EKS-NOL-00147
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00147
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK369.11.4E-11059318260
StatusUnreviewed
Ensembl ProteinENSNLEP00000014055
UniProt AccessionG1RLE7;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000011560ENSNLEP00000014055ENSNLET00000014747
OrganismNomascus leucogenys
Functional Description
Protein Length536
Protein Sequence
(FASTA)
MDLSMKKFAV RRFFSVYLRR KSRSKSSSLS RLEEEGVVKE IDISHHVKEG FEKADPSQFE 60
LLKVLGQGSY GKVFLVRKVK GPDAGQLYAM KVLKKATLKV RDRVRSKMER DILAEVNHPF 120
IVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL ALDHLHSLGI 180
IYRDLKPENI LLDEEGHIKI TDFGLSKEAI DHDKRAYSFC GTIEYMAPEV VNRRGHTQSA 240
DWWSFGVLMF EMLTGSLPFQ GKDRKETMAL ILKAKLGMPQ FLSGEAQSLL RALFKRNPCN 300
RLGAGTDGVE EIKRHPFFVT IDWNTLYRKE IKPPFKPAVG RPEDTFHFDP EFTARTPTDS 360
PGVPPSANAH HLFRGFSFVA SSLIQEPSQQ DLHKVPVHPI VQQLHGNNIH FTDGYEIKED 420
IGVGSYSVCK RCVHKATDTE YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK 480
FVYLVMELMR GGELLDRILQ QRYFSEREAS DVLCTITKTM DYLHSQGGCS SRPEAE 536
Nucleotide Sequence
(FASTA)
ATGGACCTGA GCATGAAGAA GTTCGCCGTG CGCAGGTTCT TCTCCGTGTA CCTGCGCAGG 60
AAGTCGCGCT CCAAGAGCTC CAGCCTGAGC CGGCTCGAGG AAGAAGGCGT CGTGAAGGAG 120
ATAGACATCA GCCATCATGT GAAGGAGGGC TTTGAGAAGG CAGACCCTTC CCAGTTTGAG 180
CTGCTGAAGG TTTTAGGACA AGGATCCTAT GGAAAGGTGT TCCTGGTGAG AAAGGTGAAG 240
GGGCCCGACG CTGGGCAGCT CTATGCCATG AAGGTCCTTA AGAAAGCCAC CCTAAAAGTT 300
CGAGACCGAG TGAGATCGAA GATGGAGAGA GACATCTTGG CAGAAGTGAA TCACCCCTTC 360
ATTGTGAAGC TTCATTATGC CTTTCAGACG GAAGGAAAGC TCTACCTGAT CCTGGACTTC 420
CTGCGGGGAG GGGACCTCTT CACCCGGCTC TCCAAAGAGG TCATGTTCAC GGAGGAGGAT 480
GTCAAGTTCT ACCTGGCTGA GCTGGCCTTG GCTTTAGACC ATCTCCACAG CCTGGGGATC 540
ATCTACAGAG ATCTGAAGCC AGAGAACATC CTCCTGGATG AAGAGGGACA TATTAAGATC 600
ACAGATTTCG GCCTGAGTAA GGAGGCCATT GACCACGACA AGAGAGCGTA CTCCTTCTGC 660
GGGACGATCG AGTATATGGC GCCCGAGGTG GTGAACCGGC GAGGACACAC GCAGAGTGCC 720
GACTGGTGGT CCTTCGGCGT GCTCATGTTC GAGATGCTCA CGGGGTCCCT GCCGTTCCAG 780
GGGAAGGACA GGAAGGAGAC CATGGCTCTC ATCCTCAAAG CCAAGCTGGG GATGCCGCAG 840
TTCCTCAGCG GGGAGGCACA GAGTTTGCTG CGAGCTCTCT TCAAACGGAA CCCTTGCAAC 900
CGGCTGGGTG CTGGCACTGA CGGAGTGGAG GAAATTAAGC GCCATCCCTT CTTTGTGACC 960
ATAGACTGGA ATACGCTGTA CCGGAAGGAG ATCAAGCCAC CATTCAAACC AGCAGTGGGC 1020
AGGCCTGAGG ACACCTTCCA CTTCGACCCC GAGTTCACAG CACGGACGCC CACAGACTCT 1080
CCTGGCGTCC CCCCGAGTGC GAATGCTCAT CACCTGTTTA GAGGATTCAG CTTTGTGGCC 1140
TCAAGCCTGA TCCAGGAGCC CTCACAGCAA GATCTGCACA AAGTCCCAGT TCACCCAATC 1200
GTGCAGCAGT TACACGGGAA CAACATCCAC TTCACTGATG GCTACGAGAT CAAGGAGGAC 1260
ATCGGGGTGG GCTCCTACTC AGTGTGCAAG CGATGTGTGC ATAAAGCCAC GGACACCGAG 1320
TACGCCGTGA AGATCATCGA TAAGAGCAAG AGAGACCCCT CGGAAGAGAT CGAGATCCTC 1380
CTGCGGTACG GCCAGCACCC GAACATCATC ACCCTCAAGG ATGTCTATGA CGACGGCAAG 1440
TTCGTGTACC TGGTAATGGA GCTGATGCGC GGCGGGGAGC TCCTGGACCG TATCCTCCAG 1500
CAGAGATACT TCTCGGAGCG CGAAGCCAGT GACGTCCTGT GCACCATCAC CAAGACCATG 1560
GACTACCTCC ATTCCCAGGG GGGTTGTTCA TCGAGACCTG AAGCCGAGTA A 1611
Domain Profile
S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvkkkkertkeereiLeeveh  60
         fellkvlg+G+ygkvflvrkv++ d+g+lya+Kvlkka+l+++++ r+k+er+iL+ev+h
Q: 59    FELLKVLGQGSYGKVFLVRKVKGPDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNH  118
         89**********************************************************
S: 61    pfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylHsk  120
         pfivklh+afq+e klyl+l++l+Gg+L++rl+k+ +f+ee+++f+lael+lal++lHs 
Q: 119   PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSL  178
         ************************************************************
S: 121   gvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkgyd  180
         g++yrDLkpeNilldeegh+k+tDfgl+ke+i +++++aysfcgT+ey+aPev++r+g++
Q: 179   GIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMAPEVVNRRGHT  237
         ******************************99.8889999********************
S: 181   eavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvkkl  240
         +++D+ws+Gvl++emLtG+ Pf+g++rket+a ilk+k  l +p++  ls ea++l+++l
Q: 238   QSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAK--LGMPQF--LSGEAQSLLRAL  293
         **************************************..******..************
S: 241   LkkdpakRlga...taeeikehkfl  262
         +k++p +Rlga   ++eeik+h+f+
Q: 294   FKRNPCNRLGAgtdGVEEIKRHPFF  318
         **********99999********97
Domain Sequence
(FASTA)
FELLKVLGQG SYGKVFLVRK VKGPDAGQLY AMKVLKKATL KVRDRVRSKM ERDILAEVNH 60
PFIVKLHYAF QTEGKLYLIL DFLRGGDLFT RLSKEVMFTE EDVKFYLAEL ALALDHLHSL 120
GIIYRDLKPE NILLDEEGHI KITDFGLSKE AIDHDKRAYS FCGTIEYMAP EVVNRRGHTQ 180
SADWWSFGVL MFEMLTGSLP FQGKDRKETM ALILKAKLGM PQFLSGEAQS LLRALFKRNP 240
CNRLGAGTDG VEEIKRHPFF 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Pan troglodytes"; ?>
EKS-PAT-00155
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013