EKS-NOL-00135

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00135

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	555.8	2.6E-167	58	570	513

Status

Unreviewed

Ensembl Protein

ENSNLEP00000012580

UniProt Accession

G1RH80;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC7

Gene Synonyms/Alias

CDC7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000010319	ENSNLEP00000012580	ENSNLET00000013195

Organism

Nomascus leucogenys

Functional Description

Protein Length

575

Protein Sequence
(FASTA)

MEASLGIQMD EPMAFSSQHD RFQAEGSLKK NEQNFKLAGV KRDIEKLYEA VPQLSNVFKI 60

KDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPIR IAAELQCLTV AGGQDNVMGV 120

KYCFRKNDHV VIAMPYLEHE SFLDILNSLS FQEVREYMFN LFKALKRIHQ FGIVHRDVKP 180

SNFLYNRRLK KYALVDFGLA QGTHDTKIEL LKFVQSEAQQ ERCSQNKSHI ITGNKIPLSG 240

PVPKELDQQS TTKASVKRPY TNAQSQIKQG KDGKEGSVGL SVQRSVFGER NFNIHSSISH 300

ESPAVKVSNN IKGFSVIARH EQQIKTVILA NVLVQFTVLK WKHNCFILFL TCDCYATDKV 360

CSICLSRRQQ VAPRAGTPGF RAPEVLTKCP NQTTAIDMWS AGVIFLSLLS GRYPFYKASD 420

DLTALAQIMT IRGSRETIQA AKTFGKSILC SKEVPAQDLR KLCERLRGMD SNTPKLTSDV 480

QGHASHQPTI SEKTDHKASC LIQTPPGQYS GNSFKKGDSN SCEHCFDEYN TNLEGWNEVP 540

NEAYDLLDKL LDLNPASRIT AEEALLHPFF KDMSL 575

Nucleotide Sequence
(FASTA)

ATGGAGGCGT CTTTGGGGAT TCAGATGGAT GAGCCAATGG CTTTTTCTTC CCAGCATGAC 60

CGGTTTCAGG CTGAAGGCTC TTTAAAAAAA AACGAGCAGA ATTTTAAACT TGCAGGTGTT 120

AAAAGAGATA TTGAGAAGCT TTATGAAGCA GTACCACAGC TTAGTAATGT GTTTAAGATT 180

AAGGACAAAA TTGGAGAAGG CACTTTCAGC TCTGTTTATT TGGCCACAGC ACAGTTACAA 240

GTAGGACCTG AAGAGAAAAT TGCTCTAAAA CACTTGATTC CAACAAGTCA TCCTATAAGA 300

ATTGCAGCTG AACTTCAGTG CCTAACGGTG GCTGGGGGGC AAGATAACGT CATGGGAGTT 360

AAATACTGCT TTAGGAAGAA TGATCATGTA GTTATTGCTA TGCCATATCT GGAGCATGAG 420

TCGTTTTTGG ACATTTTGAA TTCTCTTTCC TTTCAAGAAG TACGGGAATA TATGTTTAAT 480

CTGTTCAAAG CTTTGAAACG CATTCATCAG TTTGGTATTG TTCACCGTGA TGTTAAGCCC 540

AGCAATTTTT TATATAATAG GCGCTTGAAA AAGTATGCCT TGGTAGACTT TGGTTTGGCC 600

CAAGGAACCC ATGATACGAA AATAGAGCTT CTTAAATTTG TCCAGTCTGA AGCTCAGCAG 660

GAAAGGTGTT CACAAAACAA ATCCCACATA ATCACAGGAA ACAAGATTCC ATTGAGTGGC 720

CCAGTACCTA AGGAGCTGGA TCAGCAGTCC ACCACAAAAG CTTCTGTTAA AAGACCCTAC 780

ACAAATGCAC AAAGTCAGAT TAAACAAGGA AAAGACGGAA AGGAGGGATC TGTAGGCCTT 840

TCTGTCCAGC GCTCTGTTTT TGGAGAAAGA AATTTCAATA TACACAGCTC CATTTCACAT 900

GAGAGCCCTG CAGTGAAAGT AAGTAATAAC ATTAAGGGCT TTTCTGTCAT TGCTAGACAT 960

GAACAACAAA TTAAAACTGT GATTTTAGCC AACGTACTTG TGCAGTTTAC AGTTCTGAAA 1020

TGGAAACATA ACTGTTTTAT ACTTTTCCTG ACCTGTGACT GCTATGCAAC AGATAAAGTT 1080

TGTAGTATTT GCCTTTCAAG GCGTCAGCAG GTTGCCCCTA GGGCAGGTAC ACCAGGATTC 1140

AGAGCACCAG AGGTCTTGAC AAAGTGCCCC AATCAAACTA CAGCAATTGA CATGTGGTCT 1200

GCAGGTGTCA TATTTCTTTC TTTGCTTAGT GGACGATATC CATTTTATAA AGCAAGTGAT 1260

GATTTAACTG CTTTGGCCCA AATTATGACA ATTAGGGGAT CCAGAGAAAC TATCCAAGCT 1320

GCTAAAACTT TTGGGAAATC AATATTATGT AGCAAAGAAG TTCCAGCACA AGACTTGAGA 1380

AAACTCTGTG AGAGACTCAG GGGTATGGAT TCTAACACTC CCAAGTTAAC AAGTGATGTA 1440

CAAGGGCATG CTTCTCATCA ACCAACTATT TCAGAGAAGA CTGACCATAA AGCTTCTTGC 1500

CTCATACAAA CACCTCCAGG ACAATACTCA GGGAATTCAT TTAAAAAGGG GGATAGTAAT 1560

AGCTGTGAGC ATTGTTTTGA TGAGTATAAT ACCAATTTAG AAGGCTGGAA TGAGGTACCC 1620

AATGAAGCTT ATGACCTGCT TGATAAACTT CTAGATCTAA ATCCAGCTTC AAGAATAACA 1680

GCAGAAGAAG CTTTGTTGCA TCCATTTTTT AAAGATATGA GTTTGTGA 1728

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fkikdkiGeGtfssvylataql++g+eekialkhliptshP+riaaeL++ltv+gGq+nv

Q: 58    FKIKDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV  117

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +g+k+cfrknd+vvi++pylehesfld+l+slsfqevreY++nL++alkr+h+fgivhrD

Q: 118   MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMFNLFKALKRIHQFGIVHRD  177

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq..............seaqkeecsrn..........l  156

         vkpsnfLynrrlkk+aLvDfGLaq              seaq+e+cs+n          +

Q: 178   VKPSNFLYNRRLKKYALVDFGLAQgthdtkiellkfvqSEAQQERCSQNkshiitgnkiP  237

         ***********************************************************9

S: 157   lsaavekevd..................................................  166

         ls++v+ke+d

Q: 238   LSGPVPKELDqqsttkasvkrpytnaqsqikqgkdgkegsvglsvqrsvfgernfnihss  297

         ************************************************************

S: 167   .....................................................tcdcygt  173

                                                              tcdcy+t

Q: 298   ishespavkvsnnikgfsviarheqqiktvilanvlvqftvlkwkhncfilflTCDCYAT  357

         ************************************************************

S: 174   dkvcsvclsrrqqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLsllsgryPffk  233

         dkvcs+clsrrqqva+raGtpGfraPevL+k+p+qttaiD+wsaGvi+LsllsgryPf+k

Q: 358   DKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYK  417

         ************************************************************

S: 234   asddlealaeivtilGsreiikaakafgksvllskevp......................  271

         asddl+ala+i+ti+Gsre+i+aak+fgks+l+skevp

Q: 418   ASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPaqdlrklcerlrgmdsntpklt  477

         ************************************************************

S: 272   ........................................dsdsye..............  277

                                                 ds+s+e

Q: 478   sdvqghashqptisektdhkascliqtppgqysgnsfkkgDSNSCEhcfdeyntnlegwn  537

         ***************************************988888788899999999999

S: 278   ..PdeaydlldkllelnPakritaeealkhpff  308

           P+eaydlldkll+lnPa+ritaeeal+hpff

Q: 538   evPNEAYDLLDKLLDLNPASRITAEEALLHPFF  570

         99******************************8

Domain Sequence
(FASTA)

FKIKDKIGEG TFSSVYLATA QLQVGPEEKI ALKHLIPTSH PIRIAAELQC LTVAGGQDNV 60

MGVKYCFRKN DHVVIAMPYL EHESFLDILN SLSFQEVREY MFNLFKALKR IHQFGIVHRD 120

VKPSNFLYNR RLKKYALVDF GLAQGTHDTK IELLKFVQSE AQQERCSQNK SHIITGNKIP 180

LSGPVPKELD QQSTTKASVK RPYTNAQSQI KQGKDGKEGS VGLSVQRSVF GERNFNIHSS 240

ISHESPAVKV SNNIKGFSVI ARHEQQIKTV ILANVLVQFT VLKWKHNCFI LFLTCDCYAT 300

DKVCSICLSR RQQVAPRAGT PGFRAPEVLT KCPNQTTAID MWSAGVIFLS LLSGRYPFYK 360

ASDDLTALAQ IMTIRGSRET IQAAKTFGKS ILCSKEVPAQ DLRKLCERLR GMDSNTPKLT 420

SDVQGHASHQ PTISEKTDHK ASCLIQTPPG QYSGNSFKKG DSNSCEHCFD EYNTNLEGWN 480

EVPNEAYDLL DKLLDLNPAS RITAEEALLH PFF 513

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013