EKS-NOL-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	330.5	8.1E-99	904	1174	271

Status

Unreviewed

Ensembl Protein

ENSNLEP00000014804

UniProt Accession

G1RNJ0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000012193	ENSNLEP00000014804	ENSNLET00000015548

Organism

Nomascus leucogenys

Functional Description

Protein Length

1194

Protein Sequence
(FASTA)

MPAEPAARSM PLRHWGTARG SKPVGDGAQP MAAMGGLKVL LHWAGPGGGE PWVTFSESSL 60

TAEEVCIHIA HKVGITPPCF NLFALFDAQA QVWLPPNHIL EIPRDASLML YFRIRFYFRN 120

WHGMNPQEPA VYRCGPPGTE ASSDHTAQGM QLLDPASFEY LFEQGKHEFV NDVASLWELS 180

SEEEIHHFKN ESLGMAFLHL CHLALRHGIP LEEVAKKTSF KDCIPRSFRR HIRQHSALTR 240

LRLRNVFRRF LRDFQPGRLS QQMVMVKYLA TLERLAPRFG TERVPVCHLR LLAQAEGEPC 300

YIRDSGEAPT DPGPESAAGP PTHEVLVTGT GGIQWWPVQE EVNKEEASSG SSGRNLQASL 360

SGKKAKAHKA VGQPADRPQE PLWAYFCDFR DITHVVLKER SVSIHRQDNK CLELSLPSRA 420

AALSFVSLVD GYFRLTADSS HYLCHEVAPP RLVMSIRDGI HGPLLEPFVQ AKLRPEDGLY 480

LIHWSTSHPY RLILTVAQRS QAPDGMQSLR LRKFPIEQQN GAFVLEGWGR SFPSVRELGA 540

ALQGCLLRAG DDCFSLRRCC LPQPGETSNL IIMRGARAST RTFNLSQLSF HRVDQKEITQ 600

LSHLGQGTRT NVYEGRLRVE GSGDPEEGKM DDEDPLVPGR DRGQELRVVL KVLDPSHHDI 660

ALALYETASL MSQVSHAHLA FVHGVCVRDP AVVMCTSAVS HVCATILQPE RQSLGLASVP 720

LLSGHTPSPA HLENKNLVHG NVCGRNILLA RLGLAEGTSP FIKLSDPGVS LGALSREERV 780

ERIPWMAPEC LPGGPNSLST AMDKWGFGAT LLEICFDGEA PLQSRNPSEK EHFYQRQHRL 840

PEPSCPELAT LTSQCLTYEP TQRPSFRTIL RDLTRLQPHN LADILTVNPD SLASDPTVFH 900

KRYLKKIRDL GEGHFGKVSL YCYDPTNDGT GEMVAVKALK ADCGPQHRLG WKQEIDILRT 960

LYHEHIVKYK GCCEDQGEKS LQLVMEYVPL GSLRDYLPRH SVGLAQLLLF AQQICEGMAY 1020

LHAQHYIHRD LAARNVLLDN DRLVKIGDFG LAKAVPEGHE YYRVREDGDS PVFWYAPECL 1080

KEYKFYYASD VWSFGVTLYE LLTHCDSSQS PPTKFLELIG VAQGQMTVLR LTELLERGER 1140

LPRPNKCPCE VYHLMKNCWE TEASFRPTFE NLIPILKTVH EKYQGQAPSV FSVC 1194

Nucleotide Sequence
(FASTA)

ATGCCTGCTG AGCCAGCTGC CAGGAGCATG CCTCTGCGCC ACTGGGGGAC GGCCAGGGGC 60

AGCAAACCTG TTGGGGATGG AGCCCAGCCC ATGGCTGCCA TGGGGGGCCT GAAGGTGCTT 120

CTGCACTGGG CTGGTCCAGG CGGTGGGGAG CCCTGGGTCA CTTTCAGTGA GTCATCGCTG 180

ACAGCTGAGG AAGTCTGCAT CCACATTGCA CATAAAGTTG GTATCACTCC TCCTTGTTTC 240

AATCTCTTCG CCCTCTTCGA TGCTCAAGCC CAAGTCTGGT TGCCCCCAAA CCACATCCTG 300

GAGATCCCCA GAGACGCAAG TCTGATGCTA TATTTCCGCA TAAGGTTTTA TTTCCGGAAC 360

TGGCATGGCA TGAATCCTCA GGAACCGGCT GTGTACCGTT GTGGGCCCCC AGGAACCGAG 420

GCATCCTCAG ATCACACAGC ACAGGGGATG CAACTCCTGG ACCCAGCCTC ATTTGAGTAC 480

CTCTTTGAGC AGGGCAAGCA TGAGTTTGTG AATGACGTGG CATCACTGTG GGAGCTGTCG 540

AGCGAGGAGG AGATCCACCA CTTTAAGAAT GAGAGCCTGG GCATGGCCTT TCTGCACCTC 600

TGTCACCTCG CTCTCCGCCA TGGCATCCCC CTGGAGGAGG TGGCCAAGAA GACCAGCTTC 660

AAGGACTGCA TCCCGCGCTC CTTCCGTCGG CATATCCGTC AGCACAGCGC CCTGACCCGG 720

CTGCGCCTTC GGAACGTCTT CCGCAGGTTC CTGCGGGACT TCCAGCCGGG CCGACTCTCC 780

CAGCAGATGG TCATGGTCAA ATACCTAGCC ACACTCGAGC GGCTGGCACC CCGCTTCGGC 840

ACAGAGCGTG TGCCCGTGTG CCACCTGAGG CTGCTGGCCC AGGCCGAGGG GGAGCCCTGC 900

TATATCAGGG ACAGTGGGGA GGCCCCTACA GACCCTGGCC CTGAGTCTGC TGCTGGGCCC 960

CCAACCCACG AGGTGCTGGT GACAGGCACT GGTGGCATCC AGTGGTGGCC AGTACAGGAG 1020

GAGGTGAACA AGGAGGAGGC TTCTAGTGGT AGCAGTGGCA GGAACCTCCA AGCCAGCCTG 1080

TCTGGGAAGA AGGCCAAGGC TCACAAGGCA GTTGGCCAGC CGGCGGACAG GCCGCAGGAG 1140

CCACTGTGGG CCTACTTCTG CGACTTCCGG GACATCACCC ACGTGGTGCT GAAAGAGCGC 1200

AGTGTCAGCA TCCACCGGCA GGACAACAAG TGCCTGGAGC TGAGTCTGCC TTCCCGGGCT 1260

GCGGCGCTGT CCTTCGTGTC GCTGGTGGAT GGCTATTTCC GCCTGACGGC CGACTCCAGC 1320

CACTACCTGT GCCATGAGGT GGCTCCCCCA CGGCTGGTGA TGAGCATCCG GGATGGGATC 1380

CACGGACCTC TGCTGGAGCC ATTTGTGCAG GCCAAGCTAC GGCCCGAGGA CGGCCTGTAC 1440

CTCATTCACT GGAGCACCAG CCACCCCTAC CGCCTGATCC TCACAGTGGC CCAGCGTAGC 1500

CAGGCACCAG ACGGCATGCA GAGCTTGCGG CTCCGGAAGT TCCCCATTGA GCAGCAGAAC 1560

GGGGCCTTCG TGCTGGAGGG CTGGGGCCGG TCCTTCCCTA GCGTTCGGGA ACTTGGGGCT 1620

GCCTTGCAGG GCTGCTTGCT GAGGGCCGGG GATGACTGCT TCTCTCTGCG TCGCTGTTGC 1680

CTGCCCCAAC CAGGAGAAAC CTCCAATCTC ATCATCATGC GGGGGGCTCG GGCCAGCACC 1740

AGGACATTCA ACCTCAGCCA GCTCAGCTTC CACCGGGTTG ACCAGAAGGA GATCACCCAG 1800

CTGTCCCACT TGGGCCAGGG CACAAGGACC AATGTGTATG AGGGCCGCCT GCGAGTGGAG 1860

GGCAGCGGGG ACCCTGAGGA GGGCAAGATG GATGACGAGG ACCCCCTCGT GCCTGGCAGG 1920

GACCGTGGGC AGGAGCTACG AGTGGTGCTC AAAGTGCTGG ACCCTAGTCA CCATGACATT 1980

GCCCTGGCCT TATACGAGAC AGCCAGCCTC ATGAGCCAGG TCTCCCACGC GCACCTGGCC 2040

TTCGTGCATG GCGTCTGTGT GCGTGACCCC GCCGTGGTGA TGTGCACCTC TGCAGTGAGC 2100

CATGTTTGTG CCACTATACT CCAACCTGAG AGACAGAGTT TGGGGTTGGC ATCTGTGCCC 2160

CTCCTGAGTG GCCACACCCC CTCTCCTGCC CACCTCGAGA ACAAGAACCT TGTTCATGGT 2220

AATGTGTGTG GCCGGAACAT CCTGCTGGCC CGGCTGGGGC TGGCAGAGGG CACCAGCCCC 2280

TTCATCAAGC TGAGTGATCC CGGCGTGAGC CTGGGCGCCC TCTCCAGGGA GGAGCGGGTG 2340

GAGAGGATCC CCTGGATGGC CCCCGAATGC CTACCAGGTG GGCCCAACAG CCTAAGCACT 2400

GCCATGGACA AGTGGGGGTT TGGCGCCACC CTCCTGGAGA TCTGCTTTGA CGGAGAGGCC 2460

CCTCTGCAGA GCCGCAACCC CTCCGAGAAG GAGCATTTCT ACCAGAGGCA GCACCGGCTG 2520

CCTGAGCCCT CCTGCCCAGA GCTGGCCACA CTCACCAGCC AGTGTCTGAC CTATGAGCCA 2580

ACCCAGAGGC CATCATTCCG CACCATCCTG CGTGACCTCA CCCGGCTGCA GCCCCACAAT 2640

CTTGCTGACA TCTTGACTGT GAACCCGGAC TCACTGGCGT CAGACCCTAC GGTTTTCCAC 2700

AAGCGCTATT TGAAAAAGAT CCGAGATCTG GGCGAGGGTC ACTTCGGCAA GGTCAGCTTG 2760

TACTGCTACG ATCCGACCAA CGACGGCACT GGCGAGATGG TGGCGGTGAA AGCCCTCAAG 2820

GCAGACTGCG GCCCCCAGCA CCGCTTGGGC TGGAAGCAGG AGATTGACAT TCTGCGCACG 2880

CTCTATCACG AGCACATCGT CAAGTACAAG GGCTGCTGCG AGGACCAAGG CGAGAAGTCG 2940

CTGCAGCTGG TCATGGAGTA CGTGCCCCTG GGCAGCCTCC GAGACTACCT GCCCCGGCAC 3000

AGCGTCGGGC TGGCCCAGCT GCTGCTCTTC GCCCAGCAGA TCTGCGAGGG CATGGCCTAT 3060

CTGCACGCGC AGCACTACAT CCACCGAGAC CTAGCCGCGC GCAACGTGCT TCTGGACAAC 3120

GACAGGCTGG TCAAGATCGG GGACTTTGGC CTAGCCAAAG CCGTGCCCGA AGGCCACGAG 3180

TACTACCGCG TGCGCGAGGA TGGGGACAGC CCCGTGTTCT GGTATGCCCC AGAGTGCCTG 3240

AAGGAGTATA AGTTCTACTA TGCGTCCGAT GTCTGGTCGT TCGGGGTGAC CCTGTATGAG 3300

CTGCTGACGC ACTGTGACTC CAGCCAGAGC CCCCCTACGA AATTCCTTGA GCTCATAGGC 3360

GTTGCTCAGG GTCAGATGAC AGTTCTGAGA CTCACCGAGT TGCTGGAACG AGGGGAGAGG 3420

CTGCCACGGC CCAACAAATG TCCCTGTGAG GTCTATCATC TCATGAAGAA CTGCTGGGAG 3480

ACAGAGGCGT CCTTCCGCCC AACCTTTGAG AACCTCATAC CCATCCTGAA GACAGTCCAT 3540

GAGAAGTACC AAGGCCAGGC TCCTTCAGTG TTCAGCGTGT GCTGA 3585

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k+Lk ++g++++ ++k+e++il++l+h

Q: 904   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKaDCGPQHRLGWKQEIDILRTLYH  963

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         ehivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL

Q: 964   EHIVKYKGCCEDQGEKslQLVMEYVPLGSLRDYLPRH--SVGLAQLLLFAQQICEGMAYL  1021

         ****************9********************..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+

Q: 1022  HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  1075

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+e+k +++asdvWsFgvtlyellt c++++sp    l+ ++ +       r++el

Q: 1076  APECLKEYK-FYYASDVWSFGVTLYELLThCDSSQSPptkfLELIGVAqgqmtvlRLTEL  1134

         *********.****************************88855555556667789*****

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         le++erlp+p+ cp+e+++lm+nc+++e+s+rp+F++++

Q: 1135  LERGERLPRPNkCPCEVYHLMKNCWETEASFRPTFENLIP  1174

         ************************************9975

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKALKADC GPQHRLGWKQ EIDILRTLYH 60

EHIVKYKGCC EDQGEKSLQL VMEYVPLGSL RDYLPRHSVG LAQLLLFAQQ ICEGMAYLHA 120

QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEY 180

KFYYASDVWS FGVTLYELLT HCDSSQSPPT KFLELIGVAQ GQMTVLRLTE LLERGERLPR 240

PNKCPCEVYH LMKNCWETEA SFRPTFENLI P 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013