EKS-NOL-00376

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-NOL-00376

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	474.0	1.1E-142	38	299	262

Status

Unreviewed

Ensembl Protein

ENSNLEP00000015042

UniProt Accession

G1RP78;

Protein Name

Protein Synonyms/Alias

Gene Name

DAPK2

Gene Synonyms/Alias

DAPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSNLEG00000012381	ENSNLEP00000015042	ENSNLET00000015793

Organism

Nomascus leucogenys

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MAVLTTGFFL FQGCMFQASM RSPNMEPFKQ QKVEDFYDIG EELGSGQFAI VKKCREKSTG 60

LEYAAKFIKK RQSRASRRGV SREEIEREVS ILRQVLHHNV ITLHDVYENR TDVVLILELV 120

SGGELFDFLA QKESLSEEEA TSFIKQILDG VNYLHTKKIA HFDLKPENIM LLDKNIPIPH 180

IKLIDFGLAH EIEDGVEFKN IFGTPEFVAP EIVNYEPLGL EADMWSIGVI TYILLSGASP 240

FLGDTKQETL ANITAVSYDF DEEFFSQTSE LAKDFIRKLL VKETRKRLTI QEALRHPWIT 300

PVDNQQAMVR RESVVNLENF RKQYVRRRWK LSFSIVSLCN HLTRSLMKKV HLRPDEDLRN 360

CESDTEEDIA RRKALHPRRR SSTS 384

Nucleotide Sequence
(FASTA)

ATGGCTGTCC TAACCACAGG TTTCTTCCTA TTTCAGGGTT GTATGTTCCA GGCCTCAATG 60

AGGAGTCCAA ACATGGAGCC ATTCAAGCAG CAGAAGGTGG AGGACTTTTA TGACATCGGA 120

GAGGAGCTGG GGAGTGGCCA GTTTGCCATC GTGAAGAAGT GCCGGGAGAA GAGCACGGGG 180

CTTGAGTATG CAGCCAAGTT CATCAAGAAG CGGCAGAGCC GGGCGAGCCG GCGCGGTGTG 240

AGCCGGGAGG AGATCGAGCG GGAGGTGAGC ATCCTGCGGC AGGTGCTGCA CCACAATGTC 300

ATCACACTGC ACGACGTCTA CGAGAACCGC ACCGACGTGG TGCTCATCCT TGAGCTAGTG 360

TCTGGCGGAG AGCTCTTCGA TTTCCTGGCC CAGAAGGAGT CACTGAGTGA GGAGGAGGCC 420

ACCAGCTTCA TTAAGCAGAT CCTGGATGGG GTGAACTACC TTCACACAAA GAAAATTGCT 480

CACTTTGATC TCAAGCCAGA AAACATTATG TTGTTAGACA AGAATATTCC CATTCCACAC 540

ATCAAGCTGA TTGACTTTGG TCTGGCTCAC GAAATAGAAG ACGGAGTTGA ATTTAAGAAT 600

ATTTTTGGGA CGCCGGAATT TGTTGCTCCA GAAATTGTGA ACTACGAGCC CCTGGGTCTG 660

GAGGCTGACA TGTGGAGCAT AGGCGTCATC ACCTACATCC TCTTAAGTGG AGCATCCCCT 720

TTCCTGGGAG ACACGAAGCA GGAAACACTG GCAAATATCA CAGCAGTGAG TTACGACTTT 780

GATGAGGAAT TCTTCAGCCA GACGAGCGAG CTGGCCAAGG ACTTCATTCG GAAGCTTCTG 840

GTTAAAGAGA CTCGGAAACG GCTCACAATC CAAGAGGCTC TCAGACACCC CTGGATCACG 900

CCAGTGGACA ACCAGCAAGC CATGGTGCGC AGGGAGTCTG TGGTCAATCT GGAGAACTTC 960

AGGAAGCAGT ATGTCCGCAG GCGGTGGAAG CTCTCCTTCA GCATCGTGTC CCTGTGCAAC 1020

CACCTCACCC GCTCGCTGAT GAAGAAGGTG CACCTGAGGC CGGATGAGGA CCTGAGGAAC 1080

TGTGAGAGTG ACACTGAGGA GGACATTGCC AGGAGGAAAG CCCTCCACCC TCGGAGGAGG 1140

AGCAGCACCT CCTAA 1155

Domain Profile

S: 2     etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs  61

         ++g+elgsG+fa+v+kcrekstG eyaakf+kkr++++srrgvsreeierev++l+++

Q: 38    DIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL-  96

         689********************************************************.

S: 62    epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs  121

         ++nvi+lh+vyen++dv+lilelv+GGelfd+la+keslseeeat+++kqil+gv+ylh+

Q: 97    HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT  156

         9***********************************************************

S: 122   kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye  181

         kki+h+dlkPeni+lldk++p ++iklidfGl+++ie+g+e+k+i+GtPefvaPeivnye

Q: 157   KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE  216

         ************************************************************

S: 182   plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi  241

         pl+le+dmwsiGvityillsgasPflGdtkqetl+ni+av++df+ee+fs++selakdfi

Q: 217   PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFI  276

         ************************************************************

S: 242   rrllvkdpekrltieeclehswl  264

         r+llvk+++krlti+e+l+h+w+

Q: 277   RKLLVKETRKRLTIQEALRHPWI  299

         **********************8

Domain Sequence
(FASTA)

DIGEELGSGQ FAIVKKCREK STGLEYAAKF IKKRQSRASR RGVSREEIER EVSILRQVLH 60

HNVITLHDVY ENRTDVVLIL ELVSGGELFD FLAQKESLSE EEATSFIKQI LDGVNYLHTK 120

KIAHFDLKPE NIMLLDKNIP IPHIKLIDFG LAHEIEDGVE FKNIFGTPEF VAPEIVNYEP 180

LGLEADMWSI GVITYILLSG ASPFLGDTKQ ETLANITAVS YDFDEEFFSQ TSELAKDFIR 240

KLLVKETRKR LTIQEALRHP WI 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043276	; P:anoikis
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013