGCCCC CAAAGAAAAT 2100

AGACATCTGT ACAATGATCC TGTGCCAAGG AGAGTTGGTA GCTTTTACAG AGTGCCATCT 2160

CCACGTCCAG ACAATTCTTT CCATGAAAAT AATGTGTCAA CTAGAGTTTC TTCTCTACCA 2220

TCAGAGAGCA GTTCTGGAAC CAACCACTCA AAAAGACAAC CAGCATTCGA TCCATGGAAA 2280

AGTCCTGAAA ATATTAGTCA TTCAGAGCAA CTCAAGGAAA AAGAGAAGCA AGGATTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAATCT CAAACAGTAC CCAATTCCGA CAGCCCTGAT 2400

CTTCTTACGT TGCAGAAATC CATTCATTCT ACTAGCACTC CAAGCAGCAG ACCAAAGGAG 2460

TGGCGCCCCG AGAAGATCTC AGATCTACAG ACCCAAAGCC AGCCATTGAA ATCACTGCGC 2520

AAGTTGTTAC ATCTCTCTTC GGCCTCGAAT CACCCGGCTT CCTCAGATCC CCGCTTCCAG 2580

CCCTTAACAG CTCAACAAAC CAAAAATTCC TTCTCAGAAA TTCGGATTCA CCCTCTGAGC 2640

CAGGCCTCTG GCGGGAGCAG CAACATCCGG CAGGAACCCG CACCGAAGGG CAGGCCAGCC 2700

CTCCAGCTGC CAGGTCAGAT GGATCCTGGT TGGCATGTGT CCTCTGTGAC CAGGAGTGCC 2760

ACAGAGGGCC CTTCCTACTC TGAACAGCTG GGTGCCAAAA GTGGGCCAAA TGGGCACCCC 2820

TATAACAGAA CAAATCGCTC ACGAATGCCA AATCTGAATG ATTTAAAAGA GACAGCCTTG 2880

TAA 2883

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   VNHPQSLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013