EKS-NOL-00337
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00337
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src441.67.2E-133240489250
StatusUnreviewed
Ensembl ProteinENSNLEP00000011876
UniProt AccessionG1RF76;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000009721ENSNLEP00000011876ENSNLET00000012458
OrganismNomascus leucogenys
Functional Description
Protein Length504
Protein Sequence
(FASTA)
MGCMKSKFLQ VRGNTFSKTE TSANPHCPVY VPDPTSTIKP GPNSNNSNTP GIREGSEDII 60
VVALYDYEAI HHEDLSFQKG DQMVVLEESG EWWKARSLAT RKEGYIPSNY VARVDSLETE 120
EWFFKGISRK DAERQLLAPG NMLGSFMIRD SETTKGSYSL SVRDYDPRQG DTVKHYKIRT 180
LDNGGFYISP RSTFSTLQEL VDHYKKGSDG LCQKLSVPCV SSKPQKPWEK DAWEIPRESL 240
KLEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF LAEANVMKTL QHDKLVKLHA 300
VVTEEPIYII TEFMAKGSLL DFLKSDEGSQ QPLPKLIDFS AQIAEGMAFI EQRNYIHRDL 360
RAANILVSAS LVCKIADFGL ARIIEDNEYT AREGAKFPIK WTAPEAINFG SFTIKSDVWS 420
FGILLMEIIT YGRIPYPGMS NPEVIRALER GYRMPRPENC PEELYNIMMR CWKNRPEERP 480
TFEYIQSVLD DFYTATESQY QQQP 504
Nucleotide Sequence
(FASTA)
ATGGGGTGCA TGAAGTCCAA ATTCCTCCAG GTCAGAGGCA ATACGTTCTC AAAAACTGAA 60
ACCAGCGCCA ACCCACACTG CCCTGTGTAC GTGCCGGATC CCACATCCAC CATCAAGCCG 120
GGGCCTAATA GCAACAACAG CAACACACCA GGAATCAGGG AGGGCTCTGA GGACATCATC 180
GTGGTTGCCC TGTATGATTA CGAGGCCATT CACCACGAAG ACCTCAGCTT CCAGAAGGGG 240
GACCAGATGG TGGTCCTAGA GGAATCCGGG GAGTGGTGGA AGGCTCGATC CCTGGCCACT 300
CGGAAGGAAG GCTACATCCC AAGCAACTAT GTCGCCCGTG TTGACTCTCT GGAGACAGAG 360
GAGTGGTTTT TCAAGGGCAT CAGCCGGAAG GACGCAGAGC GACAACTCCT GGCTCCAGGC 420
AACATGCTGG GCTCCTTCAT GATCCGGGAT AGCGAGACCA CTAAAGGAAG CTACTCTTTG 480
TCCGTGCGAG ACTACGACCC TCGGCAGGGA GATACCGTGA AACATTACAA GATCCGGACC 540
CTGGACAATG GGGGCTTCTA CATATCCCCC CGAAGCACCT TCAGCACTCT GCAGGAGCTG 600
GTGGACCACT ACAAGAAGGG GAGCGACGGG CTCTGCCAGA AACTGTCGGT GCCCTGTGTG 660
TCTTCCAAGC CCCAGAAGCC TTGGGAGAAA GATGCCTGGG AGATCCCTCG GGAATCCCTC 720
AAGCTGGAAA AGAAACTTGG AGCTGGGCAG TTTGGGGAAG TCTGGATGGC CACCTACAAC 780
AAGCACACCA AGGTGGCAGT GAAGACGATG AAGCCAGGGA GCATGTCGGT GGAGGCCTTC 840
CTGGCAGAGG CCAACGTGAT GAAAACTCTG CAGCATGACA AGCTGGTCAA ACTTCATGCG 900
GTGGTCACTG AGGAGCCCAT CTACATCATC ACGGAGTTCA TGGCCAAAGG AAGCTTGCTG 960
GACTTTCTGA AAAGTGATGA GGGCAGCCAG CAGCCATTGC CAAAACTCAT TGACTTCTCA 1020
GCCCAGATTG CAGAAGGCAT GGCCTTCATC GAGCAGAGGA ACTACATCCA CCGAGACCTC 1080
CGAGCTGCCA ACATCTTGGT CTCTGCATCC CTCGTGTGTA AGATTGCTGA CTTTGGCCTG 1140
GCCCGGATCA TTGAGGACAA CGAGTACACA GCTCGGGAAG GGGCCAAATT CCCCATCAAG 1200
TGGACAGCTC CTGAAGCCAT CAACTTTGGC TCCTTCACCA TCAAGTCAGA CGTCTGGTCC 1260
TTTGGTATCC TGCTGATGGA GATCATCACC TATGGCCGGA TCCCTTACCC AGGGATGTCA 1320
AACCCTGAAG TGATCCGAGC TCTGGAGCGT GGATACCGGA TGCCTCGCCC GGAGAACTGC 1380
CCAGAGGAGC TCTACAACAT CATGATGCGC TGCTGGAAAA ACCGTCCGGA GGAGCGGCCC 1440
ACCTTCGAAT ACATCCAGAG TGTGCTGGAC GACTTCTACA CGGCCACAGA GAGCCAGTAC 1500
CAACAGCAGC CATGA 1515
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 240   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH  299
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv+e ePiyi+te+makGslldflk++eg++++lpkl+d++aq+aeGma++e++n+ihr
Q: 300   AVVTE-EPIYIITEFMAKGSLLDFLKSDEGSQQPLPKLIDFSAQIAEGMAFIEQRNYIHR  358
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 359   DLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  418
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+ei+t+G++PypGm+n ev++++ergyr+prpe+cpeely+++++cwk++pee
Q: 419   WSFGILLMEIITYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE  478
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 479   RPTFEYIQSVL  489
         *******9976
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANVMKT LQHDKLVKLH 60
AVVTEEPIYI ITEFMAKGSL LDFLKSDEGS QQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARIIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEII TYGRIPYPGM SNPEVIRALE RGYRMPRPEN CPEELYNIMM RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-DIO-00065
EKS-EQC-00360
EKS-ERE-00004
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MIM-00060
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-POA-00365
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XET-00485
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013