EKS-NOL-00142
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-NOL-00142
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR476.91.4E-143476749274
StatusUnreviewed
Ensembl ProteinENSNLEP00000014960
UniProt AccessionG1RNZ6;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1
Gene Synonyms/Alias FGFR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSNLEG00000012322ENSNLEP00000014960ENSNLET00000015707
OrganismNomascus leucogenys
Functional Description
Protein Length817
Protein Sequence
(FASTA)
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD 60
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120
ALPSSEDDDD DDDSSSEEKE TDNTKPNPVA PYWTSPEKME KKLHAVPAAK TVKFKCPSSG 180
TPNPTLRWLK NGKEFKPDHR IGGYKVRYAT WSIIMDSVVP SDKGNYTCIV ENEYGSINHT 240
YQLDVVERSP HRPILQAGLP ANKTVALGSN VEFMCKVYSD PQPHIQWLKH IEVNGSKIGP 300
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL 360
EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIIYKMKSG TKKSDFHSQM AVHKLAKSIP 420
LRRQVTVSAD SSASMNSGVL LVRPSRLSSS GTPMLAGVSE YELPEDPRWE LPRDRLVLGK 480
PLGEGCFGQV VLAEAIGLDK DKPNRVTKVA VKMLKSDATE KDLSDLISEM EMMKMIGKHK 540
NIINLLGACT QDGPLYVIVE YASKGNLREY LQARRPPGLE YCYNPSHNPE EQLSSKDLVS 600
CAYQVARGME YLASKKCIHR DLAARNVLVT EDNVMKIADF GLARDIHHID YYKKTTNVSA 660
DGAALCWLTP CGSPPICRWS FGVLLWEIFT LGGSPYPGVP VEELFKLLKE GHRMDKPSNC 720
TNELYMMMRD CWHAVPSQRP TFKQLVEDLD RIVALTSNQE YLDLSMPLDQ YSPSFPDTRS 780
STCSSGEDSV FSHEPLPEEP CLPRHPAQLA NGGLKRR 817
Nucleotide Sequence
(FASTA)
ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACC 60
GCTAGGCCGT CCCCGACCTT GCCTGAACAA GCCCAGCCCT GGGGAGCCCC TGTGGAAGTG 120
GAGTCCTTCC TGGTCCACCC CGGTGACCTG CTGCAGCTGC GCTGTCGGCT GCGGGACGAT 180
GTGCAGAGCA TCAACTGGCT GCGGGACGGG GTGCAGCTGG CGGAAAGCAA CCGCACCCGC 240
ATCACAGGGG AGGAGGTAGA GGTGCAGGAC TCCGTGCCCG CAGACTCCGG CCTCTATGCT 300
TGCGTAACCA GCAGCCCCTC GGGCAGTGAC ACCACCTACT TCTCCGTCAA TGTTTCAGAT 360
GCTCTCCCCT CCTCGGAGGA TGATGATGAT GATGATGACT CCTCTTCAGA GGAGAAAGAA 420
ACAGATAACA CCAAACCAAA CCCCGTAGCT CCATATTGGA CATCCCCAGA AAAGATGGAA 480
AAGAAATTGC ATGCAGTGCC GGCTGCCAAG ACAGTGAAGT TCAAATGCCC TTCCAGTGGG 540
ACCCCAAACC CCACACTGCG CTGGTTGAAA AATGGCAAAG AATTCAAACC TGACCACAGA 600
ATTGGAGGCT ACAAGGTCCG TTATGCCACC TGGAGCATCA TAATGGACTC CGTGGTGCCC 660
TCTGACAAGG GCAACTACAC CTGCATTGTG GAGAATGAGT ACGGCAGCAT CAACCACACG 720
TACCAGCTGG ATGTCGTGGA GCGGTCCCCT CACCGGCCCA TCCTGCAAGC AGGGTTGCCC 780
GCCAACAAGA CAGTGGCCCT GGGTAGCAAT GTGGAGTTCA TGTGTAAGGT GTACAGTGAC 840
CCGCAGCCGC ACATCCAGTG GCTAAAGCAC ATCGAGGTGA ACGGGAGCAA GATTGGTCCA 900
GACAACCTGC CTTATGTCCA GATCTTGAAG ACTGCTGGAG TTAATACCAC CGACAAAGAG 960
ATGGAGGTGC TTCACTTAAG AAATGTCTCC TTTGAGGACG CAGGGGAGTA TACGTGCTTG 1020
GCGGGTAACT CTATCGGACT CTCCCATCAC TCTGCATGGT TGACCGTTCT GGAAGCCCTG 1080
GAAGAGAGGC CGGCAGTGAT GACCTCGCCC CTGTACCTGG AGATCATCAT CTATTGCACA 1140
GGGGCCTTCC TCATCTCCTG CATGGTGGGG TCGGTCATCA TCTACAAGAT GAAGAGTGGT 1200
ACCAAGAAGA GTGACTTCCA CAGCCAGATG GCTGTGCACA AGCTGGCCAA GAGCATCCCT 1260
CTGCGCAGAC AGGTAACAGT GTCTGCTGAC TCCAGTGCAT CCATGAACTC TGGGGTTCTT 1320
CTGGTTCGGC CGTCACGGCT CTCTTCCAGT GGGACTCCCA TGCTAGCAGG GGTCTCTGAG 1380
TATGAGCTTC CCGAAGACCC TCGCTGGGAG CTGCCTCGGG ACAGACTGGT CTTAGGCAAA 1440
CCCCTGGGAG AGGGCTGCTT TGGGCAGGTG GTGTTGGCAG AGGCCATCGG GCTGGACAAG 1500
GACAAACCCA ACCGTGTGAC CAAAGTGGCT GTGAAGATGT TGAAGTCGGA CGCAACAGAG 1560
AAAGACTTGT CAGACCTGAT CTCAGAAATG GAGATGATGA AGATGATCGG GAAGCATAAG 1620
AATATCATCA ACCTGCTGGG GGCCTGCACG CAGGATGGTC CCTTGTATGT CATCGTGGAG 1680
TATGCCTCCA AGGGCAACCT GCGGGAGTAC CTGCAGGCCC GGAGGCCCCC AGGGCTGGAA 1740
TACTGCTACA ACCCCAGCCA CAACCCAGAG GAGCAGCTCT CCTCCAAGGA CCTGGTGTCC 1800
TGCGCCTACC AGGTGGCCCG AGGCATGGAG TATCTGGCCT CCAAGAAGTG CATACACCGA 1860
GACCTGGCAG CCAGGAATGT CCTGGTGACA GAGGACAATG TGATGAAGAT AGCAGACTTT 1920
GGCCTCGCAC GGGACATTCA CCACATCGAC TACTATAAAA AGACAACCAA CGTGAGTGCC 1980
GATGGGGCCG CCCTGTGCTG GTTAACACCC TGTGGCTCTC CACCCATTTG CAGGTGGTCT 2040
TTCGGGGTGC TCCTGTGGGA GATCTTCACT CTGGGCGGCT CCCCATACCC CGGTGTGCCT 2100
GTGGAGGAGC TTTTCAAGCT GCTGAAGGAG GGTCACCGCA TGGACAAGCC CAGTAACTGC 2160
ACCAACGAGC TGTACATGAT GATGCGGGAC TGCTGGCATG CAGTGCCCTC ACAGAGACCC 2220
ACCTTCAAGC AGCTGGTGGA AGACCTGGAC CGCATCGTGG CCTTGACCTC CAACCAGGAG 2280
TACCTGGACC TGTCCATGCC CCTGGACCAG TACTCCCCCA GCTTTCCCGA CACCCGGAGC 2340
TCTACGTGCT CCTCAGGGGA GGATTCCGTC TTCTCTCATG AGCCGCTGCC CGAGGAGCCC 2400
TGCCTGCCCC GACACCCAGC CCAGCTTGCC AATGGCGGAC TCAAACGCCG C 2451
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+
Q: 476   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  535
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++
Q: 536   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  595
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt
Q: 596   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  655
         ************************************************************
S: 181   tnGrl...pvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllk  237
         tn       + w++p        +     wsfGvllwei+tlGgspypg++veelfkllk
Q: 656   TNVSAdgaALCWLTPCG------SPPICRWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK  709
         **754111566776654......445567*******************************
S: 238   eGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         eGhrm+kp++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 710   EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  749
         **************************************97
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120
KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180
TNVSADGAAL CWLTPCGSPP ICRWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD 240
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDL 274
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00140
EKS-ANC-00142
EKS-BOT-00147
EKS-CAJ-00152
EKS-CAF-00156
EKS-CAP-00148
EKS-CII-00090
EKS-CIS-00182
EKS-DAR-00434
EKS-EQC-00147
EKS-FEC-00138
EKS-GAM-00076
EKS-GAG-00126
EKS-GAA-00173
EKS-GOG-00148
EKS-HOS-00154
EKS-ICT-00142
EKS-LAC-00157
EKS-LOA-00147
EKS-MAM-00145
EKS-MEG-00114
EKS-MOD-00148
EKS-MUM-00153
EKS-MUP-00152
EKS-MYL-00157
EKS-ORA-00126
EKS-ORC-00139
EKS-ORL-00171
EKS-OTG-00153
EKS-PAT-00139
EKS-PES-00133
EKS-PEM-00079
EKS-POA-00144
EKS-RAN-00147
EKS-SAH-00143
EKS-SUS-00129
EKS-TAG-00177
EKS-TAR-00192
EKS-TEN-00184
EKS-XET-00136
EKS-XIM-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0043410; P:positive regulation of MAPK cascade
GO:0045666; P:positive regulation of neuron differentiation
GO:0010863; P:positive regulation of phospholipase C activity
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013