EPS-NOL-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-NOL-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	239.9	3.8E-71	94	344	251

Status

Unreviewed

Ensembl Protein

ENSNLEP00000011778

UniProt Accession

G1REX8;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000009677	ENSNLEP00000011778	ENSNLET00000012358

Organism

Nomascus leucogenys

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSTAALITLV RSGGNQVRRR VLLSSRLLQD DRRVTPTCHS STSEPRCSRF DPDGSGSPAT 60

WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASQ IGKRKENEDR FDFAQLTDEV 120

LYFAVYDGHG GPAAADFCHT HMEKCIMDLL PKEKNLETLL TLAFLEIDKA FSSHARLSAD 180

ATLLTSGTTA TVALLRDGIE LVVASVGDSR AILCRKGKPM KLTTDHTPER KDEKERIKKC 240

GGFVAWNSLG QPHVNGRLAM TRSIGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPN KAAHAVTEQA IQYGTEDNST AVVVPFGAWG KYKNSEINFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCAACAG CTGCCTTAAT TACTTTGGTC AGAAGTGGTG GGAACCAGGT GAGAAGGAGA 60

GTGCTGCTAA GCTCCCGCCT GCTGCAGGAC GACAGGCGGG TGACACCCAC ATGCCACAGC 120

TCCACTTCAG AGCCTAGGTG TTCTCGGTTT GACCCAGACG GTAGTGGGAG TCCAGCTACC 180

TGGGACAATT TTGGGATCTG GGATAACCGC ATCGATGAGC CAATTCTGCT GCCACCCAGC 240

ATTAAGTATG GCAAGCCAAT TCCCAAAATC AGCTTGGAAA ATGTGGGGTG CGCCTCACAG 300

ATTGGCAAAC GGAAAGAGAA TGAAGATCGG TTTGACTTCG CTCAGCTGAC AGATGAGGTC 360

CTGTACTTTG CAGTGTATGA TGGACACGGT GGACCTGCAG CAGCTGATTT CTGTCATACC 420

CACATGGAGA AATGTATTAT GGATTTGCTT CCTAAGGAGA AGAACTTGGA AACTCTGTTG 480

ACCTTGGCTT TTCTAGAAAT AGATAAAGCC TTTTCGAGTC ATGCCCGCCT GTCTGCTGAT 540

GCAACTCTTC TGACCTCTGG GACTACTGCA ACAGTAGCCC TATTGCGAGA TGGTATTGAA 600

CTGGTTGTAG CCAGTGTTGG GGACAGCCGG GCTATTTTGT GTAGAAAAGG AAAACCCATG 660

AAGCTGACCA CTGACCATAC TCCAGAAAGA AAAGATGAAA AAGAAAGGAT CAAGAAATGT 720

GGTGGTTTTG TAGCTTGGAA TAGTTTGGGG CAGCCTCACG TAAATGGCAG GCTTGCAATG 780

ACAAGAAGTA TTGGAGATTT GGACCTTAAG ACCAGTGGTG TCATAGCAGA ACCTGAAACT 840

AAGAGGATTA AGTTACATCA TGCTGATGAC AGCTTCCTGG TCCTCACCAC AGATGGAATT 900

AACTTCATGG TGAATAGTCA AGAGATTTGT GATTTTGTCA ATCAGTGCCA TGATCCCAAC 960

AAAGCAGCCC ATGCGGTGAC TGAACAGGCA ATACAGTATG GTACTGAGGA TAACAGTACT 1020

GCAGTAGTAG TGCCTTTTGG TGCCTGGGGA AAATATAAGA ACTCTGAAAT CAACTTCTCA 1080

TTCAGCAGAA GCTTTGCCTC CAGTGGACGA TGGGCCTGA 1119

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s+ g+r+e ed++    +f++ +++   + +f+vyDGhgg  +a+fc++++++++

Q: 94    NVGCASQIGKRKENEDRF----DFAQLTDE---VLYFAVYDGHGGPAAADFCHTHMEKCI  146

         5899**************....57887666...78*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

            l     +e+++++ l+ aFl++d+++   ++++l+ d+    sG+ta+val++d  +

Q: 147   MDLLP----KEKNLETLLTLAFLEIDKAF--SSHARLSADAtlltSGTTATVALLRDGiE  200

         ***87....********************..44444444445799*************9*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l+va vGdSra+Lcr+gk+++l++dH+p+r+dE+eRi++ gg v+ ++ g+ +v+G La+

Q: 201   LVVASVGDSRAILCRKGKPMKLTTDHTPERKDEKERIKKCGGFVAWNSlGQpHVNGRLAM  260

         ********************************************98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R++Gdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++++

Q: 261   TRSIGDLDLKtSGVIAEPETKRIKLHHADDsFLVLTTDGINFMVNSQEICDFVNQCHD--  318

         **********566************999999***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           +++aa+ ++++a+++g++dn +a+vv

Q: 319   --PNKAAHAVTEQAIQYGTEDNSTAVVV  344

         ..***********************997

Domain Sequence
(FASTA)

NVGCASQIGK RKENEDRFDF AQLTDEVLYF AVYDGHGGPA AADFCHTHME KCIMDLLPKE 60

KNLETLLTLA FLEIDKAFSS HARLSADATL LTSGTTATVA LLRDGIELVV ASVGDSRAIL 120

CRKGKPMKLT TDHTPERKDE KERIKKCGGF VAWNSLGQPH VNGRLAMTRS IGDLDLKTSG 180

VIAEPETKRI KLHHADDSFL VLTTDGINFM VNSQEICDFV NQCHDPNKAA HAVTEQAIQY 240

GTEDNSTAVV V 251

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013