EKS-NOL-00367
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00367
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR605.62.9E-182600958359
StatusUnreviewed
Ensembl ProteinENSNLEP00000012499
UniProt AccessionG1RGZ9;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000010243ENSNLEP00000012499ENSNLET00000013110
OrganismNomascus leucogenys
Functional Description
Protein Length1106
Protein Sequence
(FASTA)
MRLPGAMPAL ALKGQLLLLP LLLLLEPHVS QGLVITPPGP ELVLNVSSTF VLTCSGSAPV 60
VWERMSQEPP QEMAKAQDGT FSSVLTLTNL TGLDTGEYFC THNDSRGLEP DERKRLYIFV 120
PDPTVGFLPN DAEELFIFLT EITEITIPCR VTDPQLVVTL HEKKGDIALP VPYDYQRGFS 180
GIFEDRSYIC KTTIGDREVD SDAYYVYRLQ VSSINVSVNA VQTVVRQGEN ITLMCIVIGN 240
EVVNFEWTYP RKESGRLVEP VTDFLLDMPY HIRSILHIPS AELEDSGTYT CNVTESVNDH 300
QDEKAINITV VESGYVRLLG EVGTLQFAEL HRSRTLQVVF EAYPPPTVLW FKDNRTLGDS 360
SAGEIALSTR NMSETRYVSE LTLVRVKVAE AGHYTMRAFH EDAEVQLSFQ LQINVPVRVL 420
ELSESHPDSG EQTVRCRGRG MPQPNIIWSA CRDLKRCPRE LPPMLLGNSS EEESQLETNV 480
TYWEEEQEFE VVSTLRLQHV DRPLSVRCTL RNAVGQDTQE VIVVPHSLPF KVVVISAILA 540
LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL 600
VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 660
HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHHSDKRRP PSAELYSNAL 720
PVGLPLPSHV SLTGESDGGY MDMSKDESVD YVPMLDMKGD VKYADIESSN YMAPYDNYVP 780
SAPERTCRAT LINESPVLSY MDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 840
KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 900
GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER 960
LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RLPGFHGLRS PLDTSSVLYT AVQPNEGDND 1020
YIIPLPDPKP EVADEGPLEG SPSLASSTLN EVNTSSTISC DSPLEPQEEP EPEPQLELQV 1080
EPEPELEQLP DSGCPAPRAE AEDSFL 1106
Nucleotide Sequence
(FASTA)
ATGCGGCTTC CGGGTGCGAT GCCAGCTCTG GCCCTTAAAG GCCAGCTGCT GTTGCTGCCC 60
CTCCTGTTAC TGCTGGAACC ACACGTCTCT CAGGGCCTGG TCATCACACC CCCGGGGCCA 120
GAGCTTGTCC TCAATGTCTC CAGCACCTTT GTTCTGACCT GCTCGGGTTC AGCTCCGGTG 180
GTGTGGGAAC GGATGTCCCA GGAGCCCCCA CAGGAGATGG CCAAGGCCCA GGATGGCACC 240
TTCTCCAGCG TGCTGACACT GACCAACCTC ACTGGGCTAG ACACGGGAGA ATACTTTTGC 300
ACCCACAATG ATTCCCGTGG ACTGGAGCCC GATGAGCGGA AACGGCTCTA TATCTTTGTG 360
CCAGATCCCA CCGTGGGCTT CCTCCCTAAT GACGCCGAGG AACTATTCAT CTTTCTCACG 420
GAAATAACTG AGATCACCAT TCCATGCCGA GTAACAGACC CACAGCTGGT GGTGACACTG 480
CACGAGAAGA AAGGGGACAT TGCATTGCCT GTCCCCTACG ATTACCAACG TGGCTTTTCT 540
GGTATCTTTG AGGACAGAAG CTACATCTGC AAAACCACCA TTGGGGACAG GGAGGTGGAT 600
TCCGATGCCT ACTATGTCTA CAGACTCCAG GTGTCATCCA TCAACGTCTC TGTGAACGCA 660
GTGCAGACTG TGGTCCGCCA GGGTGAGAAC ATCACCCTCA TGTGCATTGT GATCGGGAAC 720
GAGGTGGTCA ACTTCGAGTG GACATACCCC CGCAAAGAAA GTGGGCGGCT GGTGGAACCG 780
GTGACTGACT TCCTCTTGGA TATGCCTTAC CACATCCGCT CCATCCTGCA CATCCCCAGT 840
GCCGAGTTAG AAGACTCGGG GACCTACACC TGCAATGTGA CGGAGAGTGT GAACGACCAT 900
CAGGATGAAA AGGCCATCAA CATCACTGTG GTTGAGAGCG GCTACGTGCG GCTCCTGGGA 960
GAGGTGGGCA CACTACAATT TGCTGAGCTG CATCGGAGCC GGACACTGCA GGTAGTGTTC 1020
GAGGCCTACC CACCGCCCAC TGTCCTGTGG TTCAAAGACA ACCGCACCCT GGGCGACTCC 1080
AGCGCTGGCG AAATTGCCCT GTCCACACGC AACATGTCGG AGACCCGGTA TGTGTCAGAG 1140
CTAACACTGG TTCGCGTGAA GGTGGCAGAG GCTGGCCACT ACACCATGCG GGCCTTCCAT 1200
GAGGACGCTG AGGTCCAGCT CTCCTTCCAG CTACAGATCA ATGTCCCTGT CCGAGTGCTG 1260
GAGCTAAGTG AGAGCCACCC TGACAGCGGG GAACAGACAG TCCGCTGTCG TGGCCGGGGC 1320
ATGCCCCAGC CGAACATCAT CTGGTCTGCC TGCAGAGACC TCAAAAGGTG TCCGCGGGAG 1380
CTGCCGCCCA TGCTGCTGGG GAACAGTTCC GAAGAGGAGA GCCAGCTGGA GACTAACGTG 1440
ACATACTGGG AGGAGGAGCA GGAGTTTGAG GTGGTGAGCA CACTGCGTCT GCAGCACGTG 1500
GATCGGCCAC TGTCGGTGCG CTGCACGCTG CGCAACGCTG TGGGCCAGGA CACGCAGGAG 1560
GTCATCGTGG TGCCACACTC CTTGCCCTTT AAGGTGGTGG TGATCTCAGC CATCCTGGCC 1620
CTGGTGGTGC TCACCATCAT CTCCCTTATC ATCCTCATCA TGCTTTGGCA GAAGAAGCCA 1680
CGTTACGAGA TCCGATGGAA GGTGATTGAG TCTGTGAGCT CTGACGGCCA TGAGTACATC 1740
TACGTGGACC CCATGCAGCT GCCCTATGAC TCCACGTGGG AGCTGCCGCG GGACCAGCTT 1800
GTGCTGGGAC GCACCCTCGG TTCTGGGGCC TTTGGGCAGG TGGTGGAGGC CACGGCTCAT 1860
GGCCTGAGCC ATTCTCAGGC CACGATGAAA GTGGCCGTCA AGATGCTTAA ATCCACAGCC 1920
CGCAGCAGTG AGAAGCAAGC CCTTATGTCG GAGCTGAAGA TCATGAGTCA CCTTGGGCCC 1980
CACCTGAACG TGGTCAACCT GTTGGGGGCC TGCACCAAAG GAGGACCCAT CTATATCATC 2040
ACTGAGTACT GCCGCTACGG AGACCTGGTG GACTACCTGC ACCGCAACAA ACACACCTTC 2100
CTGCAGCACC ACTCCGACAA GCGCCGCCCG CCCAGCGCGG AGCTCTACAG CAATGCACTG 2160
CCCGTTGGGC TCCCCCTGCC CAGCCATGTG TCCTTGACTG GGGAGAGCGA CGGTGGCTAC 2220
ATGGACATGA GCAAGGACGA GTCGGTGGAC TACGTGCCCA TGCTGGACAT GAAAGGAGAC 2280
GTCAAATACG CAGACATCGA GTCCTCCAAC TACATGGCCC CTTACGATAA CTACGTTCCC 2340
TCTGCCCCTG AGAGGACCTG TCGGGCGACT TTGATCAACG AATCTCCAGT GCTAAGCTAC 2400
ATGGACCTCG TGGGCTTCAG CTACCAGGTG GCCAATGGCA TGGAGTTTCT GGCCTCCAAG 2460
AACTGCGTCC ACAGAGACCT GGCAGCTAGG AACGTGCTCA TCTGTGAAGG CAAGCTGGTC 2520
AAGATCTGTG ACTTTGGCCT GGCTCGAGAC ATCATGCGGG ACTCGAATTA CATCTCCAAA 2580
GGCAGCACCT TTTTGCCTTT GAAGTGGATG GCTCCGGAGA GCATCTTCAA CAGCCTCTAC 2640
ACCACCCTGA GCGACGTGTG GTCCTTCGGG ATCCTGCTCT GGGAGATCTT CACCTTGGGT 2700
GGCACCCCTT ACCCAGAGCT GCCCATGAAT GAACAGTTCT ACAATGCCAT CAAACGGGGT 2760
TACCGCATGG CCCAGCCTGC CCATGCCTCC GACGAGATCT ATGAGATCAT GCAGAAGTGC 2820
TGGGAAGAGA AGTTTGAGAT TCGGCCCCCC TTCTCCCAGC TGGTGCTGCT TCTCGAGAGA 2880
CTGTTGGGCG AAGGTTACAA AAAGAAGTAC CAGCAGGTGG ATGAGGAGTT TCTGAGGAGT 2940
GACCACCCAG CCATCCTTCG GTCCCAGGCC CGCTTGCCCG GGTTCCATGG CCTCCGATCT 3000
CCCCTGGACA CCAGCTCCGT CCTCTATACT GCCGTGCAGC CCAATGAGGG TGACAACGAC 3060
TATATCATCC CCCTGCCTGA CCCCAAACCC GAGGTTGCTG ACGAGGGCCC ACTGGAGGGC 3120
TCCCCCAGCC TAGCCAGCTC CACCCTGAAT GAAGTCAACA CCTCCTCAAC CATCTCCTGT 3180
GACAGCCCCC TGGAGCCCCA GGAGGAACCA GAGCCAGAGC CCCAGCTTGA GCTCCAGGTG 3240
GAGCCAGAGC CGGAGCTGGA ACAGCTGCCG GATTCGGGGT GCCCTGCGCC TCGGGCAGAA 3300
GCAGAGGACA GCTTCCTGTA G 3321
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 600   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  659
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++++k++++++el+s+a
Q: 660   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNA  719
         ************************************************************
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
         l+++  l s++sl+ es++ y+d++kd                ++d++ss++++++++++
Q: 720   LPVGLPLPSHVSLTGESDGGYMDMSKDesvdyvpmldmkgdvkYADIESSNYMAPYDNYV  779
         ************************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          sa er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk
Q: 780   PSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  838
         **************9.9*******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+
Q: 839   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  898
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll
Q: 899   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  958
         ********************************************************9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQHHSDKRR PPSAELYSNA 120
LPVGLPLPSH VSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV 180
PSAPERTCRA TLINESPVLS YMDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0060326; P:cell chemotaxis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013