EKS-NOL-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	510.3	8.5E-154	179	437	259

Status

Unreviewed

Ensembl Protein

ENSNLEP00000014604

UniProt Accession

G1RMZ0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000012021	ENSNLEP00000014604	ENSNLET00000015331

Organism

Nomascus leucogenys

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

ALVNVKLWAI DRQCFQTIMM RTGLIKHTEY MEFLKSVPTF QSLPEEILSK LADVLEETHY 60

ENGEYIIRQG ARGDTFFIIS KGTVNVTRED SPSEDPVFLR TLGKGDWFGE KALQGEDVRT 120

ANVIAAEAVT CLVIDRDSFK HLIGGLDDVS NKAYEDAEAK AKYEAEAAFF ANLKLSDFNI 180

IDTLGVGGFG RVELVQLKSE ESKTFAMKIL KKRHIVDTRQ QEHIRSEKQI MQGAHSDFIV 240

RLYRTFKDSK YLYMLMEACL GGELWTILRD RGSFEDSTTR FYTACVVEAF AYLHSKGIIY 300

RDLKPENLIL DHRGYAKLVD FGFAKKIGFG KKTWTFCGTP EYVAPEIILN KGHDISADYW 360

SLGILMYELL TGSPPFSGPD PMKTYNIILR GIDMIEFPKK IAKNAANLIK KLCRDNPSER 420

LGNLKNGVKD IQKHKWFEGF NWEGLRKGTL TPPIIPSVAS PTDTSNFDSF PEDNDEPPPD 480

DNSGWDIDF 489

Nucleotide Sequence
(FASTA)

GCTCTTGTAA ATGTAAAACT CTGGGCCATT GATCGACAAT GTTTTCAAAC AATAATGATG 60

AGGACAGGAC TCATCAAGCA TACCGAGTAT ATGGAATTTT TAAAAAGTGT TCCAACATTC 120

CAGAGCCTTC CTGAAGAGAT CCTCAGCAAG CTCGCTGATG TCCTTGAAGA GACCCACTAT 180

GAAAATGGAG AATATATTAT CAGGCAAGGT GCAAGAGGGG ACACCTTCTT TATCATCAGC 240

AAAGGAACGG TAAATGTCAC TCGTGAAGAC TCACCAAGTG AAGACCCAGT CTTTCTTAGA 300

ACTTTAGGAA AAGGAGACTG GTTTGGAGAG AAAGCCTTGC AGGGGGAAGA TGTGAGAACA 360

GCAAACGTAA TTGCTGCAGA AGCTGTAACC TGCCTTGTGA TTGACAGAGA CTCTTTCAAA 420

CATTTGATTG GAGGGCTGGA TGATGTTTCT AATAAAGCAT ATGAAGATGC AGAAGCTAAA 480

GCAAAATATG AAGCTGAAGC GGCTTTCTTC GCCAACCTGA AGCTGTCTGA TTTCAACATC 540

ATTGATACCC TTGGAGTTGG AGGTTTTGGA CGAGTAGAAC TGGTTCAGTT GAAAAGTGAA 600

GAATCCAAAA CCTTTGCAAT GAAGATTCTC AAGAAACGTC ACATTGTGGA CACAAGACAG 660

CAGGAGCACA TCCGCTCAGA GAAGCAGATC ATGCAGGGGG CTCATTCCGA TTTCATAGTG 720

AGACTGTACA GAACATTTAA GGACAGCAAA TATTTGTATA TGTTGATGGA AGCTTGTCTA 780

GGTGGAGAGC TCTGGACCAT TCTCAGGGAT AGAGGTTCGT TTGAAGATTC TACAACCAGA 840

TTTTACACAG CATGTGTGGT AGAAGCTTTT GCCTATCTAC ATTCCAAAGG AATCATTTAC 900

AGGGACCTCA AGCCAGAAAA TCTCATCCTA GATCACCGAG GTTATGCTAA ACTGGTTGAT 960

TTTGGCTTTG CAAAGAAAAT AGGATTTGGA AAGAAAACAT GGACTTTTTG TGGGACTCCA 1020

GAGTATGTAG CCCCAGAGAT CATCCTGAAC AAAGGCCATG ACATTTCAGC CGACTACTGG 1080

TCACTGGGAA TCCTAATGTA TGAACTCCTG ACTGGCAGCC CACCTTTCTC AGGCCCAGAT 1140

CCTATGAAAA CCTATAACAT CATATTGAGG GGGATTGACA TGATAGAATT TCCAAAGAAG 1200

ATTGCCAAAA ATGCTGCTAA TTTAATTAAA AAACTATGCA GGGACAATCC ATCAGAAAGA 1260

TTAGGGAATT TGAAAAATGG AGTAAAAGAC ATTCAAAAGC ACAAATGGTT TGAGGGCTTT 1320

AATTGGGAAG GCTTAAGAAA AGGTACCTTG ACACCTCCTA TAATACCAAG TGTTGCATCA 1380

CCCACAGACA CAAGCAATTT TGACAGTTTC CCTGAGGACA ATGATGAACC ACCACCTGAT 1440

GACAACTCAG GATGGGATAT AGACTTC 1467

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 179   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  238

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 239   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  298

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 299   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  358

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+

Q: 359   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  418

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 419   ERLGNLKNGVKDIQKHKWF  437

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005246	; F:calcium channel regulator activity
GO:0004692	; F:cGMP-dependent protein kinase activity
GO:0090331	; P:negative regulation of platelet aggregation
GO:0043087	; P:regulation of GTPase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013