EKS-NOL-00109

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00109

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	394.6	2.1E-118	46	309	264

Status

Unreviewed

Ensembl Protein

ENSNLEP00000012324

UniProt Accession

G1RGH4;

Protein Name

Protein Synonyms/Alias

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000010108	ENSNLEP00000012324	ENSNLET00000012923

Organism

Nomascus leucogenys

Functional Description

Protein Length

954

Protein Sequence
(FASTA)

MKKFFDSRRE QGGSGLGSGS SGGGGSTSGL GSGYIGRVFG IGRQQVTVDE VLAEGGFAIV 60

FLVRTSNGMK CALKRMFVNN EHDLQVCKRE IQIMRDLSGH KNIVGYIDSS INNVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN KFQNPQTEGV NAVEDEIKKY TTLSYRAPEM VNLYSGKIIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGNFTIPDNS RYSQDMHCLI RYMLEPDPDK 300

RPDIYQVSYF SFKLFKKECP IPNVQNSPIP AKLPEPVKAS EAAAKKTQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRATVQPPP QLAGSSNQPG LLASVPQPKP 420

QAPPSQPLPQ TQAKQPQAPP TPQQTPSTQA QATPQHQQQL FLKQQQQQQQ PPPPQQQPAG 480

TFYQQQQQAQ TQQFQAVHPA TQQPAIAQFP VVSQGGSQQQ LMQNFYQQQQ QQQQQQQQQL 540

ATALHQQQLM TQQAALQQKP TVAGGQQPQP QPAAAPQPAP AQEPAVRINQ SSGHKSSNNP 600

TSAVQGQKVG SLTPPSSPKT QRAGHRRILS DVTHSAVFGV PASKSTQLLQ AAAAEASLNK 660

SKSATTTPSG SPRTSQQNVY NPSEGSTWNP FDDDNFSKLT AEELLNKDFA KLGEGKHPEK 720

LGGSAESLIP GFQSTQGDAF ATTSFSAGTA EKRKGGQTVD SGLPLLSVSD PFIPLQVPDA 780

PEKLIEGLKS PDTSLLLPDL LPMTDPFGST SDAVIEKADV AVESLIPGLE PPVPQRLPSQ 840

TESVTSNRTD SLTGEDSLLD CSLLSNPTTD LLEEFAPTAI SAPVHKAAED SNLISGFDVP 900

EGSDKVAEDE FDPIPVLITK NPQGGHSRNS SGSSESSLPN LARSLLLVDQ LIDL 954

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 60

AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTTGGC 120

ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCAG AAGGTGGATT TGCTATTGTA 180

TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 240

GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGACCT GTCAGGGCAC 300

AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 360

GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 420

CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 480

GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 540

AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG TGCCACCAAC 600

AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 660

ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 720

ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 780

CCATTTGGGG AGAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 840

CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 900

AGGCCAGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TATTCAAGAA AGAGTGCCCA 960

ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 1020

GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 1080

GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 1140

ATCCTTCCCA TCCAGCCAGC CCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 1200

CAGCTTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 1260

CAAGCCCCAC CCAGCCAGCC TCTGCCACAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 1320

ACTCCACAGC AGACGCCTTC CACTCAGGCC CAGGCCACAC CCCAGCACCA GCAGCAACTC 1380

TTCCTCAAGC AGCAACAGCA GCAGCAACAG CCACCGCCAC CACAGCAGCA GCCGGCAGGC 1440

ACGTTTTACC AGCAGCAGCA GCAGGCCCAG ACTCAGCAGT TTCAGGCAGT ACATCCAGCA 1500

ACCCAGCAAC CAGCAATTGC TCAGTTCCCT GTGGTGTCCC AAGGAGGCTC TCAACAGCAG 1560

CTAATGCAGA ATTTCTACCA GCAGCAGCAG CAGCAACAAC AACAGCAACA GCAACAGCTG 1620

GCCACAGCCC TGCATCAACA ACAGCTGATG ACTCAGCAGG CTGCCTTGCA GCAAAAGCCC 1680

ACTGTGGCAG GAGGACAGCA GCCCCAGCCA CAGCCAGCTG CAGCCCCACA GCCAGCCCCT 1740

GCCCAGGAGC CAGCGGTAAG AATCAACCAG AGCTCAGGGC ACAAAAGCAG CAACAACCCC 1800

ACCTCTGCCG TCCAGGGGCA GAAAGTTGGA TCTCTCACTC CACCCTCATC CCCCAAAACC 1860

CAACGTGCTG GGCACAGGCG TATTCTCAGT GACGTAACCC ACAGTGCAGT CTTTGGGGTC 1920

CCTGCCAGCA AATCAACCCA GCTGCTCCAG GCAGCTGCAG CTGAGGCCAG TCTCAATAAG 1980

TCCAAGTCTG CAACCACCAC TCCATCAGGC TCTCCTCGGA CCTCTCAACA AAACGTTTAT 2040

AATCCTTCAG AAGGGTCTAC GTGGAATCCC TTCGATGACG ATAATTTCTC CAAACTCACA 2100

GCTGAAGAAC TGCTAAACAA GGACTTTGCC AAGCTGGGGG AAGGCAAACA TCCCGAGAAG 2160

CTTGGAGGCT CAGCTGAGAG TTTGATCCCA GGCTTTCAAT CAACCCAAGG TGATGCTTTT 2220

GCTACGACCT CATTTTCTGC TGGAACTGCT GAAAAAAGGA AGGGTGGGCA GACTGTGGAC 2280

TCTGGCCTCC CGCTTCTAAG CGTGTCTGAT CCTTTCATTC CTCTACAAGT ACCTGATGCA 2340

CCAGAAAAAC TAATTGAGGG ACTCAAATCT CCTGACACTT CTCTTCTGCT CCCTGACCTC 2400

TTGCCTATGA CAGATCCTTT TGGTAGCACT TCCGATGCTG TAATTGAAAA AGCTGATGTT 2460

GCTGTTGAGA GTCTCATACC AGGACTGGAG CCCCCAGTTC CCCAGCGCCT CCCATCTCAG 2520

ACGGAATCTG TGACCTCGAA TCGCACAGAT TCTCTCACCG GGGAAGATTC CCTGCTTGAT 2580

TGCTCTCTGC TCTCTAACCC TACTACTGAC CTTCTGGAAG AGTTTGCCCC CACAGCAATC 2640

TCTGCTCCAG TCCATAAAGC TGCAGAAGAT AGTAATCTCA TCTCAGGTTT TGATGTCCCT 2700

GAGGGCTCGG ACAAGGTGGC TGAAGATGAG TTTGACCCTA TTCCTGTATT GATAACCAAA 2760

AACCCACAAG GTGGGCACTC TAGAAACAGC AGTGGGAGCT CTGAGTCCAG TCTTCCCAAC 2820

CTAGCCAGGT CTTTACTGCT GGTGGATCAG CTCATAGACC TG 2862

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +s+g k+alKr++vn+e+dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.99**************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a+++ei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEDEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys+++i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGNFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         ys+++++li++mle+dp++Rp+i+qv++

Q: 282   YSQDMHCLIRYMLEPDPDKRPDIYQVSY  309

         **************************87

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT SNGMKCALKR MFVNNEHDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINNVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QTEGVNAVED EIKKYTTLSY 180

RAPEMVNLYS GKIITTKADI WALGCLLYKL CYFTLPFGES QVAICDGNFT IPDNSRYSQD 240

MHCLIRYMLE PDPDKRPDIY QVSY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013