EKS-NOL-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	482.2	3.1E-145	44	298	255

Status

Unreviewed

Ensembl Protein

ENSNLEP00000012062

UniProt Accession

G1RFR6;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKACB

Gene Synonyms/Alias

PRKACB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000009888	ENSNLEP00000012062	ENSNLET00000012651

Organism

Nomascus leucogenys

Functional Description

Protein Length

351

Protein Sequence
(FASTA)

MGNAATAKKG SEVESVKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL GTGSFGRVML 60

VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVRLEYA FKDNSNLYMV 120

MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY 180

IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 240

ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT 300

TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE F 351

Nucleotide Sequence
(FASTA)

ATGGGGAACG CGGCGACCGC CAAGAAAGGC AGCGAGGTGG AGAGCGTGAA AGAGTTTCTA 60

GCTAAAGCCA AAGAAGACTT TTTGAAAAAA TGGGAGAATC CAACTCAGAA TAATGCCGGA 120

CTTGAAGATT TTGAAAGGAA AAAAACCCTT GGAACAGGTT CATTTGGAAG AGTCATGTTG 180

GTAAAACACA AAGCCACTGA ACAGTATTAT GCCATGAAGA TCTTAGATAA GCAGAAGGTT 240

GTTAAACTGA AGCAAATAGA GCATACTTTG AATGAGAAAA GAATATTACA GGCAGTGAAT 300

TTTCCTTTCC TTGTTCGACT GGAATATGCT TTTAAGGATA ATTCTAATTT ATACATGGTT 360

ATGGAATATG TCCCTGGGGG TGAAATGTTT TCACATCTAA GAAGAATTGG AAGGTTCAGT 420

GAGCCCCATG CACGGTTCTA TGCAGCTCAG ATAGTGCTAA CATTTGAGTA CCTCCATTCA 480

CTAGACCTCA TCTACAGAGA TCTAAAACCT GAAAATCTCT TAATTGACCA TCAAGGCTAT 540

ATCCAGGTCA CAGACTTTGG GTTTGCCAAA AGAGTTAAAG GCAGAACTTG GACATTATGT 600

GGAACTCCAG AGTATTTGGC TCCAGAAATA ATTCTCAGCA AGGGCTACAA TAAGGCAGTG 660

GATTGGTGGG CATTAGGAGT GCTAATCTAT GAAATGGCAG CTGGCTATCC CCCATTCTTT 720

GCAGACCAAC CAATTCAGAT TTATGAAAAG ATTGTTTCTG GAAAGGTCCG ATTCCCATCC 780

CACTTCAGTT CAGATCTCAA GGACCTTCTA CGGAACCTGC TGCAGGTGGA TTTGACCAAG 840

AGATTTGGGA ATCTAAAGAA TGGTGTCAGT GATATAAAAA CTCACAAGTG GTTTGCCACG 900

ACAGATTGGA TTGCTATTTA CCAGAGGAAG GTTGAAGCTC CATTCATACC AAAGTTTAGA 960

GGCTCTGGAG ATACCAGCAA CTTTGATGAC TATGAAGAAG AAGATATCCG TGTCTCTATA 1020

ACAGAAAAAT GTGCAAAAGA ATTTGGTGAA TTTTAA 1056

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         fer+ktlGtGsfGrv+lv++k++++yya+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 44    FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF  103

         799*********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lv+l+++fkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 104   LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  163

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 164   IYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  223

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 224   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG  283

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik+hkwf

Q: 284   NLKNGVSDIKTHKWF  298

         **************9

Domain Sequence
(FASTA)

FERKKTLGTG SFGRVMLVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60

LVRLEYAFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDHQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG 240

NLKNGVSDIK THKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005524	; F:ATP binding
GO:0004691	; F:cAMP-dependent protein kinase activity
GO:0000287	; F:magnesium ion binding

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013