EKS-NOL-00429

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00429

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	334.2	6.0E-100	22	312	291

Status

Unreviewed

Ensembl Protein

ENSNLEP00000014367

UniProt Accession

G1RMA3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000011809	ENSNLEP00000014367	ENSNLET00000015079

Organism

Nomascus leucogenys

Functional Description

Protein Length

587

Protein Sequence
(FASTA)

MAEKGDCIAS VYGYDLGGRF VDFQPLGFGV NGLVLSAVDS RACRKVAVKK IALSDARSMK 60

HALREIKIIR RLDHDNIVKV YEVLGPKGTD LQGELFKFSV AYIVQEYMET DLARLLEQGT 120

LAEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL 240

ILETIPVIRE EDKDELLRVM PSFVSSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR 300

LTAEMGLQHP YMSPYSCPED EPTSQHPFRI EDEIDDIVLM AANQSQLSNW DTCSSRYPVS 360

LSSDLEWRPD RCQDASEVQR DPRAGSAPLA EDVQVDPRKD SHSSSERFLE QSHSSMERAF 420

ETDYGRSCDY KVGSPSYLDK LLWRDNKPHH YSEPKLILDL SHWKQAAGAP PTATGLVDTG 480

AREDEPASLF LEIAQWVKST QGGPEHASPP AEDPERRLSA SPPGRPAPVD GSASPQFDLD 540

VFISRALKLC TKPEDLPDNK LGDLNGACIP EHPGDLVQTE AFSKERW 587

Nucleotide Sequence
(FASTA)

ATGGCTGAGA AGGGTGACTG CATCGCCAGT GTCTACGGGT ATGACCTCGG TGGGCGCTTT 60

GTTGACTTCC AACCCCTGGG CTTCGGTGTC AATGGTTTGG TGCTGTCGGC CGTGGACAGC 120

CGGGCCTGCC GGAAGGTCGC CGTGAAGAAG ATTGCCCTGA GCGATGCCCG CAGCATGAAG 180

CACGCGCTCC GAGAGATCAA GATCATTCGG CGCCTGGACC ACGACAACAT CGTCAAAGTG 240

TATGAGGTGC TCGGGCCCAA GGGAACTGAC CTGCAGGGTG AGCTGTTCAA GTTCAGCGTG 300

GCCTACATCG TCCAGGAGTA CATGGAGACC GACCTGGCAC GCCTGCTGGA GCAGGGCACG 360

CTGGCAGAAG AGCATGCCAA GCTGTTCATG TACCAGCTGC TCCGCGGGCT CAAGTACATC 420

CACTCCGCCA ACGTGCTGCA CAGGGACCTG AAGCCCGCCA ACATCTTCAT CAGCACAGAG 480

GACCTCGTGC TCAAGATTGG GGATTTCGGG CTGGCAAGGA TCGTTGATCA GCATTACTCC 540

CACAAGGGTT ATCTGTCAGA AGGGTTGGTA ACAAAGTGGT ACCGTTCCCC ACGACTGCTC 600

CTCTCCCCCA ATAACTACAC AAAAGCCATC GACATGTGGG CCGCCGGCTG CATCCTGGCT 660

GAGATGCTTA CAGGGAGAAT GCTCTTTGCT GGGGCCCATG AGCTGGAGCA GATGCAACTC 720

ATCCTGGAGA CCATCCCTGT AATCCGGGAG GAAGACAAGG ACGAGCTGCT CAGGGTGATG 780

CCTTCCTTTG TCAGCAGCAC CTGGGAGGTG AAGAGGCCTC TGCGCAAGCT GCTCCCCGAA 840

GTGAACAGTG AAGCCATCGA CTTTCTGGAG AAGATCCTGA CCTTTAACCC CATGGATCGC 900

CTAACAGCTG AGATGGGGCT GCAACACCCC TACATGAGCC CATACTCGTG CCCTGAGGAC 960

GAGCCCACCT CGCAACACCC CTTCCGCATT GAGGATGAGA TCGACGACAT CGTGCTGATG 1020

GCCGCTAACC AGAGCCAGCT GTCCAACTGG GACACGTGCA GTTCCAGGTA CCCTGTGAGC 1080

CTGTCGTCGG ACCTCGAGTG GCGACCCGAC CGTTGCCAGG ACGCCAGTGA GGTGCAGCGC 1140

GACCCGCGCG CGGGTTCGGC GCCACTGGCG GAGGACGTGC AGGTGGACCC GCGCAAGGAC 1200

TCGCACAGCA GCTCCGAGCG CTTCCTAGAG CAGTCGCACT CGTCCATGGA GCGCGCCTTC 1260

GAGACCGACT ACGGGCGCTC CTGCGACTAC AAGGTGGGGT CGCCTTCCTA CCTGGACAAG 1320

CTGCTGTGGC GCGACAACAA GCCACACCAC TACTCGGAGC CCAAGCTCAT CCTGGACCTG 1380

TCGCACTGGA AGCAGGCGGC CGGCGCGCCC CCTACGGCCA CGGGGCTGGT AGACACGGGG 1440

GCGCGCGAGG ACGAGCCGGC CAGCCTCTTC CTGGAGATCG CGCAGTGGGT CAAGAGCACG 1500

CAGGGCGGCC CCGAGCACGC TAGCCCGCCC GCCGAAGACC CCGAGCGCCG CTTGTCTGCC 1560

TCGCCCCCAG GCCGCCCGGC CCCGGTGGAC GGCAGCGCCA GCCCCCAGTT CGACCTGGAC 1620

GTGTTCATCT CCCGCGCCCT GAAGCTCTGC ACCAAGCCCG AGGACCTGCC GGACAATAAA 1680

CTGGGCGACC TCAATGGTGC GTGCATCCCC GAGCACCCTG GTGACCTCGT GCAGACCGAG 1740

GCCTTCTCCA AAGAAAGGTG GTGA 1764

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg G +g+v+savd+r+ ++va+kk++  ++++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +++v+ p+      el +++  Y+v+e+metdL++++++ +l +eh+kl++yq+lrglky

Q: 80    VYEVLGPKGtdlqgELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKY  139

         *******9888888899*******************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++ile+++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++++s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+

Q: 260   -MPSFVSSTWEVKR-PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM  312

         .9*******99988.9**************************************7

Domain Sequence
(FASTA)

DFQPLGFGVN GLVLSAVDSR ACRKVAVKKI ALSDARSMKH ALREIKIIRR LDHDNIVKVY 60

EVLGPKGTDL QGELFKFSVA YIVQEYMETD LARLLEQGTL AEEHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG AHELEQMQLI LETIPVIREE DKDELLRVMP 240

SFVSSTWEVK RPLRKLLPEV NSEAIDFLEK ILTFNPMDRL TAEMGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013