EKS-NOL-00115

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00115

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	481.8	4.7E-145	1096	1356	261

Status

Unreviewed

Ensembl Protein

ENSNLEP00000014096

UniProt Accession

G1RLI8;

Protein Name

Protein Synonyms/Alias

Hepatocyte growth factor receptor;

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000011530	ENSNLEP00000014096	ENSNLET00000014789

Organism

Nomascus leucogenys

Functional Description

Protein Length

1408

Protein Sequence
(FASTA)

MKTPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSKMNVNMK YQLPNFTAET PIQNVILHEH 60

HIFLGATNYI YVLNEEELQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL 120

VVDTYYDDQL ISCGSINRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL 180

GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE 240

FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL 300

TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS 360

AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF 420

TTALQRVDLF MGQFSEVLLT SVSTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL 480

LDSHPVSPEV IVEHPLNQNG YTLVVTGKKI TKIPLSGLGC RHFQSCSQCL SAPPFVQCGW 540

CHDKCVRSEE CPSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK 600

TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSITI SNGHGTTQYS TFSYVDPVIT 660

SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF 720

AVKLKIDLAN RETNIFSYRE DPIVYEIHPT KSFISTWWKE PLNIVSFLFC FASGGSTITG 780

VGKNLNSVSV PRMVINVHEA GRNFTVACQH RSNSEIICCT TPSLQQLNLQ LPLKTKAFFM 840

LDGILSKYFD LIYVHNPVFK PFEKPVMISM GNENVLEIKG NDIDPEAVKG EVLKVGNKSC 900

ENIHLHSEAV LCTVPNDLLK LNSELNIEWK QAISSTVLGK VIVQPDQNFT GLIAGVVSIS 960

VALLLLLGFF LWLKKRKQIK DLGSELVRYD ARVHTPHLDR LVSARSVSPT TEMVSNESVD 1020

YRATFPEDQF PNSSQNGSCR QVQYPLTDMS PILTSGDSDI SSPLLQNTVH IDLSALNPEL 1080

VQAVQHVVIG PSSLIVHFNE VIGRGHFGCV YHGTLLDNDG KKIHCAVKSL NRITDIGEVS 1140

QFLTEGIIMK DFSHPNVLSL LGICLRSEGS PLVVLPYMKH GDLRNFIRNE THNPTVKDLI 1200

GFGLQVAKGM KYLASKKFVH RDLAARNCML DEKFTVKVAD FGLARDMYDK EYYSVHNKTG 1260

AKLPVKWMAL ESLQTQKFTT KSDVWSFGVL LWELMTRGAP PYPDVNTFDI TVYLLQGRRL 1320

LQPEYCPDPL YEVMLKCWHP KAEMRPSFSE LVSRISAIFS TFIGEHYVHV NATYVNVKCV 1380

APYPSLLSSE DNADNEVDTR PASFWETS 1408

Nucleotide Sequence
(FASTA)

ATGAAGACTC CCGCTGTGCT TGCACCTGGC ATCCTCGTGC TCTTGTTTAC CTTGGTGCAG 60

AGGAGCAATG GGGAGTGTAA AGAGGCACTA GCAAAGTCCA AGATGAATGT GAATATGAAG 120

TATCAGCTTC CCAACTTCAC CGCGGAAACA CCCATCCAGA ATGTCATTCT ACATGAGCAT 180

CACATTTTCC TCGGTGCCAC TAACTACATT TATGTTTTAA ACGAGGAAGA ACTTCAGAAG 240

GTTGCTGAGT ACAAGACCGG GCCTGTGCTG GAACACCCAG ATTGTTTCCC ATGTCAGGAC 300

TGCAGCAGCA AAGCCAATTT ATCAGGAGGT GTTTGGAAAG ATAACATCAA CATGGCTCTG 360

GTTGTCGACA CCTACTATGA TGATCAACTC ATTAGCTGTG GCAGCATCAA TAGAGGGACC 420

TGCCAGCGAC ATGTCTTTCC CCACAATCAT ACTGCTGACA TACAGTCGGA GGTTCACTGC 480

ATATTCTCCC CACAGATAGA AGAGCCCAGC CAGTGTCCTG ACTGCGTGGT GAGCGCCCTG 540

GGAGCCAAAG TCCTTTCATC TGTAAAGGAC CGGTTCATCA ACTTCTTTGT AGGCAATACC 600

ATAAATTCCT CTTATTTCCC AGATCATCCG TTGCATTCGA TATCAGTGAG AAGGCTAAAG 660

GAAACGAAAG ATGGTTTTAT GTTTTTGACG GACCAGTCCT ACATTGATGT TTTACCTGAG 720

TTCAGAGATT CTTACCCCAT TAAGTATGTC CATGCCTTTG AAAGCAACAA TTTTATTTAC 780

TTCTTGACGG TCCAAAGGGA AACTCTAGAT GCTCAGACTT TTCACACAAG AATAATCAGG 840

TTCTGTTCCA TAAACTCTGG ATTGCATTCC TACATGGAAA TGCCTCTGGA GTGTATTCTC 900

ACAGAAAAGA GAAAAAAGAG ATCCACAAAG AAGGAAGTGT TTAATATCCT TCAGGCTGCA 960

TATGTCAGCA AGCCTGGGGC CCAACTTGCT AGACAAATAG GAGCCAGCCT GAATGATGAC 1020

ATTCTCTTCG GGGTGTTCGC ACAAAGCAAG CCAGATTCTG CCGAACCAAT GGATCGATCT 1080

GCCATGTGTG CATTCCCTAT CAAATATGTC AACGACTTCT TCAACAAGAT CGTCAACAAA 1140

AACAATGTGA GATGTCTCCA GCATTTTTAC GGACCCAATC ATGAGCACTG TTTTAATAGG 1200

ACACTTCTGA GAAATTCATC AGGCTGTGAA GCGCGCCGTG ATGAATATCG AACAGAGTTT 1260

ACCACAGCTT TGCAGCGCGT TGACTTATTC ATGGGTCAAT TCAGCGAAGT CCTCTTAACA 1320

TCTGTATCCA CCTTCATTAA AGGAGACCTC ACCATAGCTA ATCTTGGGAC ATCAGAGGGT 1380

CGCTTCATGC AGGTTGTGGT TTCTCGATCA GGACCATCAA CCCCTCATGT TAATTTTCTC 1440

CTGGACTCCC ATCCAGTGTC TCCAGAAGTG ATTGTGGAGC ATCCATTAAA CCAGAATGGC 1500

TACACACTGG TTGTCACTGG GAAGAAGATC ACGAAGATCC CATTGAGTGG CTTGGGCTGC 1560

AGACATTTCC AGTCCTGCAG TCAGTGCCTC TCTGCCCCGC CCTTTGTTCA GTGTGGCTGG 1620

TGCCACGACA AATGTGTGCG ATCGGAGGAA TGCCCGAGCG GGACATGGAC TCAACAGATC 1680

TGTCTGCCTG CAATCTACAA GGTTTTCCCA AATAGTGCAC CCCTTGAAGG AGGGACAAGG 1740

CTGACCATAT GTGGCTGGGA CTTTGGATTT CGGAGGAATA ATAAATTTGA TTTAAAGAAA 1800

ACTAGAGTTC TCCTTGGAAA CGAGAGCTGC ACCTTGACTT TAAGTGAGAG CACGATGAAT 1860

ACATTGAAAT GCACAGTTGG TCCTGCCATG AATAAGCATT TCAATATGTC CATAACTATT 1920

TCAAATGGCC ATGGGACAAC ACAATACAGT ACATTCTCCT ATGTGGATCC TGTAATAACA 1980

AGTATTTCGC CAAAATACGG TCCTATGGCT GGTGGCACTT TACTTACTTT AACTGGAAAT 2040

TACCTAAACA GTGGGAATTC TAGACACATT TCAATTGGTG GAAAAACATG TACTTTAAAA 2100

AGTGTGTCAA ACAGTATTCT TGAATGTTAT ACCCCAGCCC AAACCATTTC AACTGAGTTT 2160

GCTGTTAAAT TGAAAATTGA CTTAGCCAAC CGAGAGACAA ACATCTTCAG TTACCGGGAA 2220

GATCCCATTG TCTATGAAAT TCATCCAACC AAATCTTTTA TTAGTACTTG GTGGAAAGAA 2280

CCTCTCAACA TTGTCAGTTT TCTATTTTGC TTTGCCAGTG GTGGGAGCAC AATAACAGGT 2340

GTTGGGAAAA ACCTGAATTC AGTTAGTGTC CCGAGGATGG TCATAAATGT GCACGAAGCA 2400

GGAAGGAACT TTACAGTGGC ATGTCAACAT CGCTCTAATT CAGAGATAAT CTGCTGTACC 2460

ACTCCTTCCC TGCAACAGCT GAATCTGCAA CTCCCCCTGA AAACCAAAGC CTTTTTCATG 2520

TTAGATGGGA TCCTTTCCAA ATACTTTGAT CTCATTTATG TACATAATCC TGTGTTTAAG 2580

CCTTTTGAAA AGCCAGTGAT GATCTCAATG GGCAATGAAA ATGTACTGGA AATTAAGGGA 2640

AATGATATTG ACCCTGAAGC AGTTAAAGGT GAAGTGTTAA AAGTTGGAAA TAAGAGCTGT 2700

GAGAATATAC ACTTACATTC TGAAGCCGTT TTATGCACGG TCCCCAATGA CCTGCTGAAA 2760

TTGAACAGCG AGCTAAATAT AGAGTGGAAG CAAGCAATTT CTTCAACCGT CCTTGGAAAA 2820

GTAATAGTTC AACCAGATCA GAATTTCACA GGATTGATTG CTGGTGTTGT CTCAATATCA 2880

GTAGCACTGT TATTACTACT TGGGTTTTTC CTGTGGCTGA AAAAGAGGAA ACAAATTAAA 2940

GATCTGGGCA GTGAATTAGT TCGCTATGAT GCAAGAGTAC ACACTCCTCA TTTGGATAGG 3000

CTTGTAAGTG CCCGAAGTGT AAGCCCAACT ACAGAAATGG TTTCAAATGA ATCTGTAGAC 3060

TACCGAGCTA CTTTTCCAGA AGATCAGTTT CCTAATTCAT CTCAGAACGG TTCATGCCGA 3120

CAAGTGCAGT ATCCTCTGAC AGACATGTCC CCCATCCTAA CTAGTGGGGA CTCTGATATA 3180

TCCAGTCCAT TACTGCAAAA TACTGTCCAC ATTGACCTCA GTGCTCTAAA TCCAGAGCTG 3240

GTCCAGGCAG TGCAGCATGT AGTGATTGGG CCCAGTAGCC TGATTGTGCA TTTCAATGAA 3300

GTCATAGGAA GAGGGCATTT TGGTTGTGTA TATCATGGGA CTTTGTTGGA CAATGATGGC 3360

AAGAAAATTC ACTGTGCTGT GAAATCCTTG AACAGAATCA CTGACATAGG AGAAGTTTCC 3420

CAATTTCTGA CAGAGGGAAT CATCATGAAA GATTTCAGTC ATCCCAATGT CCTCTCGCTC 3480

CTGGGAATCT GCCTGCGAAG TGAAGGGTCT CCGCTGGTGG TCCTACCATA CATGAAACAT 3540

GGAGATCTTC GAAATTTCAT TCGAAATGAG ACTCATAATC CAACTGTAAA AGATCTTATT 3600

GGCTTTGGTC TTCAAGTAGC CAAAGGCATG AAATATCTTG CGAGCAAAAA GTTTGTCCAC 3660

AGAGACTTGG CTGCAAGAAA CTGTATGCTG GATGAAAAAT TCACAGTCAA GGTTGCTGAT 3720

TTTGGTCTTG CCAGAGACAT GTATGATAAA GAATACTATA GTGTACACAA CAAAACAGGT 3780

GCAAAGCTGC CAGTGAAGTG GATGGCTTTG GAAAGTCTGC AAACTCAAAA GTTTACCACC 3840

AAGTCAGATG TGTGGTCCTT TGGCGTGCTC CTCTGGGAGC TGATGACAAG AGGAGCCCCA 3900

CCTTATCCTG ATGTGAACAC CTTTGATATA ACTGTTTACT TGTTGCAAGG GAGAAGACTC 3960

CTACAACCCG AATACTGCCC AGACCCCTTA TATGAAGTAA TGCTAAAATG CTGGCACCCT 4020

AAAGCCGAAA TGCGCCCATC CTTTTCTGAA CTGGTGTCCC GGATATCAGC GATCTTCTCT 4080

ACTTTCATTG GGGAGCACTA TGTCCATGTG AACGCTACTT ATGTGAATGT AAAATGTGTT 4140

GCTCCATATC CTTCTCTGTT GTCATCAGAA GATAACGCTG ATAATGAGGT GGACACACGA 4200

CCAGCCTCCT TCTGGGAGAC ATCATAG 4227

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1096  VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1155

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1156  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1215

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1216  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1275

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1276  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1334

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1335  LKCWHPKAEMRPSFSELVSRIS  1356

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDGKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAEMR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0048754	; P:branching morphogenesis of a tube
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013