EKS-NOL-00106
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00106
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MLCK400.13.6E-120286540255
StatusUnreviewed
Ensembl ProteinENSNLEP00000011793
UniProt AccessionG1REZ3;
Protein Name
Protein Synonyms/Alias
Gene NameMYLK2
Gene Synonyms/Alias MYLK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000009678ENSNLEP00000011793ENSNLET00000012374
OrganismNomascus leucogenys
Functional Description
Protein Length596
Protein Sequence
(FASTA)
MATENGAVEL GIQNPSTDKA PKGPAGERPL GAGKDPGPPD PKKAHDPPTL KKDAKAPASE 60
KGDGTLAQPS TSSQGPKGEG DRGGGPAEGS AGPPAALPQQ TATPQTSVKK PKAEQGASGS 120
RDPGEPRVGK KAAEGQAAAR RGSPAFLHSP SCPAIISSSE KLLAKKPPSE ASELTFEGVP 180
MTHSPTDPRP AKAEEGKNIL AESQKEVGEK TPGQAGQAKV QGDTSRGIEF QAVPSEKSEV 240
GQALCLTARE EDCFQILDDC PPPPAPFPHR MVELRTGNVS SEFSMNSKEA LGGGKFGAVC 300
TCMEKATGLK LAAKVIKKQT PKDKEMVLLE IEVMNQLNHR NLIQLYAAIE TPHEIVLFME 360
YIEGGELFER IVDEDYHLTE VDTMVFVRQI CDGILFMHKM RVLHLDLKPE NILCVNTTGH 420
LVKIIDFGLA RRYNPNEKLK VNFGTPEFLS PEVVNYDQIS DKTDMWSMGV ITYMLLSGLS 480
PFLGDDDTET LNNVLSGNWY FDEETFEAVS DEAKDFVSNL IVKDQRARMS AAQCLAHPWL 540
NNLAEKAKRC NRRLKSQILL KKYLMKRRWK KNFIAVSAAN RFKKISSSGA LMALGV 596
Nucleotide Sequence
(FASTA)
ATGGCGACAG AAAATGGAGC AGTTGAGCTG GGAATTCAGA ACCCGTCAAC AGACAAGGCA 60
CCTAAAGGTC CCGCAGGTGA AAGACCCCTG GGTGCAGGGA AAGACCCTGG CCCCCCAGAC 120
CCAAAGAAAG CTCATGATCC ACCCACCCTG AAGAAAGATG CCAAAGCCCC TGCCTCAGAG 180
AAAGGGGATG GTACCCTGGC CCAACCCTCA ACTAGCAGCC AAGGCCCCAA AGGAGAGGGT 240
GACAGGGGTG GGGGGCCCGC GGAGGGCAGT GCTGGGCCCC CAGCAGCCCT GCCCCAGCAG 300
ACTGCGACGC CCCAGACCAG TGTCAAGAAG CCCAAGGCTG AGCAGGGAGC CTCAGGCAGC 360
CGGGATCCTG GAGAGCCCAG GGTGGGCAAG AAGGCAGCAG AGGGCCAAGC AGCAGCCAGG 420
AGGGGCTCAC CTGCCTTTCT GCATAGCCCC AGCTGTCCCG CCATCATCTC CAGTTCTGAG 480
AAGCTGCTGG CCAAGAAGCC CCCAAGTGAG GCATCAGAGC TCACCTTTGA AGGGGTGCCC 540
ATGACCCACA GCCCCACGGA TCCCAGGCCA GCCAAGGCAG AAGAGGGAAA GAACATCCTG 600
GCAGAGAGCC AGAAGGAAGT GGGAGAGAAA ACCCCAGGCC AGGCTGGCCA GGCTAAGGTG 660
CAAGGGGACA CCTCGAGGGG GATCGAGTTC CAGGCTGTTC CCTCAGAGAA ATCCGAGGTG 720
GGGCAGGCCC TCTGTCTCAC AGCCAGGGAG GAGGACTGCT TCCAAATTTT GGATGATTGC 780
CCGCCACCCC CGGCCCCCTT CCCTCACCGC ATGGTGGAGC TGAGGACCGG GAATGTCAGC 840
AGTGAATTCA GTATGAACTC CAAGGAGGCG CTCGGAGGTG GCAAGTTTGG GGCAGTCTGT 900
ACCTGCATGG AGAAAGCCAC AGGCCTCAAG CTGGCAGCCA AAGTCATCAA GAAACAGACT 960
CCCAAAGACA AGGAAATGGT GTTGCTGGAG ATTGAGGTCA TGAACCAGCT GAACCACCGC 1020
AATCTGATCC AGCTCTATGC AGCCATCGAG ACTCCACATG AGATCGTCCT GTTCATGGAG 1080
TACATCGAGG GCGGAGAGCT CTTCGAGAGG ATTGTGGATG AGGACTACCA TCTGACCGAG 1140
GTGGACACCA TGGTGTTTGT CAGGCAGATC TGTGATGGGA TCCTCTTCAT GCACAAGATG 1200
AGGGTTTTGC ACCTGGACCT CAAGCCAGAG AACATCCTGT GTGTCAACAC CACCGGGCAT 1260
TTGGTGAAGA TCATTGACTT CGGCCTGGCA CGGAGGTATA ACCCCAACGA GAAGCTGAAG 1320
GTGAACTTTG GGACCCCAGA GTTCCTGTCA CCTGAGGTGG TGAATTATGA CCAAATCTCC 1380
GATAAGACAG ACATGTGGAG TATGGGGGTG ATCACCTACA TGCTGCTGAG CGGCCTCTCC 1440
CCCTTCCTGG GAGATGATGA CACAGAGACC CTAAACAACG TTCTATCTGG CAACTGGTAC 1500
TTTGACGAAG AGACCTTTGA GGCCGTATCA GACGAGGCCA AAGACTTTGT CTCCAACCTC 1560
ATCGTCAAGG ACCAGAGGGC CCGGATGAGC GCTGCCCAGT GTCTCGCCCA CCCCTGGCTC 1620
AACAACCTGG CGGAGAAAGC CAAGCGCTGT AACCGACGCC TTAAGTCCCA GATCTTGCTT 1680
AAGAAATACC TCATGAAGAG GCGTTGGAAG AAAAACTTCA TTGCTGTCAG CGCTGCCAAC 1740
CGCTTCAAGA AGATCAGCAG CTCGGGGGCA CTGATGGCTC TGGGGGTCTG A 1791
Domain Profile
S: 2     sikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliql  61
         + ke+lg Gkfg+v++++ek+tg klaak++k +++kdke+v  Eie++nql+H++liql
Q: 286   NSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQL  345
         67899*******************************************************
S: 62    ydafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHl  121
         y+a+e+ +eivl++E++eggelferiv+edy+ltE ++++fvrq+++++ ++Hk++++Hl
Q: 346   YAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHL  405
         ************************************************************
S: 122   dlkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDm  181
         dlkpenil+++++++ +K+idFGlar+++++eklkv+fgtpef++PEvvn++++s +tDm
Q: 406   DLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDM  465
         ************************************************************
S: 182   WsvGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkek  241
         Ws+Gvity+LlsGlsPFlgd+d+etl+nv s+++ fdee+f++vs+eakdF+s+l+vk++
Q: 466   WSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQ  525
         ************************************************************
S: 242   kkRmsaeeaLkhkwl  256
         ++Rmsa+++L+h+wl
Q: 526   RARMSAAQCLAHPWL  540
         **************8
Domain Sequence
(FASTA)
NSKEALGGGK FGAVCTCMEK ATGLKLAAKV IKKQTPKDKE MVLLEIEVMN QLNHRNLIQL 60
YAAIETPHEI VLFMEYIEGG ELFERIVDED YHLTEVDTMV FVRQICDGIL FMHKMRVLHL 120
DLKPENILCV NTTGHLVKII DFGLARRYNP NEKLKVNFGT PEFLSPEVVN YDQISDKTDM 180
WSMGVITYML LSGLSPFLGD DDTETLNNVL SGNWYFDEET FEAVSDEAKD FVSNLIVKDQ 240
RARMSAAQCL AHPWL 255
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00105
EKS-BOT-00115
EKS-CAJ-00117
EKS-CAF-00118
EKS-CAP-00112
EKS-DAR-00368
EKS-EQC-00111
EKS-FEC-00107
EKS-GAG-00095
EKS-GOG-00114
EKS-HOS-00117
EKS-ICT-00109
EKS-LOA-00111
EKS-MAM-00113
EKS-MIM-00051
EKS-MOD-00113
EKS-MUM-00116
EKS-MUP-00117
EKS-ORC-00108
EKS-OTG-00118
EKS-RAN-00113
EKS-SAH-00107
EKS-SUS-00101
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0055008; P:cardiac muscle tissue morphogenesis
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0010628; P:positive regulation of gene expression
GO:0046777; P:protein autophosphorylation
GO:0032971; P:regulation of muscle filament sliding
GO:0035914; P:skeletal muscle cell differentiation
GO:0006941; P:striated muscle contraction
KEGG
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013